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AARVARTVRAAVATLMTATVLSGCATNGLGDLPLPAPGIGSGGYRLTALFSNVLNLPDSAKVKLAGADVG QVDEMHVRNFTAVTTLRILDGVRLPKGSTAELRSATPLGDVFVSIRPPAGASADGPLLTDGDTIGLDSTT AAATVESVLSSAALASNGGAVRNLTNVVNGFGKATGDQGQAFGDLINDSNRLLGALNSRSVQISEALTQT SQLADQLDAKNQVVTDIVTAAGPATETLASNTAQLSELLLMMGDTTRQLQKFPSIAGTDTSGRSIIADAN TIAKAWNDVAVDPDTSLAAFNRIFPTAIKATAGNSLSLHASLDQLVLGSIPDVGSYADVGLHGPKRYNWA QLAGSVKYTLWRLQERVVGKGAFGQEAPVGPSPTEPGVIEPVPPAPGPGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4512c | - | - | 100% (401) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1006c | - | e-173 | 76.13% (398) | putative MCE family protein |
| M. abscessus ATCC 19977 | MAB_4564c | - | e-135 | 60.88% (386) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 2e-21 | 28.17% (252) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0006 | - | 1e-143 | 64.91% (399) | hypothetical protein Mflv_0006 |
| M. tuberculosis H37Rv | Rv1970 | lprM | 4e-22 | 26.64% (259) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 3e-24 | 27.51% (269) | putative lipoprotein |
| M. marinum M | MMAR_3868 | mce5E | 1e-145 | 65.23% (394) | Mce family protein, Mce5E |
| M. avium 104 | MAV_2384 | - | 1e-145 | 65.00% (400) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1147 | - | 1e-143 | 63.87% (393) | mce related protein |
| M. thermoresistible (build 8) | TH_4097 | - | 1e-137 | 61.77% (395) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_3800 | mce5E | 1e-143 | 64.72% (394) | Mce family protein, Mce5E |
| M. vanbaalenii PYR-1 | Mvan_0963 | - | 1e-139 | 61.31% (398) | hypothetical protein Mvan_0963 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3868|M.marinum_M --------MSGFG-----KAAAAIAMTTLLSSGCAANGLDSLPLP-APTL
MUL_3800|M.ulcerans_Agy99 --------MSGFG-----KAAAAIAVTTLLSSGCAANGLDSLPLP-APTL
MAV_2384|M.avium_104 --------MTATGARGRLTALAAAMAVTTATAGCATNGLASLPLP-APGL
MAB_4512c|M.abscessus_ATCC_199 --------MAARVAR-TVRAAVATLMTATVLSGCATNGLGDLPLP-APGI
Mflv_0006|M.gilvum_PYR-GCK -----------MMTRRAATALAVAMTTCLSVTSCATEGLSSLPLP-APGG
Mvan_0963|M.vanbaalenii_PYR-1 ------------MAIRAKGLMALLVTTSLSVSACATEGLASLPLP-APSG
MSMEG_1147|M.smegmatis_MC2_155 ------MMAASPKRLRKVRLVAAFAMT-VIVSGCATNGLADLPLP-APGV
TH_4097|M.thermoresistible__bu ---------MSVLRLR--RLVPALVTVGCLVSGCATNGLADLPLP-APGV
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
Rv1970|M.tuberculosis_H37Rv -----------------MRIGLTLVMIAAVVASCGWRGLNSLPLPGTQGN
:.*. .*: .:.:*
MMAR_3868|M.marinum_M GSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVARNYTAVTRLRIT
MUL_3800|M.ulcerans_Agy99 GSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVARNYTAVTRLRIT
MAV_2384|M.avium_104 GSGGYSLNAVFSNALNLPMNAKVKLAGADVGQLESMVARNYTALTRLRIR
MAB_4512c|M.abscessus_ATCC_199 GSGGYRLTALFSNVLNLPDSAKVKLAGADVGQVDEMHVRNFTAVTTLRIL
Mflv_0006|M.gilvum_PYR-GCK GSGGYTLTAVFSNALNLPAMAKVKLAGADIGQLESMQARDYTAVTTLRIR
Mvan_0963|M.vanbaalenii_PYR-1 GSGGYTLTAVFSNALNVPMMAKVKLAGADVGELESMQARDYTAVTTLRIR
MSMEG_1147|M.smegmatis_MC2_155 GSGGYRITAIFSNALNLPANAKVKLAGADIGEMDSMVARNYTAVTTLRIM
TH_4097|M.thermoresistible__bu GSGGYRLTAEFTNALNLPANAKVKLAGADVGEVESMVARDYLAVTTLRIM
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLK
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLKNWVATLTLGLN
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQGWHALVTMRLD
* *.: : . ..:. : ::* :*.. :* : : :.: * : :
MMAR_3868|M.marinum_M DDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAMLKDGDTIGLDST
MUL_3800|M.ulcerans_Agy99 DDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAMLKDGDTIGLDST
MAV_2384|M.avium_104 DGVQLPRGSTAELRTATPLGDVFVALKPPPGD-HDAPLLKNGDTIGLEST
MAB_4512c|M.abscessus_ATCC_199 DGVRLPKGSTAELRSATPLGDVFVSIRPPAGASADGPLLTDGDTIGLDST
Mflv_0006|M.gilvum_PYR-GCK EGVLLPVGSTAELRSATPLGDVFVSIKPPPSAGQGTPLLTDGDTIGLEST
Mvan_0963|M.vanbaalenii_PYR-1 EGVQLPKGSTAELRSATPLGDVFIAIKPPPSVQPGAALLRDGDTIGLEST
MSMEG_1147|M.smegmatis_MC2_155 EGVRLPEGSTAELRSATPLGDVFIAIKPPAPVEPGTPLLKDGDTIDLDAT
TH_4097|M.thermoresistible__bu DGVRLPRGSTAELRSATPLGDVFVAIKPPIDVPPDTPMLRDGDTIGKDST
Mb0179|M.bovis_AF2122/97 KDVTLPKNATAKIGQTSLLGSQHVELAAPP-DPSPVPLK-DGDTIPLKRS
MLBr_02593|M.leprae_Br4923 KDVQLPKNTTAKIGQTSLLGSQHVELAAPA-NPSLELLK-NGDTIPLKNS
Rv1970|M.tuberculosis_H37Rv GDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLR-DGSLIALSHG
.* ** .:**:: :: **. .: : .* : :*. * .
MMAR_3868|M.marinum_M TAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGDQGQAFGNLIRKS
MUL_3800|M.ulcerans_Agy99 TAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGDQGQAFGNLIRKS
MAV_2384|M.avium_104 AAAATVESVLSSAAVLVNGGAVRNFTNIINGFGKATGDQGQAFGDMIRKS
MAB_4512c|M.abscessus_ATCC_199 TAAATVESVLSSAALASNGGAVRNLTNVVNGFGKATGDQGQAFGDLINDS
Mflv_0006|M.gilvum_PYR-GCK TAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGQAFGELIRKT
Mvan_0963|M.vanbaalenii_PYR-1 TAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGRAFGDLIRKT
MSMEG_1147|M.smegmatis_MC2_155 AAAATVESVLSSAAILVNGGAVRNFTNLINGMGKATGDQGQAFGNLIRKT
TH_4097|M.thermoresistible__bu KAAATVESVLASAAILVNGGAVRNFTNIINGLGKATGDEGQAFGNLVRKT
Mb0179|M.bovis_AF2122/97 SAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKL
MLBr_02593|M.leprae_Br4923 SVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAFLTKL
Rv1970|M.tuberculosis_H37Rv SAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGLIGQL
. .:.*..*:: : .**.: :. : : . .. : :: .
MMAR_3868|M.marinum_M NRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTELMAAAEPAADALA
MUL_3800|M.ulcerans_Agy99 NRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTELMAAAEPAADALA
MAV_2384|M.avium_104 NELLGTLDARSDQISAALTQLSTLADQLDAKNHTITDLMTAAGPATSALA
MAB_4512c|M.abscessus_ATCC_199 NRLLGALNSRSVQISEALTQTSQLADQLDAKNQVVTDIVTAAGPATETLA
Mflv_0006|M.gilvum_PYR-GCK NHTLGTLNGRSEEIKTALTETSQLAAQLEAKNQSLAEVMDAAAPATSTLA
Mvan_0963|M.vanbaalenii_PYR-1 NSTLGTMNARSGEISTAITETSRLAAQMEAKNAALGEVMDAAGPAADTLA
MSMEG_1147|M.smegmatis_MC2_155 NNTLATLTARSEEISTAMTETSRLAQQISAKNQALSDVMAQARPATDTLA
TH_4097|M.thermoresistible__bu NATLAKLNARSAEISTAMTETSRLASEIAAKNQVLSEVMAEARPATDTLA
Mb0179|M.bovis_AF2122/97 DTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLIKHFA
MLBr_02593|M.leprae_Br4923 DTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLIKHFA
Rv1970|M.tuberculosis_H37Rv DTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDALAVLA
: : : :* . . * . :. . : :*
MMAR_3868|M.marinum_M ANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIRDLNTIAGAANDI
MUL_3800|M.ulcerans_Agy99 ANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIRDLNTIAGAANDI
MAV_2384|M.avium_104 DNTGELSEVAQQVGDTSRLLARFPALGGTDTSGRSMIRDLNTIAGAANDV
MAB_4512c|M.abscessus_ATCC_199 SNTAQLSELLLMMGDTTRQLQKFPSIAGTDTSGRSIIADANTIAKAWNDV
Mflv_0006|M.gilvum_PYR-GCK AQTNGIADLVLTVGATTEQLRKFPSIAGTDTSGRSVIADASRIAGAWNDV
Mvan_0963|M.vanbaalenii_PYR-1 AHTDEIADLVQQVGATAELLRRFPSIAGSDTSGRSVIADANQIAGAWNDV
MSMEG_1147|M.smegmatis_MC2_155 AHTTQIADLVTQIGDVSDQLRKFPSIAGADTSGRSVIADANTVAGAWNDV
TH_4097|M.thermoresistible__bu GHATEIADLVERFGGISDQAHRFPSIAGTDTSGRSVIADANTIANAWNDV
Mb0179|M.bovis_AF2122/97 DKQELLINASDAVGRLSQSADQYLSAARGD-----LHQDLQALQCPLKEL
MLBr_02593|M.leprae_Br4923 DTKNLLINAVGSVGQLSQAVDQYLSEARGP-----LHTDLQALACPLREL
Rv1970|M.tuberculosis_H37Rv DERDTLVEAAEQLSKFSALTVDSVNKTTAN-----LVTELRQLGPVLESL
: : .. : : : : ..:
MMAR_3868|M.marinum_M AVSPDTSWLALNRMIPPMVKSTAGGALSVRASVDRLVLGSIPDIGFPGDI
MUL_3800|M.ulcerans_Agy99 AVSPDTSWLALNRMIPPMVKSTARGALSVRASVDRLVLGSIPDIGFPGDV
MAV_2384|M.avium_104 AVSPDTSWQSINRLIPALVKSTAGNSISVNVSVDKIMLGSLPDIGFPGDI
MAB_4512c|M.abscessus_ATCC_199 AVDPDTSLAAFNRIFPTAIKATAGNSLSLHASLDQLVLGSIPDVGSYADV
Mflv_0006|M.gilvum_PYR-GCK VLAPGADLYSLNRLMPPFIKSTTSNAIAVRASIDRLVLGSIPDIGFAGDP
Mvan_0963|M.vanbaalenii_PYR-1 VLAPGADLYSLNKLMPPFIKSTTSNAIAVNASIDRLVLGSIPDIGFAGDS
MSMEG_1147|M.smegmatis_MC2_155 ALAPDATLYALNRLLPPFIKSMSSGAISLDASVDRLILGSTPDIGFAGDQ
TH_4097|M.thermoresistible__bu ALAPGATLYALNRLMPPFIKTMSGGSVALDASVDRLVWGHHPDIGFAGDP
Mb0179|M.bovis_AF2122/97 RRAAPYLVGALKLILTQPFDVDT---------VPQLVRGDYMNLSLTLDL
MLBr_02593|M.leprae_Br4923 GRGAPYFIGAMKLILTQPYDVDT---------VPKIMRGDYQNVSLTLDV
Rv1970|M.tuberculosis_H37Rv ANSGPALTRSLSLLATFPFPNET---------FQNFQRGEYANLTAIVDL
::. : . : . .: * :: *
MMAR_3868|M.marinum_M GLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQLPVMPDPEVPGEI
MUL_3800|M.ulcerans_Agy99 GLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQLPVMPDPEVPDEI
MAV_2384|M.avium_104 GLHGPHHYNVNLLVGTLKYTLWRLQERVVGRGPNAPQVPVVPDPTVPGQI
MAB_4512c|M.abscessus_ATCC_199 GLHGPKRYNWAQLAGSVKYTLWRLQERVVGKGAFGQEAPVGPSPTEPGVI
Mflv_0006|M.gilvum_PYR-GCK GLHGPKRYNWHQLVGSLRYTLLRLQERVVGKGPGVPQMPVIPSPTEPGQW
Mvan_0963|M.vanbaalenii_PYR-1 GLHGPKRYNWHQLVGSLQYTLYRLQERIVGKGPGVPQVPVMPHPTEPGLI
MSMEG_1147|M.smegmatis_MC2_155 GLHGPKRHDWHQLVGTLKYTLLRLQERVVGQGPGVPQVPVIPSPTEPGEI
TH_4097|M.thermoresistible__bu GLHGPKWSDWHQLVGTLQYTLFRLQERVVGKGPDVPQLPVIPSPTEPGEI
Mb0179|M.bovis_AF2122/97 TYS---AIDNAFLTGTGFSGALRALEQSFGRD-PETMIPDIRYTPNPNDA
MLBr_02593|M.leprae_Br4923 TYS---AMDNAVLTGTGLSGALRALEQSFGRD-PETMIPDVRYTTNPNDA
Rv1970|M.tuberculosis_H37Rv TLS---RIDQGLLTGTRWECHLTQLELQWGR--TIGQFPSP-CTAGYRGT
: : *: * *: * .
MMAR_3868|M.marinum_M QIAPPLSPQPPGPPP---------------------
MUL_3800|M.ulcerans_Agy99 QIAPPLSPQPPGPPP---------------------
MAV_2384|M.avium_104 DVAPGPPPPQPGSPP---------------------
MAB_4512c|M.abscessus_ATCC_199 EPVP--PAPGPGR-----------------------
Mflv_0006|M.gilvum_PYR-GCK APAPPPGPVPPGPAP-----------AVAPPAPGVP
Mvan_0963|M.vanbaalenii_PYR-1 VPVPAPAP-PPG--------------APAPEAPR--
MSMEG_1147|M.smegmatis_MC2_155 IVEPGAAAPPEDAPAPEPAPAAQAPAPLPAEAPR--
TH_4097|M.thermoresistible__bu IPAPGPAAG-----------------AAPEEAPR--
Mb0179|M.bovis_AF2122/97 PGGPLVERGNRQC-----------------------
MLBr_02593|M.leprae_Br4923 PGGPLVERADRRC-----------------------
Rv1970|M.tuberculosis_H37Rv PGNPLTIAYRWDQGP---------------------
*