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MKAGKRKALAVACSAVMASSGCATNGLASLPLPAPGIGSGGYLLNAVFSNALNLPAHAKVKLAGADVGQL ESMVARNYTAVTTLRIMDGVRVPVGSTAELRSATPLGDVFVAIKPPVPADPSAPLLKAGDTIGLPATRAA ATVESVLSSAALLVNGGAVRNFTNIVNGAGKATGDQGRAFGDLINRTNSLLTKLNARSDQIDAAVTETAA LADRLDAKNQAITDVLRAVGPATDVLSGNADDIADVVDELGATTRQLSKFPSIAGTDKTGRSVIKDANAI AAAWNDVVLSPDTSLAGLNRLIPPFVKATPSQAISVRGSFDRLVLGSRPGTGAETGGFKGDPAFHGPMRR DWNYLIGSIKYVLWRLQERVVGRGPQTPMGQSPWTPSGPPLPPAPAGQAPPDPMVPEPPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0106 | - | - | 100% (410) | mce related protein |
| M. avium 104 | MAV_2384 | - | e-138 | 62.56% (406) | mce related protein |
| M. avium 104 | MAV_5011 | - | 2e-22 | 25.90% (251) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 2e-23 | 24.67% (381) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0006 | - | 1e-141 | 64.88% (410) | hypothetical protein Mflv_0006 |
| M. tuberculosis H37Rv | Rv0593 | lprL | 3e-24 | 28.83% (326) | MCE-family lipoprotein LprL |
| M. leprae Br4923 | MLBr_02593 | lprK | 7e-23 | 26.34% (262) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4512c | - | 1e-134 | 62.69% (394) | putative Mce family protein |
| M. marinum M | MMAR_3868 | mce5E | 1e-134 | 60.74% (405) | Mce family protein, Mce5E |
| M. smegmatis MC2 155 | MSMEG_1147 | - | 1e-141 | 60.99% (423) | mce related protein |
| M. thermoresistible (build 8) | TH_4097 | - | 1e-134 | 61.68% (394) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_3800 | mce5E | 1e-134 | 60.74% (405) | Mce family protein, Mce5E |
| M. vanbaalenii PYR-1 | Mvan_0963 | - | 1e-138 | 62.53% (403) | hypothetical protein Mvan_0963 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3868|M.marinum_M -------------------------MSGFGKAAAAIAMTTLLSSGCAANG
MUL_3800|M.ulcerans_Agy99 -------------------------MSGFGKAAAAIAVTTLLSSGCAANG
MAB_4512c|M.abscessus_ATCC_199 ---------------------MAARVARTVRAAVATLMTATVLSGCATNG
Mflv_0006|M.gilvum_PYR-GCK -----------------------MMTRRAATALAVAMTTCLSVTSCATEG
Mvan_0963|M.vanbaalenii_PYR-1 ------------------------MAIRAKGLMALLVTTSLSVSACATEG
MSMEG_1147|M.smegmatis_MC2_155 ------------------MMAASPKRLRKVRLVAAFAMT-VIVSGCATNG
TH_4097|M.thermoresistible__bu ---------------------MSVLRLR--RLVPALVTVGCLVSGCATNG
MAV_0106|M.avium_104 ------------------------MKAGKRKALAVACSAVMASSGCATNG
Mb0179|M.bovis_AF2122/97 ---MMSVLAR--------MRVMRHRAWQG----LVLLVLALLLSSCGWRG
MLBr_02593|M.leprae_Br4923 MRRAMSVVHT--------SRVR-HQTWRG----LVMLVAALLLSSCGWRG
Rv0593|M.tuberculosis_H37Rv MRCGVSAGSANGKPNRWTLRCGVSAGHRGSVFLLAVLLAPVVLTSCTWRG
:.* .*
MMAR_3868|M.marinum_M LDSLPLP-APTLGSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVA
MUL_3800|M.ulcerans_Agy99 LDSLPLP-APTLGSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVA
MAB_4512c|M.abscessus_ATCC_199 LGDLPLP-APGIGSGGYRLTALFSNVLNLPDSAKVKLAGADVGQVDEMHV
Mflv_0006|M.gilvum_PYR-GCK LSSLPLP-APGGGSGGYTLTAVFSNALNLPAMAKVKLAGADIGQLESMQA
Mvan_0963|M.vanbaalenii_PYR-1 LASLPLP-APSGGSGGYTLTAVFSNALNVPMMAKVKLAGADVGELESMQA
MSMEG_1147|M.smegmatis_MC2_155 LADLPLP-APGVGSGGYRITAIFSNALNLPANAKVKLAGADIGEMDSMVA
TH_4097|M.thermoresistible__bu LADLPLP-APGVGSGGYRLTAEFTNALNLPANAKVKLAGADVGEVESMVA
MAV_0106|M.avium_104 LASLPLP-APGIGSGGYLLNAVFSNALNLPAHAKVKLAGADVGQLESMVA
Mb0179|M.bovis_AF2122/97 ISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKL
MLBr_02593|M.leprae_Br4923 ISNVSIPGGPGSGKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINL
Rv0593|M.tuberculosis_H37Rv IANVPLPVGRGMGPDRMTIYVQMPDTLALNTNSRVRVADVWVGTVRDISL
: .:.:* . * . : . ..:.* : ::* :*.. :* : :
MMAR_3868|M.marinum_M RNYTAVTRLRITDDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAM
MUL_3800|M.ulcerans_Agy99 RNYTAVTRLRITDDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAM
MAB_4512c|M.abscessus_ATCC_199 RNFTAVTTLRILDGVRLPKGSTAELRSATPLGDVFVSIRPPAGASADGPL
Mflv_0006|M.gilvum_PYR-GCK RDYTAVTTLRIREGVLLPVGSTAELRSATPLGDVFVSIKPPPSAGQGTPL
Mvan_0963|M.vanbaalenii_PYR-1 RDYTAVTTLRIREGVQLPKGSTAELRSATPLGDVFIAIKPPPSVQPGAAL
MSMEG_1147|M.smegmatis_MC2_155 RNYTAVTTLRIMEGVRLPEGSTAELRSATPLGDVFIAIKPPAPVEPGTPL
TH_4097|M.thermoresistible__bu RDYLAVTTLRIMDGVRLPRGSTAELRSATPLGDVFVAIKPPIDVPPDTPM
MAV_0106|M.avium_104 RNYTAVTTLRIMDGVRVPVGSTAELRSATPLGDVFVAIKPPVPADPSAPL
Mb0179|M.bovis_AF2122/97 KNWVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPP--DPSPVP
MLBr_02593|M.leprae_Br4923 KNWVATLTLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPA--NPSLEL
Rv0593|M.tuberculosis_H37Rv RNWIATLTLELEPTVRLPANATAKIGQTSLLGTQHVELAAPP--IPSPQP
::: *. * : * :* .:**:: :: ** .: : .*
MMAR_3868|M.marinum_M LKDGDTIGLDSTTAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGD
MUL_3800|M.ulcerans_Agy99 LKDGDTIGLDSTTAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGD
MAB_4512c|M.abscessus_ATCC_199 LTDGDTIGLDSTTAAATVESVLSSAALASNGGAVRNLTNVVNGFGKATGD
Mflv_0006|M.gilvum_PYR-GCK LTDGDTIGLESTTAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGD
Mvan_0963|M.vanbaalenii_PYR-1 LRDGDTIGLESTTAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGD
MSMEG_1147|M.smegmatis_MC2_155 LKDGDTIDLDATAAAATVESVLSSAAILVNGGAVRNFTNLINGMGKATGD
TH_4097|M.thermoresistible__bu LRDGDTIGKDSTKAAATVESVLASAAILVNGGAVRNFTNIINGLGKATGD
MAV_0106|M.avium_104 LKAGDTIGLPATRAAATVESVLSSAALLVNGGAVRNFTNIVNGAGKATGD
Mb0179|M.bovis_AF2122/97 LKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTG
MLBr_02593|M.leprae_Br4923 LKNGDTIPLKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHG
Rv0593|M.tuberculosis_H37Rv LKSGDTIGLKNSSAYPTVERTLASVALILTGGGIVNLDVIQTEILNILDG
* **** : . .*.* .*:* : **.: *: : .
MMAR_3868|M.marinum_M QGQAFGNLIRKSNRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTEL
MUL_3800|M.ulcerans_Agy99 QGQAFGNLIRKSNRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTEL
MAB_4512c|M.abscessus_ATCC_199 QGQAFGDLINDSNRLLGALNSRSVQISEALTQTSQLADQLDAKNQVVTDI
Mflv_0006|M.gilvum_PYR-GCK QGQAFGELIRKTNHTLGTLNGRSEEIKTALTETSQLAAQLEAKNQSLAEV
Mvan_0963|M.vanbaalenii_PYR-1 QGRAFGDLIRKTNSTLGTMNARSGEISTAITETSRLAAQMEAKNAALGEV
MSMEG_1147|M.smegmatis_MC2_155 QGQAFGNLIRKTNNTLATLTARSEEISTAMTETSRLAQQISAKNQALSDV
TH_4097|M.thermoresistible__bu EGQAFGNLVRKTNATLAKLNARSAEISTAMTETSRLASEIAAKNQVLSEV
MAV_0106|M.avium_104 QGRAFGDLINRTNSLLTKLNARSDQIDAAVTETAALADRLDAKNQAITDV
Mb0179|M.bovis_AF2122/97 RADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRV
MLBr_02593|M.leprae_Br4923 RADQIHAFLTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQI
Rv0593|M.tuberculosis_H37Rv HAGQIREFLERLATFTAELNNQRGDLTRAIDSTNQLLTIIANRNDTLDRV
.. : :: : : :: .: . * : :. : :
MMAR_3868|M.marinum_M MAAAEPAADALAANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIR
MUL_3800|M.ulcerans_Agy99 MAAAEPAADALAANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIR
MAB_4512c|M.abscessus_ATCC_199 VTAAGPATETLASNTAQLSELLLMMGDTTRQLQKFPSIAGTDTSGRSIIA
Mflv_0006|M.gilvum_PYR-GCK MDAAAPATSTLAAQTNGIADLVLTVGATTEQLRKFPSIAGTDTSGRSVIA
Mvan_0963|M.vanbaalenii_PYR-1 MDAAGPAADTLAAHTDEIADLVQQVGATAELLRRFPSIAGSDTSGRSVIA
MSMEG_1147|M.smegmatis_MC2_155 MAQARPATDTLAAHTTQIADLVTQIGDVSDQLRKFPSIAGADTSGRSVIA
TH_4097|M.thermoresistible__bu MAEARPATDTLAGHATEIADLVERFGGISDQAHRFPSIAGTDTSGRSVIA
MAV_0106|M.avium_104 LRAVGPATDVLSGNADDIADVVDELGATTRQLSKFPSIAGTDKTGRSVIK
Mb0179|M.bovis_AF2122/97 LTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAARGD-----LHQ
MLBr_02593|M.leprae_Br4923 LTDIPPLIKHFADTKNLLINAVGSVGQLSQAVDQYLSEARGP-----LHT
Rv0593|M.tuberculosis_H37Rv LTDVPPLIEHFADTGQLFADATESLGRFSEVANRALAATRPN-----LHQ
: * . :: : : .* : : : :
MMAR_3868|M.marinum_M DLNTIAGAANDIAVSPDTSWLALNRMIPPMVKSTAGGALSVRASVDRLVL
MUL_3800|M.ulcerans_Agy99 DLNTIAGAANDIAVSPDTSWLALNRMIPPMVKSTARGALSVRASVDRLVL
MAB_4512c|M.abscessus_ATCC_199 DANTIAKAWNDVAVDPDTSLAAFNRIFPTAIKATAGNSLSLHASLDQLVL
Mflv_0006|M.gilvum_PYR-GCK DASRIAGAWNDVVLAPGADLYSLNRLMPPFIKSTTSNAIAVRASIDRLVL
Mvan_0963|M.vanbaalenii_PYR-1 DANQIAGAWNDVVLAPGADLYSLNKLMPPFIKSTTSNAIAVNASIDRLVL
MSMEG_1147|M.smegmatis_MC2_155 DANTVAGAWNDVALAPDATLYALNRLLPPFIKSMSSGAISLDASVDRLIL
TH_4097|M.thermoresistible__bu DANTIANAWNDVALAPGATLYALNRLMPPFIKTMSGGSVALDASVDRLVW
MAV_0106|M.avium_104 DANAIAAAWNDVVLSPDTSLAGLNRLIPPFVKATPSQAISVRGSFDRLVL
Mb0179|M.bovis_AF2122/97 DLQALQCPLKELRRAAPYLVGALKLILTQPFDVD---------TVPQLVR
MLBr_02593|M.leprae_Br4923 DLQALACPLRELGRGAPYFIGAMKLILTQPYDVD---------TVPKIMR
Rv0593|M.tuberculosis_H37Rv TLQSLQRPLRQLERASPYVVGALKLGLTAPFNID---------EVPNVIR
. : . .:: . .:: :. . . .::
MMAR_3868|M.marinum_M GSIPDIG-----FPGDIGLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGP
MUL_3800|M.ulcerans_Agy99 GSIPDIG-----FPGDVGLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGP
MAB_4512c|M.abscessus_ATCC_199 GSIPDVG-----SYADVGLHGPKRYNWAQLAGSVKYTLWRLQERVVGKGA
Mflv_0006|M.gilvum_PYR-GCK GSIPDIG-----FAGDPGLHGPKRYNWHQLVGSLRYTLLRLQERVVGKGP
Mvan_0963|M.vanbaalenii_PYR-1 GSIPDIG-----FAGDSGLHGPKRYNWHQLVGSLQYTLYRLQERIVGKGP
MSMEG_1147|M.smegmatis_MC2_155 GSTPDIG-----FAGDQGLHGPKRHDWHQLVGTLKYTLLRLQERVVGQGP
TH_4097|M.thermoresistible__bu GHHPDIG-----FAGDPGLHGPKWSDWHQLVGTLQYTLFRLQERVVGKGP
MAV_0106|M.avium_104 GSRPGTGAETGGFKGDPAFHGPMRRDWNYLIGSIKYVLWRLQERVVGRGP
Mb0179|M.bovis_AF2122/97 GDYMNLS-----LTLDLTYS---AIDNAFLTGTGFSGALRALEQSFGRDP
MLBr_02593|M.leprae_Br4923 GDYQNVS-----LTLDVTYS---AMDNAVLTGTGLSGALRALEQSFGRDP
Rv0593|M.tuberculosis_H37Rv GDYVNVS-----ATFDVTLS---ALDNALLSGTGISGMLRALEQAWGRDP
* . . * : : *: * *: *:..
MMAR_3868|M.marinum_M GSPQLPVMPDPEVPGEIQIAPPLSP-------------------QPPGPP
MUL_3800|M.ulcerans_Agy99 GSPQLPVMPDPEVPDEIQIAPPLSP-------------------QPPGPP
MAB_4512c|M.abscessus_ATCC_199 FGQEAPVGPSPTEPGVIEPVPP-----------------------APGPG
Mflv_0006|M.gilvum_PYR-GCK GVPQMPVIPSPTEPGQWAPAPPPGPVPPGPAP-----------AVAPPAP
Mvan_0963|M.vanbaalenii_PYR-1 GVPQVPVMPHPTEPGLIVPVPAPAP-PPG--------------APAPEAP
MSMEG_1147|M.smegmatis_MC2_155 GVPQVPVIPSPTEPGEIIVEPGAAAPPEDAPAPEPAPAAQAPAPLPAEAP
TH_4097|M.thermoresistible__bu DVPQLPVIPSPTEPGEIIPAPGPAAG-----------------AAPEEAP
MAV_0106|M.avium_104 QTPMGQSPWTPSGP-PLPPAPAGQAPPD---------------PMVPEPP
Mb0179|M.bovis_AF2122/97 E-TMIPDIRYTPNPNDAPGGPLVER---------------------GNRQ
MLBr_02593|M.leprae_Br4923 E-TMIPDVRYTTNPNDAPGGPLVER---------------------ADRR
Rv0593|M.tuberculosis_H37Rv D-TMIPDVRYTPNPNDAPGGPLVER---------------------AE--
. * *
MMAR_3868|M.marinum_M P--
MUL_3800|M.ulcerans_Agy99 P--
MAB_4512c|M.abscessus_ATCC_199 R--
Mflv_0006|M.gilvum_PYR-GCK GVP
Mvan_0963|M.vanbaalenii_PYR-1 R--
MSMEG_1147|M.smegmatis_MC2_155 R--
TH_4097|M.thermoresistible__bu R--
MAV_0106|M.avium_104 R--
Mb0179|M.bovis_AF2122/97 C--
MLBr_02593|M.leprae_Br4923 C--
Rv0593|M.tuberculosis_H37Rv ---