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VRCGVSAGSANGKPNRWTLRCGVSAGHRGSVFLLAVLLAPVVLTSCTWRGIANVPLPVGRGMGPDRMTIY VQMPDTLALNTNSRVRVADVWVGTVRDISLRNWIATLTLELEPTVRLPANATAKIGQTSLLGTQHVELAA PPIPSPQPLKSGDTIGLKNSSAYPTVERTLASVALILTGGGIVNLDVIQTEILNILDGHAGQIREFLERL ATFTAELNNQRGDLTRAIDSTNQLLTIIANRNDTLDRVLTDVPPLIEHFADTGQLFADATESLGRFSEVA NRALAATRPNLHQTLQSLQRPLRQLERASPYVVGALKLGLTAPFNIDEVPNVIRGDYVNVSATFDVTLSA LDNALLSGTGISGMLRALEQAWGRDPDTMIPDVRYTPNPNDAPGGPLVERAE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0593 | lprL | - | 100% (402) | POSSIBLE MCE-FAMILY LIPOPROTEIN LPRL (MCE-FAMILY LIPOPROTEIN MCE2E) |
| M. tuberculosis H37Rv | Rv0173 | lprK | e-139 | 65.67% (367) | MCE-family lipoprotein LprK |
| M. tuberculosis H37Rv | Rv1970 | lprM | 6e-65 | 38.92% (370) | MCE-family lipoprotein LprM |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 1e-139 | 65.67% (367) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0707 | - | 1e-145 | 68.11% (370) | virulence factor Mce family protein |
| M. leprae Br4923 | MLBr_02593 | lprK | 1e-130 | 61.25% (369) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 8e-50 | 33.75% (323) | MCE-family protein LprN |
| M. marinum M | MMAR_0416 | lprK | 1e-136 | 61.48% (405) | MCE family lipoprotein LprK |
| M. avium 104 | MAV_4547 | - | 1e-165 | 77.78% (378) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0138 | - | 1e-141 | 65.98% (391) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_2780 | - | 1e-140 | 68.11% (370) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1066 | lprK | 1e-134 | 61.36% (396) | MCE family lipoprotein LprK |
| M. vanbaalenii PYR-1 | Mvan_0138 | - | 1e-145 | 68.65% (370) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0416|M.marinum_M MRRGVSVMGAIGKSKQSAARRGVGAMRAVSRRAWQGLALLMVALVLS---
MUL_1066|M.ulcerans_Agy99 -------MGAIGKSKQSTARRGVGAMRAVSRRAWQGLALLMVALVLS---
MLBr_02593|M.leprae_Br4923 MRR---AMSVVHTSR-------------VRHQTWRGLVMLVAALLLS---
Mb0179|M.bovis_AF2122/97 ------MMSVLARMR------------VMRHRAWQGLVLLVLALLLS---
Rv0593|M.tuberculosis_H37Rv -------MRCGVSAGSANGKPNRWTLRCGVSAGHRGSVFLLAVLLAPVVL
MAV_4547|M.avium_104 ---------MVFAAHTAGAGP---VMRRVAVAGRRALVVALAAMLT----
Mflv_0707|M.gilvum_PYR-GCK -------------------------MSRLGTLAKRAVALGAAALVLT---
Mvan_0138|M.vanbaalenii_PYR-1 -------------------------MGKWTRLARRTVALAAAAVVLT---
TH_2780|M.thermoresistible__bu ------------VTTVTTVTT---VKRTVTRATRRSLALLTIALVLT---
MSMEG_0138|M.smegmatis_MC2_155 -------------MRLLKGFP---KMRNWTRVGRRTAVLAAVALVLT---
MAB_4149c|M.abscessus_ATCC_199 ----------------------------MSRNVLRAAVMGVGVAVVVS--
: .. . :
MMAR_0416|M.marinum_M -SCGWRGISNVAIPGAPGTGKGSYTVYVQVPDTLAINGNSKVMVADVPVG
MUL_1066|M.ulcerans_Agy99 -SCGWRGISNVAIPGAPGTGKGSYTVYVQVPDTLAINGNSKVMVADVPVG
MLBr_02593|M.leprae_Br4923 -SCGWRGISNVSIPGGPGSGKGAYTIYVQVPDTLAINGNSKVMVADVTVG
Mb0179|M.bovis_AF2122/97 -SCGWRGISNVAIPGGPGTGPGSYTIYVQMPDTLAINGNSRVMVADVWVG
Rv0593|M.tuberculosis_H37Rv TSCTWRGIANVPLPVGRGMGPDRMTIYVQMPDTLALNTNSRVRVADVWVG
MAV_4547|M.avium_104 -SCTWRGIADVPLPVGRGTGGDHMTIYVQMPDTLALNTNSRVRVADVWVG
Mflv_0707|M.gilvum_PYR-GCK SCGSWKGIANIPLPGGPGTGSERTTIYVQMPDTLALNVNSRVRVADVYVG
Mvan_0138|M.vanbaalenii_PYR-1 SCGSWKGISNVPLPGGPGSGSERTTIYVQMPDTLALNVNSRVRVADVYVG
TH_2780|M.thermoresistible__bu ACGSWRGIANVPLPSGPGTGG-GMTIYVQMPDTLALNVNSRVRVADVEVG
MSMEG_0138|M.smegmatis_MC2_155 SCGQWRGIANVPLPGGPGTESGSMTLYVQMPETLALNANSRVRVRDVFVG
MAB_4149c|M.abscessus_ATCC_199 -GCQFNGLNSLNLPGTAGHGSRSYTVTVELPDVTTLPQNSPVMVDDVTVG
:.*: .: :* * *: *::*:. :: ** * * ** **
MMAR_0416|M.marinum_M SIRNIQLKN-----WVATLTLGIDQGVKLPKNALAKIGQTSLLGSQHVEL
MUL_1066|M.ulcerans_Agy99 SIRNIQLKN-----WVATLTLGIDQGVKLPKNALAKIGQTSLLGSQHVEL
MLBr_02593|M.leprae_Br4923 SIRAINLKN-----WVATLTLGLNKDVQLPKNTTAKIGQTSLLGSQHVEL
Mb0179|M.bovis_AF2122/97 SIRAIKLKN-----WVATLTLSLKKDVTLPKNATAKIGQTSLLGSQHVEL
Rv0593|M.tuberculosis_H37Rv TVRDISLRN-----WIATLTLELEPTVRLPANATAKIGQTSLLGTQHVEL
MAV_4547|M.avium_104 TVRAITLKD-----WVATLRLDLDPGVRLPANATAKIGQTSLLGTQHVEL
Mflv_0707|M.gilvum_PYR-GCK RVRAIELRN-----WVATLTLDLEPNIALPVNTQAKIGQTSLLGSQHVQL
Mvan_0138|M.vanbaalenii_PYR-1 RVRAIELKN-----WIATLTLDLEPSVQLPVNTLARIGQTSLLGSQHVQL
TH_2780|M.thermoresistible__bu TVRRIELRD-----WTPVLTLALEPGIELPTNTIARIGQTSLLGSQHVEL
MSMEG_0138|M.smegmatis_MC2_155 RVRKIELIN-----WVPTLTVDVEPGIKLPKNTLAKIGQTSLLGSQHVEL
MAB_4149c|M.abscessus_ATCC_199 SVSGIDAFQKPDGSWYAGVKVSLEPEVHLPANAVAKVAQTSLLGSQHIEL
: * : * . : : :. : ** *: *::.******:**::*
MMAR_0416|M.marinum_M AAPP-NPSSQLLKNGDTIPLKNSSAYPNTEQTLASISLILRGGGIPNLEV
MUL_1066|M.ulcerans_Agy99 AAPP-NPSSQLLKNGDTIPLKNSSAYPNTEQTLASISLILRGGGIPNLEV
MLBr_02593|M.leprae_Br4923 AAPA-NPSLELLKNGDTIPLKNSSVFPTTEQTLASLSLILRGGGIPNLET
Mb0179|M.bovis_AF2122/97 AAPP-DPSPVPLKDGDTIPLKRSSAYPTTEQTLASIATLLRGGGLVNLEG
Rv0593|M.tuberculosis_H37Rv AAPP-IPSPQPLKSGDTIGLKNSSAYPTVERTLASVALILTGGGIVNLDV
MAV_4547|M.avium_104 AAPK-NPSVQRLKSGDTILLQNSSAYPTVERTLASVAVILNGGGIANLDA
Mflv_0707|M.gilvum_PYR-GCK DLPP-DPSPQRLESGDTITLENASAFPTTERVLASIASILTGGGVANLET
Mvan_0138|M.vanbaalenii_PYR-1 DLPP-DPSPQKLKSGDVIPLANASAFPTTERVLASISSILTGGGVANLET
TH_2780|M.thermoresistible__bu DPPD-DPSQQMLRDGDTIPLDQAEAFPTTERVLASVGTILTGGGIPNLEV
MSMEG_0138|M.smegmatis_MC2_155 NPPE-DPSSELLRDGDTIPLAQSSAYPTIERTLAGISGILTGGGIPNIEV
MAB_4149c|M.abscessus_ATCC_199 AAPVGEPAVGKLTGGATIPLSRTGKYPSTEEVLSALSVVVNKGNLGALQD
* *: * .* .* * .: :*. *..*:.:. :: *.: ::
MMAR_0416|M.marinum_M LQNEVYDIFHGRGDQIRGFLTRLDTFTRQLNEQRDDITHAIDSTNRLMAY
MUL_1066|M.ulcerans_Agy99 LQNEVYDIFHGRGDQIRGFLTRLDTFTRQLNEQRDDITHAIDSTNRLMAY
MLBr_02593|M.leprae_Br4923 LTNEVFNIFHGRADQIHAFLTKLDTFASQLNQQRDDITHAIDSTNRLLTY
Mb0179|M.bovis_AF2122/97 IQQEINAIVTGRADQIRAFLGKLDTFTDELNQQRDDITRAIDSTNRLLAY
Rv0593|M.tuberculosis_H37Rv IQTEILNILDGHAGQIREFLERLATFTAELNNQRGDLTRAIDSTNQLLTI
MAV_4547|M.avium_104 IQTEVLNILDGHAGQIREFLGRLDTFVTELSRQRDDLTRAIDSSNELLTV
Mflv_0707|M.gilvum_PYR-GCK IQSEVYNVLNGRADQIRDFLNQLDTFTAELNQQRDDITRAIDSTNRLLTI
Mvan_0138|M.vanbaalenii_PYR-1 IQTEIYNVLNGRADQIREFLGRLDTFTEELNRQRDDITRAIDSTNRLLAI
TH_2780|M.thermoresistible__bu IQTEVYNMLSGRAPQIRDFLTKLDTFTAELNAQRDDLTRAIDNSNELLTI
MSMEG_0138|M.smegmatis_MC2_155 IQTEVFNILNGRADQIREFLNQLDTFTDELNQQREEITRAIDSTNRLLNI
MAB_4149c|M.abscessus_ATCC_199 ITDETYNLFKGRTGNLTQVLPKLATLISSLNSQRDDIISAIEGIDKFSRV
: * :. *: :: .* :* *: .*. ** :: **:. :.:
MMAR_0416|M.marinum_M VGGRADVVDRALTDLPPLIKHFADTRDLLINAVNSVGQLSDVTGRYLSEA
MUL_1066|M.ulcerans_Agy99 VGGRADVVDRALTDLPPLIKHFADTRDLLINAVNSVGQLSDVTGRYLSEA
MLBr_02593|M.leprae_Br4923 VGGRSDVLDQILTDIPPLIKHFADTKNLLINAVGSVGQLSQAVDQYLSEA
Mb0179|M.bovis_AF2122/97 VGGRSEVLNRVLTDLPPLIKHFADKQELLINASDAVGRLSQSADQYLSAA
Rv0593|M.tuberculosis_H37Rv IANRNDTLDRVLTDVPPLIEHFADTGQLFADATESLGRFSEVANRALAAT
MAV_4547|M.avium_104 FANRRDTLDRVLTELPPLIRHFADTRELFADATESLGRFSDAADRALTDT
Mflv_0707|M.gilvum_PYR-GCK VAQRNETLDAVLTEFPPLIKHFADTRDLFGDAIESLGRISNAAVAALEPA
Mvan_0138|M.vanbaalenii_PYR-1 VGQRNQTLDAVLTEFPPLIQHFADTRDLFADAVESLGRISNAAVDALAPA
TH_2780|M.thermoresistible__bu VANRESTLDRVLTEFPPLIEHFAETRDLFADAVLALGRVSEATDTYLGQA
MSMEG_0138|M.smegmatis_MC2_155 VSQRNDTLDRVLTEFPPLIQHFAETRDLFADAVTALGRLSAAADETLSGS
MAB_4149c|M.abscessus_ATCC_199 LAEHKESLGRAIDSIEPALKVLNENRANIIEAFRSVGNLAKITDRVLRTT
.. : . :. : .. * :. : :. : :* ::*..: . * :
MMAR_0416|M.marinum_M RGNLHTDLQSLQCPLKELGRGSQYLIGALKLILTQPFDIDAVPKIFRGDY
MUL_1066|M.ulcerans_Agy99 RGNLHTDLQSLQCPLKELGRGSQYLIGALKLILTQPFDIDAVPKIFRGDY
MLBr_02593|M.leprae_Br4923 RGPLHTDLQALACPLRELGRGAPYFIGAMKLILTQPYDVDTVPKIMRGDY
Mb0179|M.bovis_AF2122/97 RGDLHQDLQALQCPLKELRRAAPYLVGALKLILTQPFDVDTVPQLVRGDY
Rv0593|M.tuberculosis_H37Rv RPNLHQTLQSLQRPLRQLERASPYVVGALKLGLTAPFNIDEVPNVIRGDY
MAV_4547|M.avium_104 RANLYRSLLSLQRPLRQLVPAAPFVAGALKLGLTAPFNIDDVAQVIRGDY
Mflv_0707|M.gilvum_PYR-GCK NGDMNQNLQNLQRPLRELGKSGPYLLGALKIFLTAPYSIENLPKAIRGDY
Mvan_0138|M.vanbaalenii_PYR-1 SDDINTNLANLQRPLRELGKSGPYLLGALKIFLTAPYNIENVPKAIRGDY
TH_2780|M.thermoresistible__bu SDPLHTNLQNLQRPLRELGRASPYLIGALKLMLTAPFNIENVPKVVRGDY
MSMEG_0138|M.smegmatis_MC2_155 NANLHTNLQNLQRPLKQLGRAAPYLVGALKLILTVPFNIDNIPKAIRGDY
MAB_4149c|M.abscessus_ATCC_199 KDDIVADLKGLYPVVRALAENRDVLIDSLDLLPTFPFSTKYLRNAVRGDY
: * * :: * . .::.: * *:. . : : .****
MMAR_0416|M.marinum_M QNVSATLDVTFSAMDNAVLTGTGFSGALRALEQSFGRD---PETMIPDVR
MUL_1066|M.ulcerans_Agy99 QNVSAALDVTFSAMDNAVLTGTGFSGALRALEQSFGLD---PETMIPDVR
MLBr_02593|M.leprae_Br4923 QNVSLTLDVTYSAMDNAVLTGTGLSGALRALEQSFGRD---PETMIPDVR
Mb0179|M.bovis_AF2122/97 MNLSLTLDLTYSAIDNAFLTGTGFSGALRALEQSFGRD---PETMIPDIR
Rv0593|M.tuberculosis_H37Rv VNVSATFDVTLSALDNALLSGTGISGMLRALEQAWGRD---PDTMIPDVR
MAV_4547|M.avium_104 VNVSAALDLTLSTIDNTMLTGTGLSGALRALEQSWGRD---PATMIPDVR
Mflv_0707|M.gilvum_PYR-GCK VNVSLTVDLTLSAIDNGFFSGTGISGMLRALEQAWGRD---PATMIPDVR
Mvan_0138|M.vanbaalenii_PYR-1 INVSLTVDLTLSAIDNGFFSGTGISGMLRALEQAWGRD---PATMIPDVR
TH_2780|M.thermoresistible__bu INVSLMLDLTLSAIDNGFLSGTGVAGMLRALEQAWGRD---PATMVPDTR
MSMEG_0138|M.smegmatis_MC2_155 INVSLKLDLTLSSVDNAFLSGTGVSGMLRALEQAWGRD---PATMIPDVR
MAB_4149c|M.abscessus_ATCC_199 LNVFVTFDLTARRLGETLFTTSFFDPNMQHFNDVVNPPEWLIGSMANLNG
*: .*:* :.: .:: : . :: ::: . :*
MMAR_0416|M.marinum_M YTPNPNDAPGGPLVERGDRQC
MUL_1066|M.ulcerans_Agy99 YTPNPNDAPGGPLVERGDRQC
MLBr_02593|M.leprae_Br4923 YTTNPNDAPGGPLVERADRRC
Mb0179|M.bovis_AF2122/97 YTPNPNDAPGGPLVERGNRQC
Rv0593|M.tuberculosis_H37Rv YTPNPNDAPGGPLVERAE---
MAV_4547|M.avium_104 YTPNPNDAPGGPLVERGE---
Mflv_0707|M.gilvum_PYR-GCK FTPNPNSAPNGPLIERSE---
Mvan_0138|M.vanbaalenii_PYR-1 FTPNPNSVPGGPLIERSE---
TH_2780|M.thermoresistible__bu FTPNPNNVPGGPLIERAE---
MSMEG_0138|M.smegmatis_MC2_155 FTPNPHDAPGGPLVERGE---
MAB_4149c|M.abscessus_ATCC_199 KETSPFDLPAPAAPQGGGR--
..* . * . : .