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MTRRAATALAVAMTTCLSVTSCATEGLSSLPLPAPGGGSGGYTLTAVFSNALNLPAMAKVKLAGADIGQL ESMQARDYTAVTTLRIREGVLLPVGSTAELRSATPLGDVFVSIKPPPSAGQGTPLLTDGDTIGLESTTAA ATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGQAFGELIRKTNHTLGTLNGRSEEIKTALTETSQ LAAQLEAKNQSLAEVMDAAAPATSTLAAQTNGIADLVLTVGATTEQLRKFPSIAGTDTSGRSVIADASRI AGAWNDVVLAPGADLYSLNRLMPPFIKSTTSNAIAVRASIDRLVLGSIPDIGFAGDPGLHGPKRYNWHQL VGSLRYTLLRLQERVVGKGPGVPQMPVIPSPTEPGQWAPAPPPGPVPPGPAPAVAPPAPGVP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0006 | - | - | 100% (413) | hypothetical protein Mflv_0006 |
| M. gilvum PYR-GCK | Mflv_4164 | - | 1e-24 | 24.10% (415) | virulence factor Mce family protein |
| M. gilvum PYR-GCK | Mflv_0648 | - | 3e-23 | 26.30% (308) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 3e-23 | 27.84% (273) | MCE-family lipoprotein LprK |
| M. tuberculosis H37Rv | Rv0173 | lprK | 3e-23 | 27.84% (273) | MCE-family lipoprotein LprK |
| M. leprae Br4923 | MLBr_02593 | lprK | 3e-23 | 25.97% (258) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_1006c | - | 1e-145 | 65.26% (403) | putative MCE family protein |
| M. marinum M | MMAR_3868 | mce5E | 1e-148 | 66.58% (395) | Mce family protein, Mce5E |
| M. avium 104 | MAV_2384 | - | 1e-144 | 64.50% (400) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1147 | - | 1e-167 | 72.57% (412) | mce related protein |
| M. thermoresistible (build 8) | TH_4097 | - | 1e-156 | 71.54% (397) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_3800 | mce5E | 1e-147 | 66.08% (395) | Mce family protein, Mce5E |
| M. vanbaalenii PYR-1 | Mvan_0963 | - | 0.0 | 81.84% (402) | hypothetical protein Mvan_0963 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0006|M.gilvum_PYR-GCK -------MMTRRAA----TALAVAMTTCLSVTSCATEGLSSLPLP-APGG
Mvan_0963|M.vanbaalenii_PYR-1 --------MAIRAK----GLMALLVTTSLSVSACATEGLASLPLP-APSG
MSMEG_1147|M.smegmatis_MC2_155 --MMAASPKRLRKV----RLVAAFAMT-VIVSGCATNGLADLPLP-APGV
TH_4097|M.thermoresistible__bu -----MSVLRLR------RLVPALVTVGCLVSGCATNGLADLPLP-APGV
MMAR_3868|M.marinum_M --------MSGFG-----KAAAAIAMTTLLSSGCAANGLDSLPLP-APTL
MUL_3800|M.ulcerans_Agy99 --------MSGFG-----KAAAAIAVTTLLSSGCAANGLDSLPLP-APTL
MAV_2384|M.avium_104 --------MTATGARGRLTALAAAMAVTTATAGCATNGLASLPLP-APGL
MAB_1006c|M.abscessus_ATCC_199 --------MAIRK-----RLAAVGAATAIALSGCATNGLGDLPLP-APGV
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
Rv0173|M.tuberculosis_H37Rv ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
:.*. .*: .:.:* .*
Mflv_0006|M.gilvum_PYR-GCK GSGGYTLTAVFSNALNLPAMAKVKLAGADIGQLESMQARDYTAVTTLRIR
Mvan_0963|M.vanbaalenii_PYR-1 GSGGYTLTAVFSNALNVPMMAKVKLAGADVGELESMQARDYTAVTTLRIR
MSMEG_1147|M.smegmatis_MC2_155 GSGGYRITAIFSNALNLPANAKVKLAGADIGEMDSMVARNYTAVTTLRIM
TH_4097|M.thermoresistible__bu GSGGYRLTAEFTNALNLPANAKVKLAGADVGEVESMVARDYLAVTTLRIM
MMAR_3868|M.marinum_M GSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVARNYTAVTRLRIT
MUL_3800|M.ulcerans_Agy99 GSGGYTLTAVFADALNLPMNAKVKLAGADVGQVESMVARNYTAVTRLRIT
MAV_2384|M.avium_104 GSGGYSLNAVFSNALNLPMNAKVKLAGADVGQLESMVARNYTALTRLRIR
MAB_1006c|M.abscessus_ATCC_199 GTGGYHLTALFSNILNLPNNAKVKLAGADVGQVDDMRVSNYTAITTLRIL
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLK
Rv0173|M.tuberculosis_H37Rv GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLK
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLKNWVATLTLGLN
* *.* : . ..: * : ::* :*.. :*.: : :: * * :
Mflv_0006|M.gilvum_PYR-GCK EGVLLPVGSTAELRSATPLGDVFVSIKPPPSAGQGTPLLTDGDTIGLEST
Mvan_0963|M.vanbaalenii_PYR-1 EGVQLPKGSTAELRSATPLGDVFIAIKPPPSVQPGAALLRDGDTIGLEST
MSMEG_1147|M.smegmatis_MC2_155 EGVRLPEGSTAELRSATPLGDVFIAIKPPAPVEPGTPLLKDGDTIDLDAT
TH_4097|M.thermoresistible__bu DGVRLPRGSTAELRSATPLGDVFVAIKPPIDVPPDTPMLRDGDTIGKDST
MMAR_3868|M.marinum_M DDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAMLKDGDTIGLDST
MUL_3800|M.ulcerans_Agy99 DDVRLPRGSTAELRTATPLGDVFVALRPPAGAGTEAAMLKDGDTIGLDST
MAV_2384|M.avium_104 DGVQLPRGSTAELRTATPLGDVFVALKPPPGD-HDAPLLKNGDTIGLEST
MAB_1006c|M.abscessus_ATCC_199 DGVRLPKGSTAELRSATPLGDVFVSIRPPAGAPSDGPILKEGDTIGLDET
Mb0179|M.bovis_AF2122/97 KDVTLPKNATAKIGQTSLLGSQHVELAAPPDP--SPVPLKDGDTIPLKRS
Rv0173|M.tuberculosis_H37Rv KDVTLPKNATAKIGQTSLLGSQHVELAAPPDP--SPVPLKDGDTIPLKRS
MLBr_02593|M.leprae_Br4923 KDVQLPKNTTAKIGQTSLLGSQHVELAAPANP--SLELLKNGDTIPLKNS
..* ** .:**:: :: **. .: : .* * :**** . :
Mflv_0006|M.gilvum_PYR-GCK TAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGQAFGELIRKT
Mvan_0963|M.vanbaalenii_PYR-1 TAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGRAFGDLIRKT
MSMEG_1147|M.smegmatis_MC2_155 AAAATVESVLSSAAILVNGGAVRNFTNLINGMGKATGDQGQAFGNLIRKT
TH_4097|M.thermoresistible__bu KAAATVESVLASAAILVNGGAVRNFTNIINGLGKATGDEGQAFGNLVRKT
MMAR_3868|M.marinum_M TAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGDQGQAFGNLIRKS
MUL_3800|M.ulcerans_Agy99 TAAATVESVLSSAAILVNGGAIRNFTNMINGFGNATGDQGQAFGNLIRKS
MAV_2384|M.avium_104 AAAATVESVLSSAAVLVNGGAVRNFTNIINGFGKATGDQGQAFGDMIRKS
MAB_1006c|M.abscessus_ATCC_199 TAAATVESVLSSAALVSNGGAVRNLTNVINGFGKATGDQGQAFGDLIKDS
Mb0179|M.bovis_AF2122/97 SAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKL
Rv0173|M.tuberculosis_H37Rv SAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKL
MLBr_02593|M.leprae_Br4923 SVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAFLTKL
. .*.*..*:* : : .**.: *: : : . ... : :: .
Mflv_0006|M.gilvum_PYR-GCK NHTLGTLNGRSEEIKTALTETSQLAAQLEAKNQSLAEVMDAAAPATSTLA
Mvan_0963|M.vanbaalenii_PYR-1 NSTLGTMNARSGEISTAITETSRLAAQMEAKNAALGEVMDAAGPAADTLA
MSMEG_1147|M.smegmatis_MC2_155 NNTLATLTARSEEISTAMTETSRLAQQISAKNQALSDVMAQARPATDTLA
TH_4097|M.thermoresistible__bu NATLAKLNARSAEISTAMTETSRLASEIAAKNQVLSEVMAEARPATDTLA
MMAR_3868|M.marinum_M NRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTELMAAAEPAADALA
MUL_3800|M.ulcerans_Agy99 NRLLATLDSRSEQISTGLSELASLAEQLDAKNQAVTELMAAAEPAADALA
MAV_2384|M.avium_104 NELLGTLDARSDQISAALTQLSTLADQLDAKNHTITDLMTAAGPATSALA
MAB_1006c|M.abscessus_ATCC_199 NRLLGTLNTRSAQISEALTQTAQLADQLDTKNQTLTDIVKEADPATETLA
Mb0179|M.bovis_AF2122/97 DTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLIKHFA
Rv0173|M.tuberculosis_H37Rv DTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLIKHFA
MLBr_02593|M.leprae_Br4923 DTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLIKHFA
: : : :*. .: . * : :. : :: * . :*
Mflv_0006|M.gilvum_PYR-GCK AQTNGIADLVLTVGATTEQLRKFPSIAGTDTSGRSVIADASRIAGAWNDV
Mvan_0963|M.vanbaalenii_PYR-1 AHTDEIADLVQQVGATAELLRRFPSIAGSDTSGRSVIADANQIAGAWNDV
MSMEG_1147|M.smegmatis_MC2_155 AHTTQIADLVTQIGDVSDQLRKFPSIAGADTSGRSVIADANTVAGAWNDV
TH_4097|M.thermoresistible__bu GHATEIADLVERFGGISDQAHRFPSIAGTDTSGRSVIADANTIANAWNDV
MMAR_3868|M.marinum_M ANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIRDLNTIAGAANDI
MUL_3800|M.ulcerans_Agy99 ANTGELSNLVVQVGDTTRLLARFPALGGTDTSGRSMIRDLNTIAGAANDI
MAV_2384|M.avium_104 DNTGELSEVAQQVGDTSRLLARFPALGGTDTSGRSMIRDLNTIAGAANDV
MAB_1006c|M.abscessus_ATCC_199 ANTAQLSQLVLQIGATTKQLEKFPSIAGTDTSGHSIIKDANTIAKAWNDV
Mb0179|M.bovis_AF2122/97 DKQELLINASDAVGRLSQSADQYLSAARG-----DLHQDLQALQCPLKEL
Rv0173|M.tuberculosis_H37Rv DKQELLINASDAVGRLSQSADQYLSAARG-----DLHQDLQALQCPLKEL
MLBr_02593|M.leprae_Br4923 DTKNLLINAVGSVGQLSQAVDQYLSEARG-----PLHTDLQALACPLREL
: : .* : :: : . : * . : . .::
Mflv_0006|M.gilvum_PYR-GCK VLAPGADLYSLNRLMPPFIKSTTSNAIAVRASIDRLVLGSIPDIGFAGDP
Mvan_0963|M.vanbaalenii_PYR-1 VLAPGADLYSLNKLMPPFIKSTTSNAIAVNASIDRLVLGSIPDIGFAGDS
MSMEG_1147|M.smegmatis_MC2_155 ALAPDATLYALNRLLPPFIKSMSSGAISLDASVDRLILGSTPDIGFAGDQ
TH_4097|M.thermoresistible__bu ALAPGATLYALNRLMPPFIKTMSGGSVALDASVDRLVWGHHPDIGFAGDP
MMAR_3868|M.marinum_M AVSPDTSWLALNRMIPPMVKSTAGGALSVRASVDRLVLGSIPDIGFPGDI
MUL_3800|M.ulcerans_Agy99 AVSPDTSWLALNRMIPPMVKSTARGALSVRASVDRLVLGSIPDIGFPGDV
MAV_2384|M.avium_104 AVSPDTSWQSINRLIPALVKSTAGNSISVNVSVDKIMLGSLPDIGFPGDI
MAB_1006c|M.abscessus_ATCC_199 AQDPTVDINALNRQFASLIKITPSDTISVRVSIDRLILGSIPDAGFKGDV
Mb0179|M.bovis_AF2122/97 RRAAPYLVGALKLILTQPFDVDT---------VPQLVRGDYMNLSLTLDL
Rv0173|M.tuberculosis_H37Rv RRAAPYLVGALKLILTQPFDVDT---------VPQLVRGDYMNLSLTLDL
MLBr_02593|M.leprae_Br4923 GRGAPYFIGAMKLILTQPYDVDT---------VPKIMRGDYQNVSLTLDV
. ::: :. . . : ::: * : .: *
Mflv_0006|M.gilvum_PYR-GCK GLHGPKRYNWHQLVGSLRYTLLRLQERVVGKGPGVPQMPVIPSPTEPGQW
Mvan_0963|M.vanbaalenii_PYR-1 GLHGPKRYNWHQLVGSLQYTLYRLQERIVGKGPGVPQVPVMPHPTEPGLI
MSMEG_1147|M.smegmatis_MC2_155 GLHGPKRHDWHQLVGTLKYTLLRLQERVVGQGPGVPQVPVIPSPTEPGEI
TH_4097|M.thermoresistible__bu GLHGPKWSDWHQLVGTLQYTLFRLQERVVGKGPDVPQLPVIPSPTEPGEI
MMAR_3868|M.marinum_M GLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQLPVMPDPEVPGEI
MUL_3800|M.ulcerans_Agy99 GLHGPHRYNWNQFIGSLKYTLWRLQERVVGRGPGSPQLPVMPDPEVPDEI
MAV_2384|M.avium_104 GLHGPHHYNVNLLVGTLKYTLWRLQERVVGRGPNAPQVPVVPDPTVPGQI
MAB_1006c|M.abscessus_ATCC_199 GSHGPKRYNWAQLVGSFKYTLWRLQERVVGKGVYGEDVPMRPSPTEPGVI
Mb0179|M.bovis_AF2122/97 TYS---AIDNAFLTGTGFSGALRALEQSFGRDPE-TMIPDIRYTPNPNDA
Rv0173|M.tuberculosis_H37Rv TYS---AIDNAFLTGTGFSGALRALEQSFGRDPE-TMIPDIRYTPNPNDA
MLBr_02593|M.leprae_Br4923 TYS---AMDNAVLTGTGLSGALRALEQSFGRDPE-TMIPDVRYTTNPNDA
: : *: * *: .*:. :* . *.
Mflv_0006|M.gilvum_PYR-GCK APAPPPGPVPPGPAP-----------AVAPPAPGVP--------------
Mvan_0963|M.vanbaalenii_PYR-1 VPVPAPAP-PPG--------------APAPEAPR----------------
MSMEG_1147|M.smegmatis_MC2_155 IVEPGAAAPPEDAPAPEPAPAAQAPAPLPAEAPR----------------
TH_4097|M.thermoresistible__bu IPAPGPAAG-----------------AAPEEAPR----------------
MMAR_3868|M.marinum_M QIAPPLSPQPPGPPP-----------------------------------
MUL_3800|M.ulcerans_Agy99 QIAPPLSPQPPGPPP-----------------------------------
MAV_2384|M.avium_104 DVAPGPPPPQPGSPP-----------------------------------
MAB_1006c|M.abscessus_ATCC_199 ERVPGPPPGAPVPPPPGQAVPAAAPAETTTPTPAPAPPPGPAPGPAVMGQ
Mb0179|M.bovis_AF2122/97 PGGPLVERGNRQC-------------------------------------
Rv0173|M.tuberculosis_H37Rv PGGPLVERGNRQC-------------------------------------
MLBr_02593|M.leprae_Br4923 PGGPLVERADRRC-------------------------------------
*