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VHPCTVPTVRFHNGVDIPQLGLGVAAIPDAEAETIVRQALDAGYRHIDTATRYGNERGVGLGISRSGVCR EEVFVTTKLWVDDFRDAASAFARSLEALGTDYVDLFLIHWPAPDYGQYVTAWQQIVQLYLSGDIRAIGVS NFEPEHVQAIVDATGVLPVINQVELHPYFQQRKLRQFNSDREIVTEAWSPLAQGIGTAEDSPLAALAAKH NKTPAQLILRWHIELGHVVIPKTCSPQRLTENLQIFDFSLSPEDLDVFAQFDQPNGRLGTHPNEGFSAHH SARSRWHRDRLARRAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2941 | - | - | 100% (296) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1528c | - | 1e-69 | 46.52% (273) | oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4120c | - | 2e-09 | 27.56% (283) | aldo/keto reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2996 | - | 6e-62 | 46.25% (253) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_4697 | - | 4e-67 | 45.79% (273) | 2,5-didehydrogluconate reductase |
| M. tuberculosis H37Rv | Rv2971 | - | 4e-61 | 45.85% (253) | oxidoreductase |
| M. leprae Br4923 | MLBr_01669 | - | 2e-59 | 43.31% (254) | putative oxidoreductase of Aldo/keto reductase family |
| M. marinum M | MMAR_1744 | - | 5e-57 | 43.31% (254) | oxidoreductase |
| M. avium 104 | MAV_1085 | - | 4e-62 | 44.53% (274) | morphine 6-dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2408 | - | 1e-68 | 45.90% (268) | 2,5-diketo-D-gluconic acid reductase A |
| M. thermoresistible (build 8) | TH_1525 | - | 1e-70 | 46.59% (279) | 2,5-diketo-D-gluconic acid reductase A |
| M. ulcerans Agy99 | MUL_1987 | - | 4e-57 | 42.91% (254) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_1769 | - | 1e-64 | 45.05% (273) | 2,5-didehydrogluconate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4697|M.gilvum_PYR-GCK ------MTHVPAIELNDGASIPQLGFGVYQISPEDTADVVRQALEVGYRH
Mvan_1769|M.vanbaalenii_PYR-1 ------MSNTPTIELNDGTGIPQLGFGVFQIPPDDTAAAVRSALEIGYRH
MAV_1085|M.avium_104 ------MSKVPTIELNDGARIPQLGFGVYQIKPDETAAAVRAALDIGYRH
TH_1525|M.thermoresistible__bu ----VNMTTVPAITLNNGAQIPQVGFGVYQIPPDQTAAAVRTALDAGYRH
MAB_2941|M.abscessus_ATCC_1997 ----MHPCTVPTVRFHNGVDIPQLGLGVAAIPDAEAETIVRQALDAGYRH
Mb2996|M.bovis_AF2122/97 MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRL
Rv2971|M.tuberculosis_H37Rv MTGESGAAAAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRL
MLBr_01669|M.leprae_Br4923 MMPSTPRTSIPSITLNDENTMPLLGLGVAELSEDETERAVLAALEIGCRL
MMAR_1744|M.marinum_M -MPGAPSPSAPSIALNDENTMPVLGMGVAGLSDDETERAVSAALEIGCRL
MUL_1987|M.ulcerans_Agy99 MMPGAPSPSAPSIALNDENTMPVLGMGVAGLSDDETERAVSAALEIGCRL
MSMEG_2408|M.smegmatis_MC2_155 --------MSPRITLNDGNSIPQVGLGVWQTPAEDTERAVAAALQAGYRH
* : ::: :* :*:** :: * **: * *
Mflv_4697|M.gilvum_PYR-GCK IDTAQMYQNEKGVGQGIRNSGIDRGDVFVTSKLNNGFHTPEDARRAFDET
Mvan_1769|M.vanbaalenii_PYR-1 IDTAEMYQNERGVGQGIRDAGIDRAEVYVTSKLNNGFHKPDDARRAFDAT
MAV_1085|M.avium_104 IDTAEMYGNEREVAQGIRDAGLDRSEVFVTSKLNNGFHEPDAARRAFDAT
TH_1525|M.thermoresistible__bu IDTAQMYGNERGVAEGIRDAGLDRGEVFITSKLNNPYHRPDDARRAFDRT
MAB_2941|M.abscessus_ATCC_1997 IDTATRYGNERGVGLGISRSGVCREEVFVTTKLWVDDFR--DAASAFARS
Mb2996|M.bovis_AF2122/97 IDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEACRAS
Rv2971|M.tuberculosis_H37Rv IDTAYAYGNEAAVGRAIAASGVAREELFVTTKLATPDQGFTRSQEACRAS
MLBr_01669|M.leprae_Br4923 IDTAAAYGNEAAVSRAIAASGIPRAQLFVTTKLATPDQGFTKSQDACNAS
MMAR_1744|M.marinum_M IDTAAAYGNEAAVGRAIAASGIPRAELFVTTKVATADHGFTASREACKAS
MUL_1987|M.ulcerans_Agy99 IDTAAAYGNEAAVGRALAASGIPRAELFVTTKVATADHGFTASREACKAS
MSMEG_2408|M.smegmatis_MC2_155 IDTAAAYRNETETGRAIANSGVPREDIFLVTKLWNSDQGYDATLAAFDAS
**** * ** .. .: :*: * ::::.:*: : * :
Mflv_4697|M.gilvum_PYR-GCK LKALEFDYVDLFLIHWPLPTLYDGDFVSTWKTLEEFTKDGRARSIGVSNF
Mvan_1769|M.vanbaalenii_PYR-1 LKALDFDYVDLFLIHWPLPTLYDGDFVSTWKTLEEFKKDGRARSIGVSNF
MAV_1085|M.avium_104 LKALGSDYVDLFLIHWPLPTLYGGDFVSTWRVLEEFARDGRARSIGVSNF
TH_1525|M.thermoresistible__bu LTELGSDYVDLFLIHWPLPMHYDGDFVSTWKTLEEFAADGRARSIGVSNF
MAB_2941|M.abscessus_ATCC_1997 LEALGTDYVDLFLIHWPAPDY--GQYVTAWQQIVQLYLSGDIRAIGVSNF
Mb2996|M.bovis_AF2122/97 LDRLGLDYVDLYLIHWPAPPV--GKYVDAWGGMIQSRGEGHARSIGVSNF
Rv2971|M.tuberculosis_H37Rv LDRLGLDYVDLYLIHWPAPPV--GKYVDAWGGMIQSRGEGHARSIGVSNF
MLBr_01669|M.leprae_Br4923 LDRLGMDYVDLYLIHWPAPPV--GQYVDAWGGMIQSRGEGHARSIGVCNF
MMAR_1744|M.marinum_M LDRLGLDYVDLYLIHWPAPAA--GKYVDAFGGLIQARGEGFTRSIGVSNF
MUL_1987|M.ulcerans_Agy99 LDRLGLDYVDLYLIHWPAPAV--GKYVDAFGGLIQARGEGFTRSIGVSNF
MSMEG_2408|M.smegmatis_MC2_155 VQRLGVDYLDLYLIHWPVPEN--NKFVDTFKAFAHLRDQGRIRSIGVSNF
: * **:**:***** * ..:* :: : . .* *:***.**
Mflv_4697|M.gilvum_PYR-GCK QVAHLQRLADETDTVPAVNQIEVHPYFANDEVRAYGTEHGIATEAWSPIA
Mvan_1769|M.vanbaalenii_PYR-1 QVAHLQRLAEETDTVPAVNQIEVHPYFANDEVRAYGREHGIATEAWSPIA
MAV_1085|M.avium_104 QVPHLERLATETDTVPAVNQVEVHPYFTNEKVRGYAREHGIAIEAWSPIA
TH_1525|M.thermoresistible__bu EPAHLDLLAAETSTVPAVNQVEIHPYFGNNDVRRYCAEHGIAVEAWAPIA
MAB_2941|M.abscessus_ATCC_1997 EPEHVQAIVDATGVLPVINQVELHPYFQQRKLRQFNSDREIVTEAWSPLA
Mb2996|M.bovis_AF2122/97 TAEHIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLA
Rv2971|M.tuberculosis_H37Rv TAENIENLIDLTFVTPAVNQIELHPLLNQDELRKANAQHTVVTQSYCPLA
MLBr_01669|M.leprae_Br4923 TEEHLSAIIDLTFVTPAVNQIELHPLLNQDEMRKSNAQHNVITQSYTPLV
MMAR_1744|M.marinum_M TEEHVSNVIDLTFVTPAVNQVELHPLLNQDELRKANAQHNVVTQSYTPLA
MUL_1987|M.ulcerans_Agy99 TEEHVSNVIDLTFVTPAVNQVELHPLLNQDELRKANAQHNVVTQSYTPLA
MSMEG_2408|M.smegmatis_MC2_155 EPEHLTTLIEETGIVPAVNQIELHPLLPQQELRDVHAKLGIATEAWSPLG
:: : * *.:**:*:** : : .:* . : ::: *:
Mflv_4697|M.gilvum_PYR-GCK QGK-VLDDPVVTRIAEATGKTPAQVVLRWHIQRGDIVFPKSVTLQRIKDN
Mvan_1769|M.vanbaalenii_PYR-1 QGK-VLDDPVVTRIAETVGKSPAQVVLRWHIQRGDIVFPKSVTLQRIKDN
MAV_1085|M.avium_104 QGD-VLGDAVINRIADGLGRTAAPVVLRWHIQRGDIVFPKTVNPDRMKSN
TH_1525|M.thermoresistible__bu KGR-VADDPVIAGIADRLGRTPAQVTLRWHIQRGDIVLPKSVTPERVRSN
MAB_2941|M.abscessus_ATCC_1997 QGIGTAEDSPLAALAAKHNKTPAQLILRWHIELGHVVIPKTCSPQRLTEN
Mb2996|M.bovis_AF2122/97 LGR-LLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASN
Rv2971|M.tuberculosis_H37Rv LGR-LLDNPTVTSIASEYVKTPAQVLLRWNLQLGNAVVVRSARPERIASN
MLBr_01669|M.leprae_Br4923 LGR-LMDNSTLTAIAAEYGKTPAQVLLRWNLQLGNAVVFRSAKAEHIASN
MMAR_1744|M.marinum_M LGQ-LADNPTVTSIAGEYGKTPTQVLLRWNLQLGNAVIFGSSNAEHIATN
MUL_1987|M.ulcerans_Agy99 LGQ-LADNPTVTSIAGEYGKTPTQVLLRWNLQLGNAVIFGSSNAEHIVTN
MSMEG_2408|M.smegmatis_MC2_155 QGS-LLADPVITGIAEQHGKTPAQVLIRWHIQLGNIVIPKSVNPERIASN
* :. : :* ::.: : :**::: *. *. : ::: *
Mflv_4697|M.gilvum_PYR-GCK FALFDFELGAEDFDAVSGLDKGEAGRIGPNPD-------------TFDYV
Mvan_1769|M.vanbaalenii_PYR-1 FALFDFELGADDFAAISGLDQGEAGRIGPNPD-------------TFDYI
MAV_1085|M.avium_104 FELFDFELDERAMEAISALDRGESGRRGPNPD-------------TFDYI
TH_1525|M.thermoresistible__bu IALFDFELSDADMAAISALDKGEAGRMGPHPD-------------KFDMI
MAB_2941|M.abscessus_ATCC_1997 LQIFDFSLSPEDLDVFAQFDQ-PNGRLGTHPNEGFSAHHSARSRWHRDRL
Mb2996|M.bovis_AF2122/97 FDVFDFELAAEHMDALGGLND--GTRVREDPL-------------TYAGT
Rv2971|M.tuberculosis_H37Rv FDVFDFELAAEHMDALGGLND--GTRVREDPL-------------TYAGT
MLBr_01669|M.leprae_Br4923 FDVFDFELAVNHMDAMNELHD--GTRLRPDPE-------------TYAGS
MMAR_1744|M.marinum_M LDVFEFELASQHMDAINGLND--GTRLREDPM-------------TFAGV
MUL_1987|M.ulcerans_Agy99 LDVFEFELASQHMDAINGLND--GTRLREDPM-------------TFAGV
MSMEG_2408|M.smegmatis_MC2_155 FDVFDFELSGQDITSIASLET--GKRLGPDPR-------------TFNFT
: :*:*.* : . :. * .*
Mflv_4697|M.gilvum_PYR-GCK PS---
Mvan_1769|M.vanbaalenii_PYR-1 P----
MAV_1085|M.avium_104 PR---
TH_1525|M.thermoresistible__bu -----
MAB_2941|M.abscessus_ATCC_1997 ARRAA
Mb2996|M.bovis_AF2122/97 -----
Rv2971|M.tuberculosis_H37Rv -----
MLBr_01669|M.leprae_Br4923 -----
MMAR_1744|M.marinum_M -----
MUL_1987|M.ulcerans_Agy99 -----
MSMEG_2408|M.smegmatis_MC2_155 G----