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SVDPSRTLSSLDLLDDDEHAQLATWGNQAVLKECPDTMPSIPAVFARQVECTPEALALTFDGQSMTYREL DEAANRLSHLLVGAGAGPGQFVALLFPRSTEAIVAILAVLKSGAAYLPIDPALPTTRIEFMLTDAAPVAA VTTAVLAHRLHGLGVPVLDVDDPAVCTQPCTAPPMPSPEDLAHLIYTSGTTGVPKGVAVTQRNVVQLFDR LDIGVELAPGQVWTQFHSYAFDFSVWEIWGALLHGGRLVVVPDSVARTPEDFHDLLMGERVTVMSQTPSA AGVLSPDGLEATALVIGAEPCPPELVDRWAPGRVMVNVYGPTETTMWACKSAPLSAGSEGHGVPIGSPVA HAASFVLDRWLRPVPDGVIGELYLAGAGVGSGYWRRTALTGARFVACPFGMPGDRMYRTGDLVSWGADGQ LQYLGRADEQIKIRGYRIELGEIQAALVRLDGVRQAAVIVREDRPGDKRIVGYITGGADPVGARAALAEQ LPAYMVPVAVVALQTLPVTVNGKLDKQGLPAPEYSGVDFRAPSTPVEEALAGIYAQVLGVDRVGADDSFF DLGGDSILAMQVAGRARAAGVLCRPRDIFVEQTVARLSRVVTLAENEIRNVDDGIGPVAPTPIMHWLHSV PGPVERFNQTVVLQAPAGAAEADIVVLLQALLDHHGTLRLHAENNDGGWSLRVPEKGAVDARACIRTVEA LSDEAVEAACSRLDPGAGAMLSALWAPAEGKLALVIHHLAVDGVSWRILLEDLNVAWAQRRSGLDVALSG AGTSFARWASLLREQALSAGVVESADVWRSVSAVPPALPVVRPGVDTYAVAGTLSVALDADVTRMLLGEV PAAFHAGVQDVLLIAFALAWNEFLGAGGAPIGIDLEGHGRAEELAADIDLSRTVGWFTAKYPAALSVGDL SWAQVSGGDSALGLVVKSVKEQLRGLPDPLSYGLLRYLNPEVALPHSDSAIGFNYLGRLGAGATEASEDI WTISHEGLSWTSASSTVPMPMAHTVELNAGILESSVESGPRLQAVWTWAPSLVDAIQVQRLSRLWFEALV GICTHVRTGGGGLTPSDILPARLTQGELDELTKCLRVADVLPLTPVQQGLLFHSAIAARADSAAAGTALA DIYAVQLNLTMTGAVDPRRLYNAMHAVVKRHPNLVARFCTRFGEPVQVIPADPMICWQQTEFESTEELER FCAAERVAACDLAGKSTFRSALVRTGGDKHRFILTFHHVVIDGWSLPILLREIFAIYFGQALAPAPSYRG FVSWLAQQDREAARAAWRKALEGFEAPTLVAPRSVPGSRGVASYRISAETTRALGDLARSQHTTVSTVLR AAWAQLLMVQTGAHDVAFGTVVSGRPALLTGADSVVGLLINTVPVRARATATTTVADLLRDMQSIHNDLL EHEHLALNEIHHLAGHDRLFDTLFLYENYPVDVSTFMGTHELGITEFTSREYNHYPLSVMALPGHELGIR IEYDTDAFDVADIGALVQRLRRILGAMTAAPARRVLSIDVLEVAERGRLDSWGNRAVLACATAASSSIPE VFARQVDRAPQAVALTFQGRSMTYRELDHAANRLAQLLASRGAGPGESIALMVPRSDDAIVALLAVLKTG AAYLPIDPAVPVARLEFMLADAAPIAVATTAELRQRLAGSSIPVLVIDEHVVDEPAAVSLQAPRPDDIAY TIYTSGTTGTPKGVAVTHRNVTQLLETLPVGLPAGPGQVWSQWHSMVFDVSVWEVWGALLHGARLMVVPE AVAGSPQHLHDLLVTEKVSVLHQTPSAIGMLDWDGVDDMAVVVAGEPCPPEVVDRWAPGRLMLNAYGPTE ATIYAAISMPLSPKTSPVPIGSPVRGGATFVLDGWLRPVPPGVVGELYLAGSGVGVGYVHRSGLTGSRFV ACPFGRPGVRMYRTGDLARYSEDGQLQYLGRTDEQVKIRGYRIELDEIRSALAELDGVEHAAVIVREDRP GDKRLVGYVTGTADPTMLRTLLGERLPQYMVPAAVVAVDAIPLTINGKLDKRSLPAPVYHDAARYREPVS PVERTIADIYAHTLGLERIGVEDSFFDVGGDSISAMRVVAAINTALDVDLEVWTIFDAPSVRSLSARLNG AVSASPIAESSRTSCASVHGRGVTQVMATDLTLDKFVDVTALIANRSRRHPRGDVREILLTGATGFLGRH LVLHWLREMEHAGGTLTCLVRGSSHEEARSRLEKSFDSGDPGLMALFRRLAADRLKVVAGDKGEPHLGLE PQTWEHLAESVDLVVDSAAFVNSVLPYEELFRPNVVGTAELIRLALTAKLKPYTFVSTSDVGRQVDRSKF TEVADIREISPSRVLDAGYANGYANSKWAAEVLLREAHDMFGLPVAVFRSSMVMADTSYAGQLNMADTIS RMVLSIMATGVAPESFYQLDMHGNRQRAHFDGLPVEFVAEAIATLGSQATDGFETYHVMNPHDDGVGIDQ FVDWLVEAGHPIERVGNFGVWLQRFEAGLRALPNPQRQNSVLQMLMVLKQHGQLRAPAPTCGSYAPADRF QAAVRRAKIGSDQDIPHISAPIILKYVTDLQMLGLL*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_3317c | - | - | 100% (2557) | peptide synthetase NRP |
M. abscessus ATCC 19977 | MAB_4098c | - | 0.0 | 65.51% (2589) | peptide synthetase NRP |
M. abscessus ATCC 19977 | MAB_4099c | - | 0.0 | 61.49% (2114) | non-ribosomal peptide synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0104 | nrp | 0.0 | 51.41% (1488) | peptide synthetase |
M. gilvum PYR-GCK | Mflv_2697 | - | 1e-149 | 34.41% (1119) | amino acid adenylation domain-containing protein |
M. tuberculosis H37Rv | Rv0101 | nrp | 0.0 | 51.41% (1488) | peptide synthetase |
M. leprae Br4923 | MLBr_00484 | fadD9 | 1e-160 | 44.09% (753) | putative acyl-CoA synthetase |
M. marinum M | MMAR_0099 | - | 0.0 | 57.51% (2151) | non-ribosomal peptide synthetase |
M. avium 104 | MAV_3243 | - | 0.0 | 64.54% (2572) | linear gramicidin synthetase subunit B |
M. smegmatis MC2 155 | MSMEG_0402 | - | 0.0 | 65.28% (2578) | linear gramicidin synthetase subunit D |
M. thermoresistible (build 8) | TH_3730 | - | 0.0 | 60.34% (2171) | PUTATIVE linear gramicidin synthetase subunit D |
M. ulcerans Agy99 | MUL_1722 | - | 1e-167 | 37.60% (1117) | fatty-acid-CoA ligase FadD9 |
M. vanbaalenii PYR-1 | Mvan_2578 | - | 1e-165 | 36.61% (1120) | thioester reductase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK --MTAAKTGAIADVMALSPLQQGLYSLTAMS--DGDDPYLIGMSADITGA MMAR_0099|M.marinum_M MTQPTKPVVDIEDVMTLSPLQLGLFALAMASGAASDDPYTVALGIDVHGS Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LDVSLLHDCAAAVLARHPNLRAGFFQGDLKRPVQVIPEKVEVLWRHVRCD MMAR_0099|M.marinum_M LDVGLLRSCALAMLKRHPNLRARFLGRGLPHPVQVVPSEVQLEWARVEAT Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK GTEVEPLEREERARRFDLGRGPAMRFLLLETGQQRWRFVITAHHIVIDGW MMAR_0099|M.marinum_M AETAGALEAQERNRGFDLEMGPAIRFLLIELPGDRWRFLITAHHIVIGGW Mb0104|M.bovis_AF2122/97 -----------------------MHRVRLSRSQRNLYNGVRQDNNPALYL Rv0101|M.tuberculosis_H37Rv -----------------------MHRVRLSRSQRNLYNGVRQDNNPALYL MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK SLSLLVSELLALYRAAGNTSALPDAPRPYRDYIGWLAARDQDHARSLWRA MMAR_0099|M.marinum_M SIALFVDELLTLYEADCNIDTLPAQPRPYRDYIGWLERCDVEQGQRQWRE Mb0104|M.bovis_AF2122/97 IGKSYRFRRLELARFLAALHATVLDNPVQLCVLENSGADYPDLVPRLRFG Rv0101|M.tuberculosis_H37Rv IGKSYRFRRLELARFLAALHATVLDNPVQLCVLENSGADYPDLVPRLRFG MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK HLADLDGPTLLAPALGAATIG-DGLPGMVELTADPSITEAVVDAARARGV MMAR_0099|M.marinum_M HLAGLAAPTLLAAPLGSSGVQPDSLPKRAELTLDEGATTSLVDGARSRGV Mb0104|M.bovis_AF2122/97 DIVRVGSADEHLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVHTHHILL Rv0101|M.tuberculosis_H37Rv DIVRVGSADEHLQSTWCSGILGKPLVRHTVHTDPNGYVTGLDVHTHHILL MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK TVNSLVQLAWALTLSSLTDRDDITFGVTVSGRPDDLAGVESMIGLFVNTV MMAR_0099|M.marinum_M TVNTLTQLAWALMLSMLTDRRDVVFGVTVSSRPAELARVESMVGLFVNTV Mb0104|M.bovis_AF2122/97 DGGATGTIEADLARYLTTDPAGETPSVGAGLAKLREAHRRETAKVEESRG Rv0101|M.tuberculosis_H37Rv DGGATGTIEADLARYLTTDPAGETPSVGAGLAKLREAHRRETAKVEESRG MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 --------MTVG-AGRRLLSIDLLDGGEHDRLDEWGNRAILTK------- MSMEG_0402|M.smegmatis_MC2_155 --------MTAEPSTRTLLSFDLLDEDEHDQIEVWGNRAVLTD------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 ---------MSVDPSRTLSSLDLLDDDEHAQLATWGNQAVLKE------- Mflv_2697|M.gilvum_PYR-GCK PLRVRLDPALTAGAQCRALQQDAATLRDHSYLGHAELRALAGVGELFDTL MMAR_0099|M.marinum_M PLRVRLDPKTTVAQQCALIQRDAARLREHAYLSHSQIRALAGMGELFDTL Mb0104|M.bovis_AF2122/97 RLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNAFDAIL Rv0101|M.tuberculosis_H37Rv RLSAVVQRELADEAYHGGHGHSVSDAPGTAAKGVLHESATICGNAFDAIL MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 ---------------------------PVKAPASIPGMFAAQVARSAEAV MSMEG_0402|M.smegmatis_MC2_155 ---------------------------PGPTPVTIPALFAEQVVRAPDAV TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 ---------------------------CPDTMPSIPAVFARQVECTPEAL Mflv_2697|M.gilvum_PYR-GCK LVYENFPPGAVAGAGTLEAAGATFTPVALQSLAHFPVTIAAHLTDGRLTV MMAR_0099|M.marinum_M LVFQNFPSLGLADGKARAVGAARFDSLTVQSPTHFPVCITAELTDARLSL Mb0104|M.bovis_AF2122/97 TLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVAT Rv0101|M.tuberculosis_H37Rv TLSEAQRVPLNVLVAAAAVAVDASLRQNTETLLVHTVDNRFGDSDLNVAT MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 ALSFEG-------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 ALVSGD-------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 ALTFDG-------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK LVEAKDGALGQITPRALGTRLLATVSRIVEGWDRPLREISISPD------ MMAR_0099|M.marinum_M SIATNANAFGDITESALGDRLVAVLQRLLPMWDRPLRDVSMLLDGQTDGD Mb0104|M.bovis_AF2122/97 CLVN---------------------------------------------- Rv0101|M.tuberculosis_H37Rv CLVN---------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ----------------------DHPVPVP--------------------- MMAR_0099|M.marinum_M TAVSEHARLDVVGNRAVLAEPLVEPVSVPGLFAAQVASRAEVTALVCGDR Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SLTYRELDRAANRLAHLLVDQGVGPGDVVGLLLERSVEAVIAILAVLKSG Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AAYLAIDVNHPDGRIGFMIEDAAPVAVITTAGLAQRLAGYPVAVIDIDDP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------------------------------VS MMAR_0099|M.marinum_M AIATCYPGYGLPFPSADNIAYLIYTSGTTGKPKGVGITHHNITQLFTSVA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK EAAPTPSP------------------------------------------ MMAR_0099|M.marinum_M ATGFTPAPGQIWTQCHSYAFDYSVWEMWGALLHGGRLVVVPELVTRSAAE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LLALLVTEGVGVLSQTPSAFYALQAEDAAQPQLGRQLCLDAVVFGGEALE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------STGVHTRFTETA-------------- MMAR_0099|M.marinum_M PARLGPWLANHGRRPRLINMYGITETTVHASFREIVRHDLGFAVSPVGVP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LANLAFFVLDGWLRPVPVGVAGELYVAGAGVGCGYWRRSGLTASRFVACP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M FGALGARMYRTGDVVRWGPDGQLQYVGRADEQVKIRGYRIELGEVAAALS Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M QLDGVDQAVVIAREDRPGDKRLVGYLVGSVDAGQARAALAQALPAYMVPA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AVVVVDSLPLTVNGKLDIRALPAPQYGATGSYRAPASPVEEVLAGIYAQV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LGLDRVAVDQSFFDLGGDSLSAMRVVAAINKSLGGDLSVRALFDAPTVAE Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M LAPGIGQGSGQWTPLVAGERPAVVPLSFAQQRLWFIDQLQGPSAVYNMAW Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK SARLG--------------------------------------------- MMAR_0099|M.marinum_M SARLSGELDAAALGAAFADVVGRHESLRTVFRAVAGVAEQLVLGVEQVDV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M RWQIIDAQGWSSRRLAAALEQQARHCFDLTVEIPLRASLFRVTDDEHVLV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VVAHHIAADGWSLRPLVTDLGVAYASRCAGRAPGWAGLAVQYVDYTLWQR Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TNLGELTDSHSGIAGQLRYWEKALEGMAERLQLPTDRAYPRVADHRGSGV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DVQWPAQLQQQVARVAREHHATSFMVIQTALAVLLAKLSGSSDVAVGVPV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AGRGDPALDELVGVFVNTVVLRVQVAGDPTFAQLLAQVRTRSLAAFEHQD Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ----------------------SVALSWD--------------------- MMAR_0099|M.marinum_M VPFEVLVERLNPVRSLTHHPLVQVVLAWQNDMSAELVLDGLDVEFAPVHT Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK ------------------------GG------------------------ MMAR_0099|M.marinum_M QTARMDLVFSLGERFTDTGAPAGIGGGVEFRTDVFDAASIAALIQRLQRV Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -------------------------------------------------- MSMEG_0402|M.smegmatis_MC2_155 -------------------------------------------------- TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 -------------------------------------------------- Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VVAMVADPDRRLSSVDLLDAAEHARLDVVGNRAVLAEPLVEPVSVPGLFA Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 ----------------RSMTYRELDEASNRLAHLLAEQGAAPGECVALLF MSMEG_0402|M.smegmatis_MC2_155 ----------------RSWTYRELDEASNRLAHVLAEHGAKPGATVAFLI TH_3730|M.thermoresistible__bu -------------------------------------------------- MAB_3317c|M.abscessus_ATCC_199 ----------------QSMTYRELDEAANRLSHLLVGAGAGPGQFVALLF Mflv_2697|M.gilvum_PYR-GCK -----------------ALTYRQLDEAADRLAAVLTASGVRTETPVAVRL MMAR_0099|M.marinum_M AQVASRAEVTALVCEDRSLTYRELDRAANRLAHLLVDQGVGPGDVVGLLL Mb0104|M.bovis_AF2122/97 ----------------SVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWL Rv0101|M.tuberculosis_H37Rv ----------------SVAQTVRFPPFASVSDVVRTLDRGYVKAVRRRWL MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 SRSDEAIVSILAVLKTGAAYLPIDPALPAARMEFMLGDATPIAAVTTAGL MSMEG_0402|M.smegmatis_MC2_155 PRSGEAILSILSVLKTGAAYLPVDPAHPDARIGFMMSDAKPVAALTTADL TH_3730|M.thermoresistible__bu --------------------------------------------VTTAEL MAB_3317c|M.abscessus_ATCC_199 PRSTEAIVAILAVLKSGAAYLPIDPALPTTRIEFMLTDAAPVAAVTTAVL Mflv_2697|M.gilvum_PYR-GCK RRGADYVVAMFAVLKAGGAIVPLDPAMPADRIEVILRRAGVTVVVDEDTV MMAR_0099|M.marinum_M ERSVEAVIAILAVLKSGAAYLAIDVNHPDGRIGFMIEDAAPVAVITTAGL Mb0104|M.bovis_AF2122/97 REEHYRRMYLAINRTSHVEALTLNFIREPCAPGLRPFLSEVPIATDIGPV Rv0101|M.tuberculosis_H37Rv REEHYRRMYLAINRTSHVEALTLNFIREPCAPGLRPFLSEVPIATDIGPV MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 RDRLEGFDLPVIDVDEAAAEIERTQPSSALPGPSPDDIAYMIYTSGTTGT MSMEG_0402|M.smegmatis_MC2_155 RSRLDQYDLAVIDMADPAIDRR---PSDALSGPRPDDLAYMTYTSGTTGV TH_3730|M.thermoresistible__bu GARLHRSGVPVIHIDDPAAPGQAG--ATTGPAPAPDDIAYIIYTSGTTGV MAB_3317c|M.abscessus_ATCC_199 AHRLHGLGVPVLDVDDPAVCTQP---CTAPPMPSPEDLAHLIYTSGTTGV Mflv_2697|M.gilvum_PYR-GCK ARATAEPP-----------AQYRP--AETLPG----QAAYVVFTSGTTGE MMAR_0099|M.marinum_M AQRLAGYPVAVIDIDDPAIATCYP--GHGLPFPSADNIAYLIYTSGTTGK Mb0104|M.bovis_AF2122/97 EGMTVASVLDEEQRTLNLAIWNRADLPACKTHPKVAERIAAALESMAAMW Rv0101|M.tuberculosis_H37Rv EGMTVASVLDEEQRTLNLAIWNRADLPACKTHPKVAERIAAALESMAAMW MUL_1722|M.ulcerans_Agy99 -------------------------------------------MSPITRE Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------MSTDTRE MLBr_00484|M.leprae_Br4923 -----------------------------MWRQQSISHRKESVMSTITKQ * : MAV_3243|M.avium_104 PKGVAVTHRNVTEFLK----TLHPKLPSGPGQVWSQWHSLVFDV------ MSMEG_0402|M.smegmatis_MC2_155 PKAVAVTHHNVTQLVS----ALHADLPSGPGQVWSQWHSLVFDV------ TH_3730|M.thermoresistible__bu PKGVAVTHRNVAALLS----ALDAELASG--QVWTQCHSLAFDF------ MAB_3317c|M.abscessus_ATCC_199 PKGVAVTQRNVVQLFD----RLDIGVELAPGQVWTQFHSYAFDF------ Mflv_2697|M.gilvum_PYR-GCK PKGVIGTHRALLAYADDHIGAILRPAADRVGRPLRIAHAWSFTFD----- MMAR_0099|M.marinum_M PKGVGITHHNITQLFTSVAATGFTPAP---GQIWTQCHSYAFDY------ Mb0104|M.bovis_AF2122/97 DRPIAMIVNDWFGIGPDGTRCQGDWPARQPSTPAWFLDSARGVHQFLGRR Rv0101|M.tuberculosis_H37Rv DRPIAMIVNDWFGIGPDGTRCQGDWPARQPSTPAWFLDSARGVHQFLGRR MUL_1722|M.ulcerans_Agy99 ER-LERRIQDLYANDPQ--------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 DR-LARRIADLYATDPQ--------------------------------- MLBr_00484|M.leprae_Br4923 EKQLARRVDDLTANDPQ--------------------------------- : : MAV_3243|M.avium_104 ---SVWETWGALLHGGRLVVVPESVAGSPDDLHDLLVAEGVTVLSQTPSA MSMEG_0402|M.smegmatis_MC2_155 ---SVWEIWGALLHGGRLVVVPESVGSSPDDLHNLLITEKVSVLCQTPSA TH_3730|M.thermoresistible__bu ---SVWEIWGPLLYGGRVVIVPDPVVRSPEDLHALLAAEQVGMLSQTPSA MAB_3317c|M.abscessus_ATCC_199 ---SVWEIWGALLHGGRLVVVPDSVARTPEDFHDLLMGERVTVMSQTPSA Mflv_2697|M.gilvum_PYR-GCK ---AAWQPLAALLDGHSVHIVDDATQRDAEALVDTIARFGVDMIDTTPSM MMAR_0099|M.marinum_M ---SVWEMWGALLHGGRLVVVPELVTRSAAELLALLVTEGVGVLSQTPSA Mb0104|M.bovis_AF2122/97 RFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDT Rv0101|M.tuberculosis_H37Rv RFVYPWVAWLVQRGAAPGDVLVFTDDDTDKTIDLLIACHLAGCGYSVCDT MUL_1722|M.ulcerans_Agy99 -----------FAAAKPVTAITAAIERPGLPLPQIIETVMTGY------- Mvan_2578|M.vanbaalenii_PYR-1 -----------FAAAAPDDAISHAIDQPGTHLPVIVQTVLDGY------- MLBr_00484|M.leprae_Br4923 -----------FAAAKPDPAVAAALAQPGLRLPQIIQTALDGY------- . : : : MAV_3243|M.avium_104 VGMLSPEG---------LDSTALVVAGEACPAEVVDRWAPGR-----VMI MSMEG_0402|M.smegmatis_MC2_155 AGMLSPEG---------LESTTLIVAGEACPTELVDRWAPGR-----VMI TH_3730|M.thermoresistible__bu FYALQTADSLQPEQARQLQLQTVVFGGEALEPQRLSAWMRNHPER-PRLI MAB_3317c|M.abscessus_ATCC_199 AGVLSPDG---------LEATALVIGAEPCPPELVDRWAPGR-----VMV Mflv_2697|M.gilvum_PYR-GCK FARLRDVGLLSTVP-----LAVLALGGEAVDPGLWQQIRQECARTGMSAF MMAR_0099|M.marinum_M FYALQAEDAAQPQLGRQLCLDAVVFGGEALEPARLGPWLANHGRR-PRLI Mb0104|M.bovis_AF2122/97 ADEISVRTNAITEHGDGILVTVVDVAATQLAVVGHDELRKVVDER--VTQ Rv0101|M.tuberculosis_H37Rv ADEISVRTNAITEHGDGILVTVVDVAATQLAVVGHDELRKVVDER--VTQ MUL_1722|M.ulcerans_Agy99 ------------------------------------ADRPALAQR--SVE Mvan_2578|M.vanbaalenii_PYR-1 ------------------------------------AERPALGQR--AVR MLBr_00484|M.leprae_Br4923 ------------------------------------AERPALGQR--VAE MAV_3243|M.avium_104 NAYGPTEATVYAAMSAP--LTAESGAPPIGSPVPGAALFVLDKWLRPAPE MSMEG_0402|M.smegmatis_MC2_155 NAYGPTEATIYAAMSEP--LTAGTGVAPIGAPVPGAALFVLDKWLRPAPE TH_3730|M.thermoresistible__bu NMYGITETTVHASFREIGAADLDDNTSPIGRPLPHLAFFVLDGWLRPVPP MAB_3317c|M.abscessus_ATCC_199 NVYGPTETTMWACKSAPLSAGSEGHGVPIGSPVAHAASFVLDRWLRPVPD Mflv_2697|M.gilvum_PYR-GCK NCYGPTETTVEAVVAEIGAHER----PTIGRPTAPTRAYVLDSWLRPVPS MMAR_0099|M.marinum_M NMYGITETTVHASFREIVRHDLGFAVSPVGVPLANLAFFVLDGWLRPVPV Mb0104|M.bovis_AF2122/97 VTHDALLATKTAYIMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAH Rv0101|M.tuberculosis_H37Rv VTHDALLATKTAYIMPTSGTTGQPKLVRISHGSLAVFCDAISRAYGWGAH MUL_1722|M.ulcerans_Agy99 FVTDAGTGHTTLRLLPH--------FETISYGELWDRISALADVLST--- Mvan_2578|M.vanbaalenii_PYR-1 FVTDPATGRTTTELLPR--------FETITYAELSRRIHAVTAALT---- MLBr_00484|M.leprae_Br4923 FTKDPKTGRTSMELLPS--------FETITYRQLGDRVGALARAWR---- . : .: MAV_3243|M.avium_104 GVVGELYIAGRGVATGYARRAGLTASRFVACPFGGPGARMYRTGDLVRWG MSMEG_0402|M.smegmatis_MC2_155 GVVGELYVAGHGVATGYIGRPDLTASRFVACPFGETGERMYRTGDLVRWG TH_3730|M.thermoresistible__bu GVVGELYVAGAGLATGYVSRSDLTSTRFVACPFGPPGTRMYRTGDLVRWD MAB_3317c|M.abscessus_ATCC_199 GVIGELYLAGAGVGSGYWRRTALTGARFVACPFGMPGDRMYRTGDLVSWG Mflv_2697|M.gilvum_PYR-GCK GAAGELYLAGGQLTRGYLGRPGETAARFVPDPF-VPGARMYRTGDVVRRA MMAR_0099|M.marinum_M GVAGELYVAGAGVGCGYWRRSGLTASRFVACPFGALGARMYRTGDVVRWG Mb0104|M.bovis_AF2122/97 DTVLQCAPLTSDISVEEIFGGAACGARLVRSAAMKTGDLAALVDDLVARE Rv0101|M.tuberculosis_H37Rv DTVLQCAPLTSDISVEEIFGGAACGARLVRSAAMKTGDLAALVDDLVARE MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 A----------------DGQLQYLGRADEQVKIRGYRIELGEIQSALAAL MSMEG_0402|M.smegmatis_MC2_155 S----------------DGQLEYLGRADEQVKIRGYRIELGEIQAALAKL TH_3730|M.thermoresistible__bu T----------------GGELHYIGRADEQVKIRGYRIELGEIQAALARL MAB_3317c|M.abscessus_ATCC_199 A----------------DGQLQYLGRADEQIKIRGYRIELGEIQAALVRL Mflv_2697|M.gilvum_PYR-GCK V----------------DGTLAFLGRSDTQVKIRGFRVEPGEVAAVLRTH MMAR_0099|M.marinum_M P----------------DGQLQYVGRADEQVKIRGYRIELGEVAAALSQL Mb0104|M.bovis_AF2122/97 TTIVDLPTAVWQLLCADGDAIDAIGRSRLRQIVIGGEAIRCSAVDKWLES Rv0101|M.tuberculosis_H37Rv TTIVDLPTAVWQLLCADGDAIDAIGRSRLRQIVIGGEAIRCSAVDKWLES MUL_1722|M.ulcerans_Agy99 ---------------------EQTVKPSDRVCLLGFNSVDYATIDMTLAR Mvan_2578|M.vanbaalenii_PYR-1 -----------------------DVHPGDRVAVLGFTSIDYTTVDMALAM MLBr_00484|M.leprae_Br4923 ---------------------HDLLHAGYRVCVLGFNSVDYAIIDMALGV :. : : * MAV_3243|M.avium_104 DGVDQAAVIAREDRPGDKRLVGYITGTADPAELRTQLGKRLPAYMVPAAV MSMEG_0402|M.smegmatis_MC2_155 DGVDQAVVIAREDRPGDKRLVGYITGTADPAQLRTALAESLPAYMVPTAV TH_3730|M.thermoresistible__bu DGVDQAAVIAREDRPGDKRLVGYITGTADPVQARAQLADRLPPYMVPAAI MAB_3317c|M.abscessus_ATCC_199 DGVRQAAVIVREDRPGDKRIVGYITGGADPVGARAALAEQLPAYMVPVAV Mflv_2697|M.gilvum_PYR-GCK PAVGQAYVAVRPHRDG-HRLTAYVTGEPQLRELRAWLGRRLPRYLMPNAI MMAR_0099|M.marinum_M DGVDQAVVIAREDRPGDKRLVGYLVGSVDAGQARAALAQALPAYMVPAAV Mb0104|M.bovis_AF2122/97 AASQGISLLSSYGPTEATVVATFLPIVCDQTTMDGALLRLGRPILPNTVF Rv0101|M.tuberculosis_H37Rv AASQGISLLSSYGPTEATVVATFLPIVCDQTTMDGALLRLGRPILPNTVF MUL_1722|M.ulcerans_Agy99 LGAVAVPLQTSAAITQLQPIVAETQPTMIAASVD---------ALADATE Mvan_2578|M.vanbaalenii_PYR-1 LGAVAVPLQTSAPATTVRPIVAETEPVVIASSVD---------ALTDAVG MLBr_00484|M.leprae_Br4923 IGAVAVPLQTSAAITQLQSIVTETEPSMIATSVN---------QLPDTVE . : :. : . MAV_3243|M.avium_104 VVLESLPLTVNGKLDKRALPAPEYHKRAGQYRAPSNHTEEILADIYAQVL MSMEG_0402|M.smegmatis_MC2_155 VVLDTIPLTVNGKLDRRALPAPEYRSAANDYRAPSTPAEQILADVYAQVL TH_3730|M.thermoresistible__bu VVLESIPLTSNNKLDVRALPAPEYRATGAEYRAPGTPLEGLLAGIFAEVL MAB_3317c|M.abscessus_ATCC_199 VALQTLPVTVNGKLDKQGLPAPEY--SGVDFRAPSTPVEEALAGIYAQVL Mflv_2697|M.gilvum_PYR-GCK VAVDRIPLTAHGKIDEPALVALEP-AADGAATRPQTPTEVELAAVLAEVL MMAR_0099|M.marinum_M VVVDSLPLTVNGKLDIRALPAPQY-GATGSYRAPASPVEEVLAGIYAQVL Mb0104|M.bovis_AF2122/97 LAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDAE Rv0101|M.tuberculosis_H37Rv LAFGEVVIVGDLVADGYLGIDGDGFGTVTAADGSRRRAFATGDRVTVDAE MUL_1722|M.ulcerans_Agy99 LALSGQTATRVLVFDHHRQVDAHRAAVESARER----------------- Mvan_2578|M.vanbaalenii_PYR-1 LALDAPTVTRLVVFDHRAGVDDHRDALISASDR----------------- MLBr_00484|M.leprae_Br4923 LILSGQAPAKLVVFDYHPEVDEQHDAVATARAR----------------- : . . * . MAV_3243|M.avium_104 GVERVGVDDSFFDLGGDSILSMQVVARARAAGVICRPRDVFVEQTVAR-- MSMEG_0402|M.smegmatis_MC2_155 GVERVGVDDSFFDLGGDSILSMQVVARARAAGIQCRPRDIFVEQTVAG-- TH_3730|M.thermoresistible__bu GVERVGVDDSFFDLGGDSILSMQVVARARAAGVQCRPRDIFVEQTVAR-- MAB_3317c|M.abscessus_ATCC_199 GVDRVGADDSFFDLGGDSILAMQVAGRARAAGVLCRPRDIFVEQTVAR-- Mflv_2697|M.gilvum_PYR-GCK GVGEIDVTADFLELGLDSIVALSVVQTARRRGVVMRAKLMLDCATVR--- MMAR_0099|M.marinum_M GLDRVAVDQSFFDLGGDSILAIQVVARARAAGVVCRPRDVFTEQTVAGLA Mb0104|M.bovis_AF2122/97 GFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVW Rv0101|M.tuberculosis_H37Rv GFPVFSGRKDAVVKISGKRVDIAEVTRRIAEDPAVSDVAVELHSGSLGVW MUL_1722|M.ulcerans_Agy99 ------------LAGS---AVVETLAEAIARGDVPRGASAGSAPGTD--- Mvan_2578|M.vanbaalenii_PYR-1 ------------LRAANSPIEVETITDIVARGSKLPVRAQFSADG----- MLBr_00484|M.leprae_Br4923 ------------LADSS--VVVESLTEVLGRGKTLPATPIPVADDS---- : . MAV_3243|M.avium_104 -LARVASDGADEEQVVDEGIGPVQATPIMRWLQTVQGPIDDFNQTMVLAA MSMEG_0402|M.smegmatis_MC2_155 -VARVAVAAG-ESHVVDEGVGPVVATPIMRWLREVDGPTGQFNQTVITQA TH_3730|M.thermoresistible__bu -LASVVKVSGGEPETVDDGTGAVVATPIMRWLRGVDGPTDQFNQTVVLQA MAB_3317c|M.abscessus_ATCC_199 -LSRVVTLAENEIRNVDDGIGPVAPTPIMHWLHSVPGPVERFNQTVVLQA Mflv_2697|M.gilvum_PYR-GCK ELAAAIDDAGSGPPSADEGSGPIALLPNAHWLYEFGDP-RRLASTEALRL MMAR_0099|M.marinum_M TVAAVFDDANDDGGHAEDSVGEVVATPIMLWLQSLDGPLKEFNQTALLQA Mb0104|M.bovis_AF2122/97 FKSQRTREGEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSD Rv0101|M.tuberculosis_H37Rv FKSQRTREGEQDAAAATRIRLVLVSLGVSSFFVVGVPNIPRKPNGKIDSD MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 PSG------------------VTADDVAVVLQALLDRHPMLRLRVED--- MSMEG_0402|M.smegmatis_MC2_155 PAG------------------VTEDDVVVILQALLDRHATLRLRVEDT-- TH_3730|M.thermoresistible__bu PPGT--------------DTAAAEADVVAVLQALIDRHPTLRMRAEGMTA MAB_3317c|M.abscessus_ATCC_199 PAG------------------AAEADIVVLLQALLDHHGTLRLHAEN--- Mflv_2697|M.gilvum_PYR-GCK PRG------------------ITGPQIRALLQSVVDAHPVLRTRLDR--- MMAR_0099|M.marinum_M PAA------------------MSYGDVIVSLQAVLDRHAMLRLQVDT--- Mb0104|M.bovis_AF2122/97 NLPRLPQWSAAGLNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGS Rv0101|M.tuberculosis_H37Rv NLPRLPQWSAAGLNTAETGQRAAGLSQIWSRQLGRAIGPDSSLLGEGIGS MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -DGAGGWNLQAPEPGSVRAADCLQSVDTLSDAVLVAARSRLNPGAGVMVS MSMEG_0402|M.smegmatis_MC2_155 QEDTDEWSLLVPEAGAVGARECLRTVDALTDDVLVEARNRLDPAAGAMVS TH_3730|M.thermoresistible__bu GDGTDDWSLFIPEPGATSAREVMHTVDTLTDEVLIAARSRLNPAAGVMLS MAB_3317c|M.abscessus_ATCC_199 --NDGGWSLRVPEKGAVDARACIRTVEALSDEAVEAACSRLDPGAGAMLS Mflv_2697|M.gilvum_PYR-GCK -AAMTLVDGGFDLP--LTEIEVGDEGSAAVARHAAAALEHLDPQRGPLWG MMAR_0099|M.marinum_M -DATGRWLLHVPAPGCVDARKCVRAVTALSDDELVQARSRLDPSAGVMVS Mb0104|M.bovis_AF2122/97 LDLIRILPETRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRP Rv0101|M.tuberculosis_H37Rv LDLIRILPETRRYLGWRLSLLDLIGADTAANLADYAPTPDAPTGEDRFRP MUL_1722|M.ulcerans_Agy99 -----------------------VSDDSLALLIYTSGSTGAPKG------ Mvan_2578|M.vanbaalenii_PYR-1 --------------------------DALSLLIYTSGSTGAPKG------ MLBr_00484|M.leprae_Br4923 -------------------------ADPLALLIYTSGSTGAPKG------ . MAV_3243|M.avium_104 AVWAS-------ETSQLALIIHHVAVDGVSWRTLIEDLNIAWAQHHSGQP MSMEG_0402|M.smegmatis_MC2_155 AVWVR-------ETSQLVLMIHHLAVDGVSWRILLEDLNIAWAQHCTGQS TH_3730|M.thermoresistible__bu AVWAR-------GSGQLVLMIHHLAVDGVSWRILVEDLNIAWAQHRTGQP MAB_3317c|M.abscessus_ATCC_199 ALWAP-------AEGKLALVIHHLAVDGVSWRILLEDLNVAWAQRRSGLD Mflv_2697|M.gilvum_PYR-GCK AVWLRGSDDADSTSSVLLLTAHVLAMDPVSWQIVIGELDAGWHALAGGRA MMAR_0099|M.marinum_M ALWVT-------SSAQLALVIHHLAIDGVSWRILLDDLNSVWEQHRSGEM Mb0104|M.bovis_AF2122/97 LVAAQ----RPAAIPLSFAQRRLWFLDQLQRPAPVYNMAVALRLRGYLDT Rv0101|M.tuberculosis_H37Rv LVAAQ----RPAAIPLSFAQRRLWFLDQLQRPAPVYNMAVALRLRGYLDT MUL_1722|M.ulcerans_Agy99 AMYPR----RNVATFWR---KRTWFEGGYEPSITLNFMPMSHVMGRQILY Mvan_2578|M.vanbaalenii_PYR-1 AMYPQ----HLVANSWRRLARSFWGDLGVFPAITLNFMPMSHVMGRGLLY MLBr_00484|M.leprae_Br4923 AMYLQ----SNVGKMWRR-SDGNWFGP-TAASITLNFMPMSHVMGRGILY : : : MAV_3243|M.avium_104 VALPAGGTSFARWSSLLAEHALTPAVVEQADAWREVVATPAVLPAVQPEV MSMEG_0402|M.smegmatis_MC2_155 IELPAGGTSFARWSALLAEHAKTDTVRDLADAWRAVTSVPQALPPVQPDT TH_3730|M.thermoresistible__bu IDLPANGTSFARWSALLADHARAPEVVEHVEAWQRVIAAPSALPAIRPER MAB_3317c|M.abscessus_ATCC_199 VALSGAGTSFARWASLLREQALSAGVVESADVWRSVSAVPPALPVVRPGV Mflv_2697|M.gilvum_PYR-GCK PAALGEHTGYRQWSNLLRERAESS-------------------------- MMAR_0099|M.marinum_M AALPAGGTSFRRWAALLAEQAYSATAVDHAAAWRQVLATPSVLPAVKPAV Mb0104|M.bovis_AF2122/97 EALGAAVADVVGRHESLRTVFPAVDGVPRQLVIEARRA------------ Rv0101|M.tuberculosis_H37Rv EALGAAVADVVGRHESLRTVFPAVDGVPRQLVIEARRA------------ MUL_1722|M.ulcerans_Agy99 GTLCNGGTAYFVVKSDLSTLFEDLALVR---------------------- Mvan_2578|M.vanbaalenii_PYR-1 GTLDAGGTAYFAARSDLSTFLEDLALVR---------------------- MLBr_00484|M.leprae_Br4923 GTLGNGGTAYFAARSDLSTLLEDLKLVR---------------------- : * MAV_3243|M.avium_104 DTYQSAEQLSVSLDVDTTRLLLGEVPAAFHAGVQDILLIAFAMAWTQVVG MSMEG_0402|M.smegmatis_MC2_155 DTYVTAGQLSASLDVETTRQLLGEVPAAFRAGVQDILLVAFGLAWTEFLN TH_3730|M.thermoresistible__bu DTYATAGQLSVSLDADTTRQLLGAVPAAFHAGVQDILLIAFGLAWAEFLG MAB_3317c|M.abscessus_ATCC_199 DTYAVAGTLSVALDADVTRMLLGEVPAAFHAGVQDVLLIAFALAWNEFLG Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M DTYATAQRLLVSLDIETTRTLLAAAPAAFHAGVQDILLIAFALAWSEFSS Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -AGTPIGIDVEGHGRHEELGPHVDLSRTVGWFTTKYPVALAIDGLDWASV MSMEG_0402|M.smegmatis_MC2_155 RSDTPIGVDVEGHGRYDELASDVDLSRTVGWFTTKYPVALTVENLPWEQV TH_3730|M.thermoresistible__bu ACDSPIGIDVEGHGRAEELAAGVDLSRTVGWFTTKYPVALTIPKLSWEQV MAB_3317c|M.abscessus_ATCC_199 AGGAPIGIDLEGHGRAEELAADIDLSRTVGWFTAKYPAALSVGDLSWAQV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M GGGSRIAIDVEGHGRHEELAFGVDLSHTLGWFTTKYPVAVSVGALRWAQV Mb0104|M.bovis_AF2122/97 ----------------------------------------DLGCDIVDAT Rv0101|M.tuberculosis_H37Rv ----------------------------------------DLGCDIVDAT MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 VAGDDALGAAVKAAKEQLRALPDGLTYGLLRYLNPDVDLGGSDPVIGFNY MSMEG_0402|M.smegmatis_MC2_155 VAGDAALGGIVKAVKEQLRSLPEGLTYGLLRYLNPEVDLGGSDPTIGFNY TH_3730|M.thermoresistible__bu RTGGDALGAAVKAAKEQLRSVPDGITYGLLRHLNPDVELGGAEPAIGFNY MAB_3317c|M.abscessus_ATCC_199 SGGDSALGLVVKSVKEQLRGLPDPLSYGLLRYLNPEVALPHSDSAIGFNY Mflv_2697|M.gilvum_PYR-GCK ----------------------DGLQFWLD-------QLGGPDPALGARR MMAR_0099|M.marinum_M VAGDAALGAVVKDAKEQLRGLPDGLLYGLIRYLNREVELAGAEPTIGFNY Mb0104|M.bovis_AF2122/97 AWPADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEHVLVAVAH---- Rv0101|M.tuberculosis_H37Rv AWPADRLQRAIEEAARHSFDLATEIPLRTWLFRIADDEHVLVAVAH---- MUL_1722|M.ulcerans_Agy99 ---------------------PTELTFVPRVWDMVFDEFQSEVDRR---- Mvan_2578|M.vanbaalenii_PYR-1 ---------------------PTQLSFVPRIWDTIHAEVSQELERR---- MLBr_00484|M.leprae_Br4923 ---------------------PTELNFVPRIWETLYDESKRAVDRR---- : MAV_3243|M.avium_104 LGRLGAAA-DLPGELWRLSPDSLSLSGAAAAVAMPLMHTVDLNAGTMDTE MSMEG_0402|M.smegmatis_MC2_155 LGRLGAGAGELSEELWRIDQDSLALSDAASAVPMPLMHTVELNAGTIDTD TH_3730|M.thermoresistible__bu LGRLAAGAGDLPDELWRIDPSGLPITEAASKIPMPLAHTVEVNAGTLDAG MAB_3317c|M.abscessus_ATCC_199 LGRLGAGATEASEDIWTISHEGLSWTSASSTVPMPMAHTVELNAGILESS Mflv_2697|M.gilvum_PYR-GCK VR------------------------------------------------ MMAR_0099|M.marinum_M LGRL-STRTTAGDDHWQIARWGSLFTDECASAELPIQLFHTVELDAVTFD Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 --DGPHLHANWTWAPSAVDRDQISRLSQLWFEALAGICAHVRAGGGGLTP MSMEG_0402|M.smegmatis_MC2_155 --NGPSLRASWTWAPSAFDEEQATRLSRLWFEALAGICAHVRGGGGGLTP TH_3730|M.thermoresistible__bu P-DGPVLQATWTWAPSLVDEAQIARLSRLWFEALGGVCAHVRSGGGGLTP MAB_3317c|M.abscessus_ATCC_199 VESGPRLQAVWTWAPSLVDAIQVQRLSRLWFEALVGICTHVRTGGGGLTP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M TEAGPQLHAQWTWATSALDRAQLNRISRLWFEALTGICAHVRAGGGGMTP Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 SDILPARLNQRQIDELSKQHQIADILPLTPLQQGLLFHASFAQ------- MSMEG_0402|M.smegmatis_MC2_155 SDVAPARLTQRQIDELSQRYDVTDVLPLTPVQQGLLFHSTFAR------- TH_3730|M.thermoresistible__bu SDIAPARLTQQQIDELADRHDIADILPLTPVQQGLLFHSAVTR------- MAB_3317c|M.abscessus_ATCC_199 SDILPARLTQGELDELTKCLRVADVLPLTPVQQGLLFHSAIAARADSAAA Mflv_2697|M.gilvum_PYR-GCK --------------------------------------PDTDR------- MMAR_0099|M.marinum_M SDIGLTRLSQHQIDQLEQRYCVADVLPLTPLQQGLLFHADAAR------- Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 -DPGDDVYAVQLGITVTGALDSHRLHDAVHTVVNRHPNLAAR--FCPQYG MSMEG_0402|M.smegmatis_MC2_155 -GIGDDVYAVQLDITITGVLDQHRLRDAVHTVVARHPNLAAR--FVEQFG TH_3730|M.thermoresistible__bu -TTADDIYAVQLDLTIAGVVDQHRLRDAVHAVVARHPNLAAR--FCTDHD MAB_3317c|M.abscessus_ATCC_199 GTALADIYAVQLNLTMTGAVDPRRLYNAMHAVVKRHPNLVAR--FCTRFG Mflv_2697|M.gilvum_PYR-GCK --AGD----VRVTVTVTGADVTARLLAGPHPVLD---------------- MMAR_0099|M.marinum_M --GGADLYVVQFDITLSGALDPRRLRTAAQEVLRRHPNLAAQFVWGEPLD Mb0104|M.bovis_AF2122/97 --------HIAADGWSVAPLTADLSAAYASRCAGRAPDWAPL-------- Rv0101|M.tuberculosis_H37Rv --------HIAADGWSVAPLTADLSAAYASRCAGRAPDWAPL-------- MUL_1722|M.ulcerans_Agy99 --------LVDG--ADRVALEAQVKAEIRNDVLG---------------- Mvan_2578|M.vanbaalenii_PYR-1 --------PSD---------ATEVIADLRRSLLG---------------- MLBr_00484|M.leprae_Br4923 --------LANSGSADRAAIKAEVMDEQRQSLLG---------------- MAV_3243|M.avium_104 EPVQVVPADPVMAWRYIQLGPE---DVDPEQKVEELCAAERAAVSDLANR MSMEG_0402|M.smegmatis_MC2_155 EPVQVLTADPMIAWRYLDLRGD---DLTPDHEIEQLCAAERSAVCDLLER TH_3730|M.thermoresistible__bu HPVQIIPTEPVAAWRYLDLRGD---DQNPEHEVQQLCAAERAAVRDLTER MAB_3317c|M.abscessus_ATCC_199 EPVQVIPADPMICWQQTEFES--------TEELERFCAAERVAACDLAGK Mflv_2697|M.gilvum_PYR-GCK -----------------------------------------VLVAALG-- MMAR_0099|M.marinum_M EPVQIILNDLVLEWRTVEFDPAGDPDAHVEQHIDEVCADERVAVADLGGG Mb0104|M.bovis_AF2122/97 -------------------------------------------------- Rv0101|M.tuberculosis_H37Rv -------------------------------------------------- MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 PAFRAALIRTADNRHRFVLTNHHIVMDGWSLPILLREILAIYYGDQLPAP MSMEG_0402|M.smegmatis_MC2_155 PTFRAALIRTSGNQHRFVLTFHHIVIDGWSLPILLQEIFAGYFGHRLPAA TH_3730|M.thermoresistible__bu PTFRAALIRTGATEHRFVLTVHHIVIDGWSLPILLQEIFAGYFGQRLPAP MAB_3317c|M.abscessus_ATCC_199 STFRSALVRTGGDKHRFILTFHHVVIDGWSLPILLREIFAIYFGQALAPA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SPFRIALIRTAPCEHRLVLTAHHIVCDGWSMPIVMQEILAAYAGQPLAAP Mb0104|M.bovis_AF2122/97 -------------------------------------------------P Rv0101|M.tuberculosis_H37Rv -------------------------------------------------P MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 ATYRSYLTWLAGQDRSAAQAAWRQVLDGFDTPTLVGPAGRMRLGRRAVES MSMEG_0402|M.smegmatis_MC2_155 APYRNFVNWLATQDATAAKAAWREVLDGFETPTLVAPPG--VPGPRGIES TH_3730|M.thermoresistible__bu ARFRDFVTWLAAQDRDAARAAWRELLDGFDTPTLIAPPG--QAGPRGSAS MAB_3317c|M.abscessus_ATCC_199 PSYRGFVSWLAQQDREAARAAWRKALEGFEAPTLVAPRS--VPGSRGVAS Mflv_2697|M.gilvum_PYR-GCK ---RTITEWRGRRNQPTP-------------PPLVALETHG--------- MMAR_0099|M.marinum_M GSYRNFLTWLAERDKSAARTAWRELFADFRHPTLVGLPDHLGLGSRGVES Mb0104|M.bovis_AF2122/97 VQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAGMPERLRLPTARPY Rv0101|M.tuberculosis_H37Rv VQYVDYTLWQREILGDLDDSDSPIAAQLAYWENALAGMPERLRLPTARPY MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 YRLSADTTRALGELARACHTTVNTVLQAGWAQLLMRLTGQHDVAFGTAVS MSMEG_0402|M.smegmatis_MC2_155 YRVSAETTRALGELARSQHTTINTVLQAAWTQLLMRMTGQRDVAFGTAVS TH_3730|M.thermoresistible__bu YRIDTETTAAIGELARTQRTTVNTVLQAAWAHLLMAMTGQRDVVFGTAVS MAB_3317c|M.abscessus_ATCC_199 YRISAETTRALGDLARSQHTTVSTVLRAAWAQLLMVQTGAHDVAFGTVVS Mflv_2697|M.gilvum_PYR-GCK -----------------------------------------RAALAEADT MMAR_0099|M.marinum_M YLLPIGITEALTELARSCRVTVNIVLQAAFAQLLSWLTGQHDVAFGTTVS Mb0104|M.bovis_AF2122/97 PPVADQRGASLVVDWPASVQQQVRRIARQHNATSFMVVAAGLAVLLSKLS Rv0101|M.tuberculosis_H37Rv PPVADQRGASLVVDWPASVQQQVRRIARQHNATSFMVVAAGLAVLLSKLS MUL_1722|M.ulcerans_Agy99 ------------------------------------------GRYTSALT Mvan_2578|M.vanbaalenii_PYR-1 ------------------------------------------GRYVTAMT MLBr_00484|M.leprae_Br4923 ------------------------------------------GRYIAAMT : MAV_3243|M.avium_104 G----------RPADLAGAESMVGLLINTVPVRANTHAETTVADLLDQLQ MSMEG_0402|M.smegmatis_MC2_155 G----------RPADLAGAESMVGLLINTVPIRAKVSADTTVGDLLRQLQ TH_3730|M.thermoresistible__bu G----------RPADLPGADRIVGLLINTIPVRARIGADTTVADLLAQLQ MAB_3317c|M.abscessus_ATCC_199 G----------RPALLTGADSVVGLLINTVPVRARATATTTVADLLRDMQ Mflv_2697|M.gilvum_PYR-GCK A----------DTADTADTSDTVGLLSAIYPLRLHEDSPGATTELIAGVP MMAR_0099|M.marinum_M G----------RPAEVAGVHSMVGLFINTVPTRARMASTTTTRELLDQLQ Mb0104|M.bovis_AF2122/97 GSPDVAVGFPIAGRSDPALDNLVGFFVNTLVLRVNLAGDPSFAELLGQVR Rv0101|M.tuberculosis_H37Rv GSPDVAVGFPIAGRSDPALDNLVGFFVNTLVLRVNLAGDPSFAELLGQVR MUL_1722|M.ulcerans_Agy99 G----------SAPISDEMKAWVEELLDMHLVEGYGSTEAGMILIDGAIR Mvan_2578|M.vanbaalenii_PYR-1 G----------SAPLSPEMRAFVENLLDVHLIDGYGSTEAGAVFVDGRVQ MLBr_00484|M.leprae_Br4923 G----------SAPTSPELKHGVESLLEMHLLEGYGSTEAGMVLFDGEVQ . * : . : MAV_3243|M.avium_104 Q---HHNDTLEHEHLALSEIHRVTGHDALFDTLFLYENYPIDTSVPLGFH MSMEG_0402|M.smegmatis_MC2_155 S---HHNDTLEHEHLALNDIHHVSGHEQLFDTLFLYESYPIDTSAFMGVQ TH_3730|M.thermoresistible__bu H---AHNDTLEHEHLALTEIHHLAGHDQLFDTLFLYESYPIDTGAFSGAQ MAB_3317c|M.abscessus_ATCC_199 S---IHNDLLEHEHLALNEIHHLAGHDRLFDTLFLYENYPVDVSTFMGTH Mflv_2697|M.gilvum_PYR-GCK AG-GIDYGLLRYLRPDTS-------------------------------- MMAR_0099|M.marinum_M S---VHYETLEHHHLALSDIHRVSGHDQLFDTLFVYENYPIDKTAAQGTG Mb0104|M.bovis_AF2122/97 ARSLAAYENQDVPFEVLVDRLKPTRALTHHPLIQVMLAWQDNPVGQLNLG Rv0101|M.tuberculosis_H37Rv ARSLAAYENQDVPFEVLVDRLKPTRALTHHPLIQVMLAWQDNPVGQLNLG MUL_1722|M.ulcerans_Agy99 RPAVLDYKLVDVPDLGYFLTDRP------HPRGELLVKTDSLFPGYYQRA Mvan_2578|M.vanbaalenii_PYR-1 RPPVIDYKLVDVADLGYFSTDRP------HPRGELLVKSETLFPGYYKRP MLBr_00484|M.leprae_Br4923 RPPVIDYKLVDVPDLGYFSTDQP------YPRGELLLKTQNMFPGYYKRP MAV_3243|M.avium_104 ELAITDVTNREYNHYPLSVMALPGRE--------LGLRVEFDTDVFDAAG MSMEG_0402|M.smegmatis_MC2_155 ELAVTEFNNREYNHYPLSVMALPGHE--------LGLRVEYDTSVFDVSE TH_3730|M.thermoresistible__bu ELAVTGFTNREFNHYPLSVMALPGHE--------LGLRIEYDTEVFDTAA MAB_3317c|M.abscessus_ATCC_199 ELGITEFTSREYNHYPLSVMALPGHE--------LGIRIEYDTDAFDVAD Mflv_2697|M.gilvum_PYR-GCK ----------------EVLKAHPEPQ--------ILLNYLGRTDLVPSGA MMAR_0099|M.marinum_M ELAISGIGCREYSHYPLVVQAMPGDQ--------LGLRVEFRTDVFDAAS Mb0104|M.bovis_AF2122/97 DLQATPMPIDTRTARMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEAQA Rv0101|M.tuberculosis_H37Rv DLQATPMPIDTRTARMDLVFSLAERFSEGSEPAGIGGAVEYRTDVFEAQA MUL_1722|M.ulcerans_Agy99 EVTADVFDADGFYRTGDIMAEVGPEQ------------------------ Mvan_2578|M.vanbaalenii_PYR-1 DVTAEMFDEDGYYRTGDIVAETGADQ------------------------ MLBr_00484|M.leprae_Br4923 EVTATVFDSDGYYQTGDIVAEVGPDR------------------------ : MAV_3243|M.avium_104 IEKLTERFQRVLSEMTADPTRRLTSLEVMDEAEHELLDAWGNRPVLSQPA MSMEG_0402|M.smegmatis_MC2_155 IETLIDRFQRLLEAMIDDPARRLSSMDVVDDDERTQLDEWANRAVLTQPV TH_3730|M.thermoresistible__bu IDALADRFRRVLESMVGDPARRLSAIEVLDAAEREQLDAWSNRAVLAD-S MAB_3317c|M.abscessus_ATCC_199 IGALVQRLRRILGAMTAAPARRVLSIDVLEVAERGRLDSWGNRAVLACAT Mflv_2697|M.gilvum_PYR-GCK IVADRLLLS------------GLSTVPEPNAAVRHELTVV---------- MMAR_0099|M.marinum_M IAALIQRLQRVVVAMVADPDRRLSSVDLLDAAEHARLDVVGNRAVLAEPL Mb0104|M.bovis_AF2122/97 IDVLIERLRKVLVAVAAAPERTVSSIDALDGTERARLDEWGNRAVLTAPA Rv0101|M.tuberculosis_H37Rv IDVLIERLRKVLVAVAAAPERTVSSIDALDGTERARLDEWGNRAVLTAPA MUL_1722|M.ulcerans_Agy99 --FVYLDRRNNVLKLSQGEFVTVSKLEAVFGDS----------------- Mvan_2578|M.vanbaalenii_PYR-1 --LTYLDRRNNVLKLSQGEFVTVSRLEAVFGNS----------------- MLBr_00484|M.leprae_Br4923 --LVYVDRRNNVLKLAQGQFVTVAKLEAAFSNS----------------- : : MAV_3243|M.avium_104 TG-TSIPALFAAQVARTPDAAALTFQGRSMSYRELDEASNRLAHLLIEEG MSMEG_0402|M.smegmatis_MC2_155 DSPQSIPEVFARQVERDPEAPAVTFEGESLNYGELDEAANQLANLLAVYG TH_3730|M.thermoresistible__bu PALESIPEVFARQVARDPGAVAVTFEGRSMTYGELDDAATELANLLAVYG MAB_3317c|M.abscessus_ATCC_199 AASSSIPEVFARQVDRAPQAVALTFQGRSMTYRELDHAANRLAQLLASRG Mflv_2697|M.gilvum_PYR-GCK -----------AAVVAHGDEPALVAQWRVLPEILSDTDVEEMQTIWQDT- MMAR_0099|M.marinum_M VEPVSVPGLFAAQVASRAEVTALVCGDRSLTYRELDRAANRLAHLLVDQG Mb0104|M.bovis_AF2122/97 PTPVSIPQMLAAQVARIPEAEAVCCGDASMTYRELDEASNRLAHRLAGCG Rv0101|M.tuberculosis_H37Rv PTPVSIPQMLAAQVARIPEAEAVCCGDASMTYRELDEASNRLAHRLAGCG MUL_1722|M.ulcerans_Agy99 --PLVRQIYIYGNSARAYLLAVIVPTQEALDAVPVEELKARLGDSLQEVA Mvan_2578|M.vanbaalenii_PYR-1 --PLVRQIYVYGNSARPYLLAVVVPTEAALAGA---DAKAAVAESLQDVA MLBr_00484|M.leprae_Br4923 --PLVRQIYIYGNSAHPYLLAVVVPTEDALATNDIEVLKPLIIDSLQKVA .: : : MAV_3243|M.avium_104 AGPGECVALLFSRSAEAIVSILAVLKTGAAYLPIDPALPAARIEFLLGDA MSMEG_0402|M.smegmatis_MC2_155 AAPGKSVALMVPRSADAIVAILAVLKTGAAYLPIDPSVPAARLEFMLGDA TH_3730|M.thermoresistible__bu AGPGESVALLMPRSADAIVAILAVLKTGAAYLPIDPAVPAARLEFMLSDA MAB_3317c|M.abscessus_ATCC_199 AGPGESIALMVPRSDDAIVALLAVLKTGAAYLPIDPAVPVARLEFMLADA Mflv_2697|M.gilvum_PYR-GCK --------------------LREVL------------------------- MMAR_0099|M.marinum_M VGPGDVVGLLLERSVEAVIAILAVLKSGAAYLAIDVNHPDGRIGFMIEDA Mb0104|M.bovis_AF2122/97 AGPGECVALLFERCAPAVVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDA Rv0101|M.tuberculosis_H37Rv AGPGECVALLFERCAPAVVAMVAVLKTGAAYLPIDPANPPPRVAFMLGDA MUL_1722|M.ulcerans_Agy99 KAAG---------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 KATG---------------------------------------------- MLBr_00484|M.leprae_Br4923 KEAD---------------------------------------------- MAV_3243|M.avium_104 EPVAVVTTAALRSRLDGCKPSVVDVDDP---ALD-GQPSAALPVPSSDNI MSMEG_0402|M.smegmatis_MC2_155 KPVAAVTTGDLRSRFDGFDLQVVEVDDP---AVE-IYPSTTLLTPSPDDI TH_3730|M.thermoresistible__bu EPIVALTTVELGTRFNGTGVPIIEVDDP---APP-MYPSSTLLPPAPDDI MAB_3317c|M.abscessus_ATCC_199 APIAVATTAELRQRLAGSSIPVLVIDEH---VVD-EPAAVSLQAPRPDDI Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M APVAVITTAGLAQRLAGYPVAVIDIDDP---AIATCYPGHGLPFPSADNI Mb0104|M.bovis_AF2122/97 VPVAAVTTAGLRSRLAGHDLPIIDVVDALAA-----YPGTPPPMPAAVNL Rv0101|M.tuberculosis_H37Rv VPVAAVTTAGLRSRLAGHDLPIIDVVDALAA-----YPGTPPPMPAAVNL MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 AYLIYTSGTTGVPKGVAVSHDNVAQLVES---LHAD-LPE--GGVWAQWH MSMEG_0402|M.smegmatis_MC2_155 AYMIYTSGTTGVPKGVAITHGNVTQVLDT---LPAE-LPAGPGAVWSQWH TH_3730|M.thermoresistible__bu AYLIYTSGTTGVPKGVAITHANVTRVLHT---LPAD-LPAGPGKVWSQWH MAB_3317c|M.abscessus_ATCC_199 AYTIYTSGTTGTPKGVAVTHRNVTQLLET---LPVG-LPAGPGQVWSQWH Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AYLIYTSGTTGKPKGVGITHHNITQLFTS---VAATGFTPAPGQIWTQCH Mb0104|M.bovis_AF2122/97 AYILYTSGTTGEPKGVGITHRNVTRLFASLPAR------LSAAQVWSQCH Rv0101|M.tuberculosis_H37Rv AYILYTSGTTGEPKGVGITHRNVTRLFASLPAR------LSAAQVWSQCH MUL_1722|M.ulcerans_Agy99 ------------------------------------------LQSYEIPR Mvan_2578|M.vanbaalenii_PYR-1 ------------------------------------------LQSYEIPR MLBr_00484|M.leprae_Br4923 ------------------------------------------LQSYEVPR MAV_3243|M.avium_104 SLVFDVSVHEIWGALLHGGRLVVVPESVAASPDELHDLLVAEGVTVLSQT MSMEG_0402|M.smegmatis_MC2_155 SLVFDVSVWEIWGALLHGGRLVIVPESIAGSPDDLHALLVSEGVNVLYQT TH_3730|M.thermoresistible__bu SLVFDVSVWEIWGALLHGGRLVIVPESITGSPDDLHDLLVAEHVDVVYQT MAB_3317c|M.abscessus_ATCC_199 SMVFDVSVWEVWGALLHGARLMVVPEAVAGSPQHLHDLLVTEKVSVLHQT Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SYAFDLSVFEMWGALLHGGRLVVVPESVTGSPADLHALLVAEQVDVLAQT Mb0104|M.bovis_AF2122/97 SYGFDASAWEIWGALLGGGRLVIVPESVAASPNDFHGLLVAEHVSVLTQT Rv0101|M.tuberculosis_H37Rv SYGFDASAWEIWGALLGGGRLVIVPESVAASPNDFHGLLVAEHVSVLTQT MUL_1722|M.ulcerans_Agy99 DFIIETTPWTLQNGLLTGIRKLARPQ------------------------ Mvan_2578|M.vanbaalenii_PYR-1 DFLLETTPFTLENGLLTGIRKLARPR------------------------ MLBr_00484|M.leprae_Br4923 DLIVETTPFSLENGLLTGIRKLAWPK------------------------ MAV_3243|M.avium_104 PSAVGMLSPEGLDSTALVVAGEACPVEIVDRWAPGRVMINAYGPTEATVY MSMEG_0402|M.smegmatis_MC2_155 PSAVRMMSPEGLEGTALVVAGEACPTEVVDRWAVDRVMINAYGPTESTIY TH_3730|M.thermoresistible__bu PSAAGMLSQRGLDSTALVVAGEACPTDLVDRWAPGRVMINAYGPTETTMC MAB_3317c|M.abscessus_ATCC_199 PSAIGMLDWDGVDDMAVVVAGEPCPPEVVDRWAPGRLMLNAYGPTEATIY Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M PSAVAMLSTQGLESTTLVVGGEACPAEVVDNWAPGRMMVNQYGPSETTMY Mb0104|M.bovis_AF2122/97 PAAVAMLPTQGLESVALVVAGEACPAALVDRWAPGRVMLNAYGPTETTIC Rv0101|M.tuberculosis_H37Rv PAAVAMLPTQGLESVALVVAGEACPAALVDRWAPGRVMLNAYGPTETTIC MUL_1722|M.ulcerans_Agy99 -------------------------------------LKKHYGELLEQIY Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------LRERYGEQLEALY MLBr_00484|M.leprae_Br4923 -------------------------------------LKQHYGARLEQLY MAV_3243|M.avium_104 AAMSTPLQPGTGSAPIGSPVPRAALFVLDRWLRPAPPGVVGELYIAGHGV MSMEG_0402|M.smegmatis_MC2_155 AAISAPLSPGSDVVPIGSPVPKGATFVLDEWLRPVPPGVVGELYLAGRGV TH_3730|M.thermoresistible__bu VAISAPLTPGSGAVPIGTPVPRAALFVLDSWMRPVPAGVIGELYVAGDGV MAB_3317c|M.abscessus_ATCC_199 AAISMPLSPKTSPVPIGSPVRGGATFVLDGWLRPVPPGVVGELYLAGSGV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VSMSAPLVPGSGPAPIGVPVPRAALFVLDGWLRPVPAGVAGELYVAGAGV Mb0104|M.bovis_AF2122/97 AAISAPLRPGSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGV Rv0101|M.tuberculosis_H37Rv AAISAPLRPGSGMPPIGVPVSGAALFVLDSWLRPVPAGVAGELYIAGAGV MUL_1722|M.ulcerans_Agy99 TDLAH--------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 TMLSE--------------------------------------------- MLBr_00484|M.leprae_Br4923 ADLVE--------------------------------------------- MAV_3243|M.avium_104 ATGYARRSGLTASRFVACPFGGPGARMYRTGDLVRWNQDGQLEYLGRADE MSMEG_0402|M.smegmatis_MC2_155 GVGYVGRSGLTGTRFVACPFGEPGARMYRTGDLVRWGDDGQLQYLGRADE TH_3730|M.thermoresistible__bu AVGYVGRSELTASRFVACPFGPPGSRMYRTGDLVRWGADGQLQYLGRADE MAB_3317c|M.abscessus_ATCC_199 GVGYVHRSGLTGSRFVACPFGRPGVRMYRTGDLARYSEDGQLQYLGRTDE Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M GCGYWRRSGLTASRFVACPFGALGARMYRTGDVVRWGPDGQLQYVGRADE Mb0104|M.bovis_AF2122/97 GVGYWRRAGLTASRFVACPFGGSGARMYRTGDLVCWRADGQLEFLGRTDD Rv0101|M.tuberculosis_H37Rv GVGYWRRAGLTASRFVACPFGGSGARMYRTGDLVCWRADGQLEFLGRTDD MUL_1722|M.ulcerans_Agy99 ---------------------------------------------GQADE Mvan_2578|M.vanbaalenii_PYR-1 ---------------------------------------------EQADE MLBr_00484|M.leprae_Br4923 ---------------------------------------------GQANA MAV_3243|M.avium_104 QVKLRGYRIELGEVQAALAGLDGVEQAAVIAREDRPGDKRLVGYITGTAD MSMEG_0402|M.smegmatis_MC2_155 QVKIRGYRIELGEIQAALSDVDGVDQAVVIAREDRPGDKRLVGYITGTAD TH_3730|M.thermoresistible__bu QVKIRGYRIELGEVQTALTAVDGVENAVVIAREDRPGDKRLVGYITGTAD MAB_3317c|M.abscessus_ATCC_199 QVKIRGYRIELDEIRSALAELDGVEHAAVIVREDRPGDKRLVGYVTGTAD Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M QVKIRGYRIELGEVAAALSQLDGVDQAVVIAREDRPGDKRLVGYLVGSVD Mb0104|M.bovis_AF2122/97 QVKIRGYRIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAP Rv0101|M.tuberculosis_H37Rv QVKIRGYRIELGEVATALAELAGVGQAVVIAREDRPGDKRLVGYATEIAP MUL_1722|M.ulcerans_Agy99 LRSLR----------------QSGADAPVLVTVCRAAAALLGGSASDVQP Mvan_2578|M.vanbaalenii_PYR-1 LRELR----------------RSGGERPALETVGRAAGALLGTTAGELEP MLBr_00484|M.leprae_Br4923 LHVLK----------------QSVANAPVLQTVSRAVGTILGVATTDLPS MAV_3243|M.avium_104 ----PVGIRIQLAERLPAYMVPAAVVVLDALPLTVNGKLDKRALPAPEYR MSMEG_0402|M.smegmatis_MC2_155 ----PAAARSELTNRLPAYMVPAAVVTLETLPLTVNGKLDRRALPAPEYQ TH_3730|M.thermoresistible__bu ----PDQARARLADRLPAYMVPTAVVVLDALPLTVNGKLDTRALPAPEYQ MAB_3317c|M.abscessus_ATCC_199 ----PTMLRTLLGERLPQYMVPAAVVAVDAIPLTINGKLDKRSLPAPVYH Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M ----AGQARAALAQALPAYMVPAAVVVVDSLPLTVNGKLDIRALPAPQYG Mb0104|M.bovis_AF2122/97 GAVDPAGLRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYG Rv0101|M.tuberculosis_H37Rv GAVDPAGLRAQLAQRLPGYLVPAAVVVIDALPLTVNGKLDHRALPAPEYG MUL_1722|M.ulcerans_Agy99 -------------------------------------------------- Mvan_2578|M.vanbaalenii_PYR-1 -------------------------------------------------- MLBr_00484|M.leprae_Br4923 -------------------------------------------------- MAV_3243|M.avium_104 KRGGEYIAPTNPTEETVAGIFARVLGMERVSIDDSFFELGGDSLSAMRVI MSMEG_0402|M.smegmatis_MC2_155 S-AQRYRAPETETEKTLAGIFAHVLGVERIGLDDSFFDLGGDSISAMRVT TH_3730|M.thermoresistible__bu D-AEQYRAPTHAVEEVLAGIYAEVLGIDKVGVDDSFFDLGGDSISSMQVV MAB_3317c|M.abscessus_ATCC_199 D-AARYREPVSPVERTIADIYAHTLGLERIGVEDSFFDVGGDSISAMRVV Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M A-TGSYRAPASPVEEVLAGIYAQVLGLDRVAVDQSFFDLGGNSILAMRVS Mb0104|M.bovis_AF2122/97 D-TNGYRAPAGPVEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMRVI Rv0101|M.tuberculosis_H37Rv D-TNGYRAPAGPVEKTVAGIFARVLGLERVGVDDSFFELGGDSLAAMRVI MUL_1722|M.ulcerans_Agy99 --------------------------------DAHFTDLGGDSLSALSFT Mvan_2578|M.vanbaalenii_PYR-1 --------------------------------SAHFTDLGGDSLSALTFA MLBr_00484|M.leprae_Br4923 --------------------------------NAHFTDLGGDSLSALTFG MAV_3243|M.avium_104 AEINTAVDGALSVRTLFDSQSVRALS---QRITSGADAENAAGPGFAAVH MSMEG_0402|M.smegmatis_MC2_155 AAVNTALDADLSVRTLFEAPTVAKLS---LHVEHDAG-ERTDRVSFAAVH TH_3730|M.thermoresistible__bu ARAR-AAGLTIRPRDIFVERTVARLAQ--VAVPTGADAAVDDAGTGPVVA MAB_3317c|M.abscessus_ATCC_199 AAINTALDVDLEVWTIFDAPSVRSLSARLNGAVSASPIAESSRTSCASVH Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M SAIEKFLGVDLPVRLMFEAPTVESLSR------------QVESPYSSVEL Mb0104|M.bovis_AF2122/97 AAINTTLNADLPVRALLHASSTRGLSQLLGRDARP--TSDPRLVSVHGDN Rv0101|M.tuberculosis_H37Rv AAINTTLNADLPVRALLHASSTRGLSQLLGRDARP--TSDPRLVSVHGDN MUL_1722|M.ulcerans_Agy99 NLLHEIFDIDVPVGVIVSPANDLQALADYVEAARKPGSSRPTFASVHGAS Mvan_2578|M.vanbaalenii_PYR-1 NLLRDIFDVDVPVGVIVSPATDLQALADYVESARRHGSVRPTFESVHGHS MLBr_00484|M.leprae_Br4923 SLLRELFDIDVPVGVIVSPVNNLVAIADYIERERQ-GTKRPTFIAIHGRD MAV_3243|M.avium_104 GADAKEVYARDLTLDKFLDATTLSTAPTLPGPSPEVRTVLLTGATGFLGR MSMEG_0402|M.smegmatis_MC2_155 GSDVTEVHARDLTLDKFIDAPTLRTATTLPRPDGAVQTVLLTGATGFLGR TH_3730|M.thermoresistible__bu TPIMRWLYDTRGPIDQFNQTVVLR------APAGVTEADVVEILQAVLDR MAB_3317c|M.abscessus_ATCC_199 GRGVTQVMATDLTLDKFVDVTALIANRSRRHPRGDVREILLTGATGFLGR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M APVELLKQGAGTPLFCLPPGGGLSWIYRNLGAYLDCPIIGIQQVPSDQEV Mb0104|M.bovis_AF2122/97 PT---EVHASDLTLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGR Rv0101|M.tuberculosis_H37Rv PT---EVHASDLTLDRFIDADTLATAVNLPGPSPELRTVLLTGATGFLGR MUL_1722|M.ulcerans_Agy99 NEQVTEVHAGDLSLDKFIDAATLAEAPRLPAANTQVRTVLLTGATGFLGR Mvan_2578|M.vanbaalenii_PYR-1 GRPGTEVHARDLTLDEFVDAATLAHAPTLPGPRAEVRTVLLTGATGFLGR MLBr_00484|M.leprae_Br4923 AG---KVHASDLTLDKFIDVSTLTAAPVLAQPGTEVRTVLLTGATGFLGR MAV_3243|M.avium_104 YLVLEWLEQLEQVDGKLICLVRARSDEEAWGRLEKTFNTGDPELLRHFQE MSMEG_0402|M.smegmatis_MC2_155 YLLLEWLRQLRRVDDKVICLVRGKSDEDARRRLEATFDT-DPLLRKHFNE TH_3730|M.thermoresistible__bu HAMLR----LRAADVENLTVPES-GAVTARGCLRTVHRLSGDELR----- MAB_3317c|M.abscessus_ATCC_199 HLVLHWLREMEHAGGTLTCLVRGSSHEEARSRLEKSFDSGDPGLMALFRR Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M EPGSVGDMARRYVDMIQAHHPDGPYNLLGWSMGGVVAHEIAVELRRRGCE Mb0104|M.bovis_AF2122/97 YLVLELLRRLDVDG-RLICLVRAESDEDARRRLEKTFDSGDPELLRHFKE Rv0101|M.tuberculosis_H37Rv YLVLELLRRLDVDG-RLICLVRAESDEDARRRLEKTFDSGDPELLRHFKE MUL_1722|M.ulcerans_Agy99 YLALEWLERMDLVDGKLICLVRAKSDTEARARLEKTFDSGAPELLAHYRA Mvan_2578|M.vanbaalenii_PYR-1 YLALEWLERMALVGGKLICLVRAKDDAAARVRLDSTFDSGDPELLRHYRR MLBr_00484|M.leprae_Br4923 YLALKWLERMDLVEGKVIALVRAKSNEDARARLDKTFDSGDPKLLAHYQE MAV_3243|M.avium_104 LAEEHLQVVAGDKGQANLGLDEQTWQQLADTVDLIVDSAAVVNGVLPYSE MSMEG_0402|M.smegmatis_MC2_155 LATERLQVVAGDKGQPNLGLDEQTWQRLAESVDLIVDSAAFVNSVLPYSE TH_3730|M.thermoresistible__bu SARAELDPAAGTMVRALWAPDTRRLALIVH--HLAVDAVSWRILVEDINI MAB_3317c|M.abscessus_ATCC_199 LAADRLKVVAGDKGEPHLGLEPQTWEHLAESVDLVVDSAAFVNSVLPYEE Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VGRLIVLDAAG-EVDSADSVAEPASESDVLELILVAAGIDIAEHPRPLTY Mb0104|M.bovis_AF2122/97 LAADRLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVN-AFPYHE Rv0101|M.tuberculosis_H37Rv LAADRLEVVAGDKSEPDLGLDQPMWRRLAETVDLIVDSAAMVN-AFPYHE MUL_1722|M.ulcerans_Agy99 LAGDHLEVLAGDKGEADLGLDRQTWQRLADTVDLIVDPAALVNHVLPYSQ Mvan_2578|M.vanbaalenii_PYR-1 LAADHLEVIAGDKADADLGLDARTWQRLADTVDLIVDPAALVNHVLPYRQ MLBr_00484|M.leprae_Br4923 LATDHLEVIAGDKGEVDLELDRQTWRRLADTVDLIVDPAALVNHVLPYSE MAV_3243|M.avium_104 LFTPNVGGTAELIRLALTTRKKPFAYVSTSDVGRQIEPSAFTEDADIRVI MSMEG_0402|M.smegmatis_MC2_155 LFGPNVVGTAELIRFALTSKLKPFNFVSTSDVGRQIEPSRFTEQADIRLV TH_3730|M.thermoresistible__bu AWGQRHTG----QPIDLPAGGTSFARWST----------LLAEYADTPEV MAB_3317c|M.abscessus_ATCC_199 LFRPNVVGTAELIRLALTAKLKPYTFVSTSDVGRQVDRSKFTEVADIREI Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M HEAEALLNQRTPVEFSLPPRRIVEIMLDNMNANQSMRLKHVPDVFDGDMI Mb0104|M.bovis_AF2122/97 LFGPNVAGTAELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVI Rv0101|M.tuberculosis_H37Rv LFGPNVAGTAELIRIALTTKLKPFTYVSTADVGAAIEPSAFTEDADIRVI MUL_1722|M.ulcerans_Agy99 LFGPNALGTAELLRLALTSKIKPYSYTSTIGVADQIPPSAFTEDADIRVI Mvan_2578|M.vanbaalenii_PYR-1 LFAPNVLGTAELLRIALTTRMKPFVYVSTIGVGAGIEPARFTEDADIRQI MLBr_00484|M.leprae_Br4923 LFGPNTLGTAELIRIALTSKQKPYIYVSTIGVGNQIEPAKFTEDSDIRVI MAV_3243|M.avium_104 SATRVIDGSYANGYGNSKWAGEVLLREAHDLCGLPVSVFRSDMILADTSY MSMEG_0402|M.smegmatis_MC2_155 SATRKIEVGYANGYGNSKWAGEVLLREAHDHCGLPVAVFRSGMIMVDPTY TH_3730|M.thermoresistible__bu VAQAGVWQQVAAXX----WP----------SCSTPTTTSSSTSTWRSTRS MAB_3317c|M.abscessus_ATCC_199 SPSRVLDAGYANGYANSKWAAEVLLREAHDMFGLPVAVFRSSMVMADTSY Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M VFSAKRDSGGRSLADSWRQYVAGDITEYPIDCTHEAMLNIESLQLFADRI Mb0104|M.bovis_AF2122/97 SPTRTVDGGWAGGYGTSKWAGEVLLREANDLCALPVAVFRCGMILADTSY Rv0101|M.tuberculosis_H37Rv SPTRTVDGGWAGGYGTSKWAGEVLLREANDLCALPVAVFRCGMILADTSY MUL_1722|M.ulcerans_Agy99 SATRAVDDSYANGYSNSKWAGEVLLREAHVLCGLPVAVFRCDMILADTTW Mvan_2578|M.vanbaalenii_PYR-1 SATRRIDDSYANGYGNSKWAGEVLLREAHDLCGLPVSVFRCDMILADTTY MLBr_00484|M.leprae_Br4923 SPTRNINNNYANGYGNSKWAGEVLLREAHDLCGLPVTVFRCDMILADTSY MAV_3243|M.avium_104 AGQLNVTDIFTRMILSIVATGTAPKSFYRLDADGNRQRSHFDALPVEFVA MSMEG_0402|M.smegmatis_MC2_155 AGQLNVTDTVSRMVLSIVATGVAPGSFYQRGDNGERQRAHFDGLPVDFVA TH_3730|M.thermoresistible__bu TGRP-------------VRTGCSTRCSSTRTIRSMRRR------------ MAB_3317c|M.abscessus_ATCC_199 AGQLNMADTISRMVLSIMATGVAPESFYQLDMHGNRQRAHFDGLPVEFVA Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M AIYLR--------------------------------------------- Mb0104|M.bovis_AF2122/97 AGQLNMSDWVTRMVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLPVTFVA Rv0101|M.tuberculosis_H37Rv AGQLNMSDWVTRMVLSLMATGIAPRSFYEPDSEGNRQRAHFDGLPVTFVA MUL_1722|M.ulcerans_Agy99 AGQLNVPDMFTRMILSLAATGIAPGSFYELAADGARQRAHYDGLPVEFIA Mvan_2578|M.vanbaalenii_PYR-1 AGQLNLPDMFTRLIFSLVATGVAPESFYHLATDGTRQRAHYDGLPVEFIA MLBr_00484|M.leprae_Br4923 AGQLNVPDMFTRMMLSLAATGIAPGSFYELDAESNRQRAHYDGLPVEFIA MAV_3243|M.avium_104 EAIAKLGAQVMD--------GFETYHVMNPHDDGIGLDEYVDWLIEAGYP MSMEG_0402|M.smegmatis_MC2_155 QAITKLGWQVARSVTDSTASGFETYHVMNPHDDGIGIDTYIDWLIEAGYP TH_3730|M.thermoresistible__bu ----WPGRKALR------------------------------------SP MAB_3317c|M.abscessus_ATCC_199 EAIATLGSQATDG--------FETYHVMNPHDDGVGIDQFVDWLVEAGHP Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -------------------------------------------------- Mb0104|M.bovis_AF2122/97 EAIAVLGARVAG----SSLAGFATYHVMNPHDDGIGLDEYVDWLIEAGYP Rv0101|M.tuberculosis_H37Rv EAIAVLGARVAG----SSLAGFATYHVMNPHDDGIGLDEYVDWLIEAGYP MUL_1722|M.ulcerans_Agy99 EAISTLGAQ--------SQDGFHTYHVMNPYDDGIGLDEFVDWLNESGCP Mvan_2578|M.vanbaalenii_PYR-1 EAISTLGSD--------VASGFRTYHVMNPHDDGIGLDEYVDWLIDAGHP MLBr_00484|M.leprae_Br4923 EAISTLGDQSL-----HDRDGFTTYHVMNPHDDGIGMDEFVDWLIDAGCP MAV_3243|M.avium_104 IERVDDFGEWLQRFETGLRGLPERQRQNSVLQMLLLLLRDPKNLQLAEPA MSMEG_0402|M.smegmatis_MC2_155 IERIEDFGEWLQRFEAALQGLSDQQRQNSVLQMLTLLKQQAGELQPPVPT TH_3730|M.thermoresistible__bu ISRAANTTTIRCRWSQCPGTSSDCASN--------------------TTP MAB_3317c|M.abscessus_ATCC_199 IERVGNFGVWLQRFEAGLRALPNPQRQNSVLQMLMVLKQHG-QLRAPAPT Mflv_2697|M.gilvum_PYR-GCK -------------------------------------------------- MMAR_0099|M.marinum_M -------------------------------------------------- Mb0104|M.bovis_AF2122/97 IRRIDDFAEWLQRFEASLGALPDRQRRHSVLPMLLASNSQR--LQPLKPT Rv0101|M.tuberculosis_H37Rv IRRIDDFAEWLQRFEASLGALPDRQRRHSVLPMLLASNSQR--LQPLKPT MUL_1722|M.ulcerans_Agy99 IQRIADYGDWLQRFETALRALPDRQRHSSLLPLLHNYR------QPERPV Mvan_2578|M.vanbaalenii_PYR-1 IRRVGDYPTWLQRFTVAITALPERQRQASLLPLLHNYQ------HPETPI MLBr_00484|M.leprae_Br4923 IQRINDYDEWLRRFEISLRALPERQRHSSLLPLLHNYQ------KPEKPL MAV_3243|M.avium_104 RGAFAPTDRFRAAVQEAKVGSDND---IPHISAPVIVKYVTDLQLLGLL MSMEG_0402|M.smegmatis_MC2_155 RGSFAPADRFQAAVRDANIGVEGE---IPHVTREVIVKYVTDLQLLGLL TH_3730|M.thermoresistible__bu RCSTPRMSRHWSAGCGGC------------------------------- MAB_3317c|M.abscessus_ATCC_199 CGSYAPADRFQAAVRRAKIGSDQD---IPHISAPIILKYVTDLQMLGLL Mflv_2697|M.gilvum_PYR-GCK ------------------------------------------------- MMAR_0099|M.marinum_M ------------------------------------------------- Mb0104|M.bovis_AF2122/97 RGCSAPTDRFRAAVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL Rv0101|M.tuberculosis_H37Rv RGCSAPTDRFRAAVRAAKVGSDKDNPDIPHVSAPTIINYVTNLQLLGLL MUL_1722|M.ulcerans_Agy99 RGSIAPTDRFRAAVQEAKIGPDKD---IPHVGAPIIVKYVSDLRLLGLL Mvan_2578|M.vanbaalenii_PYR-1 RGSIAPTDRFREAVQDAKIGPDKD---IPHVTPQIVIKYVTDLQRLGLL MLBr_00484|M.leprae_Br4923 HGSLAPTIRFRTAVQNANIGQDKD---IPHISPAIIAKYVSDLQLLGLV