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SARRRKTNGPDRRVDHEVVIIGAGLSGIGVARDLLRAGVSDITIFERAAAVGGTWRDNVYPGIGVDVPAQ AYQFRDACNPEWSRFYAKGPEVLAYIERLTDDFGVRALIRFNSEVGERHWDDDADLWRMKVNGKDVTARF VVVAAGPFPEPKPAELPGLDDFAGTILKSASWDQRVDLAGKRVAIIGTGASAVQIIPEIAREVGRLDVYQ RTPIWIFPKFDPTTPRAVKTFFRRVPLAQRLLQEGLELVYAGVLVYGVMYYANVKIVPQAVSSFLRNVTY RMAVPDKELRAKLTPDYDFGCKRPAVSSSYLQTFTRDNVDLITDPIETITRTGIRTRGGAQRDIDVLVLA TGFRLFYDPQIYRDTPVTGRDGFDLGDFYAHQLPQSYHGISIPGLPNYFQVFGHYGWTGGTWHSVVDTAG AHISRVIAQAQRLGATDVEVRRQAAADWTAQVRGRYATSLFQVGNCATANSYYFDHNGESAYIRPMSTQA ARRSSRTFPLHDYAFEGHAEPERAAAVANKAVV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4050c | - | - | 100% (524) | monooxygenase |
| M. abscessus ATCC 19977 | MAB_4042c | - | e-125 | 44.64% (504) | monooxygenase |
| M. abscessus ATCC 19977 | MAB_0142c | - | e-104 | 40.67% (504) | putative monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1428c | - | 1e-110 | 43.81% (493) | monoxygenase |
| M. gilvum PYR-GCK | Mflv_3377 | - | 1e-104 | 39.84% (492) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv1393c | - | 1e-110 | 43.81% (493) | monoxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 2e-29 | 26.59% (425) | putative monooxygenase |
| M. marinum M | MMAR_2207 | - | 1e-110 | 44.42% (493) | monoxygenase |
| M. avium 104 | MAV_3378 | - | 1e-108 | 43.57% (498) | lipolytic enzyme |
| M. smegmatis MC2 155 | MSMEG_0816 | - | 1e-103 | 38.76% (498) | flavin-binding monooxygenase |
| M. thermoresistible (build 8) | TH_2450 | - | 3e-89 | 36.49% (518) | PUTATIVE putative FAD dependent oxidoreductase |
| M. ulcerans Agy99 | MUL_1793 | - | 1e-108 | 44.58% (489) | monoxygenase |
| M. vanbaalenii PYR-1 | Mvan_2671 | - | 1e-106 | 43.17% (498) | cyclohexanone monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3377|M.gilvum_PYR-GCK -----------MSTEQLDAVIVGAGFGGMGAAIQLD-RLGYQKIAILDRE
MSMEG_0816|M.smegmatis_MC2_155 -----------MRPVVHDAVIVGAGFAGLGAAIQLK-KMSFDDFVILERE
Mb1428c|M.bovis_AF2122/97 ------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDYLVVEAG
Rv1393c|M.tuberculosis_H37Rv ------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDYLVVEAG
MMAR_2207|M.marinum_M ----------MSIEPDYQIVIVGAGFSGIGAAISLD-KAGFGDYLVIEAG
MUL_1793|M.ulcerans_Agy99 -------------------MIVGAGFSGIGAAISLD-KAGFGDYLVIEAG
MAV_3378|M.avium_104 --------MSSPAVPDHHTLIIGAGFSGIGAAIKLD-KAGLPDYRVIEAG
Mvan_2671|M.vanbaalenii_PYR-1 -------------MHDVETVIVGAGFSGIGAAIGLD-RVGMSDYVVVEAG
MAB_4050c|M.abscessus_ATCC_199 MSARRRKTNGPDRRVDHEVVIIGAGLSGIGVARDLL-RAGVSDITIFERA
TH_2450|M.thermoresistible__bu ------MTVTGDVRPEYDVAIIGAGPGGIAAAHKLR-RRGITDIAILERG
MLBr_00065|M.leprae_Br4923 -------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSYVILEKR
*:*** .*:..* * : . :.:
Mflv_3377|M.gilvum_PYR-GCK DDLGGTWHVNRYPGLTVDVPSTTYSYWFEPNPYWSRLYAPGTELKSYAVH
MSMEG_0816|M.smegmatis_MC2_155 DDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPSWSRLFSTGREIKRYADD
Mb1428c|M.bovis_AF2122/97 DGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEH
Rv1393c|M.tuberculosis_H37Rv DGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEH
MMAR_2207|M.marinum_M DGVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGRELRAYAEH
MUL_1793|M.ulcerans_Agy99 DAVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGRELRAYAEH
MAV_3378|M.avium_104 DGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGRELKAYAEH
Mvan_2671|M.vanbaalenii_PYR-1 DEPGGTWYWNTYPGIAVDIPSFSYQFSFEQSSAWSRTYAHGHELKTYAEH
MAB_4050c|M.abscessus_ATCC_199 AAVGGTWRDNVYPGIGVDVPAQAYQFRDACNPEWSRFYAKGPEVLAYIER
TH_2450|M.thermoresistible__bu DDFGGTWRDNHYPGLAVDIPILWYQFSFNRNPRWSRVFAPGPEIHRYLTD
MLBr_00065|M.leprae_Br4923 AGMGGTWDLFRYPGIRSDSDMYTLGFRFRP-WTKCQAIADGKPILEYIKS
**** ***: * : .: : * : *
Mflv_3377|M.gilvum_PYR-GCK VADKYDLRRYMRFNTTVEGARWDEESRRWSVSLVGGH---TLTAQFLILA
MSMEG_0816|M.smegmatis_MC2_155 VADKYDVRRHIRFGTTVTGARWDEDDNVWQVSLTDGE---QLQARFLITA
Mb1428c|M.bovis_AF2122/97 CVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGG---EITARFLISA
Rv1393c|M.tuberculosis_H37Rv CVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGG---EITARFLISA
MMAR_2207|M.marinum_M CADKYGIRPRIRFNTKVLGAEFDDERSLWRLQTDPGG---ELTTRFIINA
MUL_1793|M.ulcerans_Agy99 CADKYGIRPRIRFNTKVLGAELDDERSLWRLQTDPGG---DLITRFIINA
MAV_3378|M.avium_104 CADKYGIRSRIRFNTKVLAAEFDDEQRLWRVQTDPGG---EVTARFLISA
Mvan_2671|M.vanbaalenii_PYR-1 CVDKYGLRPRIRFATTVRSADFDEAQGIWRLALDTADGPATLSARFLVNA
MAB_4050c|M.abscessus_ATCC_199 LTDDFGVRALIRFNSEVGERHWDDDADLWRMKVNGKD----VTARFVVVA
TH_2450|M.thermoresistible__bu TARSLGLYPLLRPHHDVVGQRWNAENAMWQLTVRDRP---PVTARFVISS
MLBr_00065|M.leprae_Br4923 TAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISCSFLFLC
. .: :* * . * : : *:. .
Mflv_3377|M.gilvum_PYR-GCK TGYLCQPR--KPDIPGIEDFAGTVLHAQEWDDDYSLKGRRAAIIGTGSTG
MSMEG_0816|M.smegmatis_MC2_155 TGFLSQPH--TPDIPGITEFDGKVIHTTDWDDGCSLYGRRAAVVGTGATA
Mb1428c|M.bovis_AF2122/97 CGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASA
Rv1393c|M.tuberculosis_H37Rv CGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASA
MMAR_2207|M.marinum_M SGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGIIGTGASA
MUL_1793|M.ulcerans_Agy99 SGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGIIGTGASA
MAV_3378|M.avium_104 CGVLTVPN--LPDIDGVDSFAGITMHTARWDHGQDLRGKRVAVIGTGASA
Mvan_2671|M.vanbaalenii_PYR-1 GGVLTVPK--LPDIAGVDSFAGVTMHTARWDHTQDLRGKRVAIIGTGASA
MAB_4050c|M.abscessus_ATCC_199 AGPFPEPK--PAELPGLDDFAGTILKSASWDQRVDLAGKRVAIIGTGASA
TH_2450|M.thermoresistible__bu VGGYVNAR--ATDLEGLSDFTGKVLRPNCWDDGYDTRDKRVAVIGTGSSG
MLBr_00065|M.leprae_Br4923 SGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVIGSGATA
* . . : * .* * ::. * . . :. ::*:*::.
Mflv_3377|M.gilvum_PYR-GCK VQLIPKLAD-DVAELTVYQRTPIWVMPKLDFPFGRAAQRLFAKVPATQ-Q
MSMEG_0816|M.smegmatis_MC2_155 VQLIPELAE-RVAELTVYQRTPIWVVPKVDVRFPPAVRALFARVPLTQ-R
Mb1428c|M.bovis_AF2122/97 VQVIPEMAP-IVSHLTVFQRTPIWCFPKFDVPLPTAVRWAMR-IPGGK-A
Rv1393c|M.tuberculosis_H37Rv VQVIPEMAP-IVSHLTVFQRTPIWCFPKFDVPLPTAVRWAMR-IPGGK-A
MMAR_2207|M.marinum_M VQVIPEIAP-IVKHLTVFQRTPIWCFPKFDFPLPAALRWAMR-IPGGK-A
MUL_1793|M.ulcerans_Agy99 VQVIPEIAP-IVKHLTVFQRTPIWCFPKFDFPLPAALRWAMR-IPGGK-A
MAV_3378|M.avium_104 VQVIPEIAP-IVSSLTVFQRTPIWCFPKLDVPLPAPARWAMR-FPGGK-A
Mvan_2671|M.vanbaalenii_PYR-1 VQVIPEIAP-IVERLTVFQRTPIWCFPKFDVPLSKTAQTMMR-LPFGK-S
MAB_4050c|M.abscessus_ATCC_199 VQIIPEIAR-EVGRLDVYQRTPIWIFPKFDPTTPRAVKTFFRRVPLAQRL
TH_2450|M.thermoresistible__bu AQIVSALSG-RVARLDVYQRTPNWILPRPDFALPRALQRVLELPGVAA--
MLBr_00065|M.leprae_Br4923 VTLVPALANSGAKHVTMLQRSPTYIVSQP--AKDKIAARLNRWLPDKY--
. ::. :: . : : **:* : ..:
Mflv_3377|M.gilvum_PYR-GCK FLRMSSDAFMDVMVTIAMWKFRQFRPVNTAAARIGA----------LHRF
MSMEG_0816|M.smegmatis_MC2_155 VVRAITDAIYAFMVDTAVLKHRYFRRLNIAAADLGR----------LHLA
Mb1428c|M.bovis_AF2122/97 VHRLLSQAFVEATFPIAAHYFAVFPLAKHMESAGR-----------RYLR
Rv1393c|M.tuberculosis_H37Rv VHRLLSQAFVEATFPIAAHYFAVFPLAKHMESAGR-----------RYLR
MMAR_2207|M.marinum_M LQRLLSQAYVEATFPISAHYFTVFPLARWSAVLGR-----------RYLR
MUL_1793|M.ulcerans_Agy99 LQRLLSQAYVEATFPISAHYFTVFPLARWSAVLGR-----------RYLR
MAV_3378|M.avium_104 LQRLLSQAYVELTFPISAHYFTVIPLAKRMAALGR-----------AYLR
Mvan_2671|M.vanbaalenii_PYR-1 LQRLISQAFVELTFPLAAQYFTVNPMAKRMGAVGR-----------AYLR
MAB_4050c|M.abscessus_ATCC_199 LQEGLELVYAGVLVYGVMYYANVKIVPQAVSSFLRN----------VTYR
TH_2450|M.thermoresistible__bu VLHNIGRAVFDLFFVVPIVHLMAHVPDRVLVRLLRGYDSLARFAFRVLLR
MLBr_00065|M.leprae_Br4923 ---AYTAVRWKNILRQSALYGACQKWPQRMRNILLG----------HVAR
. . .
Mflv_3377|M.gilvum_PYR-GCK LAIRDKGLRRKLTPDYDFGCKRPTLSN--TYYRTFNKKHVHLETSGIERI
MSMEG_0816|M.smegmatis_MC2_155 ASIRDPDLRSKLTPDYDFGCKRPTFSN--SYYRTFTKPHVHLQADGIDHV
Mb1428c|M.bovis_AF2122/97 QQVHDPVVREQLTPRYAVGCKRPGFHN--TYLSTFNRDNVRLVTEPIDKI
Rv1393c|M.tuberculosis_H37Rv QQVHDPVVREQLTPRYAVGCKRPGFHN--TYLSTFNRDNVRLVTEPIDKI
MMAR_2207|M.marinum_M QRVNDPVVRDQLTPRYAVGCKRPGFHN--GYLSTFNRDNVQLVTEPIEKI
MUL_1793|M.ulcerans_Agy99 QRVDDPVVRDQLTPRYAVDCKRPGFHN--GYLSTFNRDNVQLVTEPIEKI
MAV_3378|M.avium_104 RQVRDPAVREQLTPRYAVGCKRPGFHN--GYLATFNRDNVRLVTEPIDKI
Mvan_2671|M.vanbaalenii_PYR-1 KQVDDPVLRDKLTPRYAVGCKRPGFHN--TYLSTFNRDNVDLVTEPIDKI
MAB_4050c|M.abscessus_ATCC_199 MAVPDKELRAKLTPDYDFGCKRPAVSS--SYLQTFTRDNVDLITDPIETI
TH_2450|M.thermoresistible__bu AVVHDPQTRRRLMPAHGILAKRPIISG--SYLPAFNDPRTHLITTPIERI
MLBr_00065|M.leprae_Br4923 RLPKGYDVQKHFGPHYNPWEQRLCLVPDGDLFRAIRKGTVDMVTDAIDRF
. : :: * : :* . :: . : : *: .
Mflv_3377|M.gilvum_PYR-GCK EADGIVTRDGTKKVIDTLVLATGFDVWES-----NLPAIPVIGREGRDLG
MSMEG_0816|M.smegmatis_MC2_155 EPDGIVNADGSKTVIDTLVLATGFDLWEA-----NFPAIEVIGRQGRDLG
Mb1428c|M.bovis_AF2122/97 TPTAVATTDGASHEIDVLVLATGFKVLDT----DSIPTYAVTGTGGASLS
Rv1393c|M.tuberculosis_H37Rv TPTAVATTDGASHEIDVLVLATGFKVLDT----DSIPTYAVTGTGGASLS
MMAR_2207|M.marinum_M TPTAVATDDGTDHEIDVLILATGFKVLDT----DDVLTYPVIGRAGRSLS
MUL_1793|M.ulcerans_Agy99 TPTSVATDDGTDHEIDVLILATGFKVLDT----DDVLTYPVIGRAGRSLS
MAV_3378|M.avium_104 TPDAVATTDGETHEIDVLILATGFKVMDP----DSVPTFAVTGSGGRSLS
Mvan_2671|M.vanbaalenii_PYR-1 TGSGVSTTDGSLHEVDVLILATGFKVFAAHDGDDSVATFPVTGPGGRSLA
MAB_4050c|M.abscessus_ATCC_199 TRTGIRTRGGAQRDIDVLVLATGFRLFYDP---QIYRDTPVTGRDGFDLG
TH_2450|M.thermoresistible__bu TAAGVRTTDGVERPVDLIVTATGYELWTDP---ETYFPGTILGDAGFDLA
MLBr_00065|M.leprae_Br4923 TSTGIRLKSGNELRADIIVTATGLNLQLFG------------GAVATVDG
.: .* * :: *** : * . .
Mflv_3377|M.gilvum_PYR-GCK KWWRENKFQAYEGLTVPLFPNLLTQASPYAWVGMSWFDTVEYQMRHMKRL
MSMEG_0816|M.smegmatis_MC2_155 KWWRETRFQAYQGVSMPYFPNYLSLAGPYAFLGLNFFNTMEYQMRLMERL
Mb1428c|M.bovis_AF2122/97 RFWDEHRLQAYEGVSVPGYPNFFTVFGPYGYVGSSYFALIETQAHHIIRC
Rv1393c|M.tuberculosis_H37Rv RFWDEHRLQAYEGVSVPGYPNFFTVFGPYGYVGSSYFALIETQAHHIIRC
MMAR_2207|M.marinum_M QFWEEHRAQAYQGVSVPGYPNFFAVFGPYGYVGSSYFALIETQTHHILRC
MUL_1793|M.ulcerans_Agy99 QFWEEHRAQAYQGVSVPGYRNFFAVFGPYGYVGSSYFALIETQTHHILRC
MAV_3378|M.avium_104 RFWDEHRLQAYEGVTVPGFPNLFTVFGPYGYVGSSYFALIEAQTHHIVRC
Mvan_2671|M.vanbaalenii_PYR-1 RFWDDNRLQAYEGVSVPGFPNFFTVFGPYGYVGSSYFALIEAQTRHIVRC
MAB_4050c|M.abscessus_ATCC_199 DFYAHQLPQSYHGISIPGLPNYFQVFGHYGWTGGTWHSVVDTAGAHISRV
TH_2450|M.thermoresistible__bu LDYRENGLRSYGGTAHPRLPNRWEIVGPLAFVGVGWTDFVETMAEHAVRI
MLBr_00065|M.leprae_Br4923 QPVDLAQTMSYKGMMLSGLPNMIYTVG---YTNASWTLKADLVSEFFCRL
:* * . * . : . : : *
Mflv_3377|M.gilvum_PYR-GCK FGELQRRGADTFEVTEEANAEFLDRMETLLEDSVFRLGNCAN---SRSYW
MSMEG_0816|M.smegmatis_MC2_155 LGEVARRDARTFEVTEEANRRYLDRMTDALGDSLFTLGNCAS---ARSYY
Mb1428c|M.bovis_AF2122/97 LKRARRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRL---ANSYY
Rv1393c|M.tuberculosis_H37Rv LKRARRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRL---ANSYY
MMAR_2207|M.marinum_M LKRARRDGATRVEVTEEANARYFAEMMRRRYRQVFWQDSCRR---ANSYY
MUL_1793|M.ulcerans_Agy99 LKRARRDGATRVEVTEEANARYFAEMMRRRYRQVFWQDSCRR---ANSYY
MAV_3378|M.avium_104 LKRAQRLGATRVEVSEEANDRYFAEMMRRRHRQIFWQDSCRL---ANSYY
Mvan_2671|M.vanbaalenii_PYR-1 LDAARRRRATRVEVRREANDRYFAEMMRKRHRQIFWQDSCQL---SNSYY
MAB_4050c|M.abscessus_ATCC_199 IAQAQRLGATDVEVRRQAAADWTAQVRGRYATSLFQVGNCAT---ANSYY
TH_2450|M.thermoresistible__bu IDAARRRGADVVTVTDEAFGRWDARMRKAGKAARLYYTRCNPG--VNTYY
MLBr_00065|M.leprae_Br4923 LNYMNANDFDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPW
: . * . . : . .: :
Mflv_3377|M.gilvum_PYR-GCK FNSSGEAPLFRPQSIRQAVKEQETFPLSDYAIA-----------------
MSMEG_0816|M.smegmatis_MC2_155 FNPSGEATLLRPMTTRRAVAEASRFPLSDYTFA-----------------
Mb1428c|M.bovis_AF2122/97 FDKNGD-VPLRPTTTVEAYWRSRRFDLGDYRISS----------------
Rv1393c|M.tuberculosis_H37Rv FDKNGD-VPLRPTTTVEAYWRSRRFDLGDYRISS----------------
MMAR_2207|M.marinum_M FDKNGD-VPLRPTTTVEAYWRGRHFDLDNYRFGR----------------
MUL_1793|M.ulcerans_Agy99 FDKNGD-VPLRPTTTVEAYWRGRHFDLDDYRFGR----------------
MAV_3378|M.avium_104 FDKNGD-VPLRPGTTPEVYWRSRRFDLDDYRFTG----------------
Mvan_2671|M.vanbaalenii_PYR-1 FDQHGD-VPLRPASTPEAYWRSRRFPIDDYEFSC----------------
MAB_4050c|M.abscessus_ATCC_199 FDHNGESAYIRPMSTQAARRSSRTFPLHDYAFEGHAEPERAAAVANKAVV
TH_2450|M.thermoresistible__bu VNSQRDTVYHRPQTITESLVFAHRPPLTDYRFERRPAAARSAVRALRHAE
MLBr_00065|M.leprae_Br4923 RLNQNYLRDIRLIRRGKVADEGLLFAKKTTPVTV----------------
* .
Mflv_3377|M.gilvum_PYR-GCK -----
MSMEG_0816|M.smegmatis_MC2_155 -----
Mb1428c|M.bovis_AF2122/97 -----
Rv1393c|M.tuberculosis_H37Rv -----
MMAR_2207|M.marinum_M -----
MUL_1793|M.ulcerans_Agy99 -----
MAV_3378|M.avium_104 -----
Mvan_2671|M.vanbaalenii_PYR-1 -----
MAB_4050c|M.abscessus_ATCC_199 -----
TH_2450|M.thermoresistible__bu GNEAV
MLBr_00065|M.leprae_Br4923 -----