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HDVETVIVGAGFSGIGAAIGLDRVGMSDYVVVEAGDEPGGTWYWNTYPGIAVDIPSFSYQFSFEQSSAWS RTYAHGHELKTYAEHCVDKYGLRPRIRFATTVRSADFDEAQGIWRLALDTADGPATLSARFLVNAGGVLT VPKLPDIAGVDSFAGVTMHTARWDHTQDLRGKRVAIIGTGASAVQVIPEIAPIVERLTVFQRTPIWCFPK FDVPLSKTAQTMMRLPFGKSLQRLISQAFVELTFPLAAQYFTVNPMAKRMGAVGRAYLRKQVDDPVLRDK LTPRYAVGCKRPGFHNTYLSTFNRDNVDLVTEPIDKITGSGVSTTDGSLHEVDVLILATGFKVFAAHDGD DSVATFPVTGPGGRSLARFWDDNRLQAYEGVSVPGFPNFFTVFGPYGYVGSSYFALIEAQTRHIVRCLDA ARRRRATRVEVRREANDRYFAEMMRKRHRQIFWQDSCQLSNSYYFDQHGDVPLRPASTPEAYWRSRRFPI DDYEFSC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2671 | - | - | 100% (498) | cyclohexanone monooxygenase |
| M. vanbaalenii PYR-1 | Mvan_3109 | - | e-110 | 42.91% (494) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0721 | - | e-107 | 42.51% (494) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1428c | - | 0.0 | 73.04% (497) | monoxygenase |
| M. gilvum PYR-GCK | Mflv_3736 | - | 0.0 | 80.37% (438) | cyclohexanone monooxygenase |
| M. tuberculosis H37Rv | Rv1393c | - | 0.0 | 73.04% (497) | monoxygenase |
| M. leprae Br4923 | MLBr_00065 | - | 3e-26 | 24.05% (449) | putative monooxygenase |
| M. abscessus ATCC 19977 | MAB_4024c | - | 1e-136 | 47.28% (497) | monooxygenase |
| M. marinum M | MMAR_2207 | - | 0.0 | 71.46% (494) | monoxygenase |
| M. avium 104 | MAV_3378 | - | 0.0 | 75.15% (495) | lipolytic enzyme |
| M. smegmatis MC2 155 | MSMEG_0816 | - | 1e-109 | 42.37% (498) | flavin-binding monooxygenase |
| M. thermoresistible (build 8) | TH_4080 | - | 3e-81 | 37.26% (467) | PUTATIVE conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_1793 | - | 0.0 | 71.63% (490) | monoxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2671|M.vanbaalenii_PYR-1 -------------------MHDVETVIVGAGFSGIGAAIGLD-RVGMSDY
Mflv_3736|M.gilvum_PYR-GCK --------------------------MVLEHLS----------RCRSGHS
Mb1428c|M.bovis_AF2122/97 ------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDY
Rv1393c|M.tuberculosis_H37Rv ------------------MMPDYHALIVGAGFSGIGAAIKLD-RAGFSDY
MMAR_2207|M.marinum_M ----------------MSIEPDYQIVIVGAGFSGIGAAISLD-KAGFGDY
MUL_1793|M.ulcerans_Agy99 -------------------------MIVGAGFSGIGAAISLD-KAGFGDY
MAV_3378|M.avium_104 --------------MSSPAVPDHHTLIIGAGFSGIGAAIKLD-KAGLPDY
MAB_4024c|M.abscessus_ATCC_199 -----MSPAARHATTAELEQPDHEVAVIGAGFGGIGTGISLQ-RKGIHDF
MSMEG_0816|M.smegmatis_MC2_155 -----------------MRPVVHDAVIVGAGFAGLGAAIQLK-KMSFDDF
TH_4080|M.thermoresistible__bu MTVTEPSADITPANTPTQPPVRTRALIVGTGFSGLGMAIALQ-RRGI-DF
MLBr_00065|M.leprae_Br4923 -------------MVVMAETEYLDVVIVGAGISGVSAAWHLQDRCPNKSY
:: :. :
Mvan_2671|M.vanbaalenii_PYR-1 VVVEAGDEPGGTWYWNTYPGIAVDIPSFSYQFSFEQSSAWSRTYAHGHEL
Mflv_3736|M.gilvum_PYR-GCK VVP--------------------------HQFSFEQSTEWSRTYAPGREL
Mb1428c|M.bovis_AF2122/97 LVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHEL
Rv1393c|M.tuberculosis_H37Rv LVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHEL
MMAR_2207|M.marinum_M LVIEAGDGVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGREL
MUL_1793|M.ulcerans_Agy99 LVIEAGDAVGGTWFWNTYPGIAVDIPSFSYQFSFEQSPDWSRSYAPGREL
MAV_3378|M.avium_104 RVIEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGREL
MAB_4024c|M.abscessus_ATCC_199 IILDKWDQVGGTWHANTYPGVAVDIPSVVYSFSYEQRGDWSRLFAPGIEL
MSMEG_0816|M.smegmatis_MC2_155 VILEREDDLGGTWYVNHYPGLAVDVPTTTYSYFFEPNPSWSRLFSTGREI
TH_4080|M.thermoresistible__bu LMLEKADDIGGTWRDNTYPGCACDIPSHLYSFSFEPKADWRHLFSYQDEI
MLBr_00065|M.leprae_Br4923 VILEKRAGMGGTWDLFRYPGIRSDSDMYTLGFRFRP-WTKCQAIADGKPI
: : :. : : :
Mvan_2671|M.vanbaalenii_PYR-1 KTYAEHCVDKYGLRPRIRFATTVRSADFDEAQGIWRLALDTADGPATLSA
Mflv_3736|M.gilvum_PYR-GCK KSYADHCFDKYGLRSRTRFATTVRSAEFDDSAGLWRLAVESGGVQSTVTA
Mb1428c|M.bovis_AF2122/97 KAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGG---EITA
Rv1393c|M.tuberculosis_H37Rv KAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGG---EITA
MMAR_2207|M.marinum_M RAYAEHCADKYGIRPRIRFNTKVLGAEFDDERSLWRLQTDPGG---ELTT
MUL_1793|M.ulcerans_Agy99 RAYAEHCADKYGIRPRIRFNTKVLGAELDDERSLWRLQTDPGG---DLIT
MAV_3378|M.avium_104 KAYAEHCADKYGIRSRIRFNTKVLAAEFDDEQRLWRVQTDPGG---EVTA
MAB_4024c|M.abscessus_ATCC_199 QQYAESMVHKYGLRDKLRLGTSITRAEFDERNSLWRLATDGGK---EITA
MSMEG_0816|M.smegmatis_MC2_155 KRYADDVADKYDVRRHIRFGTTVTGARWDEDDNVWQVSLTDGE---QLQA
TH_4080|M.thermoresistible__bu QEYLQGVTAKYGLRRYIHFDSLVDRAHWDDTEHRWHVFTADGR---EYIA
MLBr_00065|M.leprae_Br4923 LEYIKSTAVMHGIDKYIRLNHKVTGADWSSIENRWTVQVENNGTPRMISC
* . :.: :: : * .. * :
Mvan_2671|M.vanbaalenii_PYR-1 RFLVNAGGVLTVPK--LPDIAGVDSFAGVTMHTARWDHTQDLRGKRVAII
Mflv_3736|M.gilvum_PYR-GCK RFVINAGGALTVPN--LPDIPGVDSFAGTTIHTARWDHDVDLTGKRVAII
Mb1428c|M.bovis_AF2122/97 RFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGII
Rv1393c|M.tuberculosis_H37Rv RFLISACGILTVPK--LPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGII
MMAR_2207|M.marinum_M RFIINASGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGII
MUL_1793|M.ulcerans_Agy99 RFIINASGVLTVPK--LPDIAGVDSFAGVTMHTARWDHSQELTGKRVGII
MAV_3378|M.avium_104 RFLISACGVLTVPN--LPDIDGVDSFAGITMHTARWDHGQDLRGKRVAVI
MAB_4024c|M.abscessus_ATCC_199 RYCVMAVGGLERPK--MPDIPGVHDFGGTLMHTALWDHDVALAGKRVAVI
MSMEG_0816|M.smegmatis_MC2_155 RFLITATGFLSQPH--TPDIPGITEFDGKVIHTTDWDDGCSLYGRRAAVV
TH_4080|M.thermoresistible__bu QFLISCAGALHIPS--IPDFPGRDQFAGPAFHSAQWDHSVDLTGKRVAVI
MLBr_00065|M.leprae_Br4923 SFLFLCSGYYNYEQGYAPTFLGSEDFTGPIIHPQHWPEDLDYAAKNIVVI
: . . * * : * .* * :*. * . .:. ::
Mvan_2671|M.vanbaalenii_PYR-1 GTGASAVQVIPEIAP-IVERLTVFQRTPIWCFPKFDVPLSKTAQTMMR-L
Mflv_3736|M.gilvum_PYR-GCK GTGASAVQVIPEIAP-IVARLTVFQRTPIWCFPKFDVPLSRTARAMMR-L
Mb1428c|M.bovis_AF2122/97 GTGASAVQVIPEMAP-IVSHLTVFQRTPIWCFPKFDVPLPTAVRWAMR-I
Rv1393c|M.tuberculosis_H37Rv GTGASAVQVIPEMAP-IVSHLTVFQRTPIWCFPKFDVPLPTAVRWAMR-I
MMAR_2207|M.marinum_M GTGASAVQVIPEIAP-IVKHLTVFQRTPIWCFPKFDFPLPAALRWAMR-I
MUL_1793|M.ulcerans_Agy99 GTGASAVQVIPEIAP-IVKHLTVFQRTPIWCFPKFDFPLPAALRWAMR-I
MAV_3378|M.avium_104 GTGASAVQVIPEIAP-IVSSLTVFQRTPIWCFPKLDVPLPAPARWAMR-F
MAB_4024c|M.abscessus_ATCC_199 GTGATSLQLVPAIVD-ETSHLTVFQRTPIWVGPKFDLEIGPLGRIILG-N
MSMEG_0816|M.smegmatis_MC2_155 GTGATAVQLIPELAE-RVAELTVYQRTPIWVVPKVDVRFPPAVRALFARV
TH_4080|M.thermoresistible__bu GTGASAIQIVPEIID-RVAQLQLYQRTPAWVVPRTNDELPAWLRRALENI
MLBr_00065|M.leprae_Br4923 GSGATAVTLVPALANSGAKHVTMLQRSPTYIVSQPAKDKIAARLNRWLPD
*:**::: ::* : . : : **:* : .:
Mvan_2671|M.vanbaalenii_PYR-1 PFGKSLQRLISQAFVELTFP--LAAQYFTVNPMAKRMGAVGRAYLRKQVD
Mflv_3736|M.gilvum_PYR-GCK PFGQTLQRFLSQAYVELTFP--LAAQYFTVNPMAKRMSRMGLAYLRRQVK
Mb1428c|M.bovis_AF2122/97 PGGKAVHRLLSQAFVEATFP--IAAHYFAVFPLAKHMESAGRRYLRQQVH
Rv1393c|M.tuberculosis_H37Rv PGGKAVHRLLSQAFVEATFP--IAAHYFAVFPLAKHMESAGRRYLRQQVH
MMAR_2207|M.marinum_M PGGKALQRLLSQAYVEATFP--ISAHYFTVFPLARWSAVLGRRYLRQRVN
MUL_1793|M.ulcerans_Agy99 PGGKALQRLLSQAYVEATFP--ISAHYFTVFPLARWSAVLGRRYLRQRVD
MAV_3378|M.avium_104 PGGKALQRLLSQAYVELTFP--ISAHYFTVIPLAKRMAALGRAYLRRQVR
MAB_4024c|M.abscessus_ATCC_199 SRIRSAIRAIATVGIEMAMSGQVAGPAWLINAVRRAGEAPMRRWMRSQVD
MSMEG_0816|M.smegmatis_MC2_155 PLTQRVVRAITDAIYAFMVDTAVLKHRYFRR-LNIAAADLGRLHLAASIR
TH_4080|M.thermoresistible__bu PGLRLALRGGIYALQEALAVG-----MTKYPGMLRIGHLLGKWNINRSVK
MLBr_00065|M.leprae_Br4923 KYAYTAVRWKNILRQSALYG---ACQKWPQRMRNILLGHVARRLPKGYDV
*
Mvan_2671|M.vanbaalenii_PYR-1 DPVLRDKLTPRYAVGCKRPGFHNTYLSTFNRDNVDLVTEPIDKITGSGVS
Mflv_3736|M.gilvum_PYR-GCK DPVVREKLTPRYAVGCKRPGFHNTYLATFNRDNVELVTEPIDKITGAGVA
Mb1428c|M.bovis_AF2122/97 DPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVA
Rv1393c|M.tuberculosis_H37Rv DPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVA
MMAR_2207|M.marinum_M DPVVRDQLTPRYAVGCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTAVA
MUL_1793|M.ulcerans_Agy99 DPVVRDQLTPRYAVDCKRPGFHNGYLSTFNRDNVQLVTEPIEKITPTSVA
MAV_3378|M.avium_104 DPAVREQLTPRYAVGCKRPGFHNGYLATFNRDNVRLVTEPIDKITPDAVA
MAB_4024c|M.abscessus_ATCC_199 DPVIREKLIPRYGLGCKRPSMSNEYLKTFNRDDVSLITESIECVTPDGVR
MSMEG_0816|M.smegmatis_MC2_155 DPDLRSKLTPDYDFGCKRPTFSNSYYRTFTKPHVHLQADGIDHVEPDGIV
TH_4080|M.thermoresistible__bu DPQLRAKLTPDYRLGCKRILNSSTYYPAVADPRTEVITESIDRITTDGIV
MLBr_00065|M.leprae_Br4923 QKHFGPHYNPWEQRLCLVP--DGDLFRAIRKGTVDMVTDAIDRFTSTGIR
: . : * * . :. . : :: *: . .:
Mvan_2671|M.vanbaalenii_PYR-1 TTDGSLHEVDVLILATGFKVFAAHDGDDSVATFPVTGPGGRSLARFWDDN
Mflv_3736|M.gilvum_PYR-GCK TTDGQLRDADVLILATGFKVLDTEN----VPTYRVTGSGGRSLSRFWEEN
Mb1428c|M.bovis_AF2122/97 TTDGASHEIDVLVLATGFKVLDTDS----IPTYAVTGTGGASLSRFWDEH
Rv1393c|M.tuberculosis_H37Rv TTDGASHEIDVLVLATGFKVLDTDS----IPTYAVTGTGGASLSRFWDEH
MMAR_2207|M.marinum_M TDDGTDHEIDVLILATGFKVLDTDD----VLTYPVIGRAGRSLSQFWEEH
MUL_1793|M.ulcerans_Agy99 TDDGTDHEIDVLILATGFKVLDTDD----VLTYPVIGRAGRSLSQFWEEH
MAV_3378|M.avium_104 TTDGETHEIDVLILATGFKVMDPDS----VPTFAVTGSGGRSLSRFWDEH
MAB_4024c|M.abscessus_ATCC_199 TVDGVEHVVDVLICATGFRLWDKGS----VPPFPVHGRGGQDLGEFWDRH
MSMEG_0816|M.smegmatis_MC2_155 NADGSKTVIDTLVLATGFDLWEANF-----PAIEVIGRQGRDLGKWWRET
TH_4080|M.thermoresistible__bu TSDGTERAVDVIVYATGFHVSDSYK------YVQIKGLNGEDIVDRFNRE
MLBr_00065|M.leprae_Br4923 LKSGNELRADIIVTATGLNLQLFGG--------AVATVDGQ----PVDLA
.* * :: ***: : : *
Mvan_2671|M.vanbaalenii_PYR-1 RLQAYEGVSVPGFPNFFTVFGP-YGYVGSSYFALIEAQTRHIVRCLDAAR
Mflv_3736|M.gilvum_PYR-GCK RLQAYEGVSVPGFPNFFTVFGP-YGYVGSSYFALIEAQTRHIVRCLAEAG
Mb1428c|M.bovis_AF2122/97 RLQAYEGVSVPGYPNFFTVFGP-YGYVGSSYFALIETQAHHIIRCLKRAR
Rv1393c|M.tuberculosis_H37Rv RLQAYEGVSVPGYPNFFTVFGP-YGYVGSSYFALIETQAHHIIRCLKRAR
MMAR_2207|M.marinum_M RAQAYQGVSVPGYPNFFAVFGP-YGYVGSSYFALIETQTHHILRCLKRAR
MUL_1793|M.ulcerans_Agy99 RAQAYQGVSVPGYRNFFAVFGP-YGYVGSSYFALIETQTHHILRCLKRAR
MAV_3378|M.avium_104 RLQAYEGVTVPGFPNLFTVFGP-YGYVGSSYFALIEAQTHHIVRCLKRAQ
MAB_4024c|M.abscessus_ATCC_199 RFQSYQGVSVPGYPNMFSITGP-YGFVLGSYLWMIEATSAHLARAIAETK
MSMEG_0816|M.smegmatis_MC2_155 RFQAYQGVSMPYFPNYLSLAGP-YAFLGLNFFNTMEYQMRLMERLLGEVA
TH_4080|M.thermoresistible__bu GPMAHRGTAVADLPNAYLLLGPNTGLGHNSMVYMIESQINYVIEAIKAVD
MLBr_00065|M.leprae_Br4923 QTMSYKGMMLSGLPNMIYTVGY-TNASWTLKADLVSEFFCRLLNYMNAND
::.* :. * * :. : . :
Mvan_2671|M.vanbaalenii_PYR-1 RRRATRVEVRREANDRYFAEMMRKRHRQIFWQDSCQLSNSYYFDQHGDV-
Mflv_3736|M.gilvum_PYR-GCK RRGASRVEVRREANDRYFAEMMRKRHRQIFWQDSCRLSNSYYFDQHGDV-
Mb1428c|M.bovis_AF2122/97 RTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDV-
Rv1393c|M.tuberculosis_H37Rv RTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDV-
MMAR_2207|M.marinum_M RDGATRVEVTEEANARYFAEMMRRRYRQVFWQDSCRRANSYYFDKNGDV-
MUL_1793|M.ulcerans_Agy99 RDGATRVEVTEEANARYFAEMMRRRYRQVFWQDSCRRANSYYFDKNGDV-
MAV_3378|M.avium_104 RLGATRVEVSEEANDRYFAEMMRRRHRQIFWQDSCRLANSYYFDKNGDV-
MAB_4024c|M.abscessus_ATCC_199 RRGATVCEIRQEAHDEYFRKCLKRQEKNFLFTDVCAGSNTYYLDQNGDS-
MSMEG_0816|M.smegmatis_MC2_155 RRDARTFEVTEEANRRYLDRMTDALGDSLFTLGNCASARSYYFNPSGEAT
TH_4080|M.thermoresistible__bu KAGAQALAPTREAQDRYNAELQARLGRSVWNTGGCR---SWYLDEHGNNR
MLBr_00065|M.leprae_Br4923 FDTVAVEYPGSDVEERPFMDFTPGYVLRSLDALPKQGSRTPWRLNQNYLR
. :.. . : : .
Mvan_2671|M.vanbaalenii_PYR-1 PLRPASTPEAYWRSRRFPIDDYEFSC----------------
Mflv_3736|M.gilvum_PYR-GCK PLRPASTLEAHWRSRSFPIDDYEFAVS---------------
Mb1428c|M.bovis_AF2122/97 PLRPTTTVEAYWRSRRFDLGDYRISS----------------
Rv1393c|M.tuberculosis_H37Rv PLRPTTTVEAYWRSRRFDLGDYRISS----------------
MMAR_2207|M.marinum_M PLRPTTTVEAYWRGRHFDLDNYRFGR----------------
MUL_1793|M.ulcerans_Agy99 PLRPTTTVEAYWRGRHFDLDDYRFGR----------------
MAV_3378|M.avium_104 PLRPGTTPEVYWRSRRFDLDDYRFTG----------------
MAB_4024c|M.abscessus_ATCC_199 PFRPTTHGEMYWQNRHYNLDVYRYSTASVVPETVASTAGESV
MSMEG_0816|M.smegmatis_MC2_155 LLRPMTTRRAVAEASRFPLSDYTFA-----------------
TH_4080|M.thermoresistible__bu VLWGGFTWQYRLATRTLDPAEYRFWG----------------
MLBr_00065|M.leprae_Br4923 DIRLIRRGKVADEGLLFAKKTTPVTV----------------
: .