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LRPLMTQPVFVQNILTRLANMRPAARAAVVSAAALVLVAVMAIAGIFGARTIFPAVKNMVMPYLGNAHIP LLDHTRSLCANFRDGSGLYKGNKVLLLGVEVGTVTAVTNKPDHVEVDFEIPSDMELPADVGAASYSQSVI TNRSIELTRPWSEGPKFAGAQCISTENTRTPVTVTESFSAIGELADTLMQATPGQDPGDSPGVRALNKTL KGAARSLDGVGPGFKEMLNSLTKMVGDPYKANADYRQLFENSAIVTSNWLQYWNEFAGVVTSLPEVGRLI AGISDNFAQALDNLVSLLPTLNGMVQRASGRLYKNVFDKLVPWIRDILNAYTPHILTFFNTLPPVINWLA DDIYLPNTKTHGVTYIPPRVAISPEQASAICQNLRDRNTPGSQAACAPGTGSDPVTLGLTNLIMGAALS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4033 | - | - | 100% (419) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4596c | - | 5e-22 | 32.06% (209) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1007c | - | 5e-21 | 33.95% (162) | putative MCE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 2e-16 | 24.32% (329) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_0007 | - | 1e-19 | 30.53% (226) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1969 | mce3D | 1e-17 | 25.07% (375) | MCE-family protein MCE3D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 4e-14 | 23.93% (305) | putative secreted protein |
| M. marinum M | MMAR_3867 | mce5D | 2e-20 | 34.16% (161) | MCE-family protein Mce5D |
| M. avium 104 | MAV_2385 | - | 5e-21 | 27.20% (353) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0349 | - | 9e-23 | 28.25% (269) | virulence factor mce family protein |
| M. thermoresistible (build 8) | TH_3076 | - | 5e-22 | 31.88% (207) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4916 | mce6D | 2e-19 | 26.13% (398) | MCE-family protein Mce6D |
| M. vanbaalenii PYR-1 | Mvan_0962 | - | 5e-21 | 33.17% (199) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3867|M.marinum_M --------------------MTTSKVKILAVVAAVLAVVALAGAGWWRMG
MAV_2385|M.avium_104 --------------------MTRLGTKALAVVAGVAVVAAAVGIGWWLLR
MUL_4916|M.ulcerans_Agy99 --------------------MTHR-HNLIRVGVGLVVVAALACAGWYGLA
Mflv_0007|M.gilvum_PYR-GCK --------------------MSGRAKVTALVVAGLVAVVAVAAIGWSFLS
Mvan_0962|M.vanbaalenii_PYR-1 --------------------MGTRSKLVSLAVAAVAVVVVVAAVGWSYLG
TH_3076|M.thermoresistible__bu ------------------MMRDVRTRVIALIAAGLVAVAAVAVVAVKVAR
Rv1969|M.tuberculosis_H37Rv -------------------MTTKLRRARSVLATALVLVAGVI--LAMRTA
MSMEG_0349|M.smegmatis_MC2_155 -------------------MRISKKQLTLAAGLVVVMVAGVL--VGFRMT
MLBr_02592|M.leprae_Br4923 ---------MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLY
Mb3526c|M.bovis_AF2122/97 ---------------MMGRVAMLTGSRGLRYATVIALVAALVG-GVYVLS
MAB_4033|M.abscessus_ATCC_1997 MRPLMTQPVFVQNILTRLANMRPAARAAVVSAAALVLVAVMAIAGIFGAR
: :.
MMAR_3867|M.marinum_M ADD--------------------DPMTVTAQFDSASGLYEGNVVAVLGMP
MAV_2385|M.avium_104 PDD--------------------DTITVTAQFDSASGLYEGNVVAVLGMP
MUL_4916|M.ulcerans_Agy99 RDR--------------------GPIVVTAQFDSAAGLYEGNAVAVLGIP
Mflv_0007|M.gilvum_PYR-GCK DRL--------------------DAITVTAQFDSAAGLYEGNTVAVLGMP
Mvan_0962|M.vanbaalenii_PYR-1 DRM--------------------DTISVTAQFDSAAGLYEGNTVAVLGMP
TH_3076|M.thermoresistible__bu DQL--------------------DTITVTAQFDSAAGLYVGNVVAVLGMP
Rv1969|M.tuberculosis_H37Rv DAA--------------------ARTTVVAYFDNSNGVFAGDDVLIRGVP
MSMEG_0349|M.smegmatis_MC2_155 GPA--------------------ARTTITAYFANSNGLFAGDDVLILGVP
MLBr_02592|M.leprae_Br4923 QKL--------------------TNNTVVVYFPAATALYTGDKVQIMGLR
Mb3526c|M.bovis_AF2122/97 STG--------------------NKRTIVGYFTSAVGLYPGDQVRVLGVP
MAB_4033|M.abscessus_ATCC_1997 TIFPAVKNMVMPYLGNAHIPLLDHTRSLCANFRDGSGLYKGNKVLLLGVE
: * . .:: *: * : *:
MMAR_3867|M.marinum_M VGQVTKIRPKGGYVEVEFTIDRKVKIPADAQAVTVSTSILTDRQIELTPP
MAV_2385|M.avium_104 VGKITKINPRGGYVEVEFTVDRGVKVPANAQAVTVSTSILTDRQIELTPP
MUL_4916|M.ulcerans_Agy99 VGHITKIVAKSGYAEVEFTVDRAVQVPADVQAVTISTSILTDRQIELTPA
Mflv_0007|M.gilvum_PYR-GCK VGKVVRIEPKGGYVEVEFTVDGDVAVPADVQAVTISNSILTDRQIELTPP
Mvan_0962|M.vanbaalenii_PYR-1 VGEVTKIVTKGGYVEVEFTVDGDVRVPADAMAVTISNSILTDRQIELTPP
TH_3076|M.thermoresistible__bu VGKVTEITPKTNYVEVTFTVDKDVKVPADVQAVTLSNSILTDRQIELTPP
Rv1969|M.tuberculosis_H37Rv VGKIVKIEPQPLRAKISFWFDRKYRVPADAAAAILSPQLVTGRAIQLTPP
MSMEG_0349|M.smegmatis_MC2_155 VGKVKEIEPLPERAKVTFWVDKEFQVPADATAAILSPQLVTGRAIQLTPP
MLBr_02592|M.leprae_Br4923 VGSIDSIVPAGDKMKVTFHYQNKYKVPANASAVILNPTLVASRSIQLEPP
Mb3526c|M.bovis_AF2122/97 VGEIDMIEPRSSDVKITMSVSKDVKVPVDVQAVIMSPNLVAARFIQLTPV
MAB_4033|M.abscessus_ATCC_1997 VGTVTAVTNKPDHVEVDFEIPSDMELPADVGAASYSQSVITNRSIELTRP
** : : :: : :*.:. *. . ::: * *:*
MMAR_3867|M.marinum_M YRG-GPVLQSHDTIGLTRTKTPVEFSRVLSVLDKVTKSLQGDGHGG----
MAV_2385|M.avium_104 YRG-GPVLGNHDTIGLPRTKTPVEFSSVLNVLDKVTKSLEGDGHGG----
MUL_4916|M.ulcerans_Agy99 YRG-GPTLRNHDTIGLTRTRAPVEFDRVLGMLDRLASSLQVDGRGG----
Mflv_0007|M.gilvum_PYR-GCK YRGDGPTLRDHDTIGLNRTRTPVEFARVLDVLDKLSTSLRGDGRGG----
Mvan_0962|M.vanbaalenii_PYR-1 YRGDGPMLQNHDTIGLNRTRTPVEFARVLDVLDKLSTSLRGDGKGN----
TH_3076|M.thermoresistible__bu YRG-GPTLQDHDTIGLNRTRTPVEFARVLDVLDKLALSLRGDGKGG----
Rv1969|M.tuberculosis_H37Rv YAG-GPTMADGTVIPQERTVVPVEWDDLRAQLQRLTALLQPTRPGGV---
MSMEG_0349|M.smegmatis_MC2_155 YES-GPELPDDAVIPIERTAVPVSWDDFRVQLEKLTRTLQPETPGGT---
MLBr_02592|M.leprae_Br4923 YKG-GPALGDNAVIPLERTQVPVEWDELRDSITKIISKLGPTKEQPK---
Mb3526c|M.bovis_AF2122/97 YTG-GAVLPDNGRIDLDRTAVPVEWDEVKEGLTRLAADLSPAAGELQ---
MAB_4033|M.abscessus_ATCC_1997 WSE-GPKFAGAQCISTENTRTPVTVTESFSAIGELADTLMQATPGQDPGD
: *. : . * .* .** : .: *
MMAR_3867|M.marinum_M ----GPVADVLSGGTEIVDGNGAKIKGALDALSRALRLSSDGGAQTREQI
MAV_2385|M.avium_104 ----GPIADVLGGGAEVVNGNGEKIKAALGELSKALRLSSDGGAATREQI
MUL_4916|M.ulcerans_Agy99 ----GPVAGVLDAGYDVVNGNGQHLKEAFDELSKALRLSADRGVHTREQM
Mflv_0007|M.gilvum_PYR-GCK ----GPVADVVNASAAIADGNGQQMKDALGELSTALRLSADHGQVTRDQL
Mvan_0962|M.vanbaalenii_PYR-1 ----GPVRDVVDASAAIADGNGQAMKDALGELSNALRLSSDRGEVTRDQL
TH_3076|M.thermoresistible__bu ----GPIADVVDAGAAIVDGQGRQMKDALGELSNALRLSADRGELTRDQL
Rv1969|M.tuberculosis_H37Rv ----STLGALINTAADNLRGQGATIRDTIIKLSQAISALGDH----SKDI
MSMEG_0349|M.smegmatis_MC2_155 ----SALGNFINTAADNLRGEGDNIRDALVKLSKTVTTVSDH----KDDV
MLBr_02592|M.leprae_Br4923 ----GPFGDVIESFADGLAGKGKQINATLDSLSRALTALNEG----RGDF
Mb3526c|M.bovis_AF2122/97 ----GPLGAAINQAADTLDGNGDSLHNALRELAQVAGRLGDS----RGDI
MAB_4033|M.abscessus_ATCC_1997 SPGVRALNKTLKGAARSLDGVGPGFKEMLNSLTKMVGDPYKAN----ADY
.. : * * :. : *: . :
MMAR_3867|M.marinum_M TTIIRNVSSLFDAAAANDAKLREFASTIHQVSQILADEDIGGGNTGKRLD
MAV_2385|M.avium_104 TTIVKNLSTLFDAVASNDTKLREFASTIHQVSQIMADEDLGSGNTGHKLD
MUL_4916|M.ulcerans_Agy99 TAIIENLSSLLDAAAKNDSTLRQFGSTVRQLSQIMANEGFGSGTSGQQLN
Mflv_0007|M.gilvum_PYR-GCK TTIIRNVSTLSQAAADNDATLREFGSSVRQLSQVLADENFGTGTTGKKLN
Mvan_0962|M.vanbaalenii_PYR-1 TTIIRNVSTLFEAAANNDATLREFGSTIRALSQILADENFGSGSTGRKLN
TH_3076|M.thermoresistible__bu TTIVRNVSSLAEAAARNDELLREFGSSVRAMSQILADEKLGSGTTGRKIN
Rv1969|M.tuberculosis_H37Rv FSTVTNLSTLVTALHDSADLLERLNHNLAAVTSLLADGPDKIGQAAEDLN
MSMEG_0349|M.smegmatis_MC2_155 FSTLNNLATLVSALRDSTDVLAALNRNMAAVSALLADSPDEVGQAIADLN
MLBr_02592|M.leprae_Br4923 FAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLAHSDTDLSSALQQFN
Mb3526c|M.bovis_AF2122/97 FGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLADSSANLDQTLGTLN
MAB_4033|M.abscessus_ATCC_1997 RQLFENSAIVTSNWLQYWNEFAGVVTSLPEVGRLIAGISDNFAQALDNLV
. . . : . : . :* : :
MMAR_3867|M.marinum_M QLVQRAGDLLDANREAIRQTVLNGNTTLQTVSDQ--QRDLAEILDLAPLV
MAV_2385|M.avium_104 QLIQRAGDLLDANRDNIKHAVLSGNDTLKTVTDQ--RRDLAELLDLAPLV
MUL_4916|M.ulcerans_Agy99 ALIQRTGDILNANREAIARGIANGNTTIQSVVDR--QREVTEFFDVLPLM
Mflv_0007|M.gilvum_PYR-GCK EVIVQFGEVLDTHREAIRQIVTNGNTAVTTTVDH--QRDLAEFLDVTPMT
Mvan_0962|M.vanbaalenii_PYR-1 DVINQLGEVLHTHRDAIRQIVSNGDTALTTTVEH--QRDLAEFLDLAPLT
TH_3076|M.thermoresistible__bu EVLTHAGEVLQTHRETIRDLIANGDVVLNAAVDH--ERDLKELLDVTPMT
Rv1969|M.tuberculosis_H37Rv AVVADVGSFAAEHREAIGTASDKLASITTALVDS--LDDIKQTLHISPTV
MSMEG_0349|M.smegmatis_MC2_155 SLAVDVKSFVVENRDAVGTTSDVSASISTALVQS--LDDIKQSLHIFPTT
MLBr_02592|M.leprae_Br4923 SMLSTVQSFLVKNREVLAADVNNLATVNNTVVQPEPLNGVETFLHVAPTA
Mb3526c|M.bovis_AF2122/97 QALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQ--SENIEQVLHVAGPG
MAB_4033|M.abscessus_ATCC_1997 SLLPTLNGMVQRASGRLYKNVFDKLVPWIRDILNAYTPHILTFFNTLPPV
. : : :.
MMAR_3867|M.marinum_M ADNGYNAIDRANGAVR-----------AHFLTD----RMIFDSQLTKEVC
MAV_2385|M.avium_104 ADNAYNMIDRANGSVR-----------ARFLTD----RLLFDSQYTKEIC
MUL_4916|M.ulcerans_Agy99 ADNLYNAVDRRNGSIR-----------AHQLTD----RMIFDSQFGKEVC
Mflv_0007|M.gilvum_PYR-GCK LDNIYNAIDRTNGAVR-----------VHVLTD----KVLFDTQTVKEMC
Mvan_0962|M.vanbaalenii_PYR-1 LDNIYNAIDNKNGAVR-----------VHVLTD----KVLFDTQTVKEMC
TH_3076|M.thermoresistible__bu LDNLYNVADQRNGALR-----------IKVVTD----KVLFDNQLVKEVC
Rv1969|M.tuberculosis_H37Rv LQNFNNIFEPANGALTGALAGNNMANPIAFLCG----AIQAASRLGGEQA
MSMEG_0349|M.smegmatis_MC2_155 LANFGNIYEPANGSLTGALAINNFSDPISFICG----AIEAASRLGAERS
MLBr_02592|M.leprae_Br4923 AANMNQLYHPAHGSVVGVPTITNFANPMQFICS----AIQAGSRLGYQES
Mb3526c|M.bovis_AF2122/97 ITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGSFDTAAGPSAPDYYRR
MAB_4033|M.abscessus_ATCC_1997 INWLADDIYLPNTKTHG----------VTYIPP----RVAISPEQASAIC
: : :
MMAR_3867|M.marinum_M NMMGLRQLGCSTGTLQDFGPDFGLTFVLDGMAAMGQK-------------
MAV_2385|M.avium_104 NLMGLRQLGCSTGTIQDFGPDFGLTYVLDGLAAMGQK-------------
MUL_4916|M.ulcerans_Agy99 NLMGLRQLGCSTGTLQDYGPDFGLTYLLDGLAAMGQK-------------
Mflv_0007|M.gilvum_PYR-GCK NMMGLRQLGCSTGTLQDFGPDFGLSYVLDGLTAMGQK-------------
Mvan_0962|M.vanbaalenii_PYR-1 NMMGLRQLGCSSGTLQDFGPDFGLSYVLDGLAAMGQK-------------
TH_3076|M.thermoresistible__bu NMMGLRQLGCSTGTLQDFGPDFGLTYMLEGLAAMGQR-------------
Rv1969|M.tuberculosis_H37Rv AKLCVQYLAPIVKNRQYNYPPLGANLFVGAQARPNEVTYSEDWLRP----
MSMEG_0349|M.smegmatis_MC2_155 AKLCVQYLAPIVKNRQFNFPPFGENTFVGAQARPNEITFSEDWLRP----
MLBr_02592|M.leprae_Br4923 AELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPKEVAYSEARLQPPSGY
Mb3526c|M.bovis_AF2122/97 AEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKGQIIYDTPATEAKS--
MAB_4033|M.abscessus_ATCC_1997 QNLRDRNTPGSQAACAPGTGSDPVTLGLTNLIMGAALS------------
: .
MMAR_3867|M.marinum_M --------------------------------------------------
MAV_2385|M.avium_104 --------------------------------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
Rv1969|M.tuberculosis_H37Rv -DYVAP---------------------------------VADTPPD----
MSMEG_0349|M.smegmatis_MC2_155 -DYIPP---------------------------------AQPVTQDLDPE
MLBr_02592|M.leprae_Br4923 KDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQVGPITAALMTPDSLAE
Mb3526c|M.bovis_AF2122/97 -ETPVP--------------------------------ELTWVPAGGGAP
MAB_4033|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3867|M.marinum_M --------------------------------------------------
MAV_2385|M.avium_104 --------------------------------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
Rv1969|M.tuberculosis_H37Rv ----------------------------------------------PAAA
MSMEG_0349|M.smegmatis_MC2_155 VL--------------------------------------------PAEA
MLBr_02592|M.leprae_Br4923 LMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGLQASVPIPSPRPDVVP
Mb3526c|M.bovis_AF2122/97 VG---------------------------------------NPADLQSLL
MAB_4033|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3867|M.marinum_M --------------------------
MAV_2385|M.avium_104 --------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------
TH_3076|M.thermoresistible__bu --------------------------
Rv1969|M.tuberculosis_H37Rv VTVD----PATGLRGMMMPPGGGS--
MSMEG_0349|M.smegmatis_MC2_155 APTDGSADPSAGLPGLMIPTEAGS--
MLBr_02592|M.leprae_Br4923 GPVAPTPSPAANVGDPPLPAELGAGQ
Mb3526c|M.bovis_AF2122/97 VPPAPGPAPAPPAPGAGPGEHGGGG-
MAB_4033|M.abscessus_ATCC_1997 --------------------------