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THRHNLIRVGVGLVVVAALACAGWYGLARDRGPIVVTAQFDSAAGLYEGNAVAVLGIPVGHITKIVAKSG YAEVEFTVDRAVQVPADVQAVTISTSILTDRQIELTPAYRGGPTLRNHDTIGLTRTRAPVEFDRVLGMLD RLASSLQVDGRGGGPVAGVLDAGYDVVNGNGQHLKEAFDELSKALRLSADRGVHTREQMTAIIENLSSLL DAAAKNDSTLRQFGSTVRQLSQIMANEGFGSGTSGQQLNALIQRTGDILNANREAIARGIANGNTTIQSV VDRQREVTEFFDVLPLMADNLYNAVDRRNGSIRAHQLTDRMIFDSQFGKEVCNLMGLRQLGCSTGTLQDY GPDFGLTYLLDGLAAMGQK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4916 | mce6D | - | 100% (370) | MCE-family protein Mce6D |
| M. ulcerans Agy99 | MUL_4059 | mce4D | 2e-32 | 29.51% (305) | MCE-family protein Mce4D |
| M. ulcerans Agy99 | MUL_2867 | mce3D | 6e-32 | 28.76% (299) | MCE-family protein Mce3D |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 2e-37 | 33.44% (311) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_0007 | - | 1e-132 | 64.36% (362) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 2e-37 | 33.44% (311) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 5e-28 | 28.43% (306) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1698 | - | 1e-151 | 71.08% (370) | putative Mce family protein |
| M. marinum M | MMAR_0180 | mce6D | 0.0 | 99.19% (370) | MCE-family protein Mce6D |
| M. avium 104 | MAV_2385 | - | 1e-135 | 64.19% (363) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1146 | - | 1e-123 | 60.55% (365) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3076 | - | 1e-126 | 61.33% (362) | PUTATIVE virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0962 | - | 1e-130 | 61.29% (372) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4916|M.ulcerans_Agy99 ------------MTHRHNLIRVGVGLVVVAALACAGWYGLARDRGPIVVT
MMAR_0180|M.marinum_M ------------MTHRHNLIRVGVGLVVVAALACAGWYGLARDRGPIVVT
MAB_1698|M.abscessus_ATCC_1997 ------------MTTIRKMLLICLGLALAATTAGAAWS-VTRDRGTITVT
Mflv_0007|M.gilvum_PYR-GCK -----------MSGRAKVTALVVAGLVAVVAVAAIGWSFLSDRLDAITVT
Mvan_0962|M.vanbaalenii_PYR-1 -----------MGTRSKLVSLAVAAVAVVVVVAAVGWSYLGDRMDTISVT
MSMEG_1146|M.smegmatis_MC2_155 ----------MKLLRNKVAAALLAAVVLGAVVLAVGGAYVKQQMGAITVT
TH_3076|M.thermoresistible__bu ---------MMRDVRTRVIALIAAGLVAVAAVAVVAVKVARDQLDTITVT
MAV_2385|M.avium_104 -----------MTRLGTKALAVVAGVAVVAAAVGIGWWLLRPDDDTITVT
Mb3526c|M.bovis_AF2122/97 -----MMGRVAMLTGSRGLRYATVIALVAALVGGVY--VLSSTGNKRTIV
Rv3496c|M.tuberculosis_H37Rv -----MMGRVAMLTGSRGLRYATVIALVAALVGGVY--VLSSTGNKRTIV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
. :.
MUL_4916|M.ulcerans_Agy99 AQFDSAAGLYEGNAVAVLGIPVGHITKIVAKSGYAEVEFTVDRAVQVPAD
MMAR_0180|M.marinum_M AQFDSAAGLYEGNAVAVLGIPVGHITKIVAKSGYAEVEFTVDRAVQVPAD
MAB_1698|M.abscessus_ATCC_1997 AQFDSAAGLYPGNVVAVLGMPVGQVSKITARGGYAEVEFTVDSQVKVPAD
Mflv_0007|M.gilvum_PYR-GCK AQFDSAAGLYEGNTVAVLGMPVGKVVRIEPKGGYVEVEFTVDGDVAVPAD
Mvan_0962|M.vanbaalenii_PYR-1 AQFDSAAGLYEGNTVAVLGMPVGEVTKIVTKGGYVEVEFTVDGDVRVPAD
MSMEG_1146|M.smegmatis_MC2_155 AQFDSAAGLYEGNVVAVLGMPVGEVKKIRNRNGYVEVEFTVDKGVNIPAD
TH_3076|M.thermoresistible__bu AQFDSAAGLYVGNVVAVLGMPVGKVTEITPKTNYVEVTFTVDKDVKVPAD
MAV_2385|M.avium_104 AQFDSASGLYEGNVVAVLGMPVGKITKINPRGGYVEVEFTVDRGVKVPAN
Mb3526c|M.bovis_AF2122/97 GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
Rv3496c|M.tuberculosis_H37Rv GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
* :* .** *: * ::*: ** : * . :: : . :*.:
MUL_4916|M.ulcerans_Agy99 VQAVTISTSILTDRQIELTPAYRG-GPTLRNHDTIGLTRTRAPVEFDRVL
MMAR_0180|M.marinum_M VQAVTISTSILTDRQIELTPAYRG-GPTLRNHDTIGLTRTRAPVEFDRVL
MAB_1698|M.abscessus_ATCC_1997 AQAVTLSTSILTDRQIELSPPYRG-GPELRDGDTIGLSRTRTPVEFDRVL
Mflv_0007|M.gilvum_PYR-GCK VQAVTISNSILTDRQIELTPPYRGDGPTLRDHDTIGLNRTRTPVEFARVL
Mvan_0962|M.vanbaalenii_PYR-1 AMAVTISNSILTDRQIELTPPYRGDGPMLQNHDTIGLNRTRTPVEFARVL
MSMEG_1146|M.smegmatis_MC2_155 VQAATISNSILTDRQIELTPPYRG-GPTLQNNATIGLNRTRTPVEFARVL
TH_3076|M.thermoresistible__bu VQAVTLSNSILTDRQIELTPPYRG-GPTLQDHDTIGLNRTRTPVEFARVL
MAV_2385|M.avium_104 AQAVTVSTSILTDRQIELTPPYRG-GPVLGNHDTIGLPRTKTPVEFSSVL
Mb3526c|M.bovis_AF2122/97 VQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWDEVK
Rv3496c|M.tuberculosis_H37Rv VQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWDEVK
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKG-GPALGDNAVIPLERTQVPVEWDELR
. *. :. .::: * *:* * * * *. * : * * ** .***: :
MUL_4916|M.ulcerans_Agy99 GMLDRLASSLQ-VDGRGGGPVAGVLDAGYDVVNGNGQHLKEAFDELSKAL
MMAR_0180|M.marinum_M GMLDRLASSLQ-GDGRGGGPVAGVLDAGYDVVNGNGQHLKEAFDELSKAL
MAB_1698|M.abscessus_ATCC_1997 GMLDKLSGSLR-GDGAGGGPIAAVLNAGDGVAAGNGDRIKTALDELSRAL
Mflv_0007|M.gilvum_PYR-GCK DVLDKLSTSLR-GDGRGGGPVADVVNASAAIADGNGQQMKDALGELSTAL
Mvan_0962|M.vanbaalenii_PYR-1 DVLDKLSTSLR-GDGKGNGPVRDVVDASAAIADGNGQAMKDALGELSNAL
MSMEG_1146|M.smegmatis_MC2_155 DVLDKLAGSLR-GDGKGNGPIADVLGAGASIVDGNGQQMKDALGELSNAL
TH_3076|M.thermoresistible__bu DVLDKLALSLR-GDGKGGGPIADVVDAGAAIVDGQGRQMKDALGELSNAL
MAV_2385|M.avium_104 NVLDKVTKSLE-GDGHGGGPIADVLGGGAEVVNGNGEKIKAALGELSKAL
Mb3526c|M.bovis_AF2122/97 EGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQVA
Rv3496c|M.tuberculosis_H37Rv EGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQVA
MLBr_02592|M.leprae_Br4923 DSITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRAL
: :: .* **. .: *:* :: :: .*: .
MUL_4916|M.ulcerans_Agy99 RLSADRGVHTREQMTAIIENLSSLLDAAAKNDSTLRQFGSTVRQLSQIMA
MMAR_0180|M.marinum_M RLSADRGVHTREQMTAIIENLSSLLDAAAKNDSTLRQFGSTVRQLSQIMA
MAB_1698|M.abscessus_ATCC_1997 RLGADGGAHTREQMTAIVKNVSGLLDAAARNDASLRQFGSTVRQLSDVLA
Mflv_0007|M.gilvum_PYR-GCK RLSADHGQVTRDQLTTIIRNVSTLSQAAADNDATLREFGSSVRQLSQVLA
Mvan_0962|M.vanbaalenii_PYR-1 RLSSDRGEVTRDQLTTIIRNVSTLFEAAANNDATLREFGSTIRALSQILA
MSMEG_1146|M.smegmatis_MC2_155 RLSSDRGQVTKDQLTTIVRNLSALSQAAADNDAMMREFGSSVRALSQIVA
TH_3076|M.thermoresistible__bu RLSADRGELTRDQLTTIVRNVSSLAEAAARNDELLREFGSSVRAMSQILA
MAV_2385|M.avium_104 RLSSDGGAATREQITTIVKNLSTLFDAVASNDTKLREFASTIHQVSQIMA
Mb3526c|M.bovis_AF2122/97 GRLGDS----RGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLA
Rv3496c|M.tuberculosis_H37Rv GRLGDS----RGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLA
MLBr_02592|M.leprae_Br4923 TALNEG----RGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLA
: : :: :..: : :* .* : : : .: :*
MUL_4916|M.ulcerans_Agy99 NEGFGSGTSGQQLNALIQRTGDILNANREAIARGIANGNTTIQ-SVVDRQ
MMAR_0180|M.marinum_M NEGFGSGTSGQQLNALIQRTGDILNANREAIARGIANGNTTIQ-SVVDRQ
MAB_1698|M.abscessus_ATCC_1997 DENFGSGNTGRQFNEVIEQTGNILQANRDAIRRGIANGNKSIQ-TVYDRQ
Mflv_0007|M.gilvum_PYR-GCK DENFGTGTTGKKLNEVIVQFGEVLDTHREAIRQIVTNGNTAVT-TTVDHQ
Mvan_0962|M.vanbaalenii_PYR-1 DENFGSGSTGRKLNDVINQLGEVLHTHRDAIRQIVSNGDTALT-TTVEHQ
MSMEG_1146|M.smegmatis_MC2_155 DEDLGSGTTGKKINEVLTHTGQVLETHRDAIKDLVANGDVVLNTVAVDHE
TH_3076|M.thermoresistible__bu DEKLGSGTTGRKINEVLTHAGEVLQTHRETIRDLIANGDVVLN-AAVDHE
MAV_2385|M.avium_104 DEDLGSGNTGHKLDQLIQRAGDLLDANRDNIKHAVLSGNDTLK-TVTDQR
Mb3526c|M.bovis_AF2122/97 DSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLSDQS
Rv3496c|M.tuberculosis_H37Rv DSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLSDQS
MLBr_02592|M.leprae_Br4923 HSDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNN-TVVQPE
.. . . : :: : .* :.. : : . :
MUL_4916|M.ulcerans_Agy99 --REVTEFFDVLPLMADNLYNAVDRRNGSIR----AHQLTDRMIFDSQ--
MMAR_0180|M.marinum_M --REVTEFFDVLPLMADNLYNAVDQRNGSIR----AHQLTDRMIFDSQ--
MAB_1698|M.abscessus_ATCC_1997 --REVAEFFDVLPLMADNLYNAIDQRNGAIR----AHFLADRMVFDGQ--
Mflv_0007|M.gilvum_PYR-GCK --RDLAEFLDVTPMTLDNIYNAIDRTNGAVR----VHVLTDKVLFDTQ--
Mvan_0962|M.vanbaalenii_PYR-1 --RDLAEFLDLAPLTLDNIYNAIDNKNGAVR----VHVLTDKVLFDTQ--
MSMEG_1146|M.smegmatis_MC2_155 --RDVKELLDIAPMTLDNLYNVADKKNGALR----VKVVTDKLLFDNQ--
TH_3076|M.thermoresistible__bu --RDLKELLDVTPMTLDNLYNVADQRNGALR----IKVVTDKVLFDNQ--
MAV_2385|M.avium_104 --RDLAELLDLAPLVADNAYNMIDRANGSVR----ARFLTDRLLFDSQ--
Mb3526c|M.bovis_AF2122/97 --ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGS
Rv3496c|M.tuberculosis_H37Rv --ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGS
MLBr_02592|M.leprae_Br4923 PLNGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS--
. : .:.: * : . :*:: .:: : *
MUL_4916|M.ulcerans_Agy99 --FGKEVCNLMGLRQLGCSTGTLQDYGPDFGLTYLLDGLAAMGQK-----
MMAR_0180|M.marinum_M --FGKEVCNLMGLRQLGCSTGTLQDYGPDFGLTYVLDGLAAMGQK-----
MAB_1698|M.abscessus_ATCC_1997 --MAKEICNLMGLRQLGCSTGTLQDYGPDFGLTYMLDGLAAMGQK-----
Mflv_0007|M.gilvum_PYR-GCK --TVKEMCNMMGLRQLGCSTGTLQDFGPDFGLSYVLDGLTAMGQK-----
Mvan_0962|M.vanbaalenii_PYR-1 --TVKEMCNMMGLRQLGCSSGTLQDFGPDFGLSYVLDGLAAMGQK-----
MSMEG_1146|M.smegmatis_MC2_155 --LIKEVCNMMGLRQLGCSTGTLQDFGPDFGLSSMLDGLAAMGQK-----
TH_3076|M.thermoresistible__bu --LVKEVCNMMGLRQLGCSTGTLQDFGPDFGLTYMLEGLAAMGQR-----
MAV_2385|M.avium_104 --YTKEICNLMGLRQLGCSTGTIQDFGPDFGLTYVLDGLAAMGQK-----
Mb3526c|M.bovis_AF2122/97 FDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKG
Rv3496c|M.tuberculosis_H37Rv FDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKG
MLBr_02592|M.leprae_Br4923 --AIQAGSRLGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPK
. . . : : .. : :.
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0180|M.marinum_M --------------------------------------------------
MAB_1698|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
MAV_2385|M.avium_104 --------------------------------------------------
Mb3526c|M.bovis_AF2122/97 QIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG-----
Rv3496c|M.tuberculosis_H37Rv QIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG-----
MLBr_02592|M.leprae_Br4923 EVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQV
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0180|M.marinum_M --------------------------------------------------
MAB_1698|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
MAV_2385|M.avium_104 --------------------------------------------------
Mb3526c|M.bovis_AF2122/97 ------------------------------APVGNPADLQSLLVPP----
Rv3496c|M.tuberculosis_H37Rv ------------------------------APVGNPADLQSLLVPP----
MLBr_02592|M.leprae_Br4923 GPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGL
MUL_4916|M.ulcerans_Agy99 -----------------------------------------
MMAR_0180|M.marinum_M -----------------------------------------
MAB_1698|M.abscessus_ATCC_1997 -----------------------------------------
Mflv_0007|M.gilvum_PYR-GCK -----------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 -----------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 -----------------------------------------
TH_3076|M.thermoresistible__bu -----------------------------------------
MAV_2385|M.avium_104 -----------------------------------------
Mb3526c|M.bovis_AF2122/97 -------------APGPAPAPPAPGAGPG------EHGGGG
Rv3496c|M.tuberculosis_H37Rv -------------APGPAPAPPAPGAGPG------EHGGGG
MLBr_02592|M.leprae_Br4923 QASVPIPSPRPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ