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SINVTQQGSRARRVFMIGAVSVLVVLALVGGYFGLRKAGVVDDKITVTAQFDEGSGLFVGNVVEVLGLPV GAIESVEAKGTYVEVKFNVDKDVKVPANVIAAAFTSSVLTDRHVALSPPYTEGPVLKDGDLIPLDRTRTP VGFDRVLATVDKLASAMKGDGKGGGPAADLVNIGAQAAAGNGEQVKTALDELSKALKMTTDGAETKDQLT TIIKSVSSLVNAMNENDKAIRQFGSAVHGTADVLAAERFGTGNTGRKANEVLKSTAELIEKNRDVIKGLL GNSNVTLQSLSDNQRELKETLDLLPLLLDNVDRSIDPVNGSLRLHPMLDKLLFESQFTKEICNMMGLRQL GCSTGTMADYGPDFGLTYMLDGMARMGQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4596c | - | - | 100% (379) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_1698 | - | e-111 | 56.42% (335) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4565c | - | e-109 | 52.99% (368) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 9e-37 | 31.33% (316) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_0007 | - | 1e-105 | 51.08% (372) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 9e-37 | 31.33% (316) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 3e-33 | 27.95% (322) | putative secreted protein |
| M. marinum M | MMAR_3867 | mce5D | 1e-107 | 51.53% (359) | MCE-family protein Mce5D |
| M. avium 104 | MAV_2385 | - | 1e-106 | 51.72% (377) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1146 | - | 1e-103 | 50.96% (365) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3076 | - | 1e-107 | 52.97% (370) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4916 | mce6D | 1e-101 | 49.58% (361) | MCE-family protein Mce6D |
| M. vanbaalenii PYR-1 | Mvan_0962 | - | 1e-105 | 50.67% (375) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3867|M.marinum_M -----------MTTSKVKILAVVAAVLAVVALAGAGWWRMGAD---DDPM
MAV_2385|M.avium_104 -----------MTRLGTKALAVVAGVAVVAAAVGIGWWLLRPD---DDTI
MUL_4916|M.ulcerans_Agy99 -----------MTHR-HNLIRVGVGLVVVAALACAGWYGLARD---RGPI
Mflv_0007|M.gilvum_PYR-GCK -----------MSGRAKVTALVVAGLVAVVAVAAIGWSFLSDR---LDAI
Mvan_0962|M.vanbaalenii_PYR-1 -----------MGTRSKLVSLAVAAVAVVVVVAAVGWSYLGDR---MDTI
MSMEG_1146|M.smegmatis_MC2_155 ----------MKLLRNKVAAALLAAVVLGAVVLAVGGAYVKQQ---MGAI
TH_3076|M.thermoresistible__bu ---------MMRDVRTRVIALIAAGLVAVAAVAVVAVKVARDQ---LDTI
MAB_4596c|M.abscessus_ATCC_199 ----MSINVTQQGSRARRVFMIGAVSVLVVLALVGGYFGLRKAGVVDDKI
Mb3526c|M.bovis_AF2122/97 -----MMGRVAMLTGSRGLRYATVIALVAALVGGVY--VLSST---GNKR
Rv3496c|M.tuberculosis_H37Rv -----MMGRVAMLTGSRGLRYATVIALVAALVGGVY--VLSST---GNKR
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQK---LTNN
.
MMAR_3867|M.marinum_M TVTAQFDSASGLYEGNVVAVLGMPVGQVTKIRPKGGYVEVEFTIDRKVKI
MAV_2385|M.avium_104 TVTAQFDSASGLYEGNVVAVLGMPVGKITKINPRGGYVEVEFTVDRGVKV
MUL_4916|M.ulcerans_Agy99 VVTAQFDSAAGLYEGNAVAVLGIPVGHITKIVAKSGYAEVEFTVDRAVQV
Mflv_0007|M.gilvum_PYR-GCK TVTAQFDSAAGLYEGNTVAVLGMPVGKVVRIEPKGGYVEVEFTVDGDVAV
Mvan_0962|M.vanbaalenii_PYR-1 SVTAQFDSAAGLYEGNTVAVLGMPVGEVTKIVTKGGYVEVEFTVDGDVRV
MSMEG_1146|M.smegmatis_MC2_155 TVTAQFDSAAGLYEGNVVAVLGMPVGEVKKIRNRNGYVEVEFTVDKGVNI
TH_3076|M.thermoresistible__bu TVTAQFDSAAGLYVGNVVAVLGMPVGKVTEITPKTNYVEVTFTVDKDVKV
MAB_4596c|M.abscessus_ATCC_199 TVTAQFDEGSGLFVGNVVEVLGLPVGAIESVEAKGTYVEVKFNVDKDVKV
Mb3526c|M.bovis_AF2122/97 TIVGYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKV
Rv3496c|M.tuberculosis_H37Rv TIVGYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKV
MLBr_02592|M.leprae_Br4923 TVVVYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKV
:. * . .*: *: * ::*: ** : : :: : . :
MMAR_3867|M.marinum_M PADAQAVTVSTSILTDRQIELTPPYRG-GPVLQSHDTIGLTRTKTPVEFS
MAV_2385|M.avium_104 PANAQAVTVSTSILTDRQIELTPPYRG-GPVLGNHDTIGLPRTKTPVEFS
MUL_4916|M.ulcerans_Agy99 PADVQAVTISTSILTDRQIELTPAYRG-GPTLRNHDTIGLTRTRAPVEFD
Mflv_0007|M.gilvum_PYR-GCK PADVQAVTISNSILTDRQIELTPPYRGDGPTLRDHDTIGLNRTRTPVEFA
Mvan_0962|M.vanbaalenii_PYR-1 PADAMAVTISNSILTDRQIELTPPYRGDGPMLQNHDTIGLNRTRTPVEFA
MSMEG_1146|M.smegmatis_MC2_155 PADVQAATISNSILTDRQIELTPPYRG-GPTLQNNATIGLNRTRTPVEFA
TH_3076|M.thermoresistible__bu PADVQAVTLSNSILTDRQIELTPPYRG-GPTLQDHDTIGLNRTRTPVEFA
MAB_4596c|M.abscessus_ATCC_199 PANVIAAAFTSSVLTDRHVALSPPYTE-GPVLKDGDLIPLDRTRTPVGFD
Mb3526c|M.bovis_AF2122/97 PVDVQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWD
Rv3496c|M.tuberculosis_H37Rv PVDVQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWD
MLBr_02592|M.leprae_Br4923 PANASAVILNPTLVASRSIQLEPPYKG-GPALGDNAVIPLERTQVPVEWD
*.:. *. .. .::: * : * * * *. * . * * ** .** :
MMAR_3867|M.marinum_M RVLSVLDKVTKSLQ-GDGHGGGPVADVLSGGTEIVDGNGAKIKGALDALS
MAV_2385|M.avium_104 SVLNVLDKVTKSLE-GDGHGGGPIADVLGGGAEVVNGNGEKIKAALGELS
MUL_4916|M.ulcerans_Agy99 RVLGMLDRLASSLQ-VDGRGGGPVAGVLDAGYDVVNGNGQHLKEAFDELS
Mflv_0007|M.gilvum_PYR-GCK RVLDVLDKLSTSLR-GDGRGGGPVADVVNASAAIADGNGQQMKDALGELS
Mvan_0962|M.vanbaalenii_PYR-1 RVLDVLDKLSTSLR-GDGKGNGPVRDVVDASAAIADGNGQAMKDALGELS
MSMEG_1146|M.smegmatis_MC2_155 RVLDVLDKLAGSLR-GDGKGNGPIADVLGAGASIVDGNGQQMKDALGELS
TH_3076|M.thermoresistible__bu RVLDVLDKLALSLR-GDGKGGGPIADVVDAGAAIVDGQGRQMKDALGELS
MAB_4596c|M.abscessus_ATCC_199 RVLATVDKLASAMK-GDGKGGGPAADLVNIGAQAAAGNGEQVKTALDELS
Mb3526c|M.bovis_AF2122/97 EVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELA
Rv3496c|M.tuberculosis_H37Rv EVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELA
MLBr_02592|M.leprae_Br4923 ELRDSITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLS
: : :: : . ** : *:* :: :: *:
MMAR_3867|M.marinum_M RALRLSSDGGAQTREQITTIIRNVSSLFDAAAANDAKLREFASTIHQVSQ
MAV_2385|M.avium_104 KALRLSSDGGAATREQITTIVKNLSTLFDAVASNDTKLREFASTIHQVSQ
MUL_4916|M.ulcerans_Agy99 KALRLSADRGVHTREQMTAIIENLSSLLDAAAKNDSTLRQFGSTVRQLSQ
Mflv_0007|M.gilvum_PYR-GCK TALRLSADHGQVTRDQLTTIIRNVSTLSQAAADNDATLREFGSSVRQLSQ
Mvan_0962|M.vanbaalenii_PYR-1 NALRLSSDRGEVTRDQLTTIIRNVSTLFEAAANNDATLREFGSTIRALSQ
MSMEG_1146|M.smegmatis_MC2_155 NALRLSSDRGQVTKDQLTTIVRNLSALSQAAADNDAMMREFGSSVRALSQ
TH_3076|M.thermoresistible__bu NALRLSADRGELTRDQLTTIVRNVSSLAEAAARNDELLREFGSSVRAMSQ
MAB_4596c|M.abscessus_ATCC_199 KALKMTTD-GAETKDQLTTIIKSVSSLVNAMNENDKAIRQFGSAVHGTAD
Mb3526c|M.bovis_AF2122/97 QVAGRLGD----SRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQ
Rv3496c|M.tuberculosis_H37Rv QVAGRLGD----SRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQ
MLBr_02592|M.leprae_Br4923 RALTALNE----GRGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTT
. : : :: :..: : :* .* : : : :
MMAR_3867|M.marinum_M ILADEDIGGGNTGKRLDQLVQRAGDLLDANREAIRQTVLNGNTTLQ-TVS
MAV_2385|M.avium_104 IMADEDLGSGNTGHKLDQLIQRAGDLLDANRDNIKHAVLSGNDTLK-TVT
MUL_4916|M.ulcerans_Agy99 IMANEGFGSGTSGQQLNALIQRTGDILNANREAIARGIANGNTTIQ-SVV
Mflv_0007|M.gilvum_PYR-GCK VLADENFGTGTTGKKLNEVIVQFGEVLDTHREAIRQIVTNGNTAVT-TTV
Mvan_0962|M.vanbaalenii_PYR-1 ILADENFGSGSTGRKLNDVINQLGEVLHTHRDAIRQIVSNGDTALT-TTV
MSMEG_1146|M.smegmatis_MC2_155 IVADEDLGSGTTGKKINEVLTHTGQVLETHRDAIKDLVANGDVVLNTVAV
TH_3076|M.thermoresistible__bu ILADEKLGSGTTGRKINEVLTHAGEVLQTHRETIRDLIANGDVVLN-AAV
MAB_4596c|M.abscessus_ATCC_199 VLAAERFGTGNTGRKANEVLKSTAELIEKNRDVIKGLLGNSNVTLQ-SLS
Mb3526c|M.bovis_AF2122/97 VLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLS
Rv3496c|M.tuberculosis_H37Rv VLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLS
MLBr_02592|M.leprae_Br4923 RLAHSDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNN-TVV
:* . . . : : : .: :.. : : .
MMAR_3867|M.marinum_M DQQ--RDLAEILDLAPLVADNGYNAIDRANGAVRAHFLTDRMIFDSQLTK
MAV_2385|M.avium_104 DQR--RDLAELLDLAPLVADNAYNMIDRANGSVRARFLTDRLLFDSQYTK
MUL_4916|M.ulcerans_Agy99 DRQ--REVTEFFDVLPLMADNLYNAVDRRNGSIRAHQLTDRMIFDSQFGK
Mflv_0007|M.gilvum_PYR-GCK DHQ--RDLAEFLDVTPMTLDNIYNAIDRTNGAVRVHVLTDKVLFDTQTVK
Mvan_0962|M.vanbaalenii_PYR-1 EHQ--RDLAEFLDLAPLTLDNIYNAIDNKNGAVRVHVLTDKVLFDTQTVK
MSMEG_1146|M.smegmatis_MC2_155 DHE--RDVKELLDIAPMTLDNLYNVADKKNGALRVKVVTDKLLFDNQLIK
TH_3076|M.thermoresistible__bu DHE--RDLKELLDVTPMTLDNLYNVADQRNGALRIKVVTDKVLFDNQLVK
MAB_4596c|M.abscessus_ATCC_199 DNQ--RELKETLDLLPLLLDNVDRSIDPVNGSLRLHPMLDKLLFESQFTK
Mb3526c|M.bovis_AF2122/97 DQS--ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFIC
Rv3496c|M.tuberculosis_H37Rv DQS--ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFIC
MLBr_02592|M.leprae_Br4923 QPEPLNGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFIC
: . : :.: * . . :*:: .. *
MMAR_3867|M.marinum_M EVCN---------------MMGLRQLGCSTGTLQDFGPDFGLTFVLDGMA
MAV_2385|M.avium_104 EICN---------------LMGLRQLGCSTGTIQDFGPDFGLTYVLDGLA
MUL_4916|M.ulcerans_Agy99 EVCN---------------LMGLRQLGCSTGTLQDYGPDFGLTYLLDGLA
Mflv_0007|M.gilvum_PYR-GCK EMCN---------------MMGLRQLGCSTGTLQDFGPDFGLSYVLDGLT
Mvan_0962|M.vanbaalenii_PYR-1 EMCN---------------MMGLRQLGCSSGTLQDFGPDFGLSYVLDGLA
MSMEG_1146|M.smegmatis_MC2_155 EVCN---------------MMGLRQLGCSTGTLQDFGPDFGLSSMLDGLA
TH_3076|M.thermoresistible__bu EVCN---------------MMGLRQLGCSTGTLQDFGPDFGLTYMLEGLA
MAB_4596c|M.abscessus_ATCC_199 EICN---------------MMGLRQLGCSTGTMADYGPDFGLTYMLDGMA
Mb3526c|M.bovis_AF2122/97 GGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITA
Rv3496c|M.tuberculosis_H37Rv GGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITA
MLBr_02592|M.leprae_Br4923 S----AIQAGSRLGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEV
: . *. : : : . .
MMAR_3867|M.marinum_M AMGQK---------------------------------------------
MAV_2385|M.avium_104 AMGQK---------------------------------------------
MUL_4916|M.ulcerans_Agy99 AMGQK---------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK AMGQK---------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 AMGQK---------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 AMGQK---------------------------------------------
TH_3076|M.thermoresistible__bu AMGQR---------------------------------------------
MAB_4596c|M.abscessus_ATCC_199 RMGQ----------------------------------------------
Mb3526c|M.bovis_AF2122/97 YKGQIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG--
Rv3496c|M.tuberculosis_H37Rv YKGQIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG--
MLBr_02592|M.leprae_Br4923 LPKEVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQG
:
MMAR_3867|M.marinum_M --------------------------------------------------
MAV_2385|M.avium_104 --------------------------------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
MAB_4596c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3526c|M.bovis_AF2122/97 ---------------------------------APVGNPADLQSLLVPP-
Rv3496c|M.tuberculosis_H37Rv ---------------------------------APVGNPADLQSLLVPP-
MLBr_02592|M.leprae_Br4923 QQVGPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPP
MMAR_3867|M.marinum_M --------------------------------------------
MAV_2385|M.avium_104 --------------------------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 --------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------
MAB_4596c|M.abscessus_ATCC_199 --------------------------------------------
Mb3526c|M.bovis_AF2122/97 ----------------APGPAPAPPAPGAGPG------EHGGGG
Rv3496c|M.tuberculosis_H37Rv ----------------APGPAPAPPAPGAGPG------EHGGGG
MLBr_02592|M.leprae_Br4923 IGLQASVPIPSPRPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ