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MGTRSKLVSLAVAAVAVVVVVAAVGWSYLGDRMDTISVTAQFDSAAGLYEGNTVAVLGMPVGEVTKIVTK GGYVEVEFTVDGDVRVPADAMAVTISNSILTDRQIELTPPYRGDGPMLQNHDTIGLNRTRTPVEFARVLD VLDKLSTSLRGDGKGNGPVRDVVDASAAIADGNGQAMKDALGELSNALRLSSDRGEVTRDQLTTIIRNVS TLFEAAANNDATLREFGSTIRALSQILADENFGSGSTGRKLNDVINQLGEVLHTHRDAIRQIVSNGDTAL TTTVEHQRDLAEFLDLAPLTLDNIYNAIDNKNGAVRVHVLTDKVLFDTQTVKEMCNMMGLRQLGCSSGTL QDFGPDFGLSYVLDGLAAMGQK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0962 | - | - | 100% (372) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_5199 | - | 1e-39 | 34.73% (311) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0516 | - | 5e-35 | 30.40% (329) | virulence factor Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3526c | mce4D | 2e-35 | 30.49% (305) | MCE-family protein MCE4D |
| M. gilvum PYR-GCK | Mflv_0007 | - | 1e-178 | 82.80% (372) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv3496c | mce4D | 2e-35 | 30.49% (305) | MCE-family protein MCE4D |
| M. leprae Br4923 | MLBr_02592 | mce1D | 2e-27 | 28.10% (306) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_1698 | - | 1e-132 | 62.70% (370) | putative Mce family protein |
| M. marinum M | MMAR_3867 | mce5D | 1e-139 | 67.39% (371) | MCE-family protein Mce5D |
| M. avium 104 | MAV_0105 | - | 1e-134 | 63.86% (368) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_1146 | - | 1e-152 | 71.89% (370) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3076 | - | 1e-153 | 71.27% (369) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_4916 | mce6D | 1e-130 | 61.29% (372) | MCE-family protein Mce6D |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0962|M.vanbaalenii_PYR-1 -----------MGTRSKLVSLAVAAVAVVVVVAAVGWSYLGDRMDTISVT
Mflv_0007|M.gilvum_PYR-GCK -----------MSGRAKVTALVVAGLVAVVAVAAIGWSFLSDRLDAITVT
MSMEG_1146|M.smegmatis_MC2_155 ----------MKLLRNKVAAALLAAVVLGAVVLAVGGAYVKQQMGAITVT
TH_3076|M.thermoresistible__bu ---------MMRDVRTRVIALIAAGLVAVAAVAVVAVKVARDQLDTITVT
MAV_0105|M.avium_104 ----------MTSRRRKLIALAAAAAALAAVAIGVVGHYVKARLDTMTVT
MAB_1698|M.abscessus_ATCC_1997 ------------MTTIRKMLLICLGLALAATTAGAAWS-VTRDRGTITVT
MUL_4916|M.ulcerans_Agy99 ------------MTHRHNLIRVGVGLVVVAALACAGWYGLARDRGPIVVT
MMAR_3867|M.marinum_M -----------MTTSKVKILAVVAAVLAVVALAGAGWWRMGADDDPMTVT
Mb3526c|M.bovis_AF2122/97 -----MMGRVAMLTGSRGLRYATVIALVAALVGGVY--VLSSTGNKRTIV
Rv3496c|M.tuberculosis_H37Rv -----MMGRVAMLTGSRGLRYATVIALVAALVGGVY--VLSSTGNKRTIV
MLBr_02592|M.leprae_Br4923 MSTIFDVRKLKLLRLSRAPVIVGSLVVVLALVVGFVGWRLYQKLTNNTVV
. :.
Mvan_0962|M.vanbaalenii_PYR-1 AQFDSAAGLYEGNTVAVLGMPVGEVTKIVTKGGYVEVEFTVDGDVRVPAD
Mflv_0007|M.gilvum_PYR-GCK AQFDSAAGLYEGNTVAVLGMPVGKVVRIEPKGGYVEVEFTVDGDVAVPAD
MSMEG_1146|M.smegmatis_MC2_155 AQFDSAAGLYEGNVVAVLGMPVGEVKKIRNRNGYVEVEFTVDKGVNIPAD
TH_3076|M.thermoresistible__bu AQFDSAAGLYVGNVVAVLGMPVGKVTEITPKTNYVEVTFTVDKDVKVPAD
MAV_0105|M.avium_104 AQFDSAAGLYEGNVVAVLGMPVGKVSKVTSKGSYVEAELTVDKKVKIPAA
MAB_1698|M.abscessus_ATCC_1997 AQFDSAAGLYPGNVVAVLGMPVGQVSKITARGGYAEVEFTVDSQVKVPAD
MUL_4916|M.ulcerans_Agy99 AQFDSAAGLYEGNAVAVLGIPVGHITKIVAKSGYAEVEFTVDRAVQVPAD
MMAR_3867|M.marinum_M AQFDSASGLYEGNVVAVLGMPVGQVTKIRPKGGYVEVEFTIDRKVKIPAD
Mb3526c|M.bovis_AF2122/97 GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
Rv3496c|M.tuberculosis_H37Rv GYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVD
MLBr_02592|M.leprae_Br4923 VYFPAATALYTGDKVQIMGLRVGSIDSIVPAGDKMKVTFHYQNKYKVPAN
* :* .** *: * ::*: ** : : . : : . :*.
Mvan_0962|M.vanbaalenii_PYR-1 AMAVTISNSILTDRQIELTPPYRGDGPMLQNHDTIGLNRTRTPVEFARVL
Mflv_0007|M.gilvum_PYR-GCK VQAVTISNSILTDRQIELTPPYRGDGPTLRDHDTIGLNRTRTPVEFARVL
MSMEG_1146|M.smegmatis_MC2_155 VQAATISNSILTDRQIELTPPYRG-GPTLQNNATIGLNRTRTPVEFARVL
TH_3076|M.thermoresistible__bu VQAVTLSNSILTDRQIELTPPYRG-GPTLQDHDTIGLNRTRTPVEFARVL
MAV_0105|M.avium_104 VRAVTISTSILTDRQVELTPPYRG-GPVLKNHDTIGLTRTKTPVAFDRVL
MAB_1698|M.abscessus_ATCC_1997 AQAVTLSTSILTDRQIELSPPYRG-GPELRDGDTIGLSRTRTPVEFDRVL
MUL_4916|M.ulcerans_Agy99 VQAVTISTSILTDRQIELTPAYRG-GPTLRNHDTIGLTRTRAPVEFDRVL
MMAR_3867|M.marinum_M AQAVTVSTSILTDRQIELTPPYRG-GPVLQSHDTIGLTRTKTPVEFSRVL
Mb3526c|M.bovis_AF2122/97 VQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWDEVK
Rv3496c|M.tuberculosis_H37Rv VQAVIMSPNLVAARFIQLTPVYTG-GAVLPDNGRIDLDRTAVPVEWDEVK
MLBr_02592|M.leprae_Br4923 ASAVILNPTLVASRSIQLEPPYKG-GPALGDNAVIPLERTQVPVEWDELR
. *. :. .::: * ::* * * * *. * . * * ** .** : .:
Mvan_0962|M.vanbaalenii_PYR-1 DVLDKLSTSLR-GDGKGNGPVRDVVDASAAIADGNGQAMKDALGELSNAL
Mflv_0007|M.gilvum_PYR-GCK DVLDKLSTSLR-GDGRGGGPVADVVNASAAIADGNGQQMKDALGELSTAL
MSMEG_1146|M.smegmatis_MC2_155 DVLDKLAGSLR-GDGKGNGPIADVLGAGASIVDGNGQQMKDALGELSNAL
TH_3076|M.thermoresistible__bu DVLDKLALSLR-GDGKGGGPIADVVDAGAAIVDGQGRQMKDALGELSNAL
MAV_0105|M.avium_104 DMLDKVSKSLK-GDGKGGGPIADVSDAAVAITDGNGKKILAALDELSKAL
MAB_1698|M.abscessus_ATCC_1997 GMLDKLSGSLR-GDGAGGGPIAAVLNAGDGVAAGNGDRIKTALDELSRAL
MUL_4916|M.ulcerans_Agy99 GMLDRLASSLQ-VDGRGGGPVAGVLDAGYDVVNGNGQHLKEAFDELSKAL
MMAR_3867|M.marinum_M SVLDKVTKSLQ-GDGHGGGPVADVLSGGTEIVDGNGAKIKGALDALSRAL
Mb3526c|M.bovis_AF2122/97 EGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQVA
Rv3496c|M.tuberculosis_H37Rv EGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQVA
MLBr_02592|M.leprae_Br4923 DSITKIISKLGPTKEQPKGPFGDVIESFADGLAGKGKQINATLDSLSRAL
: :: .* **. . *:* : :: *: .
Mvan_0962|M.vanbaalenii_PYR-1 RLSSDRGEVTRDQLTTIIRNVSTLFEAAANNDATLREFGSTIRALSQILA
Mflv_0007|M.gilvum_PYR-GCK RLSADHGQVTRDQLTTIIRNVSTLSQAAADNDATLREFGSSVRQLSQVLA
MSMEG_1146|M.smegmatis_MC2_155 RLSSDRGQVTKDQLTTIVRNLSALSQAAADNDAMMREFGSSVRALSQIVA
TH_3076|M.thermoresistible__bu RLSADRGELTRDQLTTIVRNVSSLAEAAARNDELLREFGSSVRAMSQILA
MAV_0105|M.avium_104 RLSSERGVTTREQLTTIITDLSSITEAAARNDAKVREFGSTTRQLSQILA
MAB_1698|M.abscessus_ATCC_1997 RLGADGGAHTREQMTAIVKNVSGLLDAAARNDASLRQFGSTVRQLSDVLA
MUL_4916|M.ulcerans_Agy99 RLSADRGVHTREQMTAIIENLSSLLDAAAKNDSTLRQFGSTVRQLSQIMA
MMAR_3867|M.marinum_M RLSSDGGAQTREQITTIIRNVSSLFDAAAANDAKLREFASTIHQVSQILA
Mb3526c|M.bovis_AF2122/97 GRLGDS----RGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLA
Rv3496c|M.tuberculosis_H37Rv GRLGDS----RGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLA
MLBr_02592|M.leprae_Br4923 TALNEG----RGDFFAVLRSLALFVNALHTDDQQFVALNQNLADFTTRLA
: : :: : .: : :* .* . : .: :*
Mvan_0962|M.vanbaalenii_PYR-1 DENFGSGSTGRKLNDVINQLGEVLHTHRDAIRQIVSNGDTALT-TTVEHQ
Mflv_0007|M.gilvum_PYR-GCK DENFGTGTTGKKLNEVIVQFGEVLDTHREAIRQIVTNGNTAVT-TTVDHQ
MSMEG_1146|M.smegmatis_MC2_155 DEDLGSGTTGKKINEVLTHTGQVLETHRDAIKDLVANGDVVLNTVAVDHE
TH_3076|M.thermoresistible__bu DEKLGSGTTGRKINEVLTHAGEVLQTHRETIRDLIANGDVVLN-AAVDHE
MAV_0105|M.avium_104 DEKFGTGATGRTINRILEEVTTLMENNRDNLKQAVRNGDTAAK-TLVDDQ
MAB_1698|M.abscessus_ATCC_1997 DENFGSGNTGRQFNEVIEQTGNILQANRDAIRRGIANGNKSIQ-TVYDRQ
MUL_4916|M.ulcerans_Agy99 NEGFGSGTSGQQLNALIQRTGDILNANREAIARGIANGNTTIQ-SVVDRQ
MMAR_3867|M.marinum_M DEDIGGGNTGKRLDQLVQRAGDLLDANREAIRQTVLNGNTTLQ-TVSDQQ
Mb3526c|M.bovis_AF2122/97 DSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLSDQS
Rv3496c|M.tuberculosis_H37Rv DSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQ-TLSDQS
MLBr_02592|M.leprae_Br4923 HSDTDLSSALQQFNSMLSTVQSFLVKNREVLAADVNNLATVNN-TVVQPE
.. . . : :: : .: :.. : : : : .
Mvan_0962|M.vanbaalenii_PYR-1 --RDLAEFLDLAPLTLDNIYNAIDNKNGAVR----VHVLTDKVLFDTQ--
Mflv_0007|M.gilvum_PYR-GCK --RDLAEFLDVTPMTLDNIYNAIDRTNGAVR----VHVLTDKVLFDTQ--
MSMEG_1146|M.smegmatis_MC2_155 --RDVKELLDIAPMTLDNLYNVADKKNGALR----VKVVTDKLLFDNQ--
TH_3076|M.thermoresistible__bu --RDLKELLDVTPMTLDNLYNVADQRNGALR----IKVVTDKVLFDNQ--
MAV_0105|M.avium_104 --RGVAELLDVLPLTLENLYNTVDQNNGAIR----VHGLLDKALTDSQ--
MAB_1698|M.abscessus_ATCC_1997 --REVAEFFDVLPLMADNLYNAIDQRNGAIR----AHFLADRMVFDGQ--
MUL_4916|M.ulcerans_Agy99 --REVTEFFDVLPLMADNLYNAVDRRNGSIR----AHQLTDRMIFDSQ--
MMAR_3867|M.marinum_M --RDLAEILDLAPLVADNGYNAIDRANGAVR----AHFLTDRMIFDSQ--
Mb3526c|M.bovis_AF2122/97 --ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGS
Rv3496c|M.tuberculosis_H37Rv --ENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGS
MLBr_02592|M.leprae_Br4923 PLNGVETFLHVAPTAAANMNQLYHPAHGSVVGVPTITNFANPMQFICS--
. : .:.: * : . :*:: . :
Mvan_0962|M.vanbaalenii_PYR-1 --TVKEMCNMMGLRQLGCSSGTLQDFGPDFGLSYVLDGLAAMGQK-----
Mflv_0007|M.gilvum_PYR-GCK --TVKEMCNMMGLRQLGCSTGTLQDFGPDFGLSYVLDGLTAMGQK-----
MSMEG_1146|M.smegmatis_MC2_155 --LIKEVCNMMGLRQLGCSTGTLQDFGPDFGLSSMLDGLAAMGQK-----
TH_3076|M.thermoresistible__bu --LVKEVCNMMGLRQLGCSTGTLQDFGPDFGLTYMLEGLAAMGQR-----
MAV_0105|M.avium_104 --SAKELCNLMHLRQLGCSTGTLQDYGPDFGLTYILDGLSAMGQ------
MAB_1698|M.abscessus_ATCC_1997 --MAKEICNLMGLRQLGCSTGTLQDYGPDFGLTYMLDGLAAMGQK-----
MUL_4916|M.ulcerans_Agy99 --FGKEVCNLMGLRQLGCSTGTLQDYGPDFGLTYLLDGLAAMGQK-----
MMAR_3867|M.marinum_M --LTKEVCNMMGLRQLGCSTGTLQDFGPDFGLTFVLDGMAAMGQK-----
Mb3526c|M.bovis_AF2122/97 FDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKG
Rv3496c|M.tuberculosis_H37Rv FDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKG
MLBr_02592|M.leprae_Br4923 --AIQAGSRLGYQESAELCAQYLSPVLDAIKFNYFPFGLNLFSTAEVLPK
. . . * : .. : :.
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
MAV_0105|M.avium_104 --------------------------------------------------
MAB_1698|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3867|M.marinum_M --------------------------------------------------
Mb3526c|M.bovis_AF2122/97 QIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG-----
Rv3496c|M.tuberculosis_H37Rv QIIYDTPATEAKS---ETPVP--------------ELTWVPAGGG-----
MLBr_02592|M.leprae_Br4923 EVAYSEARLQPPSGYKDTTVPGIWVPDTPLSHRNTQPGWIVAPGMQGQQV
Mvan_0962|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_0007|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 --------------------------------------------------
TH_3076|M.thermoresistible__bu --------------------------------------------------
MAV_0105|M.avium_104 --------------------------------------------------
MAB_1698|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_4916|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3867|M.marinum_M --------------------------------------------------
Mb3526c|M.bovis_AF2122/97 ------------------------------APVGNPADLQSLLVPP----
Rv3496c|M.tuberculosis_H37Rv ------------------------------APVGNPADLQSLLVPP----
MLBr_02592|M.leprae_Br4923 GPITAALMTPDSLAELMGGPDIEPIQSNLQTPPGPPTAYDEHPVPPPIGL
Mvan_0962|M.vanbaalenii_PYR-1 -----------------------------------------
Mflv_0007|M.gilvum_PYR-GCK -----------------------------------------
MSMEG_1146|M.smegmatis_MC2_155 -----------------------------------------
TH_3076|M.thermoresistible__bu -----------------------------------------
MAV_0105|M.avium_104 -----------------------------------------
MAB_1698|M.abscessus_ATCC_1997 -----------------------------------------
MUL_4916|M.ulcerans_Agy99 -----------------------------------------
MMAR_3867|M.marinum_M -----------------------------------------
Mb3526c|M.bovis_AF2122/97 -------------APGPAPAPPAPGAGPG------EHGGGG
Rv3496c|M.tuberculosis_H37Rv -------------APGPAPAPPAPGAGPG------EHGGGG
MLBr_02592|M.leprae_Br4923 QASVPIPSPRPDVVPGPVAPTPSPAANVGDPPLPAELGAGQ