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MTTANPVTPRIPWDSRDPYVYLEDLRAHGDVVLDENAGTWVVLGYQPAREVLGGSGWSSDPLASPQLRAQ APEFLDSSGFGRNMLFADEPDHTELRGTVRDVFTPGFIAGLREGVHTIASHVVEYPSTGEYFDFMADIAL PLPIAIIGEWLGLDDSSAAVLRQESPAIIQMLGAFADVDTVMAGTAAGVTLATELLPLAADRRAHPGDDL LSLIASNTDLPLEDVVTTALIIAIAGHETTANLLGASMVRLLTPRPDGTRLADDIDPDDPTVITELLRLD GPVLATARVATRAHTLAGNTIEGGQTVLIAIAAANRDPQVFVDPAVFRRDRTSPPLAFGYGTHHCLGSAL ARLETTLVLREVLARQPVITGPVSWRDTPAIRGPRSIPMRFQT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3316 | - | - | 100% (393) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 6e-35 | 32.14% (336) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_4456 | - | 5e-33 | 30.43% (368) | putative cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 8e-33 | 29.70% (404) | cytochrome p450 140 CYP140 |
| M. gilvum PYR-GCK | Mflv_1229 | - | 3e-39 | 32.40% (392) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1880c | cyp140 | 8e-33 | 29.70% (404) | cytochrome p450 140 CYP140 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-42 | 31.79% (346) | putative cytochrome p450 |
| M. marinum M | MMAR_5268 | cyp164A3 | 1e-40 | 31.52% (387) | cytochrome P450 164A3 Cyp164A3 |
| M. avium 104 | MAV_0358 | - | 1e-44 | 34.62% (390) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_3134 | - | 3e-38 | 30.85% (389) | cytochrome P450 107B1 |
| M. thermoresistible (build 8) | TH_3500 | - | 2e-37 | 32.81% (317) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_2979 | cyp140A5 | 3e-32 | 29.44% (411) | cytochrome P450 140A5 Cyp140A5 |
| M. vanbaalenii PYR-1 | Mvan_0317 | - | 2e-41 | 34.86% (393) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1912c|M.bovis_AF2122/97 ----------------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIAD
Rv1880c|M.tuberculosis_H37Rv ----------------MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIAD
MUL_2979|M.ulcerans_Agy99 ----------------MKDKLHWFAMHGVIRGMANIGLRRGELEARLIAD
MSMEG_3134|M.smegmatis_MC2_155 ---------------------------------------------MLRLG
MMAR_5268|M.marinum_M MLRGPVTAATHFDHTFFMRRHNVSMTTRPIEPIEFTEQVEPQAFLFQLLD
MAV_0358|M.avium_104 ------------------------MTTAP------TESAESQGLLLQLLD
Mflv_1229|M.gilvum_PYR-GCK ------------------------MTTAA----------EPQSLLLQMLD
MLBr_02088|M.leprae_Br4923 -MRTCVPTRTCVYAFIEYLSHNRPMGTNP------PSLVEAQMLLLRLID
TH_3500|M.thermoresistible__bu -----------------------------------MTSTAPDIDLTDGRF
Mvan_0317|M.vanbaalenii_PYR-1 -----------------------------------MVSVQIRYDPFDASI
MAB_3316|M.abscessus_ATCC_1997 ---------------------------------------MTTANPVTPRI
Mb1912c|M.bovis_AF2122/97 PAVATDPVPFYDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFG
Rv1880c|M.tuberculosis_H37Rv PAVATDPVPFYDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFG
MUL_2979|M.ulcerans_Agy99 PAVAANPGPFHDELRRHGRMVRTRVNYLTVDYQLAHDVLRSDDFHTISFG
MSMEG_3134|M.smegmatis_MC2_155 NSFVQNPHEVYDRLRRSGPVQRVEMWGGVPVWLVTRYQEARNLLTDPRIG
MMAR_5268|M.marinum_M PAIRADPYPLCARLRDHGPLHLPEAN----FVLFSSFGDCDEVLRHPSSC
MAV_0358|M.avium_104 PANRADPYRLYAQFRERGALQLPEAN----LAVFLSYRDCDEVLRHPSSS
Mflv_1229|M.gilvum_PYR-GCK PANRADPYPLYARIRAQGPVQLPANN----LTVFSTYAACDEILRHPHAS
MLBr_02088|M.leprae_Br4923 PGTRADPFPVYRALIDYGPMQLPGMP----LTVFSSFSDCDEALRHPLSA
TH_3500|M.thermoresistible__bu YADSASARAAYRWMRQNQPVFRDRNG----LAAAATYQAIIESERNPE-L
Mvan_0317|M.vanbaalenii_PYR-1 LNDPYPT---YRLLRDVAPVYRAEES----HTWVLSRHADVQAAALDHST
MAB_3316|M.abscessus_ATCC_1997 PWDSRDPYVYLEDLRAHGDVVLDENA----GTWVVLGYQPAREVLGGSGW
. . :
Mb1912c|M.bovis_AF2122/97 ENLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRA
Rv1880c|M.tuberculosis_H37Rv ENLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTSRA
MUL_2979|M.ulcerans_Agy99 ENLPGPLRWLERRTRDEQLHPLRPPSLLAVEPPDHTRYRKTVSAVFTSRA
MSMEG_3134|M.smegmatis_MC2_155 KDGAAASALFPPGTDG-SIGTVLGDNMLFRDPPDHTRLRRFVTSAFTAHA
MMAR_5268|M.marinum_M SDQTKSTVAQRRVEEEPALGRDFPPGFLFLDPPDHTRLRKLVSKAFAPKV
MAV_0358|M.avium_104 SDNVNSTVAKRQAAAGTAPVRQGPPGFLFLDPPDHTRLRRLVSKAFAPRV
Mflv_1229|M.gilvum_PYR-GCK SDRLKSTLAQRAIADGAQPRPFGPPGFLFLDPPDHTRLRRLVSKAFVPKV
MLBr_02088|M.leprae_Br4923 SDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKV
TH_3500|M.thermoresistible__bu FSNTGG---IRPEHPG-------MPYMIDMDDPEHLVRRKLVNHGFTRKR
Mvan_0317|M.vanbaalenii_PYR-1 YSSVDG---IFPTPPGSDFIGSFLPMMIVMDPPRHDQLRALVSRAFTPRR
MAB_3316|M.abscessus_ATCC_1997 SSDPLASPQLRAQAPEFLDSSGFGRNMLFADEPDHTELRGTVRDVFTPGF
. :: : * * * * *.
Mb1912c|M.bovis_AF2122/97 VSALRDLVEQTAINLLDRFAE-QPGIVDVVGRYCSQLPIVVISEILGVPE
Rv1880c|M.tuberculosis_H37Rv VSALRDLVEQTAINLLDRFAE-QPGIVDVVGRYCSQLPIVVISEILGVPE
MUL_2979|M.ulcerans_Agy99 VAALRDRVEQTANSLLDQLAQ-RPGVVDVVGQYCSQLPIMVISEILGVPE
MSMEG_3134|M.smegmatis_MC2_155 VRRLRPTIAGFADALLDDIAASVPGQVDLLQAFAQPLPVQVIGELLGVPE
MMAR_5268|M.marinum_M VNALRPEISSLVDGLLDRIAE--QGRFDVVSDFAYPLPVAVICRLLGVPL
MAV_0358|M.avium_104 VAALEPDIRSLVDGLLDRAAD--RGELEIVEDFAYPLPVAVICRLLGVPL
Mflv_1229|M.gilvum_PYR-GCK VKALEPEIVALVDALLADAG----GTFDAIEGLAYPLPVAVICRLLGVPL
MLBr_02088|M.leprae_Br4923 VQALEGDIAALVDSLLDKGAA--AGQFDVIADLAFPLAVAVICRLLGVPY
TH_3500|M.thermoresistible__bu VRDREDSIARLCDTLIDNVCE--RGECDFVRDIAAPLPMAVIGDMLGVAP
Mvan_0317|M.vanbaalenii_PYR-1 VAGLQGTITQMAAELFERLDEG-SGSADFVTDFAAILPAAVIADLLGVPA
MAB_3316|M.abscessus_ATCC_1997 IAGLREGVHTIASHVVEYPST--GEYFDFMADIALPLPIAIIGEWLGLDD
: . : :. : : . *. :* **:
Mb1912c|M.bovis_AF2122/97 HDRPRVLEFGELAAPSLD-----IGIPWRQYLRVQQGIRGFDCWLEGHLQ
Rv1880c|M.tuberculosis_H37Rv HDRPRVLEFGELAAPSLD-----IGIPWRQYLRVQQGIRGFDCWLEGHLQ
MUL_2979|M.ulcerans_Agy99 QDRGRVLEYGELAAPSLD-----IGVTYRQYRRIQQGITGFNSWLTAHLE
MSMEG_3134|M.smegmatis_MC2_155 RDRELFAALVVPIFTSTD-----TTVLRRAQKELTQ-------LLTDMLA
MMAR_5268|M.marinum_M EDEPQFSQASALLAQALDPFFAFTGQNAENLNDSLEAGQWLRGYLRDLIA
MAV_0358|M.avium_104 DDEPQFSRASALLAQALDPFSTITGVPAEVASERQQAGTWLRDYFHQLIE
Mflv_1229|M.gilvum_PYR-GCK ADEPEFSAASALLAQSLDPFATVTGSAGDGFEERMEAARWLRGYLRELIS
MLBr_02088|M.leprae_Br4923 EDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQLVK
TH_3500|M.thermoresistible__bu EDRGQLLKWSDDLVTGLS-----TTADEATVQAVMDAFAGYTAYTMEIIG
Mvan_0317|M.vanbaalenii_PYR-1 TDRDQFRLWSSQLVQ--------VDVNHGQTTDALAAAAAIYAYFTDFLA
MAB_3316|M.abscessus_ATCC_1997 SSAAVLRQESPAIIQMLG-----AFADVDTVMAGTAAGVTLATELLPLAA
. .
Mb1912c|M.bovis_AF2122/97 QLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNL
Rv1880c|M.tuberculosis_H37Rv QLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTVNL
MUL_2979|M.ulcerans_Agy99 QLRRNPGDDLMSQLIRVAESGDAGTYLDKSELRAIAGLVLVAGFETTVNL
MSMEG_3134|M.smegmatis_MC2_155 EKRQSPADDVLSSLVHRR---DGTDQLSEAELLGTAFLLIVAGYETTVNL
MMAR_5268|M.marinum_M LRRSQPGEDLMSGLVAVE---ESGDQLTEDEIVSTCVLLLVAGHETTVNL
MAV_0358|M.avium_104 ARRSRPGDDLLSGLIAVE---ESGDQLTEEEIVSTCNLLLIAGHETTVNL
Mflv_1229|M.gilvum_PYR-GCK QRRRDPGEDLMSGLIQVE---ESGDQLTEDEIVATCNLLLVAGHETTVNL
MLBr_02088|M.leprae_Br4923 CRRGTPGEDLISRLIELD---ESGDQLTEEEIIATCGLLLVAGHETTVNL
TH_3500|M.thermoresistible__bu KRRAEPTDDLFSILINAEVE---GQRMSDEEIVFETLLILIGGDETTRHT
Mvan_0317|M.vanbaalenii_PYR-1 DRRKNPREDLMSALANATVD---GIGLTDEEVLGFCALLLVAGYETTTNL
MAB_3316|M.abscessus_ATCC_1997 DRRAHPGDDLLSLIASNTD-------LPLEDVVTTALIIAIAGHETTANL
* * :*::* : : :: :: :.* *** :
Mb1912c|M.bovis_AF2122/97 LGNGIRMLLDTPEHLATLRQHPE-LWPNTVEEILRLDSPV-QLTARVACR
Rv1880c|M.tuberculosis_H37Rv LGNGIRMLLDTPEHLATLRQHPE-LWPNTVEEILRLDSPV-QLTARVACR
MUL_2979|M.ulcerans_Agy99 LGNGIRMLLDAPEQLETLRQRPE-LWPNAVEEILRLDSPV-QLTARVART
MSMEG_3134|M.smegmatis_MC2_155 LANGILALLRNPEQLRAVRADRS-LLPRAVEEALRFESPLNTATVRYTSA
MMAR_5268|M.marinum_M IGNAILAMLRDRRQWAQLGADPD-RAAAVVEETMRYDPPV-QLIGRIAGA
MAV_0358|M.avium_104 IGNAVLAMLRDPGQWAALGADPG-RAPAIVEETLRYDPPV-QLAGQIALD
Mflv_1229|M.gilvum_PYR-GCK IANAILALLSNDGQWSALAADPA-RVGAVVEETLRYDPPV-QLVGRIAAE
MLBr_02088|M.leprae_Br4923 IANAVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAI-HLIGRVAAK
TH_3500|M.thermoresistible__bu LSGGVEQLLRHPDQWQRLRNDPD-LVPGAIEEMLRWTSPV-KNMCRTLTA
Mvan_0317|M.vanbaalenii_PYR-1 LGNSAVVLAQHRQTRRRLAADRT-LLGPAVEELLRYDSPA-QGLSRTLTR
MAB_3316|M.abscessus_ATCC_1997 LGASMVRLLTPRPDGTRLADDIDPDDPTVITELLRLDGPV-LATARVATR
:. . : : : * :* . :
Mb1912c|M.bovis_AF2122/97 DVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFST
Rv1880c|M.tuberculosis_H37Rv DVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFST
MUL_2979|M.ulcerans_Agy99 DVEIASWPINRGEMVVAYLAGANRDPAVFPNPHRFDVERANAGRHLAFST
MSMEG_3134|M.smegmatis_MC2_155 PVTVGDVEIPSGELVVIGLLAANHDDEQFPDAHRFDVSRTHN-RHLAFGY
MMAR_5268|M.marinum_M DMVIGDVEVAKGDVMMMLVAAAHRDPAEYDRPEEFDPDRGAL-RHLGFGR
MAV_0358|M.avium_104 DMVIGGVEVPAGDVMMLLLAAANRDPAEFDRPDTFDPDRKSL-RHLGFGR
Mflv_1229|M.gilvum_PYR-GCK DMTVGTTTVPKGDNMLLLTAAAHRDPDAVDRPDEFDPDRESF-RHLGFGK
MLBr_02088|M.leprae_Br4923 DMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLAFAV
TH_3500|M.thermoresistible__bu DTEFHGTQLRKGEKMLLLFESANFDETVFENPDDFRIDRDPN-PHIAFGF
Mvan_0317|M.vanbaalenii_PYR-1 DVTLHDTTMRQGEKVLLLFGSANRDERAFPDPDVFDIERTSE-HQVAFGR
MAB_3316|M.abscessus_ATCC_1997 AHTLAGNTIEGGQTVLIAIAAANRDPQVFVDPAVFRRDRTS--PPLAFGY
. : *: :: .*: * . * .* :.*.
Mb1912c|M.bovis_AF2122/97 GRHFCLGAALARAEGEVGLRTFFDRFPDVRAAGAGSR--RDTRVLRGWST
Rv1880c|M.tuberculosis_H37Rv GRHFCLGAALARAEGEVGLRTFFDRFPDVRAAGAGSR--RDTRVLRGWST
MUL_2979|M.ulcerans_Agy99 GRHFCLGAALARAEGEVGLRTFFERFPDVRAAGAGSR--RDTRVLRGWST
MSMEG_3134|M.smegmatis_MC2_155 GVHHCVGAPLARMEAEIGFDRLLSRFEVMELVDSGPPRYRPSTLMRGVER
MMAR_5268|M.marinum_M GAHYCLGAPLARLEASVALSAIAARFPQARLD--GEPQYKTNVTLRGLES
MAV_0358|M.avium_104 GVHYCLGAPLARLEAGVALSAVTARFPRARLD--GEPQYKTNVTLRGLSR
Mflv_1229|M.gilvum_PYR-GCK GPHFCIGAPLARLEAAVALTALTSRFPGAQLA--GEPSYKQNVTLRGMSE
MLBr_02088|M.leprae_Br4923 GSHFCLGAALARLEATVTLSAISARFPQVQLA--GELVYKPNVAMRGMSA
TH_3500|M.thermoresistible__bu GTHFCLGNQLARLELTLMLRRLLQRLPDLRLASDDPLPLRPANFVSGPEA
Mvan_0317|M.vanbaalenii_PYR-1 GIHFCLGAALARMEARIALNALLDKVPDWEVDLESARRLRSG-PIRGYTS
MAB_3316|M.abscessus_ATCC_1997 GTHHCLGSALARLETTLVLREVLARQP----VITGPVSWRDTPAIRGPRS
* *.*:* *** * : : . : . : : *
Mb1912c|M.bovis_AF2122/97 LPVTLGPARSMVSP--------------------
Rv1880c|M.tuberculosis_H37Rv LPVTLGPARSMVSP--------------------
MUL_2979|M.ulcerans_Agy99 LPVTLGPARALAAS--------------------
MSMEG_3134|M.smegmatis_MC2_155 LPVILGYPHDIASTMREWSGSLPSSGEADSSFAH
MMAR_5268|M.marinum_M MTVALS----------------------------
MAV_0358|M.avium_104 LVVAV-----------------------------
Mflv_1229|M.gilvum_PYR-GCK LPITL-----------------------------
MLBr_02088|M.leprae_Br4923 LPVQV-----------------------------
TH_3500|M.thermoresistible__bu MPVVFTPTEPVSA---------------------
Mvan_0317|M.vanbaalenii_PYR-1 LPITWTTPV-------------------------
MAB_3316|M.abscessus_ATCC_1997 IPMRFQT---------------------------
: :