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MLRLGNSFVQNPHEVYDRLRRSGPVQRVEMWGGVPVWLVTRYQEARNLLTDPRIGKDGAAASALFPPGTD GSIGTVLGDNMLFRDPPDHTRLRRFVTSAFTAHAVRRLRPTIAGFADALLDDIAASVPGQVDLLQAFAQP LPVQVIGELLGVPERDRELFAALVVPIFTSTDTTVLRRAQKELTQLLTDMLAEKRQSPADDVLSSLVHRR DGTDQLSEAELLGTAFLLIVAGYETTVNLLANGILALLRNPEQLRAVRADRSLLPRAVEEALRFESPLNT ATVRYTSAPVTVGDVEIPSGELVVIGLLAANHDDEQFPDAHRFDVSRTHNRHLAFGYGVHHCVGAPLARM EAEIGFDRLLSRFEVMELVDSGPPRYRPSTLMRGVERLPVILGYPHDIASTMREWSGSLPSSGEADSSFA H
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3134 | - | - | 100% (421) | cytochrome P450 107B1 |
| M. smegmatis MC2 155 | MSMEG_0762 | - | 4e-58 | 38.84% (363) | cytochrome P450 FAS1 |
| M. smegmatis MC2 155 | MSMEG_6312 | - | 7e-58 | 35.09% (399) | cytochrome P450 107B1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1912c | cyp140 | 1e-54 | 41.49% (335) | cytochrome p450 140 CYP140 |
| M. gilvum PYR-GCK | Mflv_0225 | - | 1e-60 | 37.88% (396) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1880c | cyp140 | 1e-54 | 41.49% (335) | cytochrome p450 140 CYP140 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-56 | 36.13% (393) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 2e-57 | 33.92% (395) | cytochrome P450 |
| M. marinum M | MMAR_5268 | cyp164A3 | 5e-59 | 37.88% (359) | cytochrome P450 164A3 Cyp164A3 |
| M. avium 104 | MAV_0358 | - | 7e-61 | 36.13% (393) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_4410 | - | 3e-61 | 36.62% (396) | PUTATIVE putative cytochrome P450 107B1 |
| M. ulcerans Agy99 | MUL_2979 | cyp140A5 | 3e-56 | 36.74% (411) | cytochrome P450 140A5 Cyp140A5 |
| M. vanbaalenii PYR-1 | Mvan_0682 | - | 1e-61 | 41.26% (366) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0225|M.gilvum_PYR-GCK ---------------------------------MSQATGEAAPDLPPLHM
Mvan_0682|M.vanbaalenii_PYR-1 ---------------------------------MSQAV---RPELPPVHM
MSMEG_3134|M.smegmatis_MC2_155 -----------------------------------------MLRLGNSFV
TH_4410|M.thermoresistible__bu -----------------------------------------VTVLFDPLD
Mb1912c|M.bovis_AF2122/97 -----MKDKLHWLAMHGVIRGIAAIGIRR-----------GDLQARLIAD
Rv1880c|M.tuberculosis_H37Rv -----MKDKLHWLAMHGVIRGIAAIGIRR-----------GDLQARLIAD
MUL_2979|M.ulcerans_Agy99 -----MKDKLHWFAMHGVIRGMANIGLRR-----------GELEARLIAD
MMAR_5268|M.marinum_M MLRGPVTAATHFDHTFFMRRHNVSMTTRPIEPIEFTEQVEPQAFLFQLLD
MAV_0358|M.avium_104 ------------------------MTTAP------TESAESQGLLLQLLD
MLBr_02088|M.leprae_Br4923 -MRTCVPTRTCVYAFIEYLSHNRPMGTNP------PSLVEAQMLLLRLID
MAB_0276|M.abscessus_ATCC_1997 ----------------------MPITTDP------------GTLLLQVLD
Mflv_0225|M.gilvum_PYR-GCK RRDGFDPTPHLREIREREGVRSVTNAFGMQVYLFTRYDDIKTVLSDHSRF
Mvan_0682|M.vanbaalenii_PYR-1 RRDGFDPTPQLREIRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRF
MSMEG_3134|M.smegmatis_MC2_155 QN----PHEVYDRLRRSGPVQRVEMWGGVPVWLVTRYQEARNLLTDPRIG
TH_4410|M.thermoresistible__bu EEQLADPIPTYRALREQDPVQRIPVGG--GTWVVSRYEDVRRLLRTTAGL
Mb1912c|M.bovis_AF2122/97 PAVATDPVPFYDEVRSHGALVRNRANY-LTVDHRLAHDLLRSDDFRVVSF
Rv1880c|M.tuberculosis_H37Rv PAVATDPVPFYDEVRSHGALVRNRANY-LTVDHRLAHDLLRSDDFRVVSF
MUL_2979|M.ulcerans_Agy99 PAVAANPGPFHDELRRHGRMVRTRVNY-LTVDYQLAHDVLRSDDFHTISF
MMAR_5268|M.marinum_M PAIRADPYPLCARLRDH---GPLHLPE-ANFVLFSSFGDCDEVLRHPSSC
MAV_0358|M.avium_104 PANRADPYRLYAQFRER---GALQLPE-ANLAVFLSYRDCDEVLRHPSSS
MLBr_02088|M.leprae_Br4923 PGTRADPFPVYRALIDY---GPMQLPG-MPLTVFSSFSDCDEALRHPLSA
MAB_0276|M.abscessus_ATCC_1997 PANRANPYPVYGQLVEQTQAGPVHPPG-MDVSVLATFADCNAVLRHPQAS
* . .
Mflv_0225|M.gilvum_PYR-GCK SNGRPPGFVVPGAPPVDEETQARARAGNLLGLDPPEHQRLRRMLTPEFTH
Mvan_0682|M.vanbaalenii_PYR-1 SNTRPPGFVVPGAPPIDEDEQARSRAGNLLGLDPPEHQRLRRMLTPEFTL
MSMEG_3134|M.smegmatis_MC2_155 KDGAAASALFP---PGTDGSIGTVLGDNMLFRDPPDHTRLRRFVTSAFTA
TH_4410|M.thermoresistible__bu MQ--PPGATVP--VELAGGPAERIYRGLMVLNDPPVHTRLRKLTEKAMTR
Mb1912c|M.bovis_AF2122/97 GE-NLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTS
Rv1880c|M.tuberculosis_H37Rv GE-NLPPPLRWLERRTRGDQLHPLREPSLLAVEPPDHTRYRKTVSAVFTS
MUL_2979|M.ulcerans_Agy99 GE-NLPGPLRWLERRTRDEQLHPLRPPSLLAVEPPDHTRYRKTVSAVFTS
MMAR_5268|M.marinum_M SD-QTKSTVAQRRVEE-EPALGRDFPPGFLFLDPPDHTRLRKLVSKAFAP
MAV_0358|M.avium_104 SD-NVNSTVAKRQAAA-GTAPVRQGPPGFLFLDPPDHTRLRRLVSKAFAP
MLBr_02088|M.leprae_Br4923 SD-RLKATLAQQAIAA-GAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAP
MAB_0276|M.abscessus_ATCC_1997 SD-RRKSNIVQRQLAQ-NPNLIAR--PSFLGLDAPDHTRLRKLASKAFAP
: :: :.* * * *: ::
Mflv_0225|M.gilvum_PYR-GCK RRMQRLRPRIAEIVDTQIDALAAAG---RPADLVEHFALPIPSLVICELL
Mvan_0682|M.vanbaalenii_PYR-1 RRMRRLQPRIAEIVDAQLDALAAARDGEASADLVQHFALPIPSLVICELL
MSMEG_3134|M.smegmatis_MC2_155 HAVRRLRPTIAGFADALLDDIAASVP--GQVDLLQAFAQPLPVQVIGELL
TH_4410|M.thermoresistible__bu GAVEKLRADVERVASEALDAMLEQGE----ADAMTELAFTVPLRVICGML
Mb1912c|M.bovis_AF2122/97 RAVSALRDLVEQTAINLLDRFAEQP---GIVDVVGRYCSQLPIVVISEIL
Rv1880c|M.tuberculosis_H37Rv RAVSALRDLVEQTAINLLDRFAEQP---GIVDVVGRYCSQLPIVVISEIL
MUL_2979|M.ulcerans_Agy99 RAVAALRDRVEQTANSLLDQLAQRP---GVVDVVGQYCSQLPIMVISEIL
MMAR_5268|M.marinum_M KVVNALRPEISSLVDGLLDRIAEQ----GRFDVVSDFAYPLPVAVICRLL
MAV_0358|M.avium_104 RVVAALEPDIRSLVDGLLDRAADR----GELEIVEDFAYPLPVAVICRLL
MLBr_02088|M.leprae_Br4923 KVVQALEGDIAALVDSLLDKGAAA----GQFDVIADLAFPLAVAVICRLL
MAB_0276|M.abscessus_ATCC_1997 RVINAMAEDIQTFVDKMLDDIALR----GTFNLVTEFAYPLPVAVICRML
: : : . :* : : . :. ** :*
Mflv_0225|M.gilvum_PYR-GCK GVPYADRD-------DFQRRSAR----QLDLSIPIPERLELQREGREYMA
Mvan_0682|M.vanbaalenii_PYR-1 GVPYADRD-------DFQRRSAR----QLDLSIPIPERIELAREGRAYMG
MSMEG_3134|M.smegmatis_MC2_155 GVPERDRE-------LFAALVVP----IFTSTDTTVLR-RAQKELTQLLT
TH_4410|M.thermoresistible__bu GIPEADRAQMLDWTPDFFRIFLP----QANDADGIAACHRACQNFIDYLS
Mb1912c|M.bovis_AF2122/97 GVPEHDRPRVLEFGELAAPSLD-----IGIPWRQYLRVQQGIRGFDCWLE
Rv1880c|M.tuberculosis_H37Rv GVPEHDRPRVLEFGELAAPSLD-----IGIPWRQYLRVQQGIRGFDCWLE
MUL_2979|M.ulcerans_Agy99 GVPEQDRGRVLEYGELAAPSLD-----IGVTYRQYRRIQQGITGFNSWLT
MMAR_5268|M.marinum_M GVPLEDEPQFSQASALLAQALDPFFAFTGQNAENLNDSLEAGQWLRGYLR
MAV_0358|M.avium_104 GVPLDDEPQFSRASALLAQALDPFSTITGVPAEVASERQQAGTWLRDYFH
MLBr_02088|M.leprae_Br4923 GVPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLE
MAB_0276|M.abscessus_ATCC_1997 GVPIEDEPEFGRASALLGQGLDPVYALTGQSPANMDERFQAARWMWDYFI
*:* * . :
Mflv_0225|M.gilvum_PYR-GCK ALVAGARRHPGDDILGMLIREHG--G---ELTDDELIGVASLLLLAGHET
Mvan_0682|M.vanbaalenii_PYR-1 SLVAGARTNPGDDILGMLVREHG--A---ELTDDELVGIAGLLLLAGHET
MSMEG_3134|M.smegmatis_MC2_155 DMLAEKRQSPADDVLSSLVHRRDGTD---QLSEAELLGTAFLLIVAGYET
TH_4410|M.thermoresistible__bu EQIEYRRRTPADDIFSALVSAEDEGD---RLSRDELVATVLSLLTGGFDT
Mb1912c|M.bovis_AF2122/97 GHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFET
Rv1880c|M.tuberculosis_H37Rv GHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFET
MUL_2979|M.ulcerans_Agy99 AHLEQLRRNPGDDLMSQLIRVAESGDAGTYLDKSELRAIAGLVLVAGFET
MMAR_5268|M.marinum_M DLIALRRSQPGEDLMSGLVAVEESGD---QLTEDEIVSTCVLLLVAGHET
MAV_0358|M.avium_104 QLIEARRSRPGDDLLSGLIAVEESGD---QLTEEEIVSTCNLLLIAGHET
MLBr_02088|M.leprae_Br4923 QLVKCRRGTPGEDLISRLIELDESGD---QLTEEEIIATCGLLLVAGHET
MAB_0276|M.abscessus_ATCC_1997 DLIASRRRNLGDDLLSALIQVEEAGD---QLTEEEIISTCTLLLIAGHET
: * .:*::. *: * *: . :: .*.:*
Mflv_0225|M.gilvum_PYR-GCK TSNMLALGVLALLRHPDQLAAIRDDPAAVAP-AVEELLRWLSIVQTSIPR
Mvan_0682|M.vanbaalenii_PYR-1 TSNMLALGTLALLRHPEQLAAVREDPDAVAP-AVEELLRWLSIVHTAIPR
MSMEG_3134|M.smegmatis_MC2_155 TVNLLANGILALLRNPEQLRAVRADRSLLPR-AVEEALRFESPLNTATVR
TH_4410|M.thermoresistible__bu TMGMIGAGVFGLARQPEQLAALREDPAGLARTAVEEFIRWESPVAVTY-R
Mb1912c|M.bovis_AF2122/97 TVNLLGNGIRMLLDTPEHLATLRQHPELWPN-TVEEILRLDSPVQLTA-R
Rv1880c|M.tuberculosis_H37Rv TVNLLGNGIRMLLDTPEHLATLRQHPELWPN-TVEEILRLDSPVQLTA-R
MUL_2979|M.ulcerans_Agy99 TVNLLGNGIRMLLDAPEQLETLRQRPELWPN-AVEEILRLDSPVQLTA-R
MMAR_5268|M.marinum_M TVNLIGNAILAMLRDRRQWAQLGADPDRAAA-VVEETMRYDPPVQLIG-R
MAV_0358|M.avium_104 TVNLIGNAVLAMLRDPGQWAALGADPGRAPA-IVEETLRYDPPVQLAG-Q
MLBr_02088|M.leprae_Br4923 TVNLIANAVLAMLRNPSQWKALSSNPQRAPL-VVEETLRYDPAIHLIG-R
MAB_0276|M.abscessus_ATCC_1997 TVNLIANASLAMLRHPEQWKLLGQNADRAPL-VVEETLRYDPPVHMVA-R
* .::. . : : : . *** :* . : :
Mflv_0225|M.gilvum_PYR-GCK ITTTDVEIAGVAIPAGQLVFASLPAGNRDPEFIEHPEVLDIGRGAP-GHL
Mvan_0682|M.vanbaalenii_PYR-1 ITTTDVEIAGVSIPAGQLVFASLPSGNRDDEFIERPEVFDITRGAM-GHL
MSMEG_3134|M.smegmatis_MC2_155 YTSAPVTVGDVEIPSGELVVIGLLAANHDDEQFPDAHRFDVSRTHN-RHL
TH_4410|M.thermoresistible__bu HFVEDVTIADTTIPAGEPIWLLLLSANRDDTRFHDPDGFDVRRKPN-QHV
Mb1912c|M.bovis_AF2122/97 VACRDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHL
Rv1880c|M.tuberculosis_H37Rv VACRDVEVAGVRIKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHL
MUL_2979|M.ulcerans_Agy99 VARTDVEIASWPINRGEMVVAYLAGANRDPAVFPNPHRFDVERANAGRHL
MMAR_5268|M.marinum_M IAGADMVIGDVEVAKGDVMMMLVAAAHRDPAEYDRPEEFDPDRGAL-RHL
MAV_0358|M.avium_104 IALDDMVIGGVEVPAGDVMMLLLAAANRDPAEFDRPDTFDPDRKSL-RHL
MLBr_02088|M.leprae_Br4923 VAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHL
MAB_0276|M.abscessus_ATCC_1997 VADGEMAIRDFILPDGEWVLLMLAAAQRDPDVGPDLDVFNPDRSEI-KHL
: : : *: : : ..::* . :: * *:
Mflv_0225|M.gilvum_PYR-GCK AFGHGVHHCLGAPLARMEMAIAFPALFRRFPSLEPAEDFADVAFRSFHFI
Mvan_0682|M.vanbaalenii_PYR-1 AFGHGVHHCLGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFRSFHFI
MSMEG_3134|M.smegmatis_MC2_155 AFGYGVHHCVGAPLARMEAEIGFDRLLSRFEVMELVDS-GPPRYRPSTLM
TH_4410|M.thermoresistible__bu AFGGGRHHCIGSHLARLEGEVVFAEIARRIETIEITGD---SPRRPNFQF
Mb1912c|M.bovis_AF2122/97 AFSTGRHFCLGAALARAEGEVGLRTFFDRFPDVRAAGA---GSRRDTRVL
Rv1880c|M.tuberculosis_H37Rv AFSTGRHFCLGAALARAEGEVGLRTFFDRFPDVRAAGA---GSRRDTRVL
MUL_2979|M.ulcerans_Agy99 AFSTGRHFCLGAALARAEGEVGLRTFFERFPDVRAAGA---GSRRDTRVL
MMAR_5268|M.marinum_M GFGRGAHYCLGAPLARLEASVALSAIAARFPQARLDGE---PQYKTNVTL
MAV_0358|M.avium_104 GFGRGVHYCLGAPLARLEAGVALSAVTARFPRARLDGE---PQYKTNVTL
MLBr_02088|M.leprae_Br4923 AFAVGSHFCLGAALARLEATVTLSAISARFPQVQLAGE---LVYKPNVAM
MAB_0276|M.abscessus_ATCC_1997 AFGHGPHFCLGAPLARLEARLALSSITARFPGARLMDE---PTYKPNVTL
.*. * *.*:*: *** * : : . *: : :
Mflv_0225|M.gilvum_PYR-GCK YGLKSLEVSW-----------------------------
Mvan_0682|M.vanbaalenii_PYR-1 YGLKSLEVTW-----------------------------
MSMEG_3134|M.smegmatis_MC2_155 RGVERLPVILGYPHDIASTMREWSGSLPSSGEADSSFAH
TH_4410|M.thermoresistible__bu RSFTTLPVKMTGRSR------------------------
Mb1912c|M.bovis_AF2122/97 RGWSTLPVTLGPARSMVSP--------------------
Rv1880c|M.tuberculosis_H37Rv RGWSTLPVTLGPARSMVSP--------------------
MUL_2979|M.ulcerans_Agy99 RGWSTLPVTLGPARALAAS--------------------
MMAR_5268|M.marinum_M RGLESMTVALS----------------------------
MAV_0358|M.avium_104 RGLSRLVVAV-----------------------------
MLBr_02088|M.leprae_Br4923 RGMSALPVQV-----------------------------
MAB_0276|M.abscessus_ATCC_1997 RGLAELPVSIA----------------------------
. : *