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VIASLSDDPFWPTRKPLRASFSLLTGWGRDRPIPPGPIGLPFIGSAIPMARNPYKFLQDCHRRYGDIYRV PLPIHPLVLANHPDLVSEFMENTELKYSMSAPIQGKRLQKAVASVGCPVQVLEGQALRDRRKRLMPMFGK RHLSVVSDKFVEVFTDRIDRWLLVADTGKEVNLQAELPKVVLPAFMYAMFSTRLSDDEVLHADTATRSVM RAIASGLFLASPPNIFPLRGRENLPVSGLRLMRTIRQMIRDRRANPTDDADLLNILLAARGDSSRPLTEI DVYSEIMSAIGGGYETIVASMSWTLALLLQHPEHLDRLYDEISILHGNAPTPDDLPRLPWARACFDEGQR LQGAPINPRYAMEDTELGGYPIPKYTLVASSLYVVHRDPRWWGENAETYDPMQFFDQDRVNARPRLAFQA FGAGPHHCMGTGMAYMMAQYLLAIIFQRYRLHLRPGWQPRQFFSLSTLVKGGVPATITKA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3275 | - | - | 100% (480) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_4944c | - | e-138 | 50.21% (472) | putative cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_2151c | - | 1e-63 | 34.35% (457) | putative cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1429c | cyp132 | 7e-34 | 29.03% (434) | cytochrome P450 132 |
| M. gilvum PYR-GCK | Mflv_4801 | - | 1e-25 | 27.91% (344) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1394c | cyp132 | 4e-34 | 28.77% (438) | cytochrome P450 132 |
| M. leprae Br4923 | MLBr_02088 | - | 5e-07 | 23.94% (213) | putative cytochrome p450 |
| M. marinum M | MMAR_0281 | cyp183B1 | 6e-32 | 27.34% (428) | cytochrome P450 183B1 Cyp183B1 |
| M. avium 104 | MAV_3927 | - | 3e-24 | 23.67% (452) | cytochrome p450 |
| M. smegmatis MC2 155 | MSMEG_0822 | - | 1e-24 | 26.06% (353) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3255 | - | 2e-23 | 26.08% (372) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 4e-23 | 26.44% (329) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_0245 | - | 8e-28 | 27.81% (320) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1429c|M.bovis_AF2122/97 ----------MATATTQRPLKGPAKRMSTWTMTREAITIGFDAG------
Rv1394c|M.tuberculosis_H37Rv ----------MATATTQRPLKGPAKRMSTWTMTREAITIGFDAG------
TH_3255|M.thermoresistible__bu ---------MVVTTERADVATLPPAPRNPLPYWRQVRAVRSFHT------
Mvan_0245|M.vanbaalenii_PYR-1 ---------MVGTVEREDLGALPLAPRNPLPYRQQVRAIRTFHT------
MUL_0604|M.ulcerans_Agy99 ------------MVDPPDIRSLPLAPRNPLPYWQQLKALKTLHV------
MSMEG_0822|M.smegmatis_MC2_155 ---------MVETASPP-LTELPLAPRNTLPCREQIRCLRSFID------
MAB_3275|M.abscessus_ATCC_1997 ---------MIASLSDDPFWPTRKPLRASFSLLTGWGRDRPIPP------
MMAR_0281|M.marinum_M ----------MPTSIPIAPAALPLLGHTLPLLRNPLSFLLSLPA------
Mflv_4801|M.gilvum_PYR-GCK -----------MVDHRQPFPPLPHPPRRVPVVGDVFGFSADILT------
MAV_3927|M.avium_104 ----------MTATISTPQYLLDQARRRFTPTLNTIPGMGAIEKRLLAHE
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPG-----
Mb1429c|M.bovis_AF2122/97 -------------------DGFLGRLRGSDITRFR---------------
Rv1394c|M.tuberculosis_H37Rv -------------------DGFLGRLRGSDITRFR---------------
TH_3255|M.thermoresistible__bu -------------------GQELLRDAGGPV-------------------
Mvan_0245|M.vanbaalenii_PYR-1 -------------------GLETLRDAGGPVTRLK---------------
MUL_0604|M.ulcerans_Agy99 -------------------GSEALRDAGGSVTRIW---------------
MSMEG_0822|M.smegmatis_MC2_155 -------------------GMQRLRDVGGPVTRIV---------------
MAB_3275|M.abscessus_ATCC_1997 -------------------GPIGLPFIGSAIPMARNPYKFLQDCHRRYGD
MMAR_0281|M.marinum_M -------------------RGDLVRIRIGPATAVV---------------
Mflv_4801|M.gilvum_PYR-GCK -------------------RPPSDPGLGPVFEFR----------------
MAV_3927|M.avium_104 WQTKVLAEPPAGSGLKPVLGDAGLPILGHIIELFRGGPDYALFLYRNHGP
MLBr_02088|M.leprae_Br4923 ------------------TRADPFPVYRALIDYGP--------------M
Mb1429c|M.bovis_AF2122/97 -CAGRRFVS----ISHPDYVDHVLHEARLKYVK-----SDEYGPIRATAG
Rv1394c|M.tuberculosis_H37Rv -CAGRRFVS----ISHPDYVDHVLHEARLKYVK-----SDEYGPIRATAG
TH_3255|M.thermoresistible__bu ----KWAIPPIVLVTSPAGIRDVLNRRDALSER-----CQVHHEVRHLGG
Mvan_0245|M.vanbaalenii_PYR-1 -LAPKWLMPPMVVATSPQGARDILARGGGHIDK-----TRVHHEMRRLLG
MUL_0604|M.ulcerans_Agy99 -LGPKRLVPPMVMVTSPQGARDVLGRSGALSDRGT---LPLLKDLRRAIG
MSMEG_0822|M.smegmatis_MC2_155 -LGPRWLVPPALLVTSPQGAHDVLSLPDAVADRGG---SRNMRQLQRLMG
MAB_3275|M.abscessus_ATCC_1997 IYRVPLPIHPLVLANHPDLVSEFMENTELKYSMSAPIQGKRLQKAVASVG
MMAR_0281|M.marinum_M -------------ACTAELTHEILCDDRIFDKG-----GIFFDRFREMLG
Mflv_4801|M.gilvum_PYR-GCK -----FLGARYVVAASADAVAEVNDERRFCKHVG-----PDIDALRIMGG
MAV_3927|M.avium_104 LIYLDSPIMPAVTALGPDATQAVFSNRNKDYSQ-----KGWHPVIGPFFN
MLBr_02088|M.leprae_Br4923 QLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQAIAAGAEPRPFYA
Mb1429c|M.bovis_AF2122/97 LNLLTDEGDS--WARHRGALNSTFARRHLRGLVGLMIDPIADVTAALV--
Rv1394c|M.tuberculosis_H37Rv LNLLTDEGDS--WARHRGALNSTFARRHLRGLVGLMIDPIADVTAARV--
TH_3255|M.thermoresistible__bu DSLFVLPTDP--WRARRRALAPVFTPTAVRSYGGYMSEAAQRVADGWQ--
Mvan_0245|M.vanbaalenii_PYR-1 ANLFDLTHEP--WLPRRRALQPIFTKQHVREFAGHMATAAQTVADSWA--
MUL_0604|M.ulcerans_Agy99 ESVLNLPHDT--WLPRRRTLQPIFTKQRVAGFAGHMSEAANHILLGWP--
MSMEG_0822|M.smegmatis_MC2_155 GNLLDLPHDR--WLPRRRTLQPLFTKKHVPRFAGHMAAAAQSVAVSWA--
MAB_3275|M.abscessus_ATCC_1997 CPVQVLEGQA--LRDRRKRLMPMFGKRHLSVVSDKFVEVFTDRIDRWLLV
MMAR_0281|M.marinum_M DGLGTCPRSQ--HRRQRRLLQPAFHTQRLPGYAQTMTTEVAATVGRWQ--
Mflv_4801|M.gilvum_PYR-GCK DGLFTAYNEEPNWQRAHDLLMPAFSQQAMRGYHSAMLDAADGLVARWDGK
MAV_3927|M.avium_104 RGLMMLDFDE--HMYHRRIMQEAFTRSRLTGYVEHIDRVATDIVADWP--
MLBr_02088|M.leprae_Br4923 SSFMFLDPPD--HTRLRKLVSKAFAPKVVQALEGDIAALVDSLLDKGA--
. : : * : :
Mb1429c|M.bovis_AF2122/97 --PGAQFDMHQSMVETTLRVVANALFSQDFGPLVQSMHDLATRGLRRAEK
Rv1394c|M.tuberculosis_H37Rv --PGAQFDMHQSMVETTLRVVANALFSQDFGPLVQSMHDLATRGLRRAEK
TH_3255|M.thermoresistible__bu --AAREVDLDAECRRLTMRSLGRSVLGLDINERADAISEPMH--------
Mvan_0245|M.vanbaalenii_PYR-1 --DGTELDLDTECRKLTLRALGRSVLGLDLDEHSDAIAEPLR--------
MUL_0604|M.ulcerans_Agy99 --DGAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVT--------
MSMEG_0822|M.smegmatis_MC2_155 --DGATVDLDRACRALTLRALGRSVFGVDLDQRAEDVGPALR--------
MAB_3275|M.abscessus_ATCC_1997 ADTGKEVNLQAELPKVVLPAFMYAMFSTRLSDDEVLHADTAT--------
MMAR_0281|M.marinum_M --NGQIIDVPAEMMAITGRTLLATMFSNSLPNPALRQALDDL--------
Mflv_4801|M.gilvum_PYR-GCK ARTGASVDVPADATRVTLETIGQCAAGHPFGCFDTEDPHPFVEHMVAG--
MAV_3927|M.avium_104 -TNDARFLFHPAMKELTLDIASLVFMGHEPGTDHDLVTKVNQ--------
MLBr_02088|M.leprae_Br4923 --AAGQFDVIADLAFPLAVAVICRLLGVPYEDAPEFG-------------
. . .
Mb1429c|M.bovis_AF2122/97 LERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLR-EMQEITLTLDRAINSV
Rv1394c|M.tuberculosis_H37Rv LERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLR-EMQEITLTLDRAINSV
TH_3255|M.thermoresistible__bu --------IASSYTADRALRPVRAPRWLPTPARRRARAAVATMRRITDEM
Mvan_0245|M.vanbaalenii_PYR-1 --------TALEYIADRALQPISAPRWLPTPARRRARAASSTLHKLADKI
MUL_0604|M.ulcerans_Agy99 --------LAAKWAADRSARPVRAPHWLPTPARPRARGAYDAMYKIAADM
MSMEG_0822|M.smegmatis_MC2_155 --------TSLSWVADRASRPVNLPQWVPTRGQRKARAGNATLHRLAAEI
MAB_3275|M.abscessus_ATCC_1997 --------RSVMRAIASGLFLASPPNIFPLRGRENLPVSGLRLMRTIRQM
MMAR_0281|M.marinum_M --------TAIFAVLYWRMLTPPPLDRLPTVGNRRYHRASARLRHTIGSA
Mflv_4801|M.gilvum_PYR-GCK ---------LKGSDWVGVLRETVLPNFFARRAERRVRRHAVQMHRIADEI
MAV_3927|M.avium_104 -----------AFTTTTRAGGAIIRQPIPPFKWWRGLRARQLLEDYFSER
MLBr_02088|M.leprae_Br4923 ---------RVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQL
. . : .
Mb1429c|M.bovis_AF2122/97 IDRRLAEPTNSADLLNVLLSAD-----GGIWPRQRVRDEALTFMLAGHET
Rv1394c|M.tuberculosis_H37Rv IDRRLAEPTNSADLLNVLLSAD-----GGIWPRQRVRDEALTFMLAGHET
TH_3255|M.thermoresistible__bu LQACRADPDRDAPLVHALIRATDPET-GRGLSDEDICNDLLIFMLAGHDT
Mvan_0245|M.vanbaalenii_PYR-1 LQACRTDPTRDAPLVQALIAASDPAT-GRPLSDDEIRDELIVFMLAGHDT
MUL_0604|M.ulcerans_Agy99 LAACRADPSREAPLITALIDATGPNT-GESLSDQQICDEMVYFMILGEDT
MSMEG_0822|M.smegmatis_MC2_155 LADVRADPDRDAPLVRALLEARDPET-GRGLTDDQICDELVLFMLAGHDT
MAB_3275|M.abscessus_ATCC_1997 IRDRRANPTDDADLLNILLAARG-DS-SRPLTEIDVYSEIMSAIGGGYET
MMAR_0281|M.marinum_M VAGRRAAGVDRGDLLSAILASHEVDSSTVAFTDTEVIDQIVSFFIAGTET
Mflv_4801|M.gilvum_PYR-GCK VSERLRDGLGHHDDLLELMLTSDLDP-------ANIRYQLINFLVAGHET
MAV_3927|M.avium_104 VKERRNATGN--DMLTVLCHTEDDDG--NSFTDDDIVNHMIFLMMAAHDT
MLBr_02088|M.leprae_Br4923 VKCRRGTPGE--DLISRLIELDESGD---QLTEEEIIATCGLLLVAGHET
: : : : : . :*
Mb1429c|M.bovis_AF2122/97 TANAMSWFWYLMALNPQARDHMLTELDDVLG-MRRPTADDLGKLAWTTAC
Rv1394c|M.tuberculosis_H37Rv TANAMSWFWYLMALNPQARDHMLTELDDVLG-MRRPTADDLGKLAWTTAC
TH_3255|M.thermoresistible__bu TATALTYALWALGHHPEIQDRVAAEVAELP--DREITPHDVPRLGYTVQV
Mvan_0245|M.vanbaalenii_PYR-1 TATTLTYAMWALGHHHDVQDRVRAEVVGIG--DRELTPEDVPALGYTIQV
MUL_0604|M.ulcerans_Agy99 TSTVLTYALWALGQHCQLQDRLAAEAAELG--DRPLTPADVPRLGYTIQV
MSMEG_0822|M.smegmatis_MC2_155 TSTTLCYSLWALGHHPDIQERVYAEVAALG--DRELTTDDVPQLTYTMRV
MAB_3275|M.abscessus_ATCC_1997 IVASMSWTLALLLQHPEHLDRLYDEISILH--GNAPTPDDLPRLPWARAC
MMAR_0281|M.marinum_M TALTVAWALYLLAEHPAIEQRVHAEIDPVLA-GRAATHADLPRLGLVNRI
Mflv_4801|M.gilvum_PYR-GCK TSGALSFALYFLSRHPEVADRARAEVAEVWGDDERPGFELIAKLRYVRRV
MAV_3927|M.avium_104 STSTTTTMVYNMAAHPEWQERAREESTRLG--DGPLDIEALEKLETLELI
MLBr_02088|M.leprae_Br4923 TVNLIANAVLAMLRNPSQWKALSSNPQRAP------------------LV
: : . :
Mb1429c|M.bovis_AF2122/97 LQESQRYFSSVWIIAREAVDDDIIDG-HRIRRGTTVVIPIHHIHHDPRWW
Rv1394c|M.tuberculosis_H37Rv LQESQRYFSSVWIIAREAVDDDIIDG-HRIRRGTTVVIPIHHIHHDPRWW
TH_3255|M.thermoresistible__bu LRESLRLCPPAAGVGRLAMSDLAVDG-YRVEAGTLLAVGIQAIHRDPSLW
Mvan_0245|M.vanbaalenii_PYR-1 LHEALRLCPPAAATARMAMRDVEVDG-YRIEAGSMMAVGIYALHRDPALW
MUL_0604|M.ulcerans_Agy99 LQEAMRLRPPGPTVARRAMQDIEVDG-YRVQAGTYCLVGVYAMHRDPALW
MSMEG_0822|M.smegmatis_MC2_155 LHEALRLCPPGSGTMRMLNEEMTVDG-YRVEAGTVAIVNFYAMHRSPTLW
MAB_3275|M.abscessus_ATCC_1997 FDEGQRLQG-APINPRYAMEDTELGG-YPIPKYTLVASSLYVVHRDPRWW
MMAR_0281|M.marinum_M VTETLRLYPPGWIISRVATADVYLGG-HRIPAGATVIFSPYLIHHRPDLY
Mflv_4801|M.gilvum_PYR-GCK LDEALRLQPTVPGYYREAREDTVLAGVHPMRQGDWVLAMTMALHRDPRWG
MAV_3927|M.avium_104 MNESLRMVTPLPFNMRQAVRDTELLG-HYIPAGTNITIWPGMNHRLPELW
MLBr_02088|M.leprae_Br4923 VEETLRYDPAIHLIGRVAAKDMTIGQ-TTLTEGDTMVLLLAAANRDPAVY
. * * * : : : :: *
Mb1429c|M.bovis_AF2122/97 PD-PDRFDPGRFL-RCPTD-RPRCAYLPFGGGRRICIGQSFALMEMVLMA
Rv1394c|M.tuberculosis_H37Rv PD-PDRFDPGRFL-RCPTD-RPRCAYLPFGGGRRICIGQSFALMEMVLMA
TH_3255|M.thermoresistible__bu PD-PMVFDPDRFA-PERFKAMDRWQFVPFIGGPRSCIGEHFAMLESTLAI
Mvan_0245|M.vanbaalenii_PYR-1 ER-PLVFDPDRFS-AQNSGGRDRWQYLPFGAGPRSCIGDHFAMLEATLAL
MUL_0604|M.ulcerans_Agy99 DD-PLAFDPDRFA-PKKSKGRDRWQYLPFGGGGRSCLGDHFAMLEASLAL
MSMEG_0822|M.smegmatis_MC2_155 DA-PERFDPDRFS-PERSAGRNRWQYLPFGGGPRSCIGDHFAMLEATLAL
MAB_3275|M.abscessus_ATCC_1997 GENAETYDPMQFFDQDRVNARPRLAFQAFGAGPHHCMGTGMAYMMAQYLL
MMAR_0281|M.marinum_M AE-PERFDPDRWL-PERARAIGRNTYIPFGGGARKCIGDNFGTTEAALAL
Mflv_4801|M.gilvum_PYR-GCK GD-PDAFDPDRFA-PDRVRARPAGLYKPFGTGPRSCIGRQFALHEAVLLL
MAV_3927|M.avium_104 TD-PDKFDPERFAEPRAEHKKHRYAFAPFGGGAHKCIGMVFGQLEVKTVV
MLBr_02088|M.leprae_Br4923 SR-PDEFDPDRPS----------SRHLAFAVGSHFCLGAALARLEATVTL
. :** : . .* * : *:* :.
Mb1429c|M.bovis_AF2122/97 AIMSQHFTFD--LAPGYH-VELEATLTLRPKHGVHVIGRRR---------
Rv1394c|M.tuberculosis_H37Rv AIMSQHFTFD--LAPGYH-VELEATLTLRPKHGVHVIGRRR---------
TH_3255|M.thermoresistible__bu ATLIRSVRIRS-LDDDFP-VEVPFTTVARGPIRAVVSARR----------
Mvan_0245|M.vanbaalenii_PYR-1 ATIIRSAEIRS-SDPHFP-MIVPFTTVAAEPIRARVKSVNR------IPA
MUL_0604|M.ulcerans_Agy99 ATIIREAEIHS-LDGDFP-VAIPLPIVPAGPIRARVNQRRPSQEVCTTTL
MSMEG_0822|M.smegmatis_MC2_155 ATVIRAVSVES-QNTDLP-VETPFTVIAAAPVPARVTRR-----------
MAB_3275|M.abscessus_ATCC_1997 AIIFQRYRLHL-RPGWQPRQFFSLSTLVKGGVPATITKA-----------
MMAR_0281|M.marinum_M ATIAANWRMQR-LPGLPVRPAVAASLRPRNLALRVTARTADRVPGEPGRR
Mflv_4801|M.gilvum_PYR-GCK AVLLRRYDLVP-EPGYQLQVAQRLTLMPKDFRLTLRRRRSE---------
MAV_3927|M.avium_104 HRLLRRYRLELARPGYQPRWDYGGMPIPMDGMPIVLRPL-----------
MLBr_02088|M.leprae_Br4923 SAISARFPQVQLAGELVYKPNVAMRGMSALPVQV----------------
:
Mb1429c|M.bovis_AF2122/97 -------
Rv1394c|M.tuberculosis_H37Rv -------
TH_3255|M.thermoresistible__bu -------
Mvan_0245|M.vanbaalenii_PYR-1 ADSGGR-
MUL_0604|M.ulcerans_Agy99 SDSSASS
MSMEG_0822|M.smegmatis_MC2_155 -------
MAB_3275|M.abscessus_ATCC_1997 -------
MMAR_0281|M.marinum_M LTSREIG
Mflv_4801|M.gilvum_PYR-GCK -------
MAV_3927|M.avium_104 -------
MLBr_02088|M.leprae_Br4923 -------