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TELVGKEVTRGCPAEPHQDGPTGFGDFPRELAGQWGPLPLNPSVHEVNEIARARQRFEYSRKDPWWLTRA SFPLASSIVRGVGSPALTPPGPVGHPVVGSVPEMRREPFEFFRRCAREFGDVYRVPFPLGGSIVVVNHPD YASQVMDDPVGRYSMIGPGQAAMGVIGAAIPMLEGDKFRQRRRMLMPMFGRRHLARVAEVIADEFVRRVD RWACWADTGQVVDLQHAIAQVTLPAFLRAMFSSTITEQEISETDVDLRTFMSLMASVTMMSPLPSVLPLP GRESAPRSMWRLWRLTRRLIQQRRKNPIETPDLLSLLLEASYDDGSQLSERDLSMELMILMAGGYETVVA SLSWTLALLLGHPEHLRRLYAEVDGLAGALPTPDDLPKLAWAKACFDEGQRLQGHPLNPRFAMDDDVIGG YFIPKHTIVGPSLYSIHRDPRWWADPDTYDPNRFMDEVAARSRPRLAFMPFGSGRHHCLGTGMAYMNAQF LLAIIFQRYRLALPEGWKPKHHFNFSVTLEGGLPVTLTTV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4944c | - | - | 100% (531) | putative cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_3275 | - | e-138 | 50.21% (472) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_2151c | - | 3e-72 | 35.45% (426) | putative cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1429c | cyp132 | 2e-40 | 29.76% (410) | cytochrome P450 132 |
| M. gilvum PYR-GCK | Mflv_0056 | - | 4e-32 | 28.19% (376) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv1394c | cyp132 | 1e-40 | 29.95% (414) | cytochrome P450 132 |
| M. leprae Br4923 | MLBr_02088 | - | 4e-11 | 21.29% (404) | putative cytochrome p450 |
| M. marinum M | MMAR_0346 | cyp138A3 | 8e-38 | 30.23% (397) | cytochrome P450 138A3 Cyp138A3 |
| M. avium 104 | MAV_5160 | - | 3e-36 | 29.15% (398) | cytochrome P450 monooxygenase |
| M. smegmatis MC2 155 | MSMEG_0968 | - | 2e-33 | 28.65% (342) | cytochrome P450 |
| M. thermoresistible (build 8) | TH_3255 | - | 9e-32 | 27.36% (424) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0604 | cyp185A4 | 2e-27 | 27.33% (344) | cytochrome P450 185A4 Cyp185A4 |
| M. vanbaalenii PYR-1 | Mvan_5712 | - | 6e-33 | 27.46% (437) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1429c|M.bovis_AF2122/97 --------------------------------------------------
Rv1394c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_0056|M.gilvum_PYR-GCK ----------------------------------------------MV--
MSMEG_0968|M.smegmatis_MC2_155 ----------------------------------------------MVSD
TH_3255|M.thermoresistible__bu ----------------------------------------------MVV-
MUL_0604|M.ulcerans_Agy99 ----------------------------------------------MVD-
MMAR_0346|M.marinum_M --------------------------------------------------
MAV_5160|M.avium_104 --------------------------------------------------
Mvan_5712|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_4944c|M.abscessus_ATCC_199 MTELVGKEVTRGCPAEPHQDGPTGFGDFPRELAGQWGPLPLNPSVHEVNE
MLBr_02088|M.leprae_Br4923 --------------------------------------------------
Mb1429c|M.bovis_AF2122/97 -----------------MATATTQRP---------LKGPAKRMSTWTMTR
Rv1394c|M.tuberculosis_H37Rv -----------------MATATTQRP---------LKGPAKRMSTWTMTR
Mflv_0056|M.gilvum_PYR-GCK ----------------AGTEPGVGHL---------PLAPKNPLPYRRLLT
MSMEG_0968|M.smegmatis_MC2_155 VPAVTAPPGRSADASGANAKPDTGAL---------PLAPRNPLSLRQMAR
TH_3255|M.thermoresistible__bu ----------------TTERADVATL---------PPAPRNPLPYWRQVR
MUL_0604|M.ulcerans_Agy99 -------------------PPDIRSL---------PLAPRNPLPYWQQLK
MMAR_0346|M.marinum_M -----------------MNQAISDAP---------AVPAVKMAQATRIPK
MAV_5160|M.avium_104 -----------------MSEVATAP-----------LAAVHLPPAVRGPK
Mvan_5712|M.vanbaalenii_PYR-1 -----------------MSEATIAAHRSTADAESAPPRPVRLPPTPRIPK
MAB_4944c|M.abscessus_ATCC_199 IARARQRFEYSRKDPWWLTRASFPLASSIVRG--VGSPALTPPGPVGHPV
MLBr_02088|M.leprae_Br4923 -------------MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQML
.
Mb1429c|M.bovis_AF2122/97 EAITIGFDAGDG-FLGRLRGSDITRFRCAGRRFVS----ISHPDYVDHVL
Rv1394c|M.tuberculosis_H37Rv EAITIGFDAGDG-FLGRLRGSDITRFRCAGRRFVS----ISHPDYVDHVL
Mflv_0056|M.gilvum_PYR-GCK LVRALDTGQ----LQVRAAGGPITRVQVAPRWLFPPFVAVFSPRGVRDVL
MSMEG_0968|M.smegmatis_MC2_155 AVRALDMGQ----QVIRAAGGAVTRVQFGPRWLVPPLVAVFSPEGIRDVL
TH_3255|M.thermoresistible__bu AVRSFHTGQ----ELLRDAGGPVK-------WAIPPIVLVTSPAGIRDVL
MUL_0604|M.ulcerans_Agy99 ALKTLHVGS----EALRDAGGSVTRIWLGPKRLVPPMVMVTSPQGARDVL
MMAR_0346|M.marinum_M LLQGLAFATSRR-RMMDWLSRRNGDVFALNVPIYGHMVVVNDPQLAKQVF
MAV_5160|M.avium_104 LLQGIGFAVSRR-TMMRRLSRRYGNVFTLRLPMWGPVVMVSDPQLAKQIF
Mvan_5712|M.vanbaalenii_PYR-1 LLQGLGFSFSRQ-WTVAQIVRRYGDVFSMTLPVFGPTVMVADPALAKQLF
MAB_4944c|M.abscessus_ATCC_199 VGSVPEMRREPF-EFFRRCAREFGDVYRVPFPLGGSIVVVNHPDYASQVM
MLBr_02088|M.leprae_Br4923 LLRLIDPGTRADPFPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPL
. :
Mb1429c|M.bovis_AF2122/97 HEAR---LKYVK--SDEYGPIRATAGLNLLTDEGDSWARHRGALNSTFAR
Rv1394c|M.tuberculosis_H37Rv HEAR---LKYVK--SDEYGPIRATAGLNLLTDEGDSWARHRGALNSTFAR
Mflv_0056|M.gilvum_PYR-GCK GRND---AFSER--CIVHEEVRDMAGDSLFVLPNEPWRPRKRALQPVFTP
MSMEG_0968|M.smegmatis_MC2_155 GRND---AFAER--CIVHDEVRHAAGDSLFVLPNEQWRPRKRALQPVFTK
TH_3255|M.thermoresistible__bu NRRD---ALSER--CQVHHEVRHLGGDSLFVLPTDPWRARRRALAPVFTP
MUL_0604|M.ulcerans_Agy99 GRSG---ALSDRGTLPLLKDLRRAIGESVLNLPHDTWLPRRRTLQPIFTK
MMAR_0346|M.marinum_M TASP---EDLGN---IQPNLSRMFGSGSVFGLDGDDHRRRRRLLAPPFHG
MAV_5160|M.avium_104 TTSP---DELGN---IQPNLSRLFGSGSVFGLEGDDHRRRRRLLAPPFHG
Mvan_5712|M.vanbaalenii_PYR-1 MANT---DDVGN---IQPNLSRVLGSGSVFALDGGDHRKRRKLLTPPFHG
MAB_4944c|M.abscessus_ATCC_199 DDPV---GRYSM--IGPGQAAMGVIGAAIPMLEGDKFRQRRRMLMPMFGR
MLBr_02088|M.leprae_Br4923 SASDRLKATLAQQAIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAP
. . : : *
Mb1429c|M.bovis_AF2122/97 RHLRGLVGLMIDPIADVTAALVP------GAQFDMHQSMVETTLRVVANA
Rv1394c|M.tuberculosis_H37Rv RHLRGLVGLMIDPIADVTAARVP------GAQFDMHQSMVETTLRVVANA
Mflv_0056|M.gilvum_PYR-GCK QNVRRFGGHMSRAAEVFVDAWR------DGGDVDLDLECRRITMQSLGRS
MSMEG_0968|M.smegmatis_MC2_155 HSVRAFGGHMSRAAQTLVDEWADQWAQADSLEVDLDAVCRRVTMQSLGRS
TH_3255|M.thermoresistible__bu TAVRSYGGYMSEAAQRVADGWQ------AAREVDLDAECRRLTMRSLGRS
MUL_0604|M.ulcerans_Agy99 QRVAGFAGHMSEAANHILLGWP------DGAEVDLNAASHALVLRVVGHS
MMAR_0346|M.marinum_M KSMKNYEIIIEQETLRETANWPE------GQLFPTLPSMMRITLNAILRA
MAV_5160|M.avium_104 KSMKNYESIIEEETLRETAGWPE------GESFPTLPPMMRITLNAILRA
Mvan_5712|M.vanbaalenii_PYR-1 KSIKNYETIFEEETLREAANWPE------GQPFETLEPMMRITLNAILRA
MAB_4944c|M.abscessus_ATCC_199 RHLARVAEVIADEFVRRVDRWACWAD--TGQVVDLQHAIAQVTLPAFLRA
MLBr_02088|M.leprae_Br4923 KVVQALEGDIAALVDSLLDKGAA------AGQFDVIADLAFPLAVAVICR
: : . . .
Mb1429c|M.bovis_AF2122/97 LFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYS
Rv1394c|M.tuberculosis_H37Rv LFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYS
Mflv_0056|M.gilvum_PYR-GCK VLGVDLNESADVIAEHMH----------------VASSYTADRALRPVRA
MSMEG_0968|M.smegmatis_MC2_155 VLGIDLNERADVIVEHMH----------------VASSYATDRALRPLRA
TH_3255|M.thermoresistible__bu VLGLDINERADAISEPMH----------------IASSYTADRALRPVRA
MUL_0604|M.ulcerans_Agy99 VFGLDLQDKADVITTGVT----------------LAAKWAADRSARPVRA
MMAR_0346|M.marinum_M VFGADGAELDELRRIIPP-----------------WTTLGSRLASMPKPK
MAV_5160|M.avium_104 VFGAEGAELDELRRLIPP-----------------WVTLGSRLAALPKPQ
Mvan_5712|M.vanbaalenii_PYR-1 VFGADGAHLDELRRIIPP-----------------WVTLGSRLAVLPTPH
MAB_4944c|M.abscessus_ATCC_199 MFSSTITEQEISETDVDLR----------------TFMSLMASVTMMSPL
MLBr_02088|M.leprae_Br4923 LLGVPYEDAPEFG----------------------RVSALLVQSVDPFIT
::.
Mb1429c|M.bovis_AF2122/97 GVHLPPPLR-EMQEITLTLDRAINSVIDRRLAEP-TNSADLLNVLLSAD-
Rv1394c|M.tuberculosis_H37Rv GVHLPPPLR-EMQEITLTLDRAINSVIDRRLAEP-TNSADLLNVLLSAD-
Mflv_0056|M.gilvum_PYR-GCK PRWLPTPARRRAAHAVAEMRQVAADMLQVCRDDP-DRDAPLVRALMDARD
MSMEG_0968|M.smegmatis_MC2_155 PRWLPTPARRRARAAVAAMRAVTAEILQACRDDA-DRDAPLVRALMAAED
TH_3255|M.thermoresistible__bu PRWLPTPARRRARAAVATMRRITDEMLQACRADP-DRDAPLVHALIRATD
MUL_0604|M.ulcerans_Agy99 PHWLPTPARPRARGAYDAMYKIAADMLAACRADP-SREAPLITALIDATG
MMAR_0346|M.marinum_M RRYGRFSPWGRLAEYRRQYDVIIDRLIDQERSDPNFSDRTDVLALMLRST
MAV_5160|M.avium_104 R-YPRFGPWGQLDRWRRQYDGVIERLIAAEQADPNFAERTDVLALLLRST
Mvan_5712|M.vanbaalenii_PYR-1 RTYGRFSPWGRLAAYRRQYDDVIGRLIDAVQADPDFDTRDDILALLLRST
MAB_4944c|M.abscessus_ATCC_199 PSVLPLPGRESAPRSMWRLWRLTRRLIQQRRKNP--IETPDLLSLLLEAS
MLBr_02088|M.leprae_Br4923 ITGEPPEATEERLRAGVWLRDYLEQLVKCRRGTP---GEDLISRLIELD-
:: . : *:
Mb1429c|M.bovis_AF2122/97 ---GGIWPRQRVRDEALTFMLAGHETTANAMSWFWYLMALNPQARDHMLT
Rv1394c|M.tuberculosis_H37Rv ---GGIWPRQRVRDEALTFMLAGHETTANAMSWFWYLMALNPQARDHMLT
Mflv_0056|M.gilvum_PYR-GCK PETGMALSDDDICNDLLIFMLAGHDTTATALTYALWVLGHHPDVQDRVAA
MSMEG_0968|M.smegmatis_MC2_155 PETGERLSDEDICNDLLIFMLAGHDTTATALTYALWALGHHPEIQDRVAA
TH_3255|M.thermoresistible__bu PETGRGLSDEDICNDLLIFMLAGHDTTATALTYALWALGHHPEIQDRVAA
MUL_0604|M.ulcerans_Agy99 PNTGESLSDQQICDEMVYFMILGEDTTSTVLTYALWALGQHCQLQDRLAA
MMAR_0346|M.marinum_M YDDGSRMSRKDIGDELLALLAAGHETTASTLSWAFERVTRHPELLAALVA
MAV_5160|M.avium_104 YDDGAAMSHKEIGDELLTLLAAGHETTASTLAWAFERISRHPELLARLVE
Mvan_5712|M.vanbaalenii_PYR-1 YEDGSTMSRQDIGDELLTLLAAGHETTAATLGWAFERISRHPEVLAKLVA
MAB_4944c|M.abscessus_ATCC_199 YDDGSQLSERDLSMELMILMAGGYETVVASLSWTLALLLGHPEHLRRLYA
MLBr_02088|M.leprae_Br4923 -ESGDQLTEEEIIATCGLLLVAGHETTVNLIANAVLAMLRNPSQWKALSS
* . : :: * :*. : : : . :
Mb1429c|M.bovis_AF2122/97 ELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSVWIIAREAVDDDIID
Rv1394c|M.tuberculosis_H37Rv ELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSVWIIAREAVDDDIID
Mflv_0056|M.gilvum_PYR-GCK EAA-ALGRRELEPGDVPHLKYTTQVLLEALRLCPPAAGVGRMAVRDIDVD
MSMEG_0968|M.smegmatis_MC2_155 EAR-ALGDRELTPADVPQLGYTVQVLHESLRMCPPAAGVGRLALRDIAVA
TH_3255|M.thermoresistible__bu EVA-ELPDREITPHDVPRLGYTVQVLRESLRLCPPAAGVGRLAMSDLAVD
MUL_0604|M.ulcerans_Agy99 EAA-ELGDRPLTPADVPRLGYTIQVLQEAMRLRPPGPTVARRAMQDIEVD
MMAR_0346|M.marinum_M EAE--DAGGELRQATILEVQRARTVIDFAARHVYAP---------QYQLG
MAV_5160|M.avium_104 EAD--NGGNELRQAAILEVQRARTVIDFAGRHVYPD---------VYRLG
Mvan_5712|M.vanbaalenii_PYR-1 EAE--TDGNEYRQATILEIQRSRTVIDFAGRHVYAP---------TFELG
MAB_4944c|M.abscessus_ATCC_199 EVD-GLAGALPTPDDLPKLAWAKACFDEGQRLQGHPLN-PRFAMDDDVIG
MLBr_02088|M.leprae_Br4923 NPQ-----------------RAPLVVEETLRYDPAIHLIGRVAAKDMTIG
: : . * :
Mb1429c|M.bovis_AF2122/97 GHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLR-CPTDR-PRCAYL
Rv1394c|M.tuberculosis_H37Rv GHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLR-CPTDR-PRCAYL
Mflv_0056|M.gilvum_PYR-GCK GHRVQAGTLVAVGIYALHRDPEIWPDPDRFDPDRFSPEQTAQR-DRWHFL
MSMEG_0968|M.smegmatis_MC2_155 GHRVEAGSLVALGIYAVHHDPQLWPDPEVFDPDRFSPENSRER-DRWHFI
TH_3255|M.thermoresistible__bu GYRVEAGTLLAVGIQAIHRDPSLWPDPMVFDPDRFAPERFKAM-DRWQFV
MUL_0604|M.ulcerans_Agy99 GYRVQAGTYCLVGVYAMHRDPALWDDPLAFDPDRFAPKKSKGR-DRWQYL
MMAR_0346|M.marinum_M QWMIPRGQSILVNIAQMHANPDIFPDPQRFDPQRFIGGRPST----FGWI
MAV_5160|M.avium_104 EWVIPRGYSIIVGIAQIHDNPDVFPDPRRFDPQRFIDNKPSA----LSWI
Mvan_5712|M.vanbaalenii_PYR-1 EWVIPQGYSIVVAIGQVHKRAQDFDDPDRFDPQRYIGQRPPT----FAHI
MAB_4944c|M.abscessus_ATCC_199 GYFIPKHTIVGPSLYSIHRDPRWWADPDTYDPNRFMDEVAARSRPRLAFM
MLBr_02088|M.leprae_Br4923 QTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPD-----RPSSR-----HL
: : : . : * :** :
Mb1429c|M.bovis_AF2122/97 PFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPG-YHVELEATLTLR
Rv1394c|M.tuberculosis_H37Rv PFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPG-YHVELEATLTLR
Mflv_0056|M.gilvum_PYR-GCK PFAGGARSCIGEHFARLETTLALATIVRSMRVTSSDNDFPVDVPFTTVAH
MSMEG_0968|M.smegmatis_MC2_155 PFAGGARACIGEHFARLETTLALATIIRSVVVGSVDAEFPVDVPFTTVAK
TH_3255|M.thermoresistible__bu PFIGGPRSCIGEHFAMLESTLAIATLIRSVRIRSLDDDFPVEVPFTTVAR
MUL_0604|M.ulcerans_Agy99 PFGGGGRSCLGDHFAMLEASLALATIIREAEIHSLDGDFPVAIPLPIVPA
MMAR_0346|M.marinum_M PFGGGTRRCVGAAFANMEMDVVLRTVLRNFTIEPTTAAGERLFCRGVAYT
MAV_5160|M.avium_104 PFGGGTRRCVGAAFANMEMDVVLRTVLRHFTIETTDAPDEPWHCRGVAFT
Mvan_5712|M.vanbaalenii_PYR-1 PFGGGTRRCVGAAFANVEMDIVLRTVLRHFVIETTAAPGEKMHSRGVAYT
MAB_4944c|M.abscessus_ATCC_199 PFGSGRHHCLGTGMAYMNAQFLLAIIFQRYRLALPEG-WKPKHHFNFSVT
MLBr_02088|M.leprae_Br4923 AFAVGSHFCLGAALARLEATVTLSAISARFPQVQLAG--ELVYKPNVAMR
.* * : *:* :* :: . :
Mb1429c|M.bovis_AF2122/97 PKHGVHVIGRRR----------------
Rv1394c|M.tuberculosis_H37Rv PKHGVHVIGRRR----------------
Mflv_0056|M.gilvum_PYR-GCK GPIPAHLTPR------------------
MSMEG_0968|M.smegmatis_MC2_155 GPIRANVAPRGPDHYTL-----------
TH_3255|M.thermoresistible__bu GPIRAVVSARR-----------------
MUL_0604|M.ulcerans_Agy99 GPIRARVNQRRPSQEVCTTTLSDSSASS
MMAR_0346|M.marinum_M PKNGGRIVVHRR----------------
MAV_5160|M.avium_104 PKHGGRIVVHRR----------------
Mvan_5712|M.vanbaalenii_PYR-1 PKDGGRVVMRRR----------------
MAB_4944c|M.abscessus_ATCC_199 LEGGLPVTLTTV----------------
MLBr_02088|M.leprae_Br4923 GMSALPVQV-------------------
: