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MAQVLRTQVCVAGGGPAGLMHALLLARAGINVVVLEKHGDFLRDFRGDTVHPTTMRIMDDIGLIDEFLTL PHQKVDHIAFDGDGQLRTFGDFRALKWLGYKQPYIAFIPQWDFLDFLAEKAERYPEFTLIRNAEVTDLVL EGHQVTGVRSSAREVRADVVIAADGRNSAVRAASGLQTASESSPMDVLWFRLNRRPGDPNESFAVLRRGM LLAMIHRGDYWQVAHLLPKGTGAQRGSLDAFKKRLVTARPQLREHVDDLHTWDDTSHLDVRVDRLKTWWR PGLLCIGDAAHAMSPAGGVGINLAVADAVAAANILVEPLRTGSLSDHHLEAVQRRRELPTKVVQAFQVFL QNNAIEPVLSGDLSPIKLPFFVGRWPLKFIPPIAVGRGLRPERVHTPDVH
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2614 | - | - | 100% (400) | hypothetical protein MAB_2614 |
| M. abscessus ATCC 19977 | MAB_1646c | - | 1e-86 | 43.46% (405) | hypothetical protein MAB_1646c |
| M. abscessus ATCC 19977 | MAB_4756c | - | 1e-84 | 46.45% (409) | hypothetical protein MAB_4756c |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 1e-88 | 47.76% (402) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_0304 | - | 6e-87 | 46.87% (399) | hypothetical protein Mflv_0304 |
| M. tuberculosis H37Rv | Rv1751 | - | 1e-88 | 47.76% (402) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_3394 | - | 1e-108 | 50.49% (406) | oxidoreductase |
| M. avium 104 | MAV_4364 | - | 1e-164 | 72.51% (382) | hypothetical protein MAV_4364 |
| M. smegmatis MC2 155 | MSMEG_4962 | - | 1e-89 | 47.42% (407) | hypothetical protein MSMEG_4962 |
| M. thermoresistible (build 8) | TH_1880 | - | 2e-12 | 28.03% (314) | flavin-type hydroxylase |
| M. ulcerans Agy99 | MUL_3663 | - | 4e-82 | 46.88% (352) | hypothetical protein MUL_3663 |
| M. vanbaalenii PYR-1 | Mvan_0442 | - | 2e-90 | 46.50% (400) | hypothetical protein Mvan_0442 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2614|M.abscessus_ATCC_1997 ----------------------------------------------MAQV
MAV_4364|M.avium_104 --------------------------------------------------
MMAR_3394|M.marinum_M ----------------------------------------------MESE
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Mflv_0304|M.gilvum_PYR-GCK -MR----------DDDTVS-------------------------------
Mvan_0442|M.vanbaalenii_PYR-1 -MRKQLGRPSGSCHHDQMN-------------------------------
MSMEG_4962|M.smegmatis_MC2_155 -MT-----------------------------------------------
MUL_3663|M.ulcerans_Agy99 -MPQPS--------------------------------------------
TH_1880|M.thermoresistible__bu --------------------------------------------------
MAB_2614|M.abscessus_ATCC_1997 LRTQVCVAGGGPAGLMHALLLARAGINVVVLEKHGDFLRDFRGDTVHPTT
MAV_4364|M.avium_104 --------------MVHALLLARAGIPVVVLEKHNDFLRDFRGDTVHPTT
MMAR_3394|M.marinum_M LRARCCVAGGGPAGMMLGYLLARAGVDVIVLEKHADFLRDFRGDTIHPST
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Mflv_0304|M.gilvum_PYR-GCK DTTTCAIVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
Mvan_0442|M.vanbaalenii_PYR-1 AKTTCAVVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
MSMEG_4962|M.smegmatis_MC2_155 EKTTCAVVGGGPAGMVLGLLLARAGIEVTVFEKHADFLRDFRGDTVHPAT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRDSRGDTVHAST
TH_1880|M.thermoresistible__bu -VYDVIVVGGGPTGMMLAGELRLHGVRVLVVEKNSEPPAHVRSLGLHVRS
:: . * *: * :.**: : . *. :* :
MAB_2614|M.abscessus_ATCC_1997 MRIMDDIGLIDEFLTLPHQKVDHIAFDG-DGQLRTFGDFRALKWLGYKQP
MAV_4364|M.avium_104 LRIMDELGLIDEFLRLPHTKIDTVAFDT-DGSIRTFGNFKVLKRLGFNQP
MMAR_3394|M.marinum_M LEVMNELGLYDQLLQRPHQPTPTLNAQF-GSFRALVADFRHLPVRG---K
Mb1780|M.bovis_AF2122/97 MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQPY---P
Rv1751|M.tuberculosis_H37Rv MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQPY---P
Mflv_0304|M.gilvum_PYR-GCK LRLLDDLGLWPRFADISHSRLDHATVDVGAGRSVTMVDFRRLRQPH---P
Mvan_0442|M.vanbaalenii_PYR-1 LRLIDELGLWPKFSALPHSRLERATVDVGAGRTITVVDFGRLRQPH---P
MSMEG_4962|M.smegmatis_MC2_155 LRLLDELGLFEKFDALPHSRVERARFDL-GGREVTVVDFGRLNLPH---R
MUL_3663|M.ulcerans_Agy99 LRLLDELGLGSQFAQIPHRLIDTISMKV-QGQPVD-LDLKHLPGAH---Q
TH_1880|M.thermoresistible__bu IEMLDQRGLLDRFLAHGQRHPVGGFFAAIAKPPAELDTAHGYVLG-----
:.:::: ** .:
MAB_2614|M.abscessus_ATCC_1997 YIAFIPQWDFLDFLAEKAERYPEFTLIRNAEVTDLVL----EGHQVTGVR
MAV_4364|M.avium_104 YIAMMPQWDFLDFIAEKASAYPEFTLIRNAEVTDLIL----EDDRVAGVR
MMAR_3394|M.marinum_M FVAMMPQWDFLDFIAKEAQRFSSFRLLMRAEVTKLIE----EPNRVTGVV
Mb1780|M.bovis_AF2122/97 YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVR
Rv1751|M.tuberculosis_H37Rv YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVR
Mflv_0304|M.gilvum_PYR-GCK YIAMVPQWDLLNLLADAGRAEPTFTLRMSTEVTGVLR----EGSRVTGVR
Mvan_0442|M.vanbaalenii_PYR-1 YIAMVPQWDLLNLLAEAGEAEPTFTLRMCTEATGLIR----EGGRVVGVR
MSMEG_4962|M.smegmatis_MC2_155 YIALVPQWDFLDLLADAAKEEPTFTLRMQTEVTGLLK----DGDTVTGVR
MUL_3663|M.ulcerans_Agy99 HIALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGRVVSAT
TH_1880|M.thermoresistible__bu -----IRQPVTDRLLAEWAAERGAVIRRGCAVVGLDQ-------DAAGIT
: . : : : .. : ...
MAB_2614|M.abscessus_ATCC_1997 S-----SAREVRADVVIAADGRNSAVRAASGLQTASESSPMDVLWFRLNR
MAV_4364|M.avium_104 T-----PHDEVRADLVIAADGRKSAVRAAAGLRTAQAHSPMDVLWFRLKW
MMAR_3394|M.marinum_M VN-TPDGEQKIHSDLVIGCDGRTSTVRAQAGLQVLSLGAPMDVLWFRMSR
Mb1780|M.bovis_AF2122/97 YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Rv1751|M.tuberculosis_H37Rv YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Mflv_0304|M.gilvum_PYR-GCK YETADG-TGELQAGLTVACDGRGSLLREKTGLRTQEFPVGFDVWWFRLPR
Mvan_0442|M.vanbaalenii_PYR-1 YQDPDG-PGELRADLTVGCDGRGSVLRGLAGLQVREFPVSFDAWWFRLPR
MSMEG_4962|M.smegmatis_MC2_155 YHGPDG-PGELRADLTVACDGRTSRVRKEAGLAPREYPVPFDVGWFRIDR
MUL_3663|M.ulcerans_Agy99 YRAQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPR
TH_1880|M.thermoresistible__bu VELADG--SVQRARYLVGCDGGRSTVRKLAGIGFPGEPARSETLLGEMSL
:: :..** * * *: :. .:
MAB_2614|M.abscessus_ATCC_1997 --RPGDPNESFAVLRRGML-LAMIHRGDYWQVAHLLPKG--TGAQRGSLD
MAV_4364|M.avium_104 --RPGDPRELFGVFRKGLM-MAMIYRGDYWQVAYLMPKG--ASPKGGSLE
MMAR_3394|M.marinum_M --RPGDPEESMGNFGRGAI-LVLINRGDYWQCGFVIAKGSIEQARRHGVE
Mb1780|M.bovis_AF2122/97 --EGDAEFSFLPRFSPGKG-LGVIPREGYFQIAYLGPKGTDAQLRERGIE
Rv1751|M.tuberculosis_H37Rv --EGDAEFSFLPRFSPGKG-LGVIPREGYFQIAYLGPKGTDAQLRERGIE
Mflv_0304|M.gilvum_PYR-GCK P-ETDEMYTLFPRLAPGRA-MIVIPREGYLQIALLIEKGTDAALRAHGLD
Mvan_0442|M.vanbaalenii_PYR-1 P-ADDSIYTLVPRIAPGKA-MIVIPREGYLQIAMLIPKGTDAERRARGLD
MSMEG_4962|M.smegmatis_MC2_155 --IKETAYQLTPRISSGQA-LILIPREGYFQAGCFLPKGGEKQLHARGLE
MUL_3663|M.ulcerans_Agy99 --RPDDPTGLAGIFNSGHG-GIAIDRGDYYQIAYIIPKGSDAQLRAQGIE
TH_1880|M.thermoresistible__bu SADPATVAAVVAEVRKTQLRFGAMPLGDGVYRVIVPAEGVAGDRAEPTLD
. : . . :* ::
MAB_2614|M.abscessus_ATCC_1997 AFKKRLVTARPQLREHVDDLHTWDDTSHLDVRVDRLKTWWRPGLLCIGDA
MAV_4364|M.avium_104 EFKERIVTAQPRLREHVNDLTSWDDTSELDVRVDRLETWWRTGLLCIGDA
MMAR_3394|M.marinum_M FFREEIVKMAPFVKDRVAEITDFDDLRLLTVSVDRLKQWHRPGLLCIGDA
Mb1780|M.bovis_AF2122/97 EFRRDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDA
Rv1751|M.tuberculosis_H37Rv EFRRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDA
Mflv_0304|M.gilvum_PYR-GCK AFHADVLALLPEAAGTVGSIASLDEVKMLDVKLNRLRCWHIEGMLCIGDA
Mvan_0442|M.vanbaalenii_PYR-1 AFRADVLALLPEAATTIETITSLDDVKHLDVRLNRLRRWHTDGLLFIGDA
MSMEG_4962|M.smegmatis_MC2_155 VFRAQVAEAVPEAS--VDRLTSWDDVKVLDVKLNRLRRWYRDGLLCIGDA
MUL_3663|M.ulcerans_Agy99 ALHRALADLMPWLADRVDALKSFDDVKLLDVQLNRLRRWYCDGALCIGDA
TH_1880|M.thermoresistible__bu EFRRRLKAFAGTDFG----AHTPRWLSRFGDATRLAERYRAGRVFLAGDA
:: : : . : : ***
MAB_2614|M.abscessus_ATCC_1997 AHAMSPAGGVGINLAVADAVAAANILVEPLR--------------TGSLS
MAV_4364|M.avium_104 AHAMSPAGGVGINLAVADAVAAANILCAPLQ--------------QGRVT
MMAR_3394|M.marinum_M AHAMSPIGGVGINLAIQDAVAAANLLISPLR--------------RGQVS
Mb1780|M.bovis_AF2122/97 AHAMSPVAGVGINLAVQDAVAAATILAEPLR--------------EHRVS
Rv1751|M.tuberculosis_H37Rv AHAMSPVAGVGINLAVQDAVAAATILAEPLR--------------EHRVS
Mflv_0304|M.gilvum_PYR-GCK AHAMSPAGGVGINLAIQDAVAAARLLAEPLR--------------RGTVT
Mvan_0442|M.vanbaalenii_PYR-1 AHAMSPAGGVGINVAIQDAVATARLLADPLR--------------RGAVT
MSMEG_4962|M.smegmatis_MC2_155 AHAMSPVGGVGINLAIADAVAAARILAEPLR--------------TGRVT
MUL_3663|M.ulcerans_Agy99 AHAMSPVGGVGINLALADAVATARMLAPSLR--------------VGRVS
TH_1880|M.thermoresistible__bu AHVHPPAGGQGLNLGIQDAFNLGWKLAAAVGGWAPDGLLDTYHAERHPVA
**. .* .* *:*:.: **. . * .: ::
MAB_2614|M.abscessus_ATCC_1997 DHHLEAVQRRRELPT---------------KVVQAFQVFLQNNAIEPVLS
MAV_4364|M.avium_104 DRDLAKVQRRRELPT---------------RIVQAVQVLMQDNAIAPNLN
MMAR_3394|M.marinum_M DADLQRVQARRELPT---------------RATQAVQVFLQKNVVTAVLG
Mb1780|M.bovis_AF2122/97 SRHLAAVRRRRAFPT---------------AVTQAVQRVLHRRLLGPLLQ
Rv1751|M.tuberculosis_H37Rv SRHLAAVRRRRAFPT---------------AVTQAVQRVLHRRLLGPLLQ
Mflv_0304|M.gilvum_PYR-GCK GRDLARVRRRRILPT---------------VVTQALQRLIDRRLLGPIVR
Mvan_0442|M.vanbaalenii_PYR-1 ERDLAAVRRRRVVPA---------------ALTQALQRQIDKRFLRPILD
MSMEG_4962|M.smegmatis_MC2_155 RRDLAAVEKRRYVPA---------------AVIQAVQRVLHIGLRRALLG
MUL_3663|M.ulcerans_Agy99 TGQLARVQARRWAPT---------------AFLQGIQRAIHAAIVAVAVT
TH_1880|M.thermoresistible__bu ADVLNNTRAQMELMSPEPGPRAVRWLLAELMDFEEVNRYLTEKITAIGVR
* .. : : : .: : :
MAB_2614|M.abscessus_ATCC_1997 GD---LSPIKLPFF----VGRWPLKFIPPIAVGRGLRPERVHTPDVH---
MAV_4364|M.avium_104 GD---LSPIHVPKI----VGFGPLQAIPPLVVGRGFRPEHVRTPDVHAR-
MMAR_3394|M.marinum_M SSQQFKAPLPVRLI----RRLPLLARIPARLIGMGVRPEHPDLAVIDKPG
Mb1780|M.bovis_AF2122/97 GRDPTPPAALLGLV----ERLPWLSAVPAYFVGVGVRPEHAPAFARRGPG
Rv1751|M.tuberculosis_H37Rv GRDPTPPAALLGLV----ERLPWLSAVPAYFVGVGVRPEHAPAFARRGPG
Mflv_0304|M.gilvum_PYR-GCK GGSGGPSPGLIRTV----ERLPWLTVIPAYLVGVGVRPERAPRFARRRPQ
Mvan_0442|M.vanbaalenii_PYR-1 GDVTGPPPALVRAI----ERAPWLTFVPAYLVGVGVRPERAPEFAKRRPT
MSMEG_4962|M.smegmatis_MC2_155 GEIRQPPERVLKAVGAVLSRFPGLAKVPAYLVGVGPLPEHAPDFARRSR-
MUL_3663|M.ulcerans_Agy99 GGPPQPPP-VVRLV----SRSVPVRRIMGYLVAIGPLPEHAPKYPRRAR-
TH_1880|M.thermoresistible__bu YHTMGDGHGLLGRR-MRDIPLTGGRLYARMHAGRGVLLDRTGTLSVSGWA
: . * ::
MAB_2614|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_4364|M.avium_104 --------------------------------------------------
MMAR_3394|M.marinum_M PT------------------------------------------------
Mb1780|M.bovis_AF2122/97 NRKGP---------------------------------------------
Rv1751|M.tuberculosis_H37Rv NRKGP---------------------------------------------
Mflv_0304|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0442|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4962|M.smegmatis_MC2_155 --------------------------------------------------
MUL_3663|M.ulcerans_Agy99 --------------------------------------------------
TH_1880|M.thermoresistible__bu DRVDHIVDPGAALDVPAVLLRPDGHVAWVGADHPGQQDLTARLSRWFGAP
MAB_2614|M.abscessus_ATCC_1997 -
MAV_4364|M.avium_104 -
MMAR_3394|M.marinum_M -
Mb1780|M.bovis_AF2122/97 -
Rv1751|M.tuberculosis_H37Rv -
Mflv_0304|M.gilvum_PYR-GCK -
Mvan_0442|M.vanbaalenii_PYR-1 -
MSMEG_4962|M.smegmatis_MC2_155 -
MUL_3663|M.ulcerans_Agy99 -
TH_1880|M.thermoresistible__bu A