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MESELRARCCVAGGGPAGMMLGYLLARAGVDVIVLEKHADFLRDFRGDTIHPSTLEVMNELGLYDQLLQR PHQPTPTLNAQFGSFRALVADFRHLPVRGKFVAMMPQWDFLDFIAKEAQRFSSFRLLMRAEVTKLIEEPN RVTGVVVNTPDGEQKIHSDLVIGCDGRTSTVRAQAGLQVLSLGAPMDVLWFRMSRRPGDPEESMGNFGRG AILVLINRGDYWQCGFVIAKGSIEQARRHGVEFFREEIVKMAPFVKDRVAEITDFDDLRLLTVSVDRLKQ WHRPGLLCIGDAAHAMSPIGGVGINLAIQDAVAAANLLISPLRRGQVSDADLQRVQARRELPTRATQAVQ VFLQKNVVTAVLGSSQQFKAPLPVRLIRRLPLLARIPARLIGMGVRPEHPDLAVIDKPGPT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3394 | - | - | 100% (411) | oxidoreductase |
| M. marinum M | MMAR_3720 | - | 9e-92 | 47.41% (386) | FAD-dependent oxidoreductase |
| M. marinum M | MMAR_2627 | - | 4e-91 | 44.56% (395) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1780 | - | 1e-91 | 44.03% (402) | hypothetical protein Mb1780 |
| M. gilvum PYR-GCK | Mflv_0304 | - | 1e-92 | 44.64% (392) | hypothetical protein Mflv_0304 |
| M. tuberculosis H37Rv | Rv1751 | - | 8e-92 | 44.03% (402) | hypothetical protein Rv1751 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2614 | - | 1e-108 | 50.49% (406) | hypothetical protein MAB_2614 |
| M. avium 104 | MAV_4364 | - | 1e-100 | 50.52% (388) | hypothetical protein MAV_4364 |
| M. smegmatis MC2 155 | MSMEG_4962 | - | 2e-96 | 45.57% (406) | hypothetical protein MSMEG_4962 |
| M. thermoresistible (build 8) | TH_0968 | - | 2e-12 | 23.69% (401) | 3-(3-hydroxy-phenyl)propionate hydroxylase |
| M. ulcerans Agy99 | MUL_3663 | - | 6e-97 | 48.10% (395) | hypothetical protein MUL_3663 |
| M. vanbaalenii PYR-1 | Mvan_0442 | - | 2e-93 | 45.39% (401) | hypothetical protein Mvan_0442 |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2614|M.abscessus_ATCC_1997 ----------------------------------------------MAQV
MAV_4364|M.avium_104 --------------------------------------------------
MMAR_3394|M.marinum_M ----------------------------------------------MESE
Mb1780|M.bovis_AF2122/97 MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Rv1751|M.tuberculosis_H37Rv MIATMPSMARRSRHDNKITTPAVDCLTIERLDSPASGAPQVTPYARALMG
Mflv_0304|M.gilvum_PYR-GCK -MR----------DDDTVS-------------------------------
Mvan_0442|M.vanbaalenii_PYR-1 -MRKQLGRPSGSCHHDQMN-------------------------------
MSMEG_4962|M.smegmatis_MC2_155 -MT-----------------------------------------------
MUL_3663|M.ulcerans_Agy99 -MPQPS--------------------------------------------
TH_0968|M.thermoresistible__bu ------------------------------------------------MT
MAB_2614|M.abscessus_ATCC_1997 LRTQVCVAGGGPAGLMHALLLARAGINVVVLEKHGDFLRDFRGDTVHPTT
MAV_4364|M.avium_104 --------------MVHALLLARAGIPVVVLEKHNDFLRDFRGDTVHPTT
MMAR_3394|M.marinum_M LRARCCVAGGGPAGMMLGYLLARAGVDVIVLEKHADFLRDFRGDTIHPST
Mb1780|M.bovis_AF2122/97 ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Rv1751|M.tuberculosis_H37Rv ETTTCAIIGGGPAGMVLGLLLARAGVQVTLLEKHGDFLRDFRGDTVHPTT
Mflv_0304|M.gilvum_PYR-GCK DTTTCAIVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
Mvan_0442|M.vanbaalenii_PYR-1 AKTTCAVVGGGPAGMVLGLLLARAGVEVTVLEKHADFLRDFRGDTVHPTT
MSMEG_4962|M.smegmatis_MC2_155 EKTTCAVVGGGPAGMVLGLLLARAGIEVTVFEKHADFLRDFRGDTVHPAT
MUL_3663|M.ulcerans_Agy99 ETTSVLVAGGGPAGMVLGLLLARAGVDVTVMEKHADFLRDSRGDTVHAST
TH_0968|M.thermoresistible__bu ERVDVVIVGAGPSGLTLANILGLQGVRTLVVEERDTLIDYPRGVGLDDEA
: . :*. *: . :.*:: :: ** :. :
MAB_2614|M.abscessus_ATCC_1997 MRIMDDIGLIDEFLTLPHQKVDHIAFDG-DGQLRTFGDFRALKWLGYKQP
MAV_4364|M.avium_104 LRIMDELGLIDEFLRLPHTKIDTVAFDT-DGSIRTFGNFKVLKRLGFNQP
MMAR_3394|M.marinum_M LEVMNELGLYDQLLQRPHQPTPTLNAQF-GSFRALVADFRHLPVRG---K
Mb1780|M.bovis_AF2122/97 MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQPY---P
Rv1751|M.tuberculosis_H37Rv MRLLDELGLWERFAALPYSEVRTATLHS-NGRAVTYIDFERLHQPY---P
Mflv_0304|M.gilvum_PYR-GCK LRLLDDLGLWPRFADISHSRLDHATVDVGAGRSVTMVDFRRLRQPH---P
Mvan_0442|M.vanbaalenii_PYR-1 LRLIDELGLWPKFSALPHSRLERATVDVGAGRTITVVDFGRLRQPH---P
MSMEG_4962|M.smegmatis_MC2_155 LRLLDELGLFEKFDALPHSRVERARFDL-GGREVTVVDFGRLNLPH---R
MUL_3663|M.ulcerans_Agy99 LRLLDELGLGSQFAQIPHRLIDTISMKV-QGQPVD-LDLKHLPGAH---Q
TH_0968|M.thermoresistible__bu LRTFQSIGLVDRILPHTVPNQILRFFDAKRRLLAEMAPPDARFGWPKRNG
:. ::.:** .: . .
MAB_2614|M.abscessus_ATCC_1997 YIAFIPQWDFLDFLAEKAERYPEFTLIRNAEVTDLVL----EGHQVTGVR
MAV_4364|M.avium_104 YIAMMPQWDFLDFIAEKASAYPEFTLIRNAEVTDLIL----EDDRVAGVR
MMAR_3394|M.marinum_M FVAMMPQWDFLDFIAKEAQRFSSFRLLMRAEVTKLIE----EPNRVTGVV
Mb1780|M.bovis_AF2122/97 YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVR
Rv1751|M.tuberculosis_H37Rv YVAMVPQWDLLNLLAEAAQAEPSFTLRMKTEVTGLLR----EGGKVTGVR
Mflv_0304|M.gilvum_PYR-GCK YIAMVPQWDLLNLLADAGRAEPTFTLRMSTEVTGVLR----EGSRVTGVR
Mvan_0442|M.vanbaalenii_PYR-1 YIAMVPQWDLLNLLAEAGEAEPTFTLRMCTEATGLIR----EGGRVVGVR
MSMEG_4962|M.smegmatis_MC2_155 YIALVPQWDFLDLLADAAKEEPTFTLRMQTEVTGLLK----DGDTVTGVR
MUL_3663|M.ulcerans_Agy99 HIALVPQWDFLELLAAAAEAEPTFRLLRSTEVTGVLWGDGPDPGRVVSAT
TH_0968|M.thermoresistible__bu FVQPMVDAELYAGLDRFDHVEVRFGHRMQNCVEASDAG-------EDGVT
.: : : :: : * . ..
MAB_2614|M.abscessus_ATCC_1997 S-----SAREVRADVVIAADGRNSAVRAASGLQTASESSPMDVLWFRLNR
MAV_4364|M.avium_104 T-----PHDEVRADLVIAADGRKSAVRAAAGLRTAQAHSPMDVLWFRLKW
MMAR_3394|M.marinum_M VN-TPDGEQKIHSDLVIGCDGRTSTVRAQAGLQVLSLGAPMDVLWFRMSR
Mb1780|M.bovis_AF2122/97 YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Rv1751|M.tuberculosis_H37Rv YQGAEG-PGELRAELTVACDGRWSIARHEAGLKAREFPVNFDVWWFKLPR
Mflv_0304|M.gilvum_PYR-GCK YETADG-TGELQAGLTVACDGRGSLLREKTGLRTQEFPVGFDVWWFRLPR
Mvan_0442|M.vanbaalenii_PYR-1 YQDPDG-PGELRADLTVGCDGRGSVLRGLAGLQVREFPVSFDAWWFRLPR
MSMEG_4962|M.smegmatis_MC2_155 YHGPDG-PGELRADLTVACDGRTSRVRKEAGLAPREYPVPFDVGWFRIDR
MUL_3663|M.ulcerans_Agy99 YRAQSGETKHMHADLTVACDGRGSTVRSALGMATRSFGAPMDVWWFRLPR
TH_0968|M.thermoresistible__bu VEFADG-HPPVRASYVVGCDGGRSTTRRLMGVSFDGTTSSTRWLVVDVAN
::: .:..** * * *: . :
MAB_2614|M.abscessus_ATCC_1997 -RPGDPNESFAVLRRGMLLAMIHRGDYWQVAHLLPKG--TGAQRGSLDAF
MAV_4364|M.avium_104 -RPGDPRELFGVFRKGLMMAMIYRGDYWQVAYLMPKG--ASPKGGSLEEF
MMAR_3394|M.marinum_M -RPGDPEESMGNFGRGAILVLINRGDYWQCGFVIAKGSIEQARRHGVEFF
Mb1780|M.bovis_AF2122/97 -EGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEF
Rv1751|M.tuberculosis_H37Rv -EGDAEFSFLPRFSPGKGLGVIPREGYFQIAYLGPKGTDAQLRERGIEEF
Mflv_0304|M.gilvum_PYR-GCK PETDEMYTLFPRLAPGRAMIVIPREGYLQIALLIEKGTDAALRAHGLDAF
Mvan_0442|M.vanbaalenii_PYR-1 PADDSIYTLVPRIAPGKAMIVIPREGYLQIAMLIPKGTDAERRARGLDAF
MSMEG_4962|M.smegmatis_MC2_155 -IKETAYQLTPRISSGQALILIPREGYFQAGCFLPKGGEKQLHARGLEVF
MUL_3663|M.ulcerans_Agy99 -RPDDPTGLAGIFNSGHGGIAIDRGDYYQIAYIIPKGSDAQLRAQGIEAL
TH_0968|M.thermoresistible__bu DPLGHPNSEVGADPARPYVSISIAHGIRRFEFMIHPHETDAEVDD--PAF
. : . :
MAB_2614|M.abscessus_ATCC_1997 KKRLVTARPQLREHVDDLHTWDDTSHLDVRVDRLKTWWRPGLLCIGDAAH
MAV_4364|M.avium_104 KERIVTAQPRLREHVNDLTSWDDTSELDVRVDRLETWWRTGLLCIGDAAH
MMAR_3394|M.marinum_M REEIVKMAPFVKDRVAEITDFDDLRLLTVSVDRLKQWHRPGLLCIGDAAH
Mb1780|M.bovis_AF2122/97 RRDVSELLPEATASVAALASTDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
Rv1751|M.tuberculosis_H37Rv RRDVSELLPEATASVAALASMDEVKHLNVKVNRLRRWHIDGLLCIGDAAH
Mflv_0304|M.gilvum_PYR-GCK HADVLALLPEAAGTVGSIASLDEVKMLDVKLNRLRCWHIEGMLCIGDAAH
Mvan_0442|M.vanbaalenii_PYR-1 RADVLALLPEAATTIETITSLDDVKHLDVRLNRLRRWHTDGLLFIGDAAH
MSMEG_4962|M.smegmatis_MC2_155 RAQVAEAVPEAS--VDRLTSWDDVKVLDVKLNRLRRWYRDGLLCIGDAAH
MUL_3663|M.ulcerans_Agy99 HRALADLMPWLADRVDALKSFDDVKLLDVQLNRLRRWYCDGALCIGDAAH
TH_0968|M.thermoresistible__bu VRRMLGRRIPYPERVDMIR----YRVYTHHSRIAGSFRKGRLLLAGDAAH
: : : : * *****
MAB_2614|M.abscessus_ATCC_1997 AMSPAGGVGINLAVADAVAAANILVEPLR---------------------
MAV_4364|M.avium_104 AMSPAGGVGINLAVADAVAAANILCAPLQ---------------------
MMAR_3394|M.marinum_M AMSPIGGVGINLAIQDAVAAANLLISPLR---------------------
Mb1780|M.bovis_AF2122/97 AMSPVAGVGINLAVQDAVAAATILAEPLR---------------------
Rv1751|M.tuberculosis_H37Rv AMSPVAGVGINLAVQDAVAAATILAEPLR---------------------
Mflv_0304|M.gilvum_PYR-GCK AMSPAGGVGINLAIQDAVAAARLLAEPLR---------------------
Mvan_0442|M.vanbaalenii_PYR-1 AMSPAGGVGINVAIQDAVATARLLADPLR---------------------
MSMEG_4962|M.smegmatis_MC2_155 AMSPVGGVGINLAIADAVAAARILAEPLR---------------------
MUL_3663|M.ulcerans_Agy99 AMSPVGGVGINLALADAVATARMLAPSLR---------------------
TH_0968|M.thermoresistible__bu LMPVWQGQGYNSGIRDAANLGWKLAAVVNGHAHDALLDTYDLERREHARA
*. * * * .: **. . * :.
MAB_2614|M.abscessus_ATCC_1997 ----------TGSLSDHHLEAVQRRRELPTKVVQAFQVFLQNN-------
MAV_4364|M.avium_104 ----------QGRVTDRDLAKVQRRRELPTRIVQAVQVLMQDN-------
MMAR_3394|M.marinum_M ----------RGQVSDADLQRVQARRELPTRATQAVQVFLQKN-------
Mb1780|M.bovis_AF2122/97 ----------EHRVSSRHLAAVRRRRAFPTAVTQAVQRVLHRR-------
Rv1751|M.tuberculosis_H37Rv ----------EHRVSSRHLAAVRRRRAFPTAVTQAVQRVLHRR-------
Mflv_0304|M.gilvum_PYR-GCK ----------RGTVTGRDLARVRRRRILPTVVTQALQRLIDRR-------
Mvan_0442|M.vanbaalenii_PYR-1 ----------RGAVTERDLAAVRRRRVVPAALTQALQRQIDKR-------
MSMEG_4962|M.smegmatis_MC2_155 ----------TGRVTRRDLAAVEKRRYVPAAVIQAVQRVLHIG-------
MUL_3663|M.ulcerans_Agy99 ----------VGRVSTGQLARVQARRWAPTAFLQGIQRAIHAA-------
TH_0968|M.thermoresistible__bu MIDLSTMVGRVISPTNRRVAALRDRLIHAASVVPTLKRYVLEMRFKPMPR
: : :. * .: .: :
MAB_2614|M.abscessus_ATCC_1997 -AIEPVLSGD---LSPIKLPFF----------------------------
MAV_4364|M.avium_104 -AIAPNLNGD---LSPIHVPKI----------------------------
MMAR_3394|M.marinum_M -VVTAVLGSSQQFKAPLPVRLI----------------------------
Mb1780|M.bovis_AF2122/97 -LLGPLLQGRDPTPPAALLGLV----------------------------
Rv1751|M.tuberculosis_H37Rv -LLGPLLQGRDPTPPAALLGLV----------------------------
Mflv_0304|M.gilvum_PYR-GCK -LLGPIVRGGSGGPSPGLIRTV----------------------------
Mvan_0442|M.vanbaalenii_PYR-1 -FLRPILDGDVTGPPPALVRAI----------------------------
MSMEG_4962|M.smegmatis_MC2_155 -LRRALLGGEIRQPPERVLKAVGAV-------------------------
MUL_3663|M.ulcerans_Agy99 -IVAVAVTGGPPQPPP-VVRLV----------------------------
TH_0968|M.thermoresistible__bu YLQGAVYHGGPRSKSSPTGTLFIQPRVDTRDAENVLLDDVLGPGFAVLCW
. . .
MAB_2614|M.abscessus_ATCC_1997 ----------VGRWPLKFIPPIAVGRG-----------------------
MAV_4364|M.avium_104 ----------VGFGPLQAIPPLVVGRG-----------------------
MMAR_3394|M.marinum_M ----------RRLPLLARIPARLIGMG-----------------------
Mb1780|M.bovis_AF2122/97 ----------ERLPWLSAVPAYFVGVG-----------------------
Rv1751|M.tuberculosis_H37Rv ----------ERLPWLSAVPAYFVGVG-----------------------
Mflv_0304|M.gilvum_PYR-GCK ----------ERLPWLTVIPAYLVGVG-----------------------
Mvan_0442|M.vanbaalenii_PYR-1 ----------ERAPWLTFVPAYLVGVG-----------------------
MSMEG_4962|M.smegmatis_MC2_155 ---------LSRFPGLAKVPAYLVGVG-----------------------
MUL_3663|M.ulcerans_Agy99 ----------SRSVPVRRIMGYLVAIG-----------------------
TH_0968|M.thermoresistible__bu SNNLRAVLGEDAFSHWKSLGATFVEARPITQLHWPGHDDPDVVVVGDRTG
: :
MAB_2614|M.abscessus_ATCC_1997 ---------------LRPERVHTPDVH-----------------------
MAV_4364|M.avium_104 ---------------FRPEHVRTPDVHAR---------------------
MMAR_3394|M.marinum_M ---------------VRPEHPDLAVIDKPGPT------------------
Mb1780|M.bovis_AF2122/97 ---------------VRPEHAPAFARRGPGNRKGP---------------
Rv1751|M.tuberculosis_H37Rv ---------------VRPEHAPAFARRGPGNRKGP---------------
Mflv_0304|M.gilvum_PYR-GCK ---------------VRPERAPRFARRRPQ--------------------
Mvan_0442|M.vanbaalenii_PYR-1 ---------------VRPERAPEFAKRRPT--------------------
MSMEG_4962|M.smegmatis_MC2_155 ---------------PLPEHAPDFARRSR---------------------
MUL_3663|M.ulcerans_Agy99 ---------------PLPEHAPKYPRRAR---------------------
TH_0968|M.thermoresistible__bu ALKGWFDVHTDSVLFLRPDRCIAAACIAQRAPETSAALSEVMCLTQGGGN
*::
MAB_2614|M.abscessus_ATCC_1997 ------------------------
MAV_4364|M.avium_104 ------------------------
MMAR_3394|M.marinum_M ------------------------
Mb1780|M.bovis_AF2122/97 ------------------------
Rv1751|M.tuberculosis_H37Rv ------------------------
Mflv_0304|M.gilvum_PYR-GCK ------------------------
Mvan_0442|M.vanbaalenii_PYR-1 ------------------------
MSMEG_4962|M.smegmatis_MC2_155 ------------------------
MUL_3663|M.ulcerans_Agy99 ------------------------
TH_0968|M.thermoresistible__bu GAASPVLHVAQSAAEPSGTATRST