For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. abscessus ATCC 19977 MAB_2557c (-)

annotation: putative isochorismatase hydrolase EntB
coordinates: 2602782 - 2603363
length: 193

DLVATAAQRVPQGMSETALLVIDMFNTYRHPDADQLAANVATIVEPLAGLVSRAQAHTDMDLIYVNDNHG
DFAAGPSAIVGAALHGAHPELVRPLVPEGEFQFVTKVRHSIFYASPLEYLLGRLRTRQLILCGQVTEQCV
LYSALDAYVRHFDVVIPTDAVAPIDPSLGESAVEMMRRNMRAELCTSTRCIH*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. abscessus ATCC 19977MAB_2557c--100% (193)putative isochorismatase hydrolase EntB
M. abscessus ATCC 19977MAB_0297-7e-0728.57% (98) isochorismatase (phenazine biosynthesis) PhzD
M. abscessus ATCC 19977MAB_3431c-7e-0525.66% (152) isochorismatase hydrolase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97-----
M. gilvum PYR-GCKMflv_4511-1e-6366.48% (179) isochorismatase hydrolase
M. tuberculosis H37Rv-----
M. leprae Br4923-----
M. marinum MMMAR_3790-5e-0639.06% (64) isochorismatase family protein
M. avium 104MAV_1736-2e-5660.34% (174) isochorismatase family protein
M. smegmatis MC2 155MSMEG_4618-9e-5857.87% (178) isochorismatase family protein
M. thermoresistible (build 8)TH_2198-1e-5961.80% (178) isochorismatase family protein
M. ulcerans Agy99-----
M. vanbaalenii PYR-1Mvan_1859-3e-6767.98% (178) isochorismatase hydrolase

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_4618|M.smegmatis_MC2_155      ------------------------------------------MSDTAVVI
TH_2198|M.thermoresistible__bu      ------------------------------------------MSDTAVVV
MAV_1736|M.avium_104                -----------------------------------------------MLV
Mflv_4511|M.gilvum_PYR-GCK          ------------------------------------MDISSAMSETALLV
Mvan_1859|M.vanbaalenii_PYR-1       ------------------------------------------MSETALLV
MAB_2557c|M.abscessus_ATCC_199      ----------------------------MDLVATAAQRVPQGMSETALLV
MMAR_3790|M.marinum_M               MPEYFSDTSRWTCSPEHVDLDIPRRFTRRVRLAAQPQHVTLDLGDAAVIV
                                                                                   :::

MSMEG_4618|M.smegmatis_MC2_155      VDMLNTYEHEDAELLAPNVEK-----IIDPLVKLIGEARDREDVDLIYVN
TH_2198|M.thermoresistible__bu      VDMFNTYDHEDAELLTPNVES-----ILDPLAKLIAEARHRDDVDLIYVN
MAV_1736|M.avium_104                VDMMNSYQHPDAENLIPNVEK-----IIEPLTGLVRRARESAGVDLVYVN
Mflv_4511|M.gilvum_PYR-GCK          IDMFNTYDHPDAEPLADNVAA-----IVDPLTELIRRSNERDDVAVVYVN
Mvan_1859|M.vanbaalenii_PYR-1       IDMFNTYTHPDAEQLADNVVE-----VVDPIAELVARAAERDDVDLVYVN
MAB_2557c|M.abscessus_ATCC_199      IDMFNTYRHPDADQLAANVAT-----IVEPLAGLVSRAQAHTDMDLIYVN
MMAR_3790|M.marinum_M               VDMQNDFCHERGWLASQGVDVRGGAGLKTPINAMLDGFRG-AQVPIIWLN
                                    :** * : *  .     .*       :  *:  ::        : ::::*

MSMEG_4618|M.smegmatis_MC2_155      DNYGDFTAQFSDIVADALDGKRPD---------LVRPILPYDG-------
TH_2198|M.thermoresistible__bu      DNHGDFTAEFSDVVRTALDGARPD---------LVRPIVPDDG-------
MAV_1736|M.avium_104                DNYGDFTAQFSDLVRSALDGARPD---------LVKPIAPVSGE------
Mflv_4511|M.gilvum_PYR-GCK          DNYGDFAAEPSDIVEAAVNGARPE---------LVRPLVPGPE-------
Mvan_1859|M.vanbaalenii_PYR-1       DNYGDFTATHSDVVRAALEGARPE---------LVRPLVPASG-------
MAB_2557c|M.abscessus_ATCC_199      DNHGDFAAGPSAIVGAALHGAHPE---------LVRPLVPEGE-------
MMAR_3790|M.marinum_M               WGTRSDRANLPPNVLHAYDGEGTGGGIGESVSLLSNAVLTANSWGAAILD
                                     .  .  *  .  *  * .*  .          * ..: .          

MSMEG_4618|M.smegmatis_MC2_155      -------CRLLTKVRHSVFYATALDYLLGRLGAKRVILAGQVTEQCILYS
TH_2198|M.thermoresistible__bu      -------CRALLKVRHSVFYATALEYLLTRLSARRVILTGQVTEQCILYS
MAV_1736|M.avium_104                -------AASLTKVRHSAFYSTALAYLLSRLGTKRLIITGQVTEQCILYT
Mflv_4511|M.gilvum_PYR-GCK          -------ARFLTKVRHSAFYATSLDYLLTRLDTRRIILTGQVTEQCVLYT
Mvan_1859|M.vanbaalenii_PYR-1       -------SRFLTKVRHSAFYATPLDYLLSRLGVRRIVLTGQVTEQCILYT
MAB_2557c|M.abscessus_ATCC_199      -------FQFVTKVRHSIFYASPLEYLLGRLRTRQLILCGQVTEQCVLYS
MMAR_3790|M.marinum_M               GLVVDDIDIHVNKHRMSGFWDTELDSILRNLGVRHLFLCGVNVDQCVYAT
                                              : * * * *: : *  :* .* .:::.: *  .:**:  :

MSMEG_4618|M.smegmatis_MC2_155      ALDAYVRHFELVVPSDAVAHIDAELGDAALEMMRRN----------MSAD
TH_2198|M.thermoresistible__bu      ALDAYVRHFEVVVPPDAVAHIDAGLGEAALQMMARN----------MSAE
MAV_1736|M.avium_104                ALDAYVRHFPVVIPTDAVAHIDPELGAAACKMMEQN----------MSAE
Mflv_4511|M.gilvum_PYR-GCK          ALDGYVRHYDVVVPPDTVAHIDDKLGTAALEMMERN----------MKAE
Mvan_1859|M.vanbaalenii_PYR-1       ALDGYVRHYDVVVPPDAVAHIDSQLGEAALEMMRRN----------MKAE
MAB_2557c|M.abscessus_ATCC_199      ALDAYVRHFDVVIPTDAVAPIDPSLGESAVEMMRRN----------MRAE
MMAR_3790|M.marinum_M               LIDAACAGYDCLLITDASATTSPSYCTEATIYNVRQCFGFTCDTAAIRAS
                                     :*.    :  :: .*: *  .      *     ::          : *.

MSMEG_4618|M.smegmatis_MC2_155      VIPAVDCLS--------
TH_2198|M.thermoresistible__bu      LPPSADCLP--------
MAV_1736|M.avium_104                LTTAADCLG--------
Mflv_4511|M.gilvum_PYR-GCK          LPESTASLP--------
Mvan_1859|M.vanbaalenii_PYR-1       LSKSTECLP--------
MAB_2557c|M.abscessus_ATCC_199      LCTSTRCIH--------
MMAR_3790|M.marinum_M               LHAPTEPHGVCGTCQPE
                                    :  ..