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TGQVDAQPYPWPFDGPVDPGRTAVLCIDWQVDFCGRGGYVDTMGYDLSLTRAGLEPTARVLAAARAVGMT IIHTREGHRPDLSDLPANKRWRSARIGAEIGVAGPCGRILVKGEPGWEIVPEVAPLPGEPIIDKPGKGAF YATDLDLVLRTRGIRYIVLTGITTDVCVHTTMREANDRGFECLILSDCTGATDAGNHAAALKMVTMQGGV FGAVADSNQLLGAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_3431c | - | - | 100% (225) | isochorismatase hydrolase |
| M. abscessus ATCC 19977 | MAB_1852c | - | 4e-10 | 28.26% (184) | isochorismatase hydrolase |
| M. abscessus ATCC 19977 | MAB_2557c | - | 9e-05 | 25.66% (152) | putative isochorismatase hydrolase EntB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2069c | pncA | 0.0001 | 26.32% (190) | pyrazinamidase/nicotinamidas PNCA (PZase) |
| M. gilvum PYR-GCK | Mflv_4334 | - | 9e-11 | 26.74% (172) | isochorismatase hydrolase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_2657 | - | 1e-79 | 75.14% (181) | isochorismatase family protein |
| M. avium 104 | MAV_1602 | - | 3e-12 | 26.67% (180) | isochorismatase family protein |
| M. smegmatis MC2 155 | MSMEG_2243 | - | 9e-13 | 27.67% (206) | isochorismatase family protein |
| M. thermoresistible (build 8) | TH_0553 | - | 8e-12 | 26.74% (172) | isochorismatase family protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_3053 | - | 7e-55 | 49.30% (213) | isochorismatase hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_3431c|M.abscessus_ATCC_199 MTGQVDAQPYPWPFDGPVDPGRTAVLCIDWQVDFCGRGGYVDTMGYDLSL
MMAR_2657|M.marinum_M -------------------------------------------MGYDLSL
Mvan_3053|M.vanbaalenii_PYR-1 MNHTVDVPAEPSSFP--LVAGRTALIVIDMQRDFLLPGGFGESLGNDVGR
MAV_1602|M.avium_104 ----------MTDLAELVAPAHTAVITQEVQGAVVGPDAGLGALAAEAR-
MSMEG_2243|M.smegmatis_MC2_155 -------------MRELVTPGRTAVVTQECQGAVIGPDAGLRALADEAQ-
Mflv_4334|M.gilvum_PYR-GCK ---------MRIPLAELVAPGHTAVVTQECQEAVVGTNAGLAALADAAR-
TH_0553|M.thermoresistible__bu ----MFILMPQPRLSDLIDPRSTALVTQECQGGVIGPQAGLPHLAAEAQ-
Mb2069c|M.bovis_AF2122/97 ---------------------MRALIIVDVQNDFCEGG----SLAVTGG-
:.
MAB_3431c|M.abscessus_ATCC_199 TRAGLEPTARVLAAARAVGMTIIHTREGHRPDLSDLPANKRWRSARIGAE
MMAR_2657|M.marinum_M VRAPLGPAQTVLEAARKLGLLIVHTREGHRPDLSDLPANKRWRSARIGAE
Mvan_3053|M.vanbaalenii_PYR-1 LLKVVPPLASLIAAARAAGVMVVHTREGHQPDLSDCPPAKLNRGTPS-KR
MAV_1602|M.avium_104 -RVALPNIVRLLPPARAAGVRIVHCLVQRRPDG---------LGSNHNAK
MSMEG_2243|M.smegmatis_MC2_155 -RVALPNIKRLLPAARAASVHVVHCLVQRRPDG---------LGSNRNAK
Mflv_4334|M.gilvum_PYR-GCK -GEALPNISRLLPVARRAGVDVVHCLVQRRADG---------RGANHNAK
TH_0553|M.thermoresistible__bu -REAIPNIGKLLDAARSAGVTVVHCLIQRRPDG---------RGSNTNAR
Mb2069c|M.bovis_AF2122/97 -----AALARAISDYLAEAADYHHVVATKDFHID--------PGDDFSGT
: . * : . .
MAB_3431c|M.abscessus_ATCC_199 IGVAGPCG----RILVKGEPGWEIVPEVAPLPGEPIIDKP-GKGAFY---
MMAR_2657|M.marinum_M IGVAGPCG----RVLTRGEPGWEIIPEMEPLPGEMVVDKL-GKGSFY---
Mvan_3053|M.vanbaalenii_PYR-1 IGDPGRYG----RILIRGEYGHDIIDELAPIDGEIVIDKP-GKGAFY---
MAV_1602|M.avium_104 IFALGRRSGQGRVDISPGTPGATLLPELGPAPSDLVLSRWHGVGPMG---
MSMEG_2243|M.smegmatis_MC2_155 IFAIGRND----VAIAPGTPGAALLPELGPEAGDLVLTRWHGLGPMG---
Mflv_4334|M.gilvum_PYR-GCK LFTVGASG----VDITPDSPGTQLVPEIDVQPSDLVLRRWHGLGPMG---
TH_0553|M.thermoresistible__bu LFAAATSFD---ADLTPGTPGASVLPEFGPEPEDLVLTRMHGVGPMT---
Mb2069c|M.bovis_AF2122/97 PDYSSSWP----PHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYSGFE
. . * . .. : :. : *.
MAB_3431c|M.abscessus_ATCC_199 -----ATDLDLVLRTRGIRYIVLTGITTDVCVHTTMREANDRGFECLILS
MMAR_2657|M.marinum_M -----ATDLELILTTRRITHLIFTGIATDVCVHTTMREANDRGYECLLLS
Mvan_3053|M.vanbaalenii_PYR-1 -----ATSLSDVLTEAGITQLLITGVTTEVCVHTTTREANDRGYQCLVVS
MAV_1602|M.avium_104 -----GTDLDAVLRNLGVSTLVVVGVSLNIAIPNVVMDAVNAAYRVVVPR
MSMEG_2243|M.smegmatis_MC2_155 -----GTDLDAVLRNLGVTTIVAVGVSVNVAITNLVMDAVNAGYHVVLPR
Mflv_4334|M.gilvum_PYR-GCK -----GTDLDAILRNLGVTTIVAVGVSVNVAILNLVMDAVNAGYRVVLPR
TH_0553|M.thermoresistible__bu -----GTDLDSVLRNLGIETIVGVGVSVNIAIPNFVMDAVNRGYRFVLPR
Mb2069c|M.bovis_AF2122/97 GVDENGTPLLNWLRQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLV
.* * * : : .*:: : .: :* . :
MAB_3431c|M.abscessus_ATCC_199 DCTGATDAGNHAAALKMVTMQGGVFGAVADSNQLLGAL------------
MMAR_2657|M.marinum_M DCTGATDYANHLAALKMITMQGGVFGAHATNGALLEAFNKVRDRRG----
Mvan_3053|M.vanbaalenii_PYR-1 DCVGSYFPEFQRVGLEMIKAQGGIFGWVADTSSVIPALARLSSIPA----
MAV_1602|M.avium_104 DAVAGVPAEY---GEAVIANTLSLLATITTTDELLRAWSRP---------
MSMEG_2243|M.smegmatis_MC2_155 DAVAGVPTDY---ADAVIDNTLSLLATVTSTDQLLQIWQP----------
Mflv_4334|M.gilvum_PYR-GCK DGVAGIPAEY---ATAVIDNTLSLLATLTITDDLISAWAATC--------
TH_0553|M.thermoresistible__bu DAVAGYPREY---AEAVIDNSLALLATVTSTDEVTGVWNGATDRRLDVDT
Mb2069c|M.bovis_AF2122/97 DLTAGVSADTTVAALEEMRTASVELVCSS---------------------
* ... . : : :
MAB_3431c|M.abscessus_ATCC_199 -
MMAR_2657|M.marinum_M -
Mvan_3053|M.vanbaalenii_PYR-1 -
MAV_1602|M.avium_104 -
MSMEG_2243|M.smegmatis_MC2_155 -
Mflv_4334|M.gilvum_PYR-GCK -
TH_0553|M.thermoresistible__bu R
Mb2069c|M.bovis_AF2122/97 -