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SGRSFRFGHDGYREAMTAATSLWLAGRAERPTPPYLDETNCTADVVVVGAGITGLITAVLLARAGKDVLV LEAYTAGAGTTGNTTAKVSLLQGTKMSKILRKHGAKVAGQYVQGNLEGQEWLAGYCDANGLSLQREDAYT YAQSEKGLASARAEYDACREVGLDADWVDAADAPDVPFPFAGGVRLPDQAQFDPMPLLDKLIVELDERNG RLVEGTRVLGVSQDSSGLKIKVRSHTGTELDVRAGQCVLATGIPILDRGGFFARLSPHRSYCLAFRVPGA VTRGMYISTDSPTRSVRYAPTADGDRLIVGGAGHTVGRRSHPSDDVDELASWAKVHWPGAIQTHYWSAQD YTPVDELPYVGPLLPGNEKVFVATGFDKWGMTNGTAAALALSSRILGGRMDWSQAFDSWSPHELSGIPTA LKVNLEVGFNMAKGWVTPILRRGDGVPDDGGVVAGPPWRMEACSVVDGVERRVSPVCPHLGGIVEWNDSD EAWECPLHGSRFAPDGTLLEGPATHGLTPAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0637 | - | - | 100% (522) | iron-sulfur binding oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_0665 | - | 4e-07 | 23.69% (401) | sarcosine oxidase subunit beta, putative |
| M. smegmatis MC2 155 | MSMEG_6264 | - | 1e-06 | 27.65% (217) | putative oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0576c | - | 4e-05 | 38.67% (75) | oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0732 | - | 0.0 | 64.29% (504) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv0561c | - | 4e-05 | 38.67% (75) | oxidoreductase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2503c | - | 1e-146 | 50.59% (508) | putative iron-sulfur binding oxidoreductase |
| M. marinum M | - | - | - | - | - |
| M. avium 104 | MAV_2749 | - | 0.0 | 66.93% (505) | FAD dependent oxidoreductase domain-containing protein |
| M. thermoresistible (build 8) | TH_1303 | - | 0.0 | 70.26% (501) | iron-sulfur binding oxidoreductase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0117 | - | 1e-179 | 61.86% (506) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2749|M.avium_104 -------------------MTSLWMSERTE-RPWAASQLDQGPASADVIV
TH_1303|M.thermoresistible__bu -------------------MTSLWLADRTN-QPPPPRTLDAGDRRADVVV
MSMEG_0637|M.smegmatis_MC2_155 MSGRSFRFGHDGYREAMTAATSLWLAGRAE-RPTPP-YLDETNCTADVVV
Mflv_0732|M.gilvum_PYR-GCK -------------------MSSLWTDGRVE-TPSRPDEVAAVR-TADVVV
Mvan_0117|M.vanbaalenii_PYR-1 -------------------MSSLWTDGRIE-IASRPDEVAQAH-TADVLV
MAB_2503c|M.abscessus_ATCC_199 -------------------MNSIWLEGRSGLVARVPLAPDDTTQTVDIAV
Mb0576c|M.bovis_AF2122/97 ---------------------------------------MSVDDSADVVV
Rv0561c|M.tuberculosis_H37Rv ---------------------------------------MSVDDSADVVV
.*: *
MAV_2749|M.avium_104 VGAGITGLMTAALLARAGKDVLVLEARTVG---ACATANTTAKISLLQGS
TH_1303|M.thermoresistible__bu VGAGITGLITAVLLARGGKDVLVVEAAYVG---AGATGNTTAKISVLQGS
MSMEG_0637|M.smegmatis_MC2_155 VGAGITGLITAVLLARAGKDVLVLEAYTAG---AGTTGNTTAKVSLLQGT
Mflv_0732|M.gilvum_PYR-GCK VGAGITGLTTALLLARAGKKVVVVEARHIG---ACATGNTTGKVSVLQGS
Mvan_0117|M.vanbaalenii_PYR-1 VGAGITGLTTAVLLARAGKKVLVVEARHVG---ACATGNTTGKVSVLQGT
MAB_2503c|M.abscessus_ATCC_199 IGAGITGLTTALLLARAGLEVVVLEARSAG---DGTTGNSTGKISALHGT
Mb0576c|M.bovis_AF2122/97 VGAGPAGSAAAAWAARAGRDVLVIDTATFPRDKPCGDGLTPRAVAELHQL
Rv0561c|M.tuberculosis_H37Rv VGAGPAGSAAAAWAARAGRDVLVIDTATFPRDKPCGDGLTPRAVAELHQL
:*** :* :* **.* .*:*::: . :. :: *:
MAV_2749|M.avium_104 QLSKVLPRHGREVTRAYVDGNREGQEWVLGHCEAHGVAVQREDAYTYAQS
TH_1303|M.thermoresistible__bu RMSKILAKHGPRRARQYVEGNLEGLEWLVRHCAAHGLSVQREDAYTFAQS
MSMEG_0637|M.smegmatis_MC2_155 KMSKILRKHGAKVAGQYVQGNLEGQEWLAGYCDANGLSLQREDAYTYAQS
Mflv_0732|M.gilvum_PYR-GCK KLANVAGKHGTDTLRAYVLGNTEGRDWLLRYCDEHGISAQREDDHAYAQN
Mvan_0117|M.vanbaalenii_PYR-1 KLARIRAKHGPDVLSAYVTGNAEGRDWLIRYHDDHGLAYQREDDHSYAQA
MAB_2503c|M.abscessus_ATCC_199 KLSRIAHRHGHAVARAYTTGNTEGRDWLLRYCEEHGVPTQTEDAYTYAQT
Mb0576c|M.bovis_AF2122/97 GLG----------------------KWLADHIRHRGLRMSG---------
Rv0561c|M.tuberculosis_H37Rv GLG----------------------KWLADHIRHRGLRMSG---------
:. .*: : .*: .
MAV_2749|M.avium_104 VRGVPSARAEFEACQAVGLPVVWQDDAE-----VPFAYHGGVRLADQAQF
TH_1303|M.thermoresistible__bu LQGVPAARTEYLAAKIAGLDVEWVDDAEG---GVPFPFHGAVRLADQAQF
MSMEG_0637|M.smegmatis_MC2_155 EKGLASARAEYDACREVGLDADWVDAADA--PDVPFPFAGGVRLPDQAQF
Mflv_0732|M.gilvum_PYR-GCK EKGLGTARKILAACREANLDAQWVDEAD-----VPFPFAGGVRLREQAQI
Mvan_0117|M.vanbaalenii_PYR-1 ESGLSTARDVLAACREAGVDAQWVDEAD-----VPFPFQGGVRVREQAQL
MAB_2503c|M.abscessus_ATCC_199 REGTAGARDEWNACLQAGLPVRWETTAD-----TPFPYYGGVRLPDQAQF
Mb0576c|M.bovis_AF2122/97 --------------FGGEVEVDWPGPSFPSYG---------------SAV
Rv0561c|M.tuberculosis_H37Rv --------------FGGEVEVDWPGPSFPSYG---------------SAV
: . * : : .
MAV_2749|M.avium_104 DPMPFLDSLAVELLGRGGRLVEHTRVRRVSWRGKGVRVHANQGS---DAA
TH_1303|M.thermoresistible__bu DPMPLLDSLVVELEERGGRLVQGLRVHKVSGRGDGLTLHARSG------A
MSMEG_0637|M.smegmatis_MC2_155 DPMPLLDKLIVELDERNGRLVEGTRVLGVSQDSSGLKIKVRSH------T
Mflv_0732|M.gilvum_PYR-GCK DPMPYLSSVVAELESHGGTVLQGVRATSVSG-VRSVTVTLRMTTRPDDTR
Mvan_0117|M.vanbaalenii_PYR-1 DPVPYLGSLVTELEKHGGTLLQGVRATTVTG-TDPVRVRFRLTDTAQDTR
MAB_2503c|M.abscessus_ATCC_199 NPAQLVESMVAQLEDHGAHFFSGMRVRSISG-RGPLRIKGDYAH---DAG
Mb0576c|M.bovis_AF2122/97 ARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRRVVSLTLADG-----
Rv0561c|M.tuberculosis_H37Rv ARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRRVVSLTLADG-----
: .. .. :. : :
MAV_2749|M.avium_104 GHDVELHADQLVLATGIPILDRGGYFARVKPSRSYCLAFK--VPGNITRP
TH_1303|M.thermoresistible__bu GDEFDLRADRCVLATGIPILDRGGFFARLEPNRSYCLAYE--VPGEITRG
MSMEG_0637|M.smegmatis_MC2_155 GTELDVRAGQCVLATGIPILDRGGFFARLSPHRSYCLAFR--VPGAVTRG
Mflv_0732|M.gilvum_PYR-GCK DEDFSITAERCVLATGIPVLDRGFFFARAEPMRSYCMAFD--VPGELTRS
Mvan_0117|M.vanbaalenii_PYR-1 DEQFSVTARHCVLATGTPILDRGMFFARVEAKRSYCLAFD--VPGDITTP
MAB_2503c|M.abscessus_ATCC_199 AGEFALEAQRCVLATGTPILDRGGFFAKLTANRSYCMSFD--VPGPITRA
Mb0576c|M.bovis_AF2122/97 ---TEVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLSTAYSDD
Rv0561c|M.tuberculosis_H37Rv ---TEVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLSTAYSDD
: . : ::* * : * :: :. :
MAV_2749|M.avium_104 MMISTDSPTRSVRYAPVPDGERLIVGGAGHT-VGR-EKSPSAALDELSAW
TH_1303|M.thermoresistible__bu MYISTDSPTRSLRYAPTGAGDLLIVGGAGHP-VGH-EKNPASSVAELDEW
MSMEG_0637|M.smegmatis_MC2_155 MYISTDSPTRSVRYAPTADGDRLIVGGAGHT-VGR-RSHPSDDVDELASW
Mflv_0732|M.gilvum_PYR-GCK MYISVDSPTRSVRYAPTPGGEKLIVGGAGHP-VGR-ADDPKSAVDELGRW
Mvan_0117|M.vanbaalenii_PYR-1 MFLSVDSPTRSVRYAPTAAGSKLIVGGAGHP-VGR-ADNPSKAVAELSHW
MAB_2503c|M.abscessus_ATCC_199 MYLSVDAPLRSVRYAPSSTGDRLVVGGAGHV-VGH-PAHAREALRELAGW
Mb0576c|M.bovis_AF2122/97 PWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSRRPADLALR
Rv0561c|M.tuberculosis_H37Rv PWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSRRPADLALR
:: . ** * :. * *. :* . :*
MAV_2749|M.avium_104 TRKHFPGAVQTHFWSAQDYTPIDHLPYVGPILPNSETIFVATGFNKWGMT
TH_1303|M.thermoresistible__bu ARRHFPGAQQRYFWSAQDYSPIDDLPYVGPILPGNESIFVAIGFDKWGMT
MSMEG_0637|M.smegmatis_MC2_155 AKVHWPGAIQTHYWSAQDYTPVDELPYVGPLLPGNEKVFVATGFDKWGMT
Mflv_0732|M.gilvum_PYR-GCK ATLHYPGAVQTHFWSAQDYHPADELPYVGPLLPKLENILVATGFDKWGMT
Mvan_0117|M.vanbaalenii_PYR-1 AALHYPGAVQTHYWSAQDYHPDDEVPFIGPLLPMHESVLVATGFDKWGMT
MAB_2503c|M.abscessus_ATCC_199 AQTHYPGATRTHSWAAQDYATISELPYAGPLLPGGKRIYLATGYDKWGMT
Mb0576c|M.bovis_AF2122/97 PLISYYTDLRRDEWGFTGQPR----AVSSALLPMGGAVSGVAGSN-WMLI
Rv0561c|M.tuberculosis_H37Rv PLISYYTDLRRDEWGFTGQPR----AVSSALLPMGGAVSGVAGSN-WMLI
. : : *. . . ..:** : . * : * :
MAV_2749|M.avium_104 NGAAAALALSSRILGGRMDWARAFASWSPHELSGLATAVQANLEVGFNLT
TH_1303|M.thermoresistible__bu NGAAAALALSSRILGGRTDWAEAFASWSPHEVSGIPKAMMLNLQVGMYLA
MSMEG_0637|M.smegmatis_MC2_155 NGTAAALALSSRILGGRMDWSQAFDSWSPHELSGIPTALKVNLEVGFNMA
Mflv_0732|M.gilvum_PYR-GCK NGVAAALALTSRILGGRMDWARAFASWSPHELSGIPTALQMNFEVGLHLA
Mvan_0117|M.vanbaalenii_PYR-1 NGVAAALALSARILGGRMDWAQTFASWRLHELRGVPTALQANMKVGLHLA
MAB_2503c|M.abscessus_ATCC_199 NGIAASLALSSQILGGRMDWANAFASWSALDLRAIPAAIRLGSRVARDFA
Mb0576c|M.bovis_AF2122/97 GDAAACVNP---LNGEGIDYGLETGRLAAELLDSRDLARLWPSLLADRYG
Rv0561c|M.tuberculosis_H37Rv GDAAACVNP---LNGEGIDYGLETGRLAAELLDSRDLARLWPSLLADRYG
.. **.: : * *:. : . * :.
MAV_2749|M.avium_104 KGWITPAVRIGRRSPVDGDGGVVSGPPWHLQARCRVDGTEHRVSPVCPHL
TH_1303|M.thermoresistible__bu RGWLTPVTRTGDRSPDDG-CGVVSGPPWHLQARSRVDGVEHRVSPVCPHL
MSMEG_0637|M.smegmatis_MC2_155 KGWVTPILRRGDGVPDDG--GVVAGPPWRMEACSVVDGVERRVSPVCPHL
Mflv_0732|M.gilvum_PYR-GCK KGWVTPVTTP-AGPPAEG-EGIVTGPPWNLRACSVVDGVERTVSPVCPHL
Mvan_0117|M.vanbaalenii_PYR-1 NGWLAPLTSS-AEEPADG-TGVVSGPPWRLRATSVVDGVQRTVSPVCPHL
MAB_2503c|M.abscessus_ATCC_199 SGWATAMLTS-----------------------------RPEHAPVCTHL
Mb0576c|M.bovis_AF2122/97 RGFSVARRLA-----------LLLTFPRFLPTTGPITMRSTALMNIAVRV
Rv0561c|M.tuberculosis_H37Rv RGFSVARRLA-----------LLLTFPRFLPTTGPITMRSTALMNIAVRV
*: .. :. ::
MAV_2749|M.avium_104 GGIVNWNDADKAWECPLHGSRFAPDGTLLEGPATRDLTASR---------
TH_1303|M.thermoresistible__bu GGIVNWNDADQAWECPLHGSRFAPDGALLEGPATRGLTAS----------
MSMEG_0637|M.smegmatis_MC2_155 GGIVEWNDSDEAWECPLHGSRFAPDGTLLEGPATHGLTPAP---------
Mflv_0732|M.gilvum_PYR-GCK GGIVEWNNIDHAWECPLHGSRFAPDGTLLEGPATRGLT------------
Mvan_0117|M.vanbaalenii_PYR-1 GGIVKWNDSDRAWECPLHGSRFAPDGALLEGPATRGLSGCRPAQLRNVSE
MAB_2503c|M.abscessus_ATCC_199 GGITTWNDAEDIWECPLHGSCFDSGGSVLWGPATEPLDRLPADGAR----
Mb0576c|M.bovis_AF2122/97 MSNLVTDD-DRDWVARVWRGGGQLSRLVDRRPPFS---------------
Rv0561c|M.tuberculosis_H37Rv MSNLVTDD-DRDWVARVWRGGGQLSRLVDRRPPFS---------------
. :: : * . : . . : *.
MAV_2749|M.avium_104 ----
TH_1303|M.thermoresistible__bu ----
MSMEG_0637|M.smegmatis_MC2_155 ----
Mflv_0732|M.gilvum_PYR-GCK ----
Mvan_0117|M.vanbaalenii_PYR-1 GLRP
MAB_2503c|M.abscessus_ATCC_199 ----
Mb0576c|M.bovis_AF2122/97 ----
Rv0561c|M.tuberculosis_H37Rv ----