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SSLWTDGRVETPSRPDEVAAVRTADVVVVGAGITGLTTALLLARAGKKVVVVEARHIGACATGNTTGKVS VLQGSKLANVAGKHGTDTLRAYVLGNTEGRDWLLRYCDEHGISAQREDDHAYAQNEKGLGTARKILAACR EANLDAQWVDEADVPFPFAGGVRLREQAQIDPMPYLSSVVAELESHGGTVLQGVRATSVSGVRSVTVTLR MTTRPDDTRDEDFSITAERCVLATGIPVLDRGFFFARAEPMRSYCMAFDVPGELTRSMYISVDSPTRSVR YAPTPGGEKLIVGGAGHPVGRADDPKSAVDELGRWATLHYPGAVQTHFWSAQDYHPADELPYVGPLLPKL ENILVATGFDKWGMTNGVAAALALTSRILGGRMDWARAFASWSPHELSGIPTALQMNFEVGLHLAKGWVT PVTTPAGPPAEGEGIVTGPPWNLRACSVVDGVERTVSPVCPHLGGIVEWNNIDHAWECPLHGSRFAPDGT LLEGPATRGLT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0732 | - | - | 100% (502) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1109 | - | 9e-08 | 34.78% (115) | FAD dependent oxidoreductase |
| M. gilvum PYR-GCK | Mflv_1296 | - | 2e-06 | 30.99% (142) | FAD dependent oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | MLBr_01226 | nadB | 3e-05 | 42.25% (71) | L-aspartate oxidase |
| M. abscessus ATCC 19977 | MAB_2503c | - | 1e-144 | 50.69% (505) | putative iron-sulfur binding oxidoreductase |
| M. marinum M | MMAR_2392 | nadB | 8e-05 | 42.25% (71) | l-aspartate oxidase NadB |
| M. avium 104 | MAV_2749 | - | 1e-179 | 60.95% (507) | FAD dependent oxidoreductase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0637 | - | 0.0 | 64.29% (504) | iron-sulfur binding oxidoreductase |
| M. thermoresistible (build 8) | TH_1303 | - | 0.0 | 63.04% (506) | iron-sulfur binding oxidoreductase |
| M. ulcerans Agy99 | MUL_4561 | - | 7e-05 | 46.94% (49) | oxidoreductase GMC-type |
| M. vanbaalenii PYR-1 | Mvan_0117 | - | 0.0 | 75.30% (502) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0732|M.gilvum_PYR-GCK ----------------------MSSLWTDGRVE-TPSRPDEVAAVR-TAD
Mvan_0117|M.vanbaalenii_PYR-1 ----------------------MSSLWTDGRIE-IASRPDEVAQAH-TAD
MAV_2749|M.avium_104 ----------------------MTSLWMSERTE-RPWAASQLDQGPASAD
TH_1303|M.thermoresistible__bu ----------------------MTSLWLADRTN-QPPPPRTLDAGDRRAD
MSMEG_0637|M.smegmatis_MC2_155 ---MSGRSFRFGHDGYREAMTAATSLWLAGRAE-RPTPP-YLDETNCTAD
MAB_2503c|M.abscessus_ATCC_199 ----------------------MNSIWLEGRSGLVARVPLAPDDTTQTVD
MLBr_01226|M.leprae_Br4923 --------------------------------------MMAVPDWKHAAD
MMAR_2392|M.marinum_M --------------------------------------MRTSPTWRDAAD
MUL_4561|M.ulcerans_Agy99 MSRTQAALASFGAALLPEERGGPTSTEFAERVDRYLSQLPTTSRLAVRAG
..
Mflv_0732|M.gilvum_PYR-GCK VVVVGAG--ITGLTTALLLARAGKKVVVVEAR--HIGACATGNTTGKVSV
Mvan_0117|M.vanbaalenii_PYR-1 VLVVGAG--ITGLTTAVLLARAGKKVLVVEAR--HVGACATGNTTGKVSV
MAV_2749|M.avium_104 VIVVGAG--ITGLMTAALLARAGKDVLVLEAR--TVGACATANTTAKISL
TH_1303|M.thermoresistible__bu VVVVGAG--ITGLITAVLLARGGKDVLVVEAA--YVGAGATGNTTAKISV
MSMEG_0637|M.smegmatis_MC2_155 VVVVGAG--ITGLITAVLLARAGKDVLVLEAY--TAGAGTTGNTTAKVSL
MAB_2503c|M.abscessus_ATCC_199 IAVIGAG--ITGLTTALLLARAGLEVVVLEAR--SAGDGTTGNSTGKISA
MLBr_01226|M.leprae_Br4923 VVVIGTG--VAGLAAALAAHRAGRNVVVLTKADQRRGETATHYAQGGIAV
MMAR_2392|M.marinum_M VVVIGTG--VAGLAAALSAHRAGRSVVLLNKAADTVGATATHYAQGGIAV
MUL_4561|M.ulcerans_Agy99 LVSLAAASYLTTGRSLARLEPAQREQVLRRVAAINPDTSAALEGLKAVAL
: :.:. :: : . . :: . :: ::
Mflv_0732|M.gilvum_PYR-GCK LQ-------GSKLANVAGKHGTDTLRAYVLGNTEGRDWLLRY-------C
Mvan_0117|M.vanbaalenii_PYR-1 LQ-------GTKLARIRAKHGPDVLSAYVTGNAEGRDWLIRY-------H
MAV_2749|M.avium_104 LQ-------GSQLSKVLPRHGREVTRAYVDGNREGQEWVLGH-------C
TH_1303|M.thermoresistible__bu LQ-------GSRMSKILAKHGPRRARQYVEGNLEGLEWLVRH-------C
MSMEG_0637|M.smegmatis_MC2_155 LQ-------GTKMSKILRKHGAKVAGQYVQGNLEGQEWLAGY-------C
MAB_2503c|M.abscessus_ATCC_199 LH-------GTKLSRIAHRHGHAVARAYTTGNTEGRDWLLRY-------C
MLBr_01226|M.leprae_Br4923 VL-------PGSDDSVDAHASDTLAAGAGMCNLDTVYSIVAEGYHAVTEL
MMAR_2392|M.marinum_M VL-------PGSDDSVDAHVADTVTAGAGLCDLEAVYSIVADGFRAVTDL
MUL_4561|M.ulcerans_Agy99 LANGADTYAPDLLARAQAHDAARSDAALDITASPDSPSVVTADVVIVG-S
: : . :
Mflv_0732|M.gilvum_PYR-GCK DEHGISAQREDDHAYAQNEKGLGTARKILAACREAN---------LDAQW
Mvan_0117|M.vanbaalenii_PYR-1 DDHGLAYQREDDHSYAQAESGLSTARDVLAACREAG---------VDAQW
MAV_2749|M.avium_104 EAHGVAVQREDAYTYAQSVRGVPSARAEFEACQAVG---------LPVVW
TH_1303|M.thermoresistible__bu AAHGLSVQREDAYTFAQSLQGVPAARTEYLAAKIAG---------LDVEW
MSMEG_0637|M.smegmatis_MC2_155 DANGLSLQREDAYTYAQSEKGLASARAEYDACREVG---------LDADW
MAB_2503c|M.abscessus_ATCC_199 EEHGVPTQTEDAYTYAQTREGTAGARDEWNACLQAG---------LPVRW
MLBr_01226|M.leprae_Br4923 VGYGARFDESIPGRWAVTCEGGHSRRRIVHAGGDATGAEVQRALDHAADV
MMAR_2392|M.marinum_M VGDGAKFDETSTGRWALTREGGHSRRRIVHAGGDATGAEVQRALDQAAGL
MUL_4561|M.ulcerans_Agy99 GAGGAMTARTLARAGLRTVVLEEGRRWTVREFRTTHP------IDRYAGL
* * . .
Mflv_0732|M.gilvum_PYR-GCK VDEAD---VPFPFAGGVRLREQAQIDP--MPYLSSVVAELESHGGTVLQG
Mvan_0117|M.vanbaalenii_PYR-1 VDEAD---VPFPFQGGVRVREQAQLDP--VPYLGSLVTELEKHGGTLLQG
MAV_2749|M.avium_104 QDDAE---VPFAYHGGVRLADQAQFDP--MPFLDSLAVELLGRGGRLVEH
TH_1303|M.thermoresistible__bu VDDAEG-GVPFPFHGAVRLADQAQFDP--MPLLDSLVVELEERGGRLVQG
MSMEG_0637|M.smegmatis_MC2_155 VDAADAPDVPFPFAGGVRLPDQAQFDP--MPLLDKLIVELDERNGRLVEG
MAB_2503c|M.abscessus_ATCC_199 ETTAD---TPFPYYGGVRLPDQAQFNP--AQLVESMVAQLEDHGAHFFSG
MLBr_01226|M.leprae_Br4923 LDIRTSHLALRVLHDGTVVNGVSVLNPNGWGIVSAPSVILASGGLGHLYG
MMAR_2392|M.marinum_M LDIRASHVALRILHDDTAVTGVLVLNPNGVGIISAPSVILATGGLGQLYS
MUL_4561|M.ulcerans_Agy99 YRGGGATIALGRLPMGRAVGGTTVVNSG-TCFRPPLAVQQRWRDEFGLDL
. : .:. . . .
Mflv_0732|M.gilvum_PYR-GCK VRATSVSG-VRSVTVTLRMTTRPDDTRDEDFSITAERCVLATGIPVLDRG
Mvan_0117|M.vanbaalenii_PYR-1 VRATTVTG-TDPVRVRFRLTDTAQDTRDEQFSVTARHCVLATGTPILDRG
MAV_2749|M.avium_104 TRVRRVSWRGKGVRVHANQGS---DAAGHDVELHADQLVLATGIPILDRG
TH_1303|M.thermoresistible__bu LRVHKVSGRGDGLTLHARSG------AGDEFDLRADRCVLATGIPILDRG
MSMEG_0637|M.smegmatis_MC2_155 TRVLGVSQDSSGLKIKVRSH------TGTELDVRAGQCVLATGIPILDRG
MAB_2503c|M.abscessus_ATCC_199 MRVRSISG-RGPLRIKGDYAH---DAGAGEFALEAQRCVLATGTPILDRG
MLBr_01226|M.leprae_Br4923 ATTNPEGSTGDGIALALWAG---VAVSDLEFIQFHPTMLFAAGTGTGGRR
MMAR_2392|M.marinum_M ATTNPDGATGDGIALALWAG---VTVSDLEFIQFHPTMLFDGSS--GGRR
MUL_4561|M.ulcerans_Agy99 ADPDRLAGRLDDVEHTLQVAP-----APRDIMGRNGNLLLDAAASLGWQA
: :. :: . :
Mflv_0732|M.gilvum_PYR-GCK FFFARAEPMRSYCMAFDV---------------PGELTRSMYISVDSPTR
Mvan_0117|M.vanbaalenii_PYR-1 MFFARVEAKRSYCLAFDV---------------PGDITTPMFLSVDSPTR
MAV_2749|M.avium_104 GYFARVKPSRSYCLAFKV---------------PGNITRPMMISTDSPTR
TH_1303|M.thermoresistible__bu GFFARLEPNRSYCLAYEV---------------PGEITRGMYISTDSPTR
MSMEG_0637|M.smegmatis_MC2_155 GFFARLSPHRSYCLAFRV---------------PGAVTRGMYISTDSPTR
MAB_2503c|M.abscessus_ATCC_199 GFFAKLTANRSYCMSFDV---------------PGPITRAMYLSVDAPLR
MLBr_01226|M.leprae_Br4923 PLVTEAIRGEGAILLDSK---------------GNSVTSGVHPLGDLAPR
MMAR_2392|M.marinum_M PLITEAIRGEGAILLDRQ---------------GRSITAGVHPLGDLAPR
MUL_4561|M.ulcerans_Agy99 APIPRNAPGCAGCCQCAIGCPSNAKFGVHLNALPQACAAGARIISDARVQ
... . : * :
Mflv_0732|M.gilvum_PYR-GCK SVRYAPTPG----------------GEKLIVGG---------------AG
Mvan_0117|M.vanbaalenii_PYR-1 SVRYAPTAA----------------GSKLIVGG---------------AG
MAV_2749|M.avium_104 SVRYAPVPD----------------GERLIVGG---------------AG
TH_1303|M.thermoresistible__bu SLRYAPTGA----------------GDLLIVGG---------------AG
MSMEG_0637|M.smegmatis_MC2_155 SVRYAPTAD----------------GDRLIVGG---------------AG
MAB_2503c|M.abscessus_ATCC_199 SVRYAPSST----------------GDRLVVGG---------------AG
MLBr_01226|M.leprae_Br4923 DVVAAAIDAR-----------LKATGDSCVYLD---------------AR
MMAR_2392|M.marinum_M DVVAAAIDAR-----------MKANGDPCAYLD---------------AR
MUL_4561|M.ulcerans_Agy99 RVLHQGGRARGVRARRPDGTAIDVRADIVIIAAGATETPTLLRRSGLGSH
: .. :
Mflv_0732|M.gilvum_PYR-GCK HPVGRADDPKSAVDELGRWATLHYPGAVQTHFWSAQDYHPADELPYVGPL
Mvan_0117|M.vanbaalenii_PYR-1 HPVGRADNPSKAVAELSHWAALHYPGAVQTHYWSAQDYHPDDEVPFIGPL
MAV_2749|M.avium_104 HTVGREKSPSAALDELSAWTRKHFPGAVQTHFWSAQDYTPIDHLPYVGPI
TH_1303|M.thermoresistible__bu HPVGHEKNPASSVAELDEWARRHFPGAQQRYFWSAQDYSPIDDLPYVGPI
MSMEG_0637|M.smegmatis_MC2_155 HTVGRRSHPSDDVDELASWAKVHWPGAIQTHYWSAQDYTPVDELPYVGPL
MAB_2503c|M.abscessus_ATCC_199 HVVGHPAHAREALRELAGWAQTHYPGATRTHSWAAQDYATISELPYAGPL
MLBr_01226|M.leprae_Br4923 GIDGFASRFPTVTAACRTVGIDPAREPIPVVPGAHYSCGGIVTDAYGQTE
MMAR_2392|M.marinum_M SIKGFESRFPTVTASCRAAGIDPVRQPIPVVPGAHYSCGGVITDVYGNTE
MUL_4561|M.ulcerans_Agy99 PRLGRNLALHPATMLAGRFDDDVYAWRGVLQSAAVHEFHESDGVLIEATA
* : . .
Mflv_0732|M.gilvum_PYR-GCK LPKLENILVATGFDKWGMT--NGVAAALALTSRILG---GRMD-WARAFA
Mvan_0117|M.vanbaalenii_PYR-1 LPMHESVLVATGFDKWGMT--NGVAAALALSARILG---GRMD-WAQTFA
MAV_2749|M.avium_104 LPNSETIFVATGFNKWGMT--NGAAAALALSSRILG---GRMD-WARAFA
TH_1303|M.thermoresistible__bu LPGNESIFVAIGFDKWGMT--NGAAAALALSSRILG---GRTD-WAEAFA
MSMEG_0637|M.smegmatis_MC2_155 LPGNEKVFVATGFDKWGMT--NGTAAALALSSRILG---GRMD-WSQAFD
MAB_2503c|M.abscessus_ATCC_199 LPGGKRIYLATGYDKWGMT--NGIAASLALSSQILG---GRMD-WANAFA
MLBr_01226|M.leprae_Br4923 LAG---LFAAGEVARTGMHGANRLASNSLLEGLVVG---GRAGRAAAAHA
MMAR_2392|M.marinum_M LPG---LFAAGEVARTGMHGANRLASNSLLEGLVVG---GRAGKGAAAHA
MUL_4561|M.ulcerans_Agy99 TPPGMGSMVFPGYGTELLDWLDRAPQVATFGAMVADRGAGSVRSVRGETV
. : : . : . : . *
Mflv_0732|M.gilvum_PYR-GCK SWSPHELSGIPTALQMNFEVGLHLAKGWVTPVTTP-AGPPAEG-EGIVTG
Mvan_0117|M.vanbaalenii_PYR-1 SWRLHELRGVPTALQANMKVGLHLANGWLAPLTSS-AEEPADG-TGVVSG
MAV_2749|M.avium_104 SWSPHELSGLATAVQANLEVGFNLTKGWITPAVRIGRRSPVDGDGGVVSG
TH_1303|M.thermoresistible__bu SWSPHEVSGIPKAMMLNLQVGMYLARGWLTPVTRTGDRSPDDG-CGVVSG
MSMEG_0637|M.smegmatis_MC2_155 SWSPHELSGIPTALKVNLEVGFNMAKGWVTPILRRGDGVPDDG--GVVAG
MAB_2503c|M.abscessus_ATCC_199 SWSALDLRAIPAAIRLGSRVARDFASGWATAMLTS---------------
MLBr_01226|M.leprae_Br4923 AAAGRAYVSKLEPVTHHALKRRELQRVMSRDAAVMRNAAGLQRLSDTLAE
MMAR_2392|M.marinum_M AAAGLAHATMPEPIAHTAPRRDDLQRAMSRDASVVRDAAGLHRLAEMLDG
MUL_4561|M.ulcerans_Agy99 VHYQVAPDDIAKLRVAVQAIGRLLFAAGAVEVLTGLPGAPTVTSPAALQD
:
Mflv_0732|M.gilvum_PYR-GCK PPWNLRACSVVDGVERTVSPVCPHLGGIVEWNNIDHAWECPLHGSRFAPD
Mvan_0117|M.vanbaalenii_PYR-1 PPWRLRATSVVDGVQRTVSPVCPHLGGIVKWNDSDRAWECPLHGSRFAPD
MAV_2749|M.avium_104 PPWHLQARCRVDGTEHRVSPVCPHLGGIVNWNDADKAWECPLHGSRFAPD
TH_1303|M.thermoresistible__bu PPWHLQARSRVDGVEHRVSPVCPHLGGIVNWNDADQAWECPLHGSRFAPD
MSMEG_0637|M.smegmatis_MC2_155 PPWRMEACSVVDGVERRVSPVCPHLGGIVEWNDSDEAWECPLHGSRFAPD
MAB_2503c|M.abscessus_ATCC_199 --------------RPEHAPVCTHLGGITTWNDAEDIWECPLHGSCFDSG
MLBr_01226|M.leprae_Br4923 APIRHVTGRRDFEDVALTLTARAVAAAALARNESRGCHHCTEYPDTAPEH
MMAR_2392|M.marinum_M -PTRGIADRNDFEDVALALAARVVGAGALARNESRGCHHRAEYPDVVPEQ
MUL_4561|M.ulcerans_Agy99 ALQRSDPRNLHLAAFHPTGTAAAGADSQICPVDATGRLRG-VDGVWVADA
.. . : .
Mflv_0732|M.gilvum_PYR-GCK GTLLEGPATRGLT----------------------------------
Mvan_0117|M.vanbaalenii_PYR-1 GALLEGPATRGLSGCRPAQLRNVSEGLRP------------------
MAV_2749|M.avium_104 GTLLEGPATRDLTASR-------------------------------
TH_1303|M.thermoresistible__bu GALLEGPATRGLTAS--------------------------------
MSMEG_0637|M.smegmatis_MC2_155 GTLLEGPATHGLTPAP-------------------------------
MAB_2503c|M.abscessus_ATCC_199 GSVLWGPATEPLDRLPADGAR--------------------------
MLBr_01226|M.leprae_Br4923 ARSTVIRLADDQNLVRAEALATVG-----------------------
MMAR_2392|M.marinum_M GRGIVVRLAGDQDTVCVEALAAVG-----------------------
MUL_4561|M.ulcerans_Agy99 SILPSCPEVNPQISIMALALAVADEVVADRSGSIYISPPACSPGPAP
. .