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MILETTGAAYEITENLLPGILDALSDDPLHELESPGNRGIEIFRKFNGPALVIPAAHSGVGASPLQTVAV MRAIATKSPSLAVATAMHHFSVATLFTLAESLQASGFEWAMLEAIASQRMLVSSAFAEGSPGQSVISPTV TARRTDGGVIVNGSKKPCSLSASMDFLSMSMALPAQDGGQRETIFALIPAQTEGVTVHPFWGTDILAGAE SDEVRLTDVFVDDQLTVPANNDGGALDLLQTIGFVWFELLITSCYLGAATALAERVFQRRRTSPTVLSEL SVRLETATLLLERIAMHLQHEAVNHRSLVGALHARYGAQDAIRDAAALSVEALGGIGFITSNDTAYLSSV CQCAPFHPPSRLSLADALARAAIGEPLRLD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2278 | - | - | 100% (380) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_1070c | - | 5e-07 | 23.17% (341) | acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4336 | - | 4e-06 | 25.28% (178) | acyl-CoA dehydrogenase FadE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1706 | fadE16 | 4e-09 | 22.54% (355) | acyl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1881 | - | 3e-06 | 22.12% (339) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1679 | fadE16 | 5e-09 | 22.54% (355) | acyl-CoA dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4535 | fadE12 | 1e-07 | 23.55% (344) | acyl-CoA dehydrogenase FadE12 |
| M. avium 104 | MAV_1088 | - | 8e-07 | 20.77% (337) | acyl-CoA dehydrogenase fadE12 |
| M. smegmatis MC2 155 | MSMEG_3668 | - | 9e-09 | 24.77% (218) | acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4603 | - | 1e-06 | 26.32% (190) | PUTATIVE acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4707 | fadE12 | 9e-08 | 23.55% (344) | acyl-CoA dehydrogenase FadE12 |
| M. vanbaalenii PYR-1 | Mvan_3173 | - | 7e-09 | 24.43% (307) | acyl-CoA dehydrogenase type 2 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1706|M.bovis_AF2122/97 --------------------------MATPGVVQEVVSVAAEHAERVDTD
Rv1679|M.tuberculosis_H37Rv --------------------------MATPGVVQEVVSVAAEHAERVDTD
MMAR_4535|M.marinum_M -------------MTDTSFIENEDRRALRKAVSEWASNYGHEYYLKKARA
MUL_4707|M.ulcerans_Agy99 ------------MMTGTSFIENEDRRALRKAVSEWASNYGHEYYLKKARA
MAV_1088|M.avium_104 -------------MTDSSFIENEERQALRKAVAEWASNYGSEYYLRKARA
Mflv_1881|M.gilvum_PYR-GCK -------------MSG--FIETEEQQALRSAVAAMVAGYGQDYYLEKSRA
MSMEG_3668|M.smegmatis_MC2_155 MTVTVPATGSHSPNHLPTDVGVLHTAQEALAAADALATEFAADSAERELH
Mvan_3173|M.vanbaalenii_PYR-1 -------MATDITDRIPDTL--LRTPADALAAAEEVAEAIAAGSAERERA
TH_4603|M.thermoresistible__bu -------------MAVDRLLPSQEAAELIELTREIADKVLDPIVDRHEKD
MAB_2278|M.abscessus_ATCC_1997 -------------------MILETTGAAYEITENLLPGILDALSDDPLHE
.
Mb1706|M.bovis_AF2122/97 CAFP-AEAVDALRKTGLLGLVLPREIGGMGSGPVEFTEVVAQLSAACGST
Rv1679|M.tuberculosis_H37Rv CAFP-AEAVDALRKTGLLGLVLPREIGGMGSGPVEFTEVVAQLSAACGST
MMAR_4535|M.marinum_M HEHT-TELWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSAL
MUL_4707|M.ulcerans_Agy99 HEHT-TELWSEAGKLGFIGVNLPEEYGGGGAGMYELSMVMEEMAAAGSAL
MAV_1088|M.avium_104 HEHT-NELWSEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSAL
Mflv_1881|M.gilvum_PYR-GCK GEHT-DELWSEAGKLGFIGVNLPEEYGGGGAGMYELSLVMEEMAAGGASL
MSMEG_3668|M.smegmatis_MC2_155 GKSL-LPQLRRVAESGLLGIVVPAAHGGPGLPASTKVEVVRRLSRGDGAL
Mvan_3173|M.vanbaalenii_PYR-1 GAVL-TPQLRLVAESGLLGISVPTAHGGPGLPASTVVEVLRRLARADGAV
TH_4603|M.thermoresistible__bu ETYP-EGVFEQLGAAGLLSLPQPEEWGGGGQPYEVYLQVLEEIAARWASV
MAB_2278|M.abscessus_ATCC_1997 LESPGNRGIEIFRKFNGPALVIPAAHSGVGASPLQTVAVMRAIATKSPSL
. .: * .* * *: :: :
Mb1706|M.bovis_AF2122/97 AMIYLMHMAAAVTVAAS-PPPGLP----DLLADMASGKQLGTLAFSEPGS
Rv1679|M.tuberculosis_H37Rv AMIYLMHMAAAVTVAAS-PPPGLP----DLLADMASGKQLGTLAFSEPGS
MMAR_4535|M.marinum_M LLMVVSPAINGTIISKFGTDEQKQ----RWLPGIADGTLTMAFAITEPDA
MUL_4707|M.ulcerans_Agy99 LLMVVSPAINGTIISKFGTDEQKQ----RWLPGIADGTLTMAFAITEPEA
MAV_1088|M.avium_104 LLMVVSPAINGTIISKFGTEEQKK----RWLPGIADGTLTMAFAITEPDA
Mflv_1881|M.gilvum_PYR-GCK LMMVVSPAINGTIIAKFGTEEQKK----RWLPGIADGTLTMAFAITEPDA
MSMEG_3668|M.smegmatis_MC2_155 GQLLLSHFVIGEAISGLGEAAPAP----RIYADTLAGAQLGN-ATAERGT
Mvan_3173|M.vanbaalenii_PYR-1 GQLLLSHFVVAQAISGLGHTQPAP----RIYADLLAGAQLGN-ASAERGT
TH_4603|M.thermoresistible__bu AVAVSVHSLSSHPLLVFGTEEQKK----RWLPGMLSGEQIGAYSLSEPQA
MAB_2278|M.abscessus_ATCC_1997 AVATAMHHFSVATLFTLAESLQASGFEWAMLEAIASQRMLVSSAFAEGSP
: : :* .
Mb1706|M.bovis_AF2122/97 RSHFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGSADGAAGDV
Rv1679|M.tuberculosis_H37Rv RSHFWAPVSTASADGDGIAVRADKSWVTSAGFADVYVVSVGSADGAAGDV
MMAR_4535|M.marinum_M GSNSHKITTTARRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKTGKL
MUL_4707|M.ulcerans_Agy99 GSNSHKITTTARRDGSDWIIKGQKVYISGIDQAQAVLVVGRTEEAKTGKL
MAV_1088|M.avium_104 GSNSHKITTTARRDGSDWILKGQKVFISGIDQAQAVLVVARTEEAKTGKL
Mflv_1881|M.gilvum_PYR-GCK GSNSHRITTTARRDGSDWILSGQKVYISGVDQAQAVLIVGRTEDHKTGNL
MSMEG_3668|M.smegmatis_MC2_155 ATALDRRTSVTQRPDGKWVLNGTKYYATGALGAAWIAVAAVIAGRED-ET
Mvan_3173|M.vanbaalenii_PYR-1 AHALDRRTTVTRR-DGHWVLNGTKYYATGTLGATWIAVAARIEGRENGDT
TH_4603|M.thermoresistible__bu GSDAAALRCAATPTDGGYVINGSKSWITHGGKADFYTLFARTG---EGSR
MAB_2278|M.abscessus_ATCC_1997 GQSVISPTVTARRTDGGVIVNGSKKPCSLSASMDFLSMSMALPAQDGGQR
.: .. : . * : : .
Mb1706|M.bovis_AF2122/97 D--LYAVPADTPGLRVAGTFTGM-GLRGNASAPMAVDIRIPDSYRLGE--
Rv1679|M.tuberculosis_H37Rv D--LYAVPADTPGLRVAGTFTGM-GLRGNASAPMAVDIRIPDSYRLGE--
MMAR_4535|M.marinum_M RPALFVVPTDTPGFTYTAIDMEL-VSPERQFQVFLDDVRLPADALVGA--
MUL_4707|M.ulcerans_Agy99 RPALFVVPTDTPGFTYTAIDMEL-VSPERQFQVFLDDVRLPADALVGA--
MAV_1088|M.avium_104 RPALFVVPTDAPGFSATPIEMEL-ISPERQFQVFLDDVRLPSDALVGA--
Mflv_1881|M.gilvum_PYR-GCK KPALFVVPTDTPGLTYTKIPMEI-VSPEFQFQVFLDEVRLPADALVGS--
MSMEG_3668|M.smegmatis_MC2_155 ATVFVRPEQDGVTLDLDKWSAFG-QRGTASGEVRLTDVVVDADLVIEEGA
Mvan_3173|M.vanbaalenii_PYR-1 ATAFVRPDQEGVTLDLESWSAFG-QRGTASGEVRLNNVVVDDDLLIDEGP
TH_4603|M.thermoresistible__bu GVSCFLVPADQPGLSFGKPEEKMGLHAVPTTSAFYDNARIDADRRIGE--
MAB_2278|M.abscessus_ATCC_1997 ETIFALIPAQTEGVTVHPFWGTDILAGAESDEVRLTDVFVDDQLTVPANN
: . : : . :
Mb1706|M.bovis_AF2122/97 AGGGFGIMMQTVLPWFNLGNAAVSLGLATAATGAAVKHVGTARLEHLGGS
Rv1679|M.tuberculosis_H37Rv AGGGFGIMMQTVLPWFNLGNAAVSLGLATAATGAAVKHVGTARLEHLGGS
MMAR_4535|M.marinum_M QDAAIAQLFAGLNPERIMG-AASAVGMGRFALNRAVDYVKTR--QVWSTP
MUL_4707|M.ulcerans_Agy99 QDAAIAQLFAGLNPERIMG-AASAVGMGRFALNRAVDYVKTR--QVWSTP
MAV_1088|M.avium_104 EDAAIAQLFAGLNPERIMG-AASSVGMGRFALARAAEYVKTR--QVWGTP
Mflv_1881|M.gilvum_PYR-GCK EDAAIAQLFAGLNPERIMG-AASAVGMGRFALAKAVEYVKGR--QVWKTP
MSMEG_3668|M.smegmatis_MC2_155 APDPVDAPPTVLGAYDQALHAAIDIGIARAALEDGAHFVRTTSRPWKEAV
Mvan_3173|M.vanbaalenii_PYR-1 PPDPITADPSVLGAFDQALHAAIDIGIARAALEDGAVFVRTRSRPWKEAL
TH_4603|M.thermoresistible__bu EGQGLQIAFSALDS-GRLGIAAVATGLAQAALDEAVAYANER--TAFGRK
MAB_2278|M.abscessus_ATCC_1997 DGGALDLLQTIGFVWFELLITSCYLGAATALAERVFQRRRTS--------
. :: * .
Mb1706|M.bovis_AF2122/97 LA------ELPTIRAQIARMGTTLAAQKAYLEVAANSVSSP---------
Rv1679|M.tuberculosis_H37Rv LA------ELPTIRAQIARMGTTLAAQKAYLEVAANSVSSP---------
MMAR_4535|M.marinum_M IG------AHQGLAHPLAQCHIEVELAKLMMQKAATLYDHG---------
MUL_4707|M.ulcerans_Agy99 IG------AHQGLAHPLAQCHIEVELAKLMMQKAATLYDHG---------
MAV_1088|M.avium_104 VG------AHQGLSHPLAQCHIEVELAKLMMQKAATLYDAG---------
Mflv_1881|M.gilvum_PYR-GCK IG------AHQGLSHPLAQNHIEVELAKLMMQKAAALYDAG---------
MSMEG_3668|M.smegmatis_MC2_155 LAGVTSAAEEPHVVRRFGELTARLYALEALLARGTAIIDAGQSEAELSRD
Mvan_3173|M.vanbaalenii_PYR-1 DAGIERADQEPHVVRRFGELTARLYALEALLARGTALIDEAYAAPEVTRD
TH_4603|M.thermoresistible__bu II------DHQGLGFLLADMAAAVATARATYLDAARRRDQG---------
MAB_2278|M.abscessus_ATCC_1997 -------------PTVLSELSVRLETATLLLERIAMHLQHEA--------
:. : : .
Mb1706|M.bovis_AF2122/97 DDTTLTHVLG-VKASVNDAALTITESAMRVCGGAAFSKHLPIERAFRDAR
Rv1679|M.tuberculosis_H37Rv DDTTLTHVLG-VKASVNDAALTITESAMRVCGGAAFSKHLPIERAFRDAR
MMAR_4535|M.marinum_M DDGGAAEAANMAKYAAAEASARSVDQAVQSMGGNGLTQEYGVAAMLTSSR
MUL_4707|M.ulcerans_Agy99 DDGGAAEAANMAKYAAAEASARSVDQAVQSMGGNGLTQEYGVAAMLTSSR
MAV_1088|M.avium_104 NDMGAAEAANMAKYAAAEAATRSVDQAVQSMGGNGLTKEYGVAAMLASAR
Mflv_1881|M.gilvum_PYR-GCK ADEAAAEAANMAKYAAGEASVRAVDQAVQSLGGNGLTKEYGVAAMLTASR
MSMEG_3668|M.smegmatis_MC2_155 TAAEASLTVAAAKALAQEYAVEIASGIFELTGASGTDSAVNLDRHWRNVR
Mvan_3173|M.vanbaalenii_PYR-1 AAAQASLTVAAAKALAQQDAVEIAGAIFELTGTSGTDGAVNLDRHWRNVR
TH_4603|M.thermoresistible__bu --RPYSQQASIAKLTATDAAMKVTTDAVQVFGGVGYTRDYRVERYMREAK
MAB_2278|M.abscessus_ATCC_1997 VNHRSLVGALHARYGAQDAIRDAAALSVEALGGIGFITSNDTAYLSSVCQ
.: . : . .. * . :
Mb1706|M.bovis_AF2122/97 AGSVMAPTADALYDFYGRAVTGLPLF------
Rv1679|M.tuberculosis_H37Rv AGSVMAPTADALYDFYGRAVTGLPLF------
MMAR_4535|M.marinum_M LARIAPISREMVLNFVAQTSLGLPRSY-----
MUL_4707|M.ulcerans_Agy99 LARIAPISREMVLNFVAQTSLGLPRSY-----
MAV_1088|M.avium_104 LGRIAPVSREMVLNFVAQTSLGLPRSY-----
Mflv_1881|M.gilvum_PYR-GCK LARIAPVSREMILNFVAQTSLGLPRSY-----
MSMEG_3668|M.smegmatis_MC2_155 THSLHDPARWKYVHLGNHTLHGTRPPRLGLVL
Mvan_3173|M.vanbaalenii_PYR-1 VHSLHDPARWKYVHLGNHTLHDTRPPRLGLIL
TH_4603|M.thermoresistible__bu IMQIFEGTNQIQRLVIARGLTR----------
MAB_2278|M.abscessus_ATCC_1997 CAPFHPPSRLSLADALARAAIGEPLRLD----
. : :