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TLHTDVAIIGAGFTGLSVAAALKRSGVHNFVVLDRRSAASSEEWRGDTVRLFALAKHLHSGHEAAALAYD AADERWTIKVAGGEDLSVRSVVLATGSRTAGDPTVPGIEAYTGVVMRGQDFRDVDLAGKRVAVVGNGAAA ATLLPEIVREAASVKLFQSSPDWVLPRQGGRIVRLLEGVPVVREATRQAWFAGRRPQRRGIMELLARIHL RRHVDDPWVRRQLTPLPLTGRPNVVIADEFYTALQAPNCKLITWPIARCSARGIRTAEGIEHHCDVIIFA SAPDDAGASQIPVTGDGGQPLPESDEISVAGFPNLFLADPPPWQPGRDAVQRIRGRVHRVAARVQGTVRP ETSIGVLPASRLTRATVALAAMGLRPLIERVPMSRLGVAASRRLVATAMTAGSPMPTNVRIDRVREQGLR GEWVHAPDSDRDGPVIFYIHGSGYVVCSSRTHRRLVARLSQASGLPAFSLDYRLAPEHPFPAAADDVRAA YQWLLSTGHAAKDIVIAADSAGGHLAVDLIAENHRMGVAQPGALVLFSPLADLTLGLSAERERDAPDPII SAAAARRLVDCYTAAQPVDSPRLRLALGPGVMLPPTLIQVGGREMMVADAEHLELMITRAGGACELQVWP GQVHVFQALPRFSSEATAAVREAARFITATLAARSELTAEQSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4052c | - | - | 100% (674) | putative lipase/esterase |
| M. abscessus ATCC 19977 | MAB_2076 | - | 9e-55 | 39.93% (293) | putative esterase/acetyl hydrolase |
| M. abscessus ATCC 19977 | MAB_2073 | - | 1e-54 | 34.26% (394) | putative monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2406 | mbtJ | 3e-69 | 48.84% (303) | putative acetyl hydrolase MBTJ |
| M. gilvum PYR-GCK | Mflv_4608 | - | 3e-53 | 33.93% (392) | FAD dependent oxidoreductase |
| M. tuberculosis H37Rv | Rv2385 | mbtJ | 3e-69 | 48.84% (303) | putative acetyl hydrolase MBTJ |
| M. leprae Br4923 | MLBr_00314 | - | 2e-36 | 34.59% (292) | putative esterase |
| M. marinum M | MMAR_3699 | mbtJ | 5e-69 | 46.69% (332) | acetyl hydrolase MbtJ |
| M. avium 104 | MAV_1798 | - | 1e-69 | 49.50% (303) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_2310 | - | 4e-34 | 26.40% (394) | monooxygenase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 6e-34 | 31.82% (352) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_3642 | mbtJ | 2e-69 | 46.69% (332) | acetyl hydrolase MbtJ |
| M. vanbaalenii PYR-1 | Mvan_1519 | - | 2e-50 | 33.33% (390) | FAD dependent oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2406|M.bovis_AF2122/97 --------------------------------------------------
Rv2385|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3699|M.marinum_M --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 --------------------------------------------------
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 MTLHTDVAIIGAGFTGLSVAAALKRSGVHNFVVLDRRSAASSEEWRGDTV
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mflv_4608|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1519|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2310|M.smegmatis_MC2_155 --------------------------------------------------
Mb2406|M.bovis_AF2122/97 --------------------------------------------------
Rv2385|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3699|M.marinum_M --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 --------------------------------------------------
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 RLFALAKHLHSGHEAAALAYDAADERWTIKVAGGEDLSVRSVVLATGSRT
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mflv_4608|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1519|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2310|M.smegmatis_MC2_155 --------------------------------------------------
Mb2406|M.bovis_AF2122/97 --------------------------------------------------
Rv2385|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3699|M.marinum_M --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 --------------------------------------------------
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 AGDPTVPGIEAYTGVVMRGQDFRDVDLAGKRVAVVGNGAAAATLLPEIVR
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mflv_4608|M.gilvum_PYR-GCK -----------MSDTTTVLIVGAGFAGLGTAIRLLQQGIDDFVVLERADE
Mvan_1519|M.vanbaalenii_PYR-1 ------------MHVHDTLIVGAGFSGLGTAIKLRQAGVDDIVIVERGQR
MSMEG_2310|M.smegmatis_MC2_155 -----MTAADQQPIRTRALVIGTGFSGLGMAIELQRRGVD-FLILEKADE
Mb2406|M.bovis_AF2122/97 --------------------------------------------------
Rv2385|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3699|M.marinum_M --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 --------------------------------------------------
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 EAASVKLFQSSPDWVLPRQGGRIVRLLEGVPVVREATRQAWFAGRRPQRR
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mflv_4608|M.gilvum_PYR-GCK VGGTWRDNTYPGAACDIPSLLYSYGFEQNPDWSRAYSGSAEILGYIKTMV
Mvan_1519|M.vanbaalenii_PYR-1 VGGTWRDNTYPGVACDIPSLLYSFSFVRNPSWSRAYPTGAEICDHIEDMA
MSMEG_2310|M.smegmatis_MC2_155 IGGTWRDNTYPGCACDIPSHMYSFSFEPKADWKHMWSFQPEIQDYLLGVT
Mb2406|M.bovis_AF2122/97 -------------------------------------------MVLRP--
Rv2385|M.tuberculosis_H37Rv -------------------------------------------MVLRP--
MMAR_3699|M.marinum_M ----------------------MTDVVPVRGSLRSRTAVAVSSIMMPP--
MUL_3642|M.ulcerans_Agy99 ----------------------MTDVVPVRGSLRSRTAVAVSSIMMPP--
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 GIMELLARIHLRRHVDDPWVRRQLTPLPLTGRPNVVIADEFYTALQAPNC
MLBr_00314|M.leprae_Br4923 --------------------------MAISAGAPVEIVESGPSIAARLAS
TH_1370|M.thermoresistible__bu -MTAPSKVPRTSPLATRAARGHYSRTFPVSDGTPSEYVEDGPSLAGRLTA
Mflv_4608|M.gilvum_PYR-GCK DKYSLSRFIRFGVNVTGLEFDEESALWTAQTADGSQFTARTAVMASGPLA
Mvan_1519|M.vanbaalenii_PYR-1 DQHGLTPLIRFDTEVTGLTFDDQSGAWTVTTKRRKQFRARTVVLASGPLA
MSMEG_2310|M.smegmatis_MC2_155 AKYGLRRHIHFNSHVDRAHWDDEELRWHVFTKTGQEYIAQFLVSGAGGLH
Mb2406|M.bovis_AF2122/97 --ITGAIPPDGPWGIWASR-------------------------------
Rv2385|M.tuberculosis_H37Rv --ITGAIPPDGPWGIWASR-------------------------------
MMAR_3699|M.marinum_M --ITAAIPPERAWGIWMTR-------------------------------
MUL_3642|M.ulcerans_Agy99 --IIAAIPPERAWGIWMTR-------------------------------
MAV_1798|M.avium_104 -----MIPPERAWGLWLSR-------------------------------
MAB_4052c|M.abscessus_ATCC_199 KLITWPIARCSARGIRTAEGIEHHCDVIIFASAPDDAGASQIPVTGDGGQ
MLBr_00314|M.leprae_Br4923 LTSRLTIRPILAVGSYVPQ-------------------------------
TH_1370|M.thermoresistible__bu LAAYLTVRPTLAIGSFAPR-------------------------------
Mflv_4608|M.gilvum_PYR-GCK NASLPDIRGLDTFDGHKIH-------------------------------
Mvan_1519|M.vanbaalenii_PYR-1 DHRFPEIRGIDSYRGHKIH-------------------------------
MSMEG_2310|M.smegmatis_MC2_155 IPQIPDIEGRESFAGAAFH-------------------------------
: . .
Mb2406|M.bovis_AF2122/97 ---------------------------------------RIIAGLMGTFG
Rv2385|M.tuberculosis_H37Rv ---------------------------------------RIIAGLMGTFG
MMAR_3699|M.marinum_M ---------------------------------------QLIARLMGTLG
MUL_3642|M.ulcerans_Agy99 ---------------------------------------QVIARLMGTLG
MAV_1798|M.avium_104 ---------------------------------------QIVARIMGTFG
MAB_4052c|M.abscessus_ATCC_199 PLPESDEISVAGFPNLFLADPPPWQPGRDAVQRIRGRVHRVAARVQGTVR
MLBr_00314|M.leprae_Br4923 -----------------------------------------LPWPFGLID
TH_1370|M.thermoresistible__bu -----------------------------------------LPWPWGLLD
Mflv_4608|M.gilvum_PYR-GCK -----------------------------------------SARWDHDYD
Mvan_1519|M.vanbaalenii_PYR-1 -----------------------------------------SASWDHDYD
MSMEG_2310|M.smegmatis_MC2_155 -----------------------------------------SAQWDHSVD
.
Mb2406|M.bovis_AF2122/97 PS-----LAGTRVEQVNSVLPDG--------------------RRVVGEW
Rv2385|M.tuberculosis_H37Rv PS-----LAGTRVEQVNSVLPDG--------------------RRVVGEW
MMAR_3699|M.marinum_M PS-----LSGTHVKPVNSVLPDG--------------------RRVVGEW
MUL_3642|M.ulcerans_Agy99 PS-----LSGTHVKPVNSVLPDG--------------------RRVVGEW
MAV_1798|M.avium_104 PS-----LSGTRVQSVDTRLPDG--------------------RRVKGEW
MAB_4052c|M.abscessus_ATCC_199 PETSIGVLPASRLTRATVALAAMGLRPLIERVPMSRLGVAASRRLVATAM
MLBr_00314|M.leprae_Br4923 HAAR-VLLPVTNAARAEVNLSNT-----------------------SAQL
TH_1370|M.thermoresistible__bu FAAR-AVRPVPGTVRATIRLPHC-----------------------TAQL
Mflv_4608|M.gilvum_PYR-GCK MSDKRVAVIGTGASAVQIIPELVKT------------------ARSVKVF
Mvan_1519|M.vanbaalenii_PYR-1 FTGKRVAVIGTGASAVQIVPELVKT------------------AAFVKVF
MSMEG_2310|M.smegmatis_MC2_155 LRGKRVAVIGTGASAIQIVPEIVKD------------------VAELHLY
.
Mb2406|M.bovis_AF2122/97 VYGPHNNA----------------INAGPGG---GAIYYVHG-SGYTMCS
Rv2385|M.tuberculosis_H37Rv VYGPHNNA----------------INAGPGG---GAIYYVHG-SGYTMCS
MMAR_3699|M.marinum_M VHGPHLPT----------------GPAPNRS---GAIYFVHG-SGYTMCS
MUL_3642|M.ulcerans_Agy99 VHGPHLPT----------------GPAPNRS---GAIYFVHG-SGYTMCS
MAV_1798|M.avium_104 VFGPRTPT----------------SEHSRPSSIAEAIYYIHG-SGYAVCS
MAB_4052c|M.abscessus_ATCC_199 TAGSPMPTNVRIDRVREQGLRGEWVHAPDSDRDGPVIFYIHG-SGYVVCS
MLBr_00314|M.leprae_Br4923 VRAAGVRP------------------ADGSG---RIVLYLHG-GAFLGCG
TH_1370|M.thermoresistible__bu VRAPGVLP------------------ADGRR---SVVLYLHG-GAFLTCG
Mflv_4608|M.gilvum_PYR-GCK QRTPGWVLPRPDFSHPQWVRTAFRRLPRVQNVGRQAWFWGHELMAVGMVW
Mvan_1519|M.vanbaalenii_PYR-1 QRTPGWVLPRLDLPMPAAVQALFAKVPATQEIARQALYWGHEASAAALVW
MSMEG_2310|M.smegmatis_MC2_155 QRTPAWVMPRVNNAFPQWLRNVFSYVPGTRALLRAAIYWIHEGVGFAMTK
. : * .
Mb2406|M.bovis_AF2122/97 PRTHRRLTSWLSSLTGLPVFS---VDYRLAPRYRFPTAATDVRAAWDWLA
Rv2385|M.tuberculosis_H37Rv PRTHRRLTSWLSSLTGLPVFS---VDYRLAPRYRFPTAATDVRAAWDWLA
MMAR_3699|M.marinum_M PRTHRRLTAWLSSLTGLPVFS---VDYRLAPRHRFPTAADDVRAGWDWLP
MUL_3642|M.ulcerans_Agy99 PRTHRRLTAWLSSLTGLPVFS---VDYRLAPRHRFPTAADDVRAGWDWLP
MAV_1798|M.avium_104 PKTHRRLTSWLSSLTGLPVFC---VDYRLAPRHRFPTAADDVRAGWDWLI
MAB_4052c|M.abscessus_ATCC_199 SRTHRRLVARLSQASGLPAFS---LDYRLAPEHPFPAAADDVRAAYQWLL
MLBr_00314|M.leprae_Br4923 ANSHRRLVETLSKLADSPILV---VNYRLLPKHSIGMALDDCHDGYQWLR
TH_1370|M.thermoresistible__bu AHTHGRLVTALSEFADSPVLV---VNYRMIPKHSVGTAIDDCYDGYQWLR
Mflv_4608|M.gilvum_PYR-GCK DTPVTTGIQLLAKANLRRQVSDTWLRRQLTPNFRAGCKRMLMSSDYYPAL
Mvan_1519|M.vanbaalenii_PYR-1 NTPMSGLVARLGKAHLRQQVKDPWMRRQLTPDFTPGCKRMLISSDYYPAL
MSMEG_2310|M.smegmatis_MC2_155 EPRLLKIGEWMGRYNINRSIKDPELRRKLTPSYRAGCKRILNSDTYYRGI
:. . : :: * . :
Mb2406|M.bovis_AF2122/97 HVCGLAAEHMVIAADSAGGHLTVDMLLQ-PEVAARPPAAVVLFS----PL
Rv2385|M.tuberculosis_H37Rv HVCGLAAEHMVIAADSAGGHLTVDMLLQ-PEVAARPPAAVVLFS----PL
MMAR_3699|M.marinum_M GACGLSPERMVVVADSAGGHLSVDLLLQ-PDVAARPPASLVLFS----PL
MUL_3642|M.ulcerans_Agy99 GACGLSPERMVVVADSAGGHLSVDLLLQ-PDVAARPPASLVLFS----PL
MAV_1798|M.avium_104 NTCGVPPEQMVIAGDSAGGHLSVDLLLQ-PGVEH--PAAMVLFS----PL
MAB_4052c|M.abscessus_ATCC_199 ST-GHAAKDIVIAADSAGGHLAVDLIAENHRMGVAQPGALVLFS----PL
MLBr_00314|M.leprae_Br4923 RL-GYDPEQIVLAGDSAGGYLALALAQR-LQDVGEEPAALVAIS----PL
TH_1370|M.thermoresistible__bu AK-GYEPDQIVLAGDSAGGYLALSLAQR-LLDEGEEPAALVALS----PL
Mflv_4608|M.gilvum_PYR-GCK QRDNCKLVSWPIATLSPNGIRTADGIEHELDCIVFATGFDVCKAGTPFPI
Mvan_1519|M.vanbaalenii_PYR-1 QRDNCKLIDWPIATLSPAGIRTSDGVEHHLDAIVFATGYDVHLSGPPFPV
MSMEG_2310|M.smegmatis_MC2_155 ADPKTQVITEGIARMTPTGIVTNDGVEHPVDIVVYATGFHVTDSYTYVDI
:. :. * : . .. * : :
Mb2406|M.bovis_AF2122/97 IDLTFRLGASRELQRPDPVVRADRAARSVALYYTGVDPAHHRLALDVAGG
Rv2385|M.tuberculosis_H37Rv IDLTFRLGASRELQRPDPVVRADRAARSVALYYTGVDPAHHRLALDVAGG
MMAR_3699|M.marinum_M IDLTFGLSAARERTKPDPAVRAATAARVVGLYHAGIDPTHHRLSLDVAGG
MUL_3642|M.ulcerans_Agy99 IDLTFGLSAARERTKPDPAVRAATAARVVGLYHAGIDPTHHRLSLDVAGG
MAV_1798|M.avium_104 YDLTFELAKARERIRPDPATRAANAIRLVGLYHSGVDLTHERLTLDVARG
MAB_4052c|M.abscessus_ATCC_199 ADLTLGLSAERERDAPDPIISAAAARRLVDCYTAAQPVDSPRLRLALGPG
MLBr_00314|M.leprae_Br4923 LQLAKKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYE
TH_1370|M.thermoresistible__bu FEIDNESRAQHPNIRTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYE
Mflv_4608|M.gilvum_PYR-GCK RGAHGRELSDEWSQ-GAYAYRSVTVAGYPNLFFTFGPNSGPGHNSALVYM
Mvan_1519|M.vanbaalenii_PYR-1 AGLNGRSLQQEWAG-HAEAYKSASAHGYPNLFFMTGPNSGPGHNSLLVYV
MSMEG_2310|M.smegmatis_MC2_155 KGAGGEDLVDRWNREGIQAHRGVAVAGMPNLFFLLGPNTALGHNSVVFMI
.
Mb2406|M.bovis_AF2122/97 ------PPLPPTLIQVGGAEILEADARQLDADIRAAGGICELQVWPDQMH
Rv2385|M.tuberculosis_H37Rv ------PPLPPTLIQVGGAEILEADARQLDADIRAAGGICELQVWPDQMH
MMAR_3699|M.marinum_M ------SPLPSTLIQAGAAEMLEADARQLAADIRTAGGRCELQVWPDQMH
MUL_3642|M.ulcerans_Agy99 ------SPLPSTLIQAGAAEMLEADARQLAADIRTAGGRCELQVWPDQMH
MAV_1798|M.avium_104 ------PVLPPTLIQAGGAEMLQADAHQLAADIRTAGGRCELQIWPHQVH
MAB_4052c|M.abscessus_ATCC_199 ------VMLPPTLIQVGGREMMVADAEHLELMITRAGGACELQVWPGQVH
MLBr_00314|M.leprae_Br4923 PLDHIAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVH
TH_1370|M.thermoresistible__bu PLDNIEPGLPRTLIHVSGSEALISDARKAARRLAAAGVPVEIRVWPGQMH
Mflv_4608|M.gilvum_PYR-GCK EAEINYIVKAIGAIIANDLSTLEVREDRQNNYHGEVQQRLGSTTWNSG-C
Mvan_1519|M.vanbaalenii_PYR-1 EGQIAYAVDAITTILNRNLRYLDVRADVQQRHNAQIQRRLTKTTWMSG-C
MSMEG_2310|M.smegmatis_MC2_155 EQQIRYVGQAIAAVDKAGAAALAPTRRAQDAFNAELQRDLSGTVFNTGGC
. : : :
Mb2406|M.bovis_AF2122/97 VFQALPRMTPEAAKAMTYVAQFIR---STTARGDL---------------
Rv2385|M.tuberculosis_H37Rv VFQALPRMTPEAAKAMTYVAQFIR---STTARGDL---------------
MMAR_3699|M.marinum_M VFQALPRMTPEAAKAMAYASAFIAGSLQDNATAEAV--------------
MUL_3642|M.ulcerans_Agy99 VFQALPRMTPEAAKAMAYASAFIAGSLQDNATAEAV--------------
MAV_1798|M.avium_104 VFQALPRMTPEAAKAMAYVARFITHALQDARALTQEVH------------
MAB_4052c|M.abscessus_ATCC_199 VFQALPRFSSEATAAVREAARFITATLAARSELTAEQSA-----------
MLBr_00314|M.leprae_Br4923 VFQAAAPMVPEATLSLRQISQYIREATASKASRDRQSL------------
TH_1370|M.thermoresistible__bu VFQIAAPFVPEAKRSLRQIGEYIREATW----------------------
Mflv_4608|M.gilvum_PYR-GCK KSWYLTNDGYNGTMYPGFATQFKRALSKVDMGDYVTTPTTARTEHHPTEH
Mvan_1519|M.vanbaalenii_PYR-1 HSWYLTADGFNASMYPGFATQYRRQM-QFRAEDYTAVA------------
MSMEG_2310|M.smegmatis_MC2_155 KSWYLDEHGVNRTLWSGMTWQYWKALRRLDPSEFEFLDQRVLARS-----
: :
Mb2406|M.bovis_AF2122/97 --------------------------------------------------
Rv2385|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3699|M.marinum_M --------------------------------------------------
MUL_3642|M.ulcerans_Agy99 --------------------------------------------------
MAV_1798|M.avium_104 --------------------------------------------------
MAB_4052c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
Mflv_4608|M.gilvum_PYR-GCK AQNGSNVAKVAQGRKAKVAQGRKSAGALPTRSDVKADILDVGVGKVPPKR
Mvan_1519|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2310|M.smegmatis_MC2_155 --------------------------------------------------
Mb2406|M.bovis_AF2122/97 ---------
Rv2385|M.tuberculosis_H37Rv ---------
MMAR_3699|M.marinum_M ---------
MUL_3642|M.ulcerans_Agy99 ---------
MAV_1798|M.avium_104 ---------
MAB_4052c|M.abscessus_ATCC_199 ---------
MLBr_00314|M.leprae_Br4923 ---------
TH_1370|M.thermoresistible__bu ---------
Mflv_4608|M.gilvum_PYR-GCK AASRVRKDA
Mvan_1519|M.vanbaalenii_PYR-1 ---------
MSMEG_2310|M.smegmatis_MC2_155 ---------