For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
KRIVVVGGGIAGVSTVGGLRANGYDGDITMIDAGGSPYDRPPLSKDYLSGKVKLADIELRPEQWYRDQQV RLISESTVAVLRPALGAVETADGTLLAADRVVLATGGGAARPPIPGSENAAIHVLRDVADAQRLRDGLRS GVRVLIVGAGLVGAEIASTAVDLGCSVVLVDPVRPPLVAAVGADMADWLHHKHRERGVVTLQAGVEAFHQ RIGEIEVSLQGEYRPQVADVVVLAVGMVPRTSLATAAGLEVDGAVVVDVRQLTSNPAILAVGDVARIRKD GRLLARSEHWDGAGASGGRAAATLMGADPPPASAPWFWTDRHGDHVEAVGQMSGADHTVLRGDVGDPGFA VFGLRDGALVGAASVNQPNIVRAARRLIDRGVQLTAEVLGDPHSDLRELLKQQRSVRISGRGED*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4368c | - | - | 100% (415) | putative rubredoxin/ferredoxin reductase |
| M. abscessus ATCC 19977 | MAB_2047c | - | 4e-59 | 36.83% (391) | ferredoxin reductase |
| M. abscessus ATCC 19977 | MAB_3838c | - | 8e-48 | 34.01% (394) | putative ferredoxin reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1900c | - | 6e-58 | 36.23% (403) | reductase |
| M. gilvum PYR-GCK | Mflv_4591 | - | 1e-54 | 34.18% (392) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
| M. tuberculosis H37Rv | Rv1869c | - | 6e-58 | 36.23% (403) | reductase |
| M. leprae Br4923 | MLBr_02387 | lpd | 4e-05 | 26.09% (138) | dihydrolipoamide dehydrogenase |
| M. marinum M | MMAR_3153 | - | 5e-56 | 35.29% (391) | ferredoxin reductase |
| M. avium 104 | MAV_2849 | - | 2e-61 | 37.56% (402) | anthranilate dioxygenase reductase |
| M. smegmatis MC2 155 | MSMEG_1460 | - | 9e-61 | 36.63% (404) | pyridine nucleotide-disulphide oxidoreductase |
| M. thermoresistible (build 8) | TH_3739 | - | 3e-50 | 33.50% (391) | PUTATIVE Pyridine nucleotide-disulphide oxidoreductase |
| M. ulcerans Agy99 | MUL_0769 | - | 9e-51 | 33.09% (414) | ferredoxin reductase |
| M. vanbaalenii PYR-1 | Mvan_1327 | - | 6e-64 | 36.79% (405) | FAD-dependent pyridine nucleotide-disulphide oxidoreductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4591|M.gilvum_PYR-GCK ------------------MTLHRAVIVGASHAGAQLAASLRQEGWDGEIV
MMAR_3153|M.marinum_M ------------------MTVQRAVIAGASHAGTQLAASLRREGWDGEIV
Mb1900c|M.bovis_AF2122/97 -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
Rv1869c|M.tuberculosis_H37Rv -----------------MASSTTFVIVGGGLAGAKAVEALRRSDFGGRII
MAV_2849|M.avium_104 -----------------MASATGFVIIGGGLAAAKAVEALRDNNFDGRII
MAB_4368c|M.abscessus_ATCC_199 --------------------MKRIVVVGGGIAGVSTVGGLRANGYDGDIT
TH_3739|M.thermoresistible__bu -----------------VSTTAGIIIVGGGLAAARTAEQLRRSEFGGPIT
MUL_0769|M.ulcerans_Agy99 MYEHHVTSSEGVTQDPGATAANGIVIIGGGLAAARTAEQLRRAGYEGQLT
MSMEG_1460|M.smegmatis_MC2_155 ------------------MTDRTFVTVGAGQTAAVAARTLRRRGFDGRII
Mvan_1327|M.vanbaalenii_PYR-1 ------------------MSRRTFVTVGAGQTAAVAARNLRRHGFDGRIV
MLBr_02387|M.leprae_Br4923 ------------------MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVV
: *.. . . :
Mflv_4591|M.gilvum_PYR-GCK LVGNESALPYHRPPLSKAYLAGKCTVDELAIRNAEFYTKQ-RIKL-MDAT
MMAR_3153|M.marinum_M LVGDESALPYQRPPLSKSYLADKCELAELAIRNSDFYAKQ-RIRL-LDAT
Mb1900c|M.bovis_AF2122/97 LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSDWYRDH-DVDVRLGVR
Rv1869c|M.tuberculosis_H37Rv LFGDEEHLPYDRPPLSKEFLAGKKSLSDFTIQTSDWYRDH-DVDVRLGVR
MAV_2849|M.avium_104 VFADEEHLPYERPPLSKEFLAGKKSLTDFTVQNSDWYRDN-DVDLRLNTR
MAB_4368c|M.abscessus_ATCC_199 MI-DAGGSPYDRPPLSKDYLSGKVKLADIELRPEQWYRDQ-QVRLISEST
TH_3739|M.thermoresistible__bu IVSDEDHLPYDRPPLSKDVLSG--KTDDVTLKPAEFYAEN-DITLLLGTA
MUL_0769|M.ulcerans_Agy99 IVSDEVHLPYDRPPLSKEVLRS--EVDDVSLKPREWYDEK-GITLRLGSA
MSMEG_1460|M.smegmatis_MC2_155 LVGDEPHAPYQRPPLSKEFLCDTAASDDLWILPEKWCADN-GVEIRTGAE
Mvan_1327|M.vanbaalenii_PYR-1 LIGDEPHPPYQRPPLSKEFLAGTENEEGLWILPPKWLQDN-DVEIITDTT
MLBr_02387|M.leprae_Br4923 EPKYWGGICLNVGCIPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIA
. :.. * . . .
Mflv_4591|M.gilvum_PYR-GCK VEVLDRSAGHLSLTTGDALPYDKLALCTGA----RPRRLSIPGADLPGVC
MMAR_3153|M.marinum_M VAAVDRSAGHVVLSTGDALPYDKLALCTGA----RPRRLPTPGADLAGVF
Mb1900c|M.bovis_AF2122/97 VSSLDRSAHTVELPDGAAVRYDKLLLATGS----APRRPPIPGSDAAGVH
Rv1869c|M.tuberculosis_H37Rv VSSLDRSAHTVELPDGAAVRYDKLLLATGS----APRRPPIPGSDAAGVH
MAV_2849|M.avium_104 VCALDAAGHTVGLPDGTTVAYDKLLLATGS----AARRPPIPGSDCAGVH
MAB_4368c|M.abscessus_ATCC_199 VAVLRPALGAVETADGTLLAADRVVLATGG----GAARPPIPGSENAAIH
TH_3739|M.thermoresistible__bu ATALDPQARKLTLADGRALEYDELIIATGL----VPKRIPT-LPDLEGIR
MUL_0769|M.ulcerans_Agy99 ATGLDTAAQTVTLADGTVLGYDELVIATGL----VPRRIPA-FPELEGIR
MSMEG_1460|M.smegmatis_MC2_155 VTRVDAATGTVEIAGQAPVRADAVLFATGG----RPRRLPVPGPRPELVH
Mvan_1327|M.vanbaalenii_PYR-1 VVRVDAAARAVEFSGGAGLQADSVLFATGG----APRRLPVDGPRPDLVH
MLBr_02387|M.leprae_Br4923 YDRSRKVSEGRVAGVHFLMKKNKITEIHGYGRFTDANTLSVELSEGVPET
: : : * . . .
Mflv_4591|M.gilvum_PYR-GCK YLRTAADVAMIRERTSP------------------------GRRAVIVGG
MMAR_3153|M.marinum_M YLRTAADGEMIREAAGP------------------------GRRAVIVGG
Mb1900c|M.bovis_AF2122/97 YLRSYNDAVALNSVLVQ------------------------GSSLAVVGA
Rv1869c|M.tuberculosis_H37Rv YLRSYNDAVALNSVLVQ------------------------GSSLAVVGA
MAV_2849|M.avium_104 YLRTYEVAVALNSFLGE------------------------GKSLAVVGA
MAB_4368c|M.abscessus_ATCC_199 VLRDVADAQRLRDGLRS------------------------GVRVLIVGA
TH_3739|M.thermoresistible__bu VLRTYDESMALRKHAGS------------------------ARNAVVIGA
MUL_0769|M.ulcerans_Agy99 VLRSFDECMALRSHASA------------------------AKRAVVIGA
MSMEG_1460|M.smegmatis_MC2_155 YLRTLDDARRLHDALAS------------------------GCRLGVIGA
Mvan_1327|M.vanbaalenii_PYR-1 YLRTLDDAARLAPVLTP------------------------GRRLAIIGA
MLBr_02387|M.leprae_Br4923 PLKVTFNNVIIATGSKTRLVPGTLLSTNVITYEEQILTRELPDSIVIVGA
*: : ::*.
Mflv_4591|M.gilvum_PYR-GCK GYIGLEAAASLRALGLEVTVLEATERVLERVTAPAVSAFFDRIHREEGVD
MMAR_3153|M.marinum_M GYIGLETAASLRALGLEVTLLEATGRVLERVTAPEVSEFFDRIHREEGVN
Mb1900c|M.bovis_AF2122/97 GWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVD
Rv1869c|M.tuberculosis_H37Rv GWIGLEVAASARQRGVDVTVVETAIQPLLAALGEAVGKVFADLHRDQGVD
MAV_2849|M.avium_104 GWIGLEVAAAARQRGVEVTVVEAARQPLTAALGETVGEVFATLHREHGVD
MAB_4368c|M.abscessus_ATCC_199 GLVGAEIASTAVDLGCSVVLVDPVRPPLVAAVGADMADWLHHKHRERGV-
TH_3739|M.thermoresistible__bu GFIGCEVAASLRGLGVHVVLVEPQPTPLAGVLGEQIGALVARLHRDEGVD
MUL_0769|M.ulcerans_Agy99 GFIGCEVAASLRGLGVEVVLVEPQPTPLAAVLGEQIGELVARLHRSEGVD
MSMEG_1460|M.smegmatis_MC2_155 GFVGLEIAATAVGLGASVTVLEAAPMPLGTVVGSRVAAEIVRLHRGNGVE
Mvan_1327|M.vanbaalenii_PYR-1 GFIGLEIAATAAAAGVEVTVLEAVPVPLARVVGPAMGEAVCRLHRDNGVD
MLBr_02387|M.leprae_Br4923 GAIGIEFGYVLKNYGVDVTIVEFLPRAMPNED-AEVSKEIEKQFKKMGIK
* :* * . * *.::: : :. . .: *:
Mflv_4591|M.gilvum_PYR-GCK IQTDALVDAMSGDGRVREVILASG---ESIPADLVIVGIGVEPNTD---L
MMAR_3153|M.marinum_M IRTGTLVEALSGDGRVREVILAGG---ESIPADLVIVGIGVEPNTE---L
Mb1900c|M.bovis_AF2122/97 LRLQTQLEEITAADGKATGLKMRD--GSTVAADAVLVAVGAKPNVE---L
Rv1869c|M.tuberculosis_H37Rv LRLQTQLEEITAADGKATGLKMRD--GSTVAADAVLVAVGAKPNVE---L
MAV_2849|M.avium_104 LRLETQVREITRADGSATGLRTTD--GSAIPADAVLVAVGARPNIE---L
MAB_4368c|M.abscessus_ATCC_199 VTLQAGVEAFHQRIGEIEVSLQGE--YRPQVADVVVLAVGMVPRTS---L
TH_3739|M.thermoresistible__bu LRCGVGVADVRGTGAVEKVVLDDG---TELDADLVVVGIGSTPATD---W
MUL_0769|M.ulcerans_Agy99 VRTGVGVAEVRGDGHVDTVVLADG---TQLDADLVVVGIGSHPATG---W
MSMEG_1460|M.smegmatis_MC2_155 LLTGVAVNGVR--TDADGVVVSTG--AQDLRFDAVVIGIGITPNTA---V
Mvan_1327|M.vanbaalenii_PYR-1 IRAGVQLAGVR--TAADGVVIDIAGAAAPLEADAVVVGIGIIPNTA---V
MLBr_02387|M.leprae_Br4923 ILTGTKVESISDNGSHVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGL
: . : . * *: .:* *
Mflv_4591|M.gilvum_PYR-GCK AAAAGLAI-DNGVVIDDQARTTDPDIVAAGDCTSH----HMARYGRRIRL
MMAR_3153|M.marinum_M AATAGLVV-DNGVVIDDQARTSDPDIVAAGDCASH----DMARYGRRIRL
Mb1900c|M.bovis_AF2122/97 AQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAA----EHPLLGTRVRT
Rv1869c|M.tuberculosis_H37Rv AQQAGLAMGEGGVLVDASLRTSDPDIYAVGDIAAA----EHPLLGTRVRT
MAV_2849|M.avium_104 AEAAGLSLADGGVLVDASLRTSDPDIYAVGDIAAA----EHPLLRTRIRT
MAB_4368c|M.abscessus_ATCC_199 ATAAGLEV-DGAVVVDVRQLTSNPAILAVGDVARI----RKDGR-LLARS
TH_3739|M.thermoresistible__bu LQGSGVEV-DNGVVCDAVGRTNVEHVWAIGDVAS-----WRNTVGKQVRV
MUL_0769|M.ulcerans_Agy99 LDGSGIAV-DNGVVCDAAGRTSAPNVWAFGDVAS-----WRDQMGHQVRV
MSMEG_1460|M.smegmatis_MC2_155 AEVSGLAV-DDGIVVDAQGRASVPNIYAAGDVARR----YSERAGKHVRI
Mvan_1327|M.vanbaalenii_PYR-1 AAASGLWV-DDGIVVDALGRTAVPGVFAAGDAARR----YSPRAGRHLRL
MLBr_02387|M.leprae_Br4923 DKVGVALTADKAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAA
. : .: * : : * ** :
Mflv_4591|M.gilvum_PYR-GCK ESVPGAGEQAKVAAATICGKSKKVAA-LPWFWSDQYDVK---LQIAGLNT
MMAR_3153|M.marinum_M ESVPSAAEQAKVAAATVCGKSKKIAA-LPWFWSDQYDLK---LQIAGLNT
Mb1900c|M.bovis_AF2122/97 EHWANALKQPAVAAAGMLGRPGEYAE-LPYLFTDQYDLG---MEYVGHAP
Rv1869c|M.tuberculosis_H37Rv EHWANALKQPAVAAAGMLGRPGEYAE-LPYLFTDQYDLG---MEYVGHAP
MAV_2849|M.avium_104 EHWANALKQPAIAVAGMLGRPGEYDE-LPYFFTDQYDLG---MEYVGHAP
MAB_4368c|M.abscessus_ATCC_199 EHWDGAGASGGRAAATLMGADPPPAS-APWFWTDRHGDH---VEAVGQMS
TH_3739|M.thermoresistible__bu EHWSNVADQARVLVPALLGQEVPVAATVPYFWSDQYDVK---IQCLGEPE
MUL_0769|M.ulcerans_Agy99 EHWSNVADQARVVVPAMLGREVSSNVVVPYFWSDQYDVK---IQCLGEPH
MSMEG_1460|M.smegmatis_MC2_155 EHFDNANRQGAAVANAMLGRDAVNDD-APWFWSDQYEHN---LQLLGEAT
Mvan_1327|M.vanbaalenii_PYR-1 EHFDNASRQGVAVANAMLGREAPSDD-PLWFWSDQYGRN---IQFVGTAS
MLBr_02387|M.leprae_Br4923 EAIAGAETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFP
* .. : : ::: .
Mflv_4591|M.gilvum_PYR-GCK GYDEVVLSGDPTRDRDFTCFYLR-AGELIAADCINRPRDFVFSKRVITQQ
MMAR_3153|M.marinum_M GYDEVVLSGDPTRERDFTCFYLR-AGELLAADCINRPRDFMFSKRVITQQ
Mb1900c|M.bovis_AF2122/97 SCDRVVFRGN-VAGREFLSFWLDGDSRVLAGMNVNVWDVVDDVKGLIRSG
Rv1869c|M.tuberculosis_H37Rv SCDRVVFRGN-VAGREFLSFWLDGDSRVLAGMNVNVWDVVDDVKGLIRSG
MAV_2849|M.avium_104 RFERVVFRGD-VAAREFVAFWLDADDRVLAGMNVNIWDVLDDVKALIRSR
MAB_4368c|M.abscessus_ATCC_199 GADHTVLRGD-VGDPGFAVFGLR-DGALVGAASVNQPNIVRAARRLIDRG
TH_3739|M.thermoresistible__bu AGD--TVHVV-SDDGRKFLAYYERDGVLTGVVGGGMPGKVMKARAKIAAG
MUL_0769|M.ulcerans_Agy99 STD--VVHLV-EDDGRKLLAYYQRDGVLVGVVGGGVPGKVMKVRAKIAAA
MSMEG_1460|M.smegmatis_MC2_155 GNL--VIRGD-VGEFEFTAFYVDTDDTLRGVFTVDRGEDVMVGRELLGRR
Mvan_1327|M.vanbaalenii_PYR-1 GTP--VIRGN-RDEFDFTGFYLEN-DTVCGAFAIDRGEDVTAARELLGRG
MLBr_02387|M.leprae_Br4923 FTANAKAHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQK
. : . . . :
Mflv_4591|M.gilvum_PYR-GCK VPIERAELMLAGPA------------------------------------
MMAR_3153|M.marinum_M VAVERAELVLAGSD------------------------------------
Mb1900c|M.bovis_AF2122/97 NPVDVDRLVDPQWPLADLTTN-----------------------------
Rv1869c|M.tuberculosis_H37Rv NPVDVDRLVDPQWPLADLTTN-----------------------------
MAV_2849|M.avium_104 APIDADRLGDPGAPLGELLG------------------------------
MAB_4368c|M.abscessus_ATCC_199 VQLTAEVLGDPHSDLRELLKQQRSVRISGRGED-----------------
TH_3739|M.thermoresistible__bu --APISEVLE----------------------------------------
MUL_0769|M.ulcerans_Agy99 --VPISEMLDESQGQTSARIPARGAGPGGPLVRWPTLTKSGRWRAEKATA
MSMEG_1460|M.smegmatis_MC2_155 --IPRAVLEDDDADLWELVDTEEVAQ------------------------
Mvan_1327|M.vanbaalenii_PYR-1 --VDAAALLDEDTDLWDLVYADEDEQVRA---------------------
MLBr_02387|M.leprae_Br4923 WDLTATELVRNVHTHPTLSEALQECFHGLIGHMINF--------------
:
Mflv_4591|M.gilvum_PYR-GCK ----------------------------
MMAR_3153|M.marinum_M ----------------------------
Mb1900c|M.bovis_AF2122/97 ----------------------------
Rv1869c|M.tuberculosis_H37Rv ----------------------------
MAV_2849|M.avium_104 ----------------------------
MAB_4368c|M.abscessus_ATCC_199 ----------------------------
TH_3739|M.thermoresistible__bu ----------------------------
MUL_0769|M.ulcerans_Agy99 SSPVARVDGIGLEPGPRRTASWPDVPGT
MSMEG_1460|M.smegmatis_MC2_155 ----------------------------
Mvan_1327|M.vanbaalenii_PYR-1 ----------------------------
MLBr_02387|M.leprae_Br4923 ----------------------------