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MGRGLPVFLAVVLLSAGCSTGGLADLPLPAPGLGAGGYRLTAVFANALNLPERAKVKLAGADIGEVESMA AVDFRAVTTLRIRHDVTLTAGSTAQLRTATPLGDVFVAITPPDQPGTGMLADGDTIPIDQTGAAATVESV LSSAAILVNGGAVHNLTNVVNGTGRAAGQDGQAFGRMIGKSNELLGKLNARSGQLDAAMTETAQLARALD GKSAQLGQVLHAAAPATATLQENAGQISDLVLLLGDTARELGKFPSIAGTDTSGRSVVADANAISRSWND VVLDPETSLLSLNRLYAPFIKITAGSAISGRAGIDRLVLGAIPDAGFGGDPGFHGPKRYDWAKFVGTIKY SLWRLQERVVGQGPAAQGFGVQGPTR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1699 | - | - | 100% (376) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4564c | - | e-128 | 63.64% (363) | putative Mce family protein |
| M. abscessus ATCC 19977 | MAB_4512c | - | e-123 | 59.78% (368) | putative Mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3525c | lprN | 5e-23 | 29.07% (313) | MCE-family lipoprotein LprN |
| M. gilvum PYR-GCK | Mflv_0006 | - | 1e-126 | 63.54% (362) | hypothetical protein Mflv_0006 |
| M. tuberculosis H37Rv | Rv3495c | lprN | 5e-23 | 29.07% (313) | MCE-family lipoprotein LprN |
| M. leprae Br4923 | MLBr_02593 | lprK | 4e-22 | 24.90% (257) | putative lipoprotein |
| M. marinum M | MMAR_0181 | mce6E | 1e-139 | 68.16% (358) | MCE family lipoprotein Mce6E |
| M. avium 104 | MAV_0106 | - | 1e-122 | 61.52% (369) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1147 | - | 1e-124 | 61.90% (357) | mce related protein |
| M. thermoresistible (build 8) | TH_4097 | - | 1e-121 | 61.26% (364) | PUTATIVE mce related protein |
| M. ulcerans Agy99 | MUL_4915 | mce6E | 1e-139 | 67.88% (358) | MCE family lipoprotein Mce6E |
| M. vanbaalenii PYR-1 | Mvan_0963 | - | 1e-124 | 61.64% (365) | hypothetical protein Mvan_0963 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0181|M.marinum_M --------MIRRLSGRPRWRLGILATVLATTACSTNGLADLPLP-APGLG
MUL_4915|M.ulcerans_Agy99 --------MIRRLSGRPRWRLGILTTVLATTACSTNGLADLPLP-APGLG
MAB_1699|M.abscessus_ATCC_1997 --------MGRGLP-------VFLAVVLLSAGCSTGGLADLPLP-APGLG
Mflv_0006|M.gilvum_PYR-GCK ----------MMTRRAATALAVAMTTCLSVTSCATEGLSSLPLP-APGGG
Mvan_0963|M.vanbaalenii_PYR-1 -----------MAIRAKGLMALLVTTSLSVSACATEGLASLPLP-APSGG
MSMEG_1147|M.smegmatis_MC2_155 -----MMAASPKRLRKVRLVAAFAMT-VIVSGCATNGLADLPLP-APGVG
TH_4097|M.thermoresistible__bu --------MSVLRLR--RLVPALVTVGCLVSGCATNGLADLPLP-APGVG
MAV_0106|M.avium_104 -----------MKAGKRKALAVACSAVMASSGCATNGLASLPLP-APGIG
Mb3525c|M.bovis_AF2122/97 ------------MNRIWLRAIILTASSALLAGCQFGGLNSLPLPGTAGHG
Rv3495c|M.tuberculosis_H37Rv ------------MNRIWLRAIILTASSALLAGCQFGGLNSLPLPGTAGHG
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVRHQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGSG
:.* *: .:.:* .. *
MMAR_0181|M.marinum_M SGGYRITAIFANALNLNEHAKVKLGGADIGLVESMTAR-----DFNAVTT
MUL_4915|M.ulcerans_Agy99 SGGYRITAIFANALNLNEHAKVKLGGADIGLVESMTAR-----DFNAVTT
MAB_1699|M.abscessus_ATCC_1997 AGGYRLTAVFANALNLPERAKVKLAGADIGEVESMAAV-----DFRAVTT
Mflv_0006|M.gilvum_PYR-GCK SGGYTLTAVFSNALNLPAMAKVKLAGADIGQLESMQAR-----DYTAVTT
Mvan_0963|M.vanbaalenii_PYR-1 SGGYTLTAVFSNALNVPMMAKVKLAGADVGELESMQAR-----DYTAVTT
MSMEG_1147|M.smegmatis_MC2_155 SGGYRITAIFSNALNLPANAKVKLAGADIGEMDSMVAR-----NYTAVTT
TH_4097|M.thermoresistible__bu SGGYRLTAEFTNALNLPANAKVKLAGADVGEVESMVAR-----DYLAVTT
MAV_0106|M.avium_104 SGGYLLNAVFSNALNLPAHAKVKLAGADVGQLESMVAR-----NYTAVTT
Mb3525c|M.bovis_AF2122/97 EGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVK
Rv3495c|M.tuberculosis_H37Rv EGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVK
MLBr_02593|M.leprae_Br4923 KGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLK-----NWVATLT
*.* : . ..:. : : * : .. :* : .: .: *. .
MMAR_0181|M.marinum_M LRIRSDVRVPVGSGAELRTATPLGDVFVSIVPPSQRAADTPTLQDGDTIA
MUL_4915|M.ulcerans_Agy99 LRIRSDVRVPVGSGAELRTATPLGDVFVSIVPPSQRAADTPTLQDGDTIA
MAB_1699|M.abscessus_ATCC_1997 LRIRHDVTLTAGSTAQLRTATPLGDVFVAITPPDQ--PGTGMLADGDTIP
Mflv_0006|M.gilvum_PYR-GCK LRIREGVLLPVGSTAELRSATPLGDVFVSIKPPPSAGQGTPLLTDGDTIG
Mvan_0963|M.vanbaalenii_PYR-1 LRIREGVQLPKGSTAELRSATPLGDVFIAIKPPPSVQPGAALLRDGDTIG
MSMEG_1147|M.smegmatis_MC2_155 LRIMEGVRLPEGSTAELRSATPLGDVFIAIKPPAPVEPGTPLLKDGDTID
TH_4097|M.thermoresistible__bu LRIMDGVRLPRGSTAELRSATPLGDVFVAIKPPIDVPPDTPMLRDGDTIG
MAV_0106|M.avium_104 LRIMDGVRVPVGSTAELRSATPLGDVFVAIKPPVPADPSAPLLKAGDTIG
Mb3525c|M.bovis_AF2122/97 LDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDR-PPTGRLVDGSRIT
Rv3495c|M.tuberculosis_H37Rv LDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDR-PPTGRLVDGSRIT
MLBr_02593|M.leprae_Br4923 LGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN--PSLELLKNGDTIP
* : .* :. .: *:: :: **. .: : .* * *. *
MMAR_0181|M.marinum_M LNKTATAATVESVLSSAAILINGGVAHNLTNVINGLGKAAGNDGEVYGEL
MUL_4915|M.ulcerans_Agy99 LNKTATAATVESVLSSAAILINGGVAHNLTNVINGLGKAAGNDGEVYGEL
MAB_1699|M.abscessus_ATCC_1997 IDQTGAAATVESVLSSAAILVNGGAVHNLTNVVNGTGRAAGQDGQAFGRM
Mflv_0006|M.gilvum_PYR-GCK LESTTAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGQAFGEL
Mvan_0963|M.vanbaalenii_PYR-1 LESTTAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGRAFGDL
MSMEG_1147|M.smegmatis_MC2_155 LDATAAAATVESVLSSAAILVNGGAVRNFTNLINGMGKATGDQGQAFGNL
TH_4097|M.thermoresistible__bu KDSTKAAATVESVLASAAILVNGGAVRNFTNIINGLGKATGDEGQAFGNL
MAV_0106|M.avium_104 LPATRAAATVESVLSSAALLVNGGAVRNFTNIVNGAGKATGDQGRAFGDL
Mb3525c|M.bovis_AF2122/97 EANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFVNL
Rv3495c|M.tuberculosis_H37Rv EANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFVNL
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
: .*.*..::: .:::. * : : : . :
MMAR_0181|M.marinum_M IRKSNELLGKLDARTGQLEDAMSQTEHLAAELDRKREVIAELLQATDPAT
MUL_4915|M.ulcerans_Agy99 IRKSNELLGKLDARTGQLEDAMSQTEHLAAELDRKREVIAELLQATDPAT
MAB_1699|M.abscessus_ATCC_1997 IGKSNELLGKLNARSGQLDAAMTETAQLARALDGKSAQLGQVLHAAAPAT
Mflv_0006|M.gilvum_PYR-GCK IRKTNHTLGTLNGRSEEIKTALTETSQLAAQLEAKNQSLAEVMDAAAPAT
Mvan_0963|M.vanbaalenii_PYR-1 IRKTNSTLGTMNARSGEISTAITETSRLAAQMEAKNAALGEVMDAAGPAA
MSMEG_1147|M.smegmatis_MC2_155 IRKTNNTLATLTARSEEISTAMTETSRLAQQISAKNQALSDVMAQARPAT
TH_4097|M.thermoresistible__bu VRKTNATLAKLNARSAEISTAMTETSRLASEIAAKNQVLSEVMAEARPAT
MAV_0106|M.avium_104 INRTNSLLTKLNARSDQIDAAVTETAALADRLDAKNQAITDVLRAVGPAT
Mb3525c|M.bovis_AF2122/97 VPRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPDAV
Rv3495c|M.tuberculosis_H37Rv VPRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPDAV
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
: : : : :: *: : : : :
MMAR_0181|M.marinum_M SVLAADASQISDLLLLMGGAATELKKFPSIAGTDSSGRSVIKDANAVAAA
MUL_4915|M.ulcerans_Agy99 SVLAADASQISDLLLLMGGAATELKKFPSIAGTDSSGRSVIKDANAVAAA
MAB_1699|M.abscessus_ATCC_1997 ATLQENAGQISDLVLLLGDTARELGKFPSIAGTDTSGRSVVADANAISRS
Mflv_0006|M.gilvum_PYR-GCK STLAAQTNGIADLVLTVGATTEQLRKFPSIAGTDTSGRSVIADASRIAGA
Mvan_0963|M.vanbaalenii_PYR-1 DTLAAHTDEIADLVQQVGATAELLRRFPSIAGSDTSGRSVIADANQIAGA
MSMEG_1147|M.smegmatis_MC2_155 DTLAAHTTQIADLVTQIGDVSDQLRKFPSIAGADTSGRSVIADANTVAGA
TH_4097|M.thermoresistible__bu DTLAGHATEIADLVERFGGISDQAHRFPSIAGTDTSGRSVIADANTIANA
MAV_0106|M.avium_104 DVLSGNADDIADVVDELGATTRQLSKFPSIAGTDKTGRSVIKDANAIAAA
Mb3525c|M.bovis_AF2122/97 RVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFG--EDLKDLYSIVKA
Rv3495c|M.tuberculosis_H37Rv RVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFG--EDLKDLYSIVKA
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLH--TDLQALACPLRE
: : : . . : : : : :
MMAR_0181|M.marinum_M WNDVALDPDARLSALSNLYAPFVKLTAGTSISGSAGIDRLVLGSIPDIG-
MUL_4915|M.ulcerans_Agy99 WNDVALDPDARLSALSNLYAPFVKLTAGTSISGSAGIDRLVLGSIPDIG-
MAB_1699|M.abscessus_ATCC_1997 WNDVVLDPETSLLSLNRLYAPFIKITAGSAISGRAGIDRLVLGAIPDAG-
Mflv_0006|M.gilvum_PYR-GCK WNDVVLAPGADLYSLNRLMPPFIKSTTSNAIAVRASIDRLVLGSIPDIG-
Mvan_0963|M.vanbaalenii_PYR-1 WNDVVLAPGADLYSLNKLMPPFIKSTTSNAIAVNASIDRLVLGSIPDIG-
MSMEG_1147|M.smegmatis_MC2_155 WNDVALAPDATLYALNRLLPPFIKSMSSGAISLDASVDRLILGSTPDIG-
TH_4097|M.thermoresistible__bu WNDVALAPGATLYALNRLMPPFIKTMSGGSVALDASVDRLVWGHHPDIG-
MAV_0106|M.avium_104 WNDVVLSPDTSLAGLNRLIPPFVKATPSQAISVRGSFDRLVLGSRPGTGA
Mb3525c|M.bovis_AF2122/97 LNDDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLT-LRRIG-
Rv3495c|M.tuberculosis_H37Rv LNDDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLT-LRRIG-
MLBr_02593|M.leprae_Br4923 LGRGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDN-
. : : : .
MMAR_0181|M.marinum_M ----FGGDPGLHGPKRYDWRKFIGSLKFTLWRLQERVVGQGPPQ------
MUL_4915|M.ulcerans_Agy99 ----FGGDPGLHGPKRYDWRKFIGSLKFTLWRLQERVVGQGPPQ------
MAB_1699|M.abscessus_ATCC_1997 ----FGGDPGFHGPKRYDWAKFVGTIKYSLWRLQERVVGQGPAAQGFGVQ
Mflv_0006|M.gilvum_PYR-GCK ----FAGDPGLHGPKRYNWHQLVGSLRYTLLRLQERVVGKGPGVPQMPVI
Mvan_0963|M.vanbaalenii_PYR-1 ----FAGDSGLHGPKRYNWHQLVGSLQYTLYRLQERIVGKGPGVPQVPVM
MSMEG_1147|M.smegmatis_MC2_155 ----FAGDQGLHGPKRHDWHQLVGTLKYTLLRLQERVVGQGPGVPQVPVI
TH_4097|M.thermoresistible__bu ----FAGDPGLHGPKWSDWHQLVGTLQYTLFRLQERVVGKGPDVPQLPVI
MAV_0106|M.avium_104 ETGGFKGDPAFHGPMRRDWNYLIGSIKYVLWRLQERVVGRGPQTPMGQSP
Mb3525c|M.bovis_AF2122/97 ---ETFFTTAYFDPNMAHMDEILNPPDFLIGELAN-LSGQAADPFKIPPG
Rv3495c|M.tuberculosis_H37Rv ---ETFFTTAYFDPNMAHMDEILNPPDFLIGELAN-LSGQAADPFKIPPG
MLBr_02593|M.leprae_Br4923 ---AVLTGTGLSGALRALEQSFGRDPETMIPDVRYTTNPNDAPGGPLVER
. .. : : : . .
MMAR_0181|M.marinum_M ---------------------------------------------
MUL_4915|M.ulcerans_Agy99 ---------------------------------------------
MAB_1699|M.abscessus_ATCC_1997 GPTR-----------------------------------------
Mflv_0006|M.gilvum_PYR-GCK PSPTEPGQWAPAPPPGPVPPGPAP-----------AVAPPAPGVP
Mvan_0963|M.vanbaalenii_PYR-1 PHPTEPGLIVPVPAPAP-PPG--------------APAPEAPR--
MSMEG_1147|M.smegmatis_MC2_155 PSPTEPGEIIVEPGAAAPPEDAPAPEPAPAAQAPAPLPAEAPR--
TH_4097|M.thermoresistible__bu PSPTEPGEIIPAPGPAAG-----------------AAPEEAPR--
MAV_0106|M.avium_104 WTPSGP-PLPPAPAGQAPPD---------------PMVPEPPR--
Mb3525c|M.bovis_AF2122/97 TASGQ----------------------------------------
Rv3495c|M.tuberculosis_H37Rv TASGQ----------------------------------------
MLBr_02593|M.leprae_Br4923 ADRRC----------------------------------------