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IRRLSGRPRWRLGILTTVLATTACSTNGLADLPLPAPGLGSGGYRITAIFANALNLNEHAKVKLGGADIG LVESMTARDFNAVTTLRIRSDVRVPVGSGAELRTATPLGDVFVSIVPPSQRAADTPTLQDGDTIALNKTA TAATVESVLSSAAILINGGVAHNLTNVINGLGKAAGNDGEVYGELIRKSNELLGKLDARTGQLEDAMSQT EHLAAELDRKREVIAELLQATDPATSVLAADASQISDLLLLMGGAATELKKFPSIAGTDSSGRSVIKDAN AVAAAWNDVALDPDARLSALSNLYAPFVKLTAGTSISGSAGIDRLVLGSIPDIGFGGDPGLHGPKRYDWR KFIGSLKFTLWRLQERVVGQGPPQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4915 | mce6E | - | 100% (375) | MCE family lipoprotein Mce6E |
| M. ulcerans Agy99 | MUL_3800 | mce5E | e-117 | 56.37% (369) | Mce family protein, Mce5E |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 9e-21 | 25.23% (321) | MCE family lipoprotein LprM |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 2e-17 | 24.22% (223) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_0006 | - | 1e-126 | 62.29% (358) | hypothetical protein Mflv_0006 |
| M. tuberculosis H37Rv | Rv1970 | lprM | 2e-19 | 24.71% (259) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 1e-18 | 23.45% (226) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_1699 | - | 1e-139 | 67.88% (358) | putative Mce family protein |
| M. marinum M | MMAR_0181 | mce6E | 0.0 | 99.73% (375) | MCE family lipoprotein Mce6E |
| M. avium 104 | MAV_0106 | - | 1e-118 | 58.29% (362) | mce related protein |
| M. smegmatis MC2 155 | MSMEG_1147 | - | 1e-122 | 61.25% (351) | mce related protein |
| M. thermoresistible (build 8) | TH_4097 | - | 1e-121 | 59.33% (359) | PUTATIVE mce related protein |
| M. vanbaalenii PYR-1 | Mvan_0963 | - | 1e-120 | 58.22% (359) | hypothetical protein Mvan_0963 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4915|M.ulcerans_Agy99 ---------MIRRLSGRPRWRLGILTTVLATTACSTNGLADLPLP-APGL
MMAR_0181|M.marinum_M ---------MIRRLSGRPRWRLGILATVLATTACSTNGLADLPLP-APGL
MAB_1699|M.abscessus_ATCC_1997 ---------MGRGLP-------VFLAVVLLSAGCSTGGLADLPLP-APGL
Mflv_0006|M.gilvum_PYR-GCK -----------MMTRRAATALAVAMTTCLSVTSCATEGLSSLPLP-APGG
Mvan_0963|M.vanbaalenii_PYR-1 ------------MAIRAKGLMALLVTTSLSVSACATEGLASLPLP-APSG
MSMEG_1147|M.smegmatis_MC2_155 ------MMAASPKRLRKVRLVAAFAMT-VIVSGCATNGLADLPLP-APGV
TH_4097|M.thermoresistible__bu ---------MSVLRLR--RLVPALVTVGCLVSGCATNGLADLPLP-APGV
MAV_0106|M.avium_104 ------------MKAGKRKALAVACSAVMASSGCATNGLASLPLP-APGI
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
Rv1970|M.tuberculosis_H37Rv -----------------MRIGLTLVMIAAVVASCGWRGLNSLPLPGTQGN
:.*. *: .:.:* .
MUL_4915|M.ulcerans_Agy99 GSGGYRITAIFANALNLNEHAKVKLGGADIGLVESMTARDFNAVTTLRIR
MMAR_0181|M.marinum_M GSGGYRITAIFANALNLNEHAKVKLGGADIGLVESMTARDFNAVTTLRIR
MAB_1699|M.abscessus_ATCC_1997 GAGGYRLTAVFANALNLPERAKVKLAGADIGEVESMAAVDFRAVTTLRIR
Mflv_0006|M.gilvum_PYR-GCK GSGGYTLTAVFSNALNLPAMAKVKLAGADIGQLESMQARDYTAVTTLRIR
Mvan_0963|M.vanbaalenii_PYR-1 GSGGYTLTAVFSNALNVPMMAKVKLAGADVGELESMQARDYTAVTTLRIR
MSMEG_1147|M.smegmatis_MC2_155 GSGGYRITAIFSNALNLPANAKVKLAGADIGEMDSMVARNYTAVTTLRIM
TH_4097|M.thermoresistible__bu GSGGYRLTAEFTNALNLPANAKVKLAGADVGEVESMVARDYLAVTTLRIM
MAV_0106|M.avium_104 GSGGYLLNAVFSNALNLPAHAKVKLAGADVGQLESMVARNYTAVTTLRIM
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKNWVATLTLSLK
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLKNWVATLTLGLN
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQGWHALVTMRLD
* *.: : . ..:. : ::* :... :* : : .: * *: :
MUL_4915|M.ulcerans_Agy99 SDVRVPVGSGAELRTATPLGDVFVSIVPPSQRAADTPTLQDGDTIALNKT
MMAR_0181|M.marinum_M SDVRVPVGSGAELRTATPLGDVFVSIVPPSQRAADTPTLQDGDTIALNKT
MAB_1699|M.abscessus_ATCC_1997 HDVTLTAGSTAQLRTATPLGDVFVAITPPDQ--PGTGMLADGDTIPIDQT
Mflv_0006|M.gilvum_PYR-GCK EGVLLPVGSTAELRSATPLGDVFVSIKPPPSAGQGTPLLTDGDTIGLEST
Mvan_0963|M.vanbaalenii_PYR-1 EGVQLPKGSTAELRSATPLGDVFIAIKPPPSVQPGAALLRDGDTIGLEST
MSMEG_1147|M.smegmatis_MC2_155 EGVRLPEGSTAELRSATPLGDVFIAIKPPAPVEPGTPLLKDGDTIDLDAT
TH_4097|M.thermoresistible__bu DGVRLPRGSTAELRSATPLGDVFVAIKPPIDVPPDTPMLRDGDTIGKDST
MAV_0106|M.avium_104 DGVRVPVGSTAELRSATPLGDVFVAIKPPVPADPSAPLLKAGDTIGLPAT
Mb0179|M.bovis_AF2122/97 KDVTLPKNATAKIGQTSLLGSQHVELAAPP--DPSPVPLKDGDTIPLKRS
MLBr_02593|M.leprae_Br4923 KDVQLPKNTTAKIGQTSLLGSQHVELAAPA--NPSLELLKNGDTIPLKNS
Rv1970|M.tuberculosis_H37Rv GDVDLPANATAKIGTTSLLGSYHIELAPPKG-EARQGKLRDGSLIALSHG
.* :. .: *:: :: **. .: : .* * *. *
MUL_4915|M.ulcerans_Agy99 ATAATVESVLSSAAILINGGVAHNLTNVINGLGKAAGNDGEVYGELIRKS
MMAR_0181|M.marinum_M ATAATVESVLSSAAILINGGVAHNLTNVINGLGKAAGNDGEVYGELIRKS
MAB_1699|M.abscessus_ATCC_1997 GAAATVESVLSSAAILVNGGAVHNLTNVVNGTGRAAGQDGQAFGRMIGKS
Mflv_0006|M.gilvum_PYR-GCK TAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGQAFGELIRKT
Mvan_0963|M.vanbaalenii_PYR-1 TAAATVESVLSSAAILVNGGAVRNFTNIINGLGKATGDQGRAFGDLIRKT
MSMEG_1147|M.smegmatis_MC2_155 AAAATVESVLSSAAILVNGGAVRNFTNLINGMGKATGDQGQAFGNLIRKT
TH_4097|M.thermoresistible__bu KAAATVESVLASAAILVNGGAVRNFTNIINGLGKATGDEGQAFGNLVRKT
MAV_0106|M.avium_104 RAAATVESVLSSAALLVNGGAVRNFTNIVNGAGKATGDQGRAFGDLINRT
Mb0179|M.bovis_AF2122/97 SAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAFLGKL
MLBr_02593|M.leprae_Br4923 SVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAFLTKL
Rv1970|M.tuberculosis_H37Rv SAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGLIGQL
. .:.*..*:: : ::.** :. : : :: :
MUL_4915|M.ulcerans_Agy99 NELLGKLDARTGQLEDAMSQTEHLAAELDRKREVIAELLQATDPATSVLA
MMAR_0181|M.marinum_M NELLGKLDARTGQLEDAMSQTEHLAAELDRKREVIAELLQATDPATSVLA
MAB_1699|M.abscessus_ATCC_1997 NELLGKLNARSGQLDAAMTETAQLARALDGKSAQLGQVLHAAAPATATLQ
Mflv_0006|M.gilvum_PYR-GCK NHTLGTLNGRSEEIKTALTETSQLAAQLEAKNQSLAEVMDAAAPATSTLA
Mvan_0963|M.vanbaalenii_PYR-1 NSTLGTMNARSGEISTAITETSRLAAQMEAKNAALGEVMDAAGPAADTLA
MSMEG_1147|M.smegmatis_MC2_155 NNTLATLTARSEEISTAMTETSRLAQQISAKNQALSDVMAQARPATDTLA
TH_4097|M.thermoresistible__bu NATLAKLNARSAEISTAMTETSRLASEIAAKNQVLSEVMAEARPATDTLA
MAV_0106|M.avium_104 NSLLTKLNARSDQIDAAVTETAALADRLDAKNQAITDVLRAVGPATDVLS
Mb0179|M.bovis_AF2122/97 DTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLIKHFA
MLBr_02593|M.leprae_Br4923 DTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLIKHFA
Rv1970|M.tuberculosis_H37Rv DTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDALAVLA
: : : :: * . * . : : : :
MUL_4915|M.ulcerans_Agy99 ADASQISDLLLLMGGAATELKKFPSIAGTDSSGRSVIKDANAVAAAWNDV
MMAR_0181|M.marinum_M ADASQISDLLLLMGGAATELKKFPSIAGTDSSGRSVIKDANAVAAAWNDV
MAB_1699|M.abscessus_ATCC_1997 ENAGQISDLVLLLGDTARELGKFPSIAGTDTSGRSVVADANAISRSWNDV
Mflv_0006|M.gilvum_PYR-GCK AQTNGIADLVLTVGATTEQLRKFPSIAGTDTSGRSVIADASRIAGAWNDV
Mvan_0963|M.vanbaalenii_PYR-1 AHTDEIADLVQQVGATAELLRRFPSIAGSDTSGRSVIADANQIAGAWNDV
MSMEG_1147|M.smegmatis_MC2_155 AHTTQIADLVTQIGDVSDQLRKFPSIAGADTSGRSVIADANTVAGAWNDV
TH_4097|M.thermoresistible__bu GHATEIADLVERFGGISDQAHRFPSIAGTDTSGRSVIADANTIANAWNDV
MAV_0106|M.avium_104 GNADDIADVVDELGATTRQLSKFPSIAGTDKTGRSVIKDANAIAAAWNDV
Mb0179|M.bovis_AF2122/97 DKQELLINASDAVGRLSQSADQYLSAARGD-----LHQDLQALQCPLKEL
MLBr_02593|M.leprae_Br4923 DTKNLLINAVGSVGQLSQAVDQYLSEARGP-----LHTDLQALACPLREL
Rv1970|M.tuberculosis_H37Rv DERDTLVEAAEQLSKFSALTVDSVNKTTAN-----LVTELRQLGPVLESL
: : .. : . : : : : ..:
MUL_4915|M.ulcerans_Agy99 ALDPDARLSALSNLYAPFVKLTAGTSISGSAGIDRLVLGSIPDIG-----
MMAR_0181|M.marinum_M ALDPDARLSALSNLYAPFVKLTAGTSISGSAGIDRLVLGSIPDIG-----
MAB_1699|M.abscessus_ATCC_1997 VLDPETSLLSLNRLYAPFIKITAGSAISGRAGIDRLVLGAIPDAG-----
Mflv_0006|M.gilvum_PYR-GCK VLAPGADLYSLNRLMPPFIKSTTSNAIAVRASIDRLVLGSIPDIG-----
Mvan_0963|M.vanbaalenii_PYR-1 VLAPGADLYSLNKLMPPFIKSTTSNAIAVNASIDRLVLGSIPDIG-----
MSMEG_1147|M.smegmatis_MC2_155 ALAPDATLYALNRLLPPFIKSMSSGAISLDASVDRLILGSTPDIG-----
TH_4097|M.thermoresistible__bu ALAPGATLYALNRLMPPFIKTMSGGSVALDASVDRLVWGHHPDIG-----
MAV_0106|M.avium_104 VLSPDTSLAGLNRLIPPFVKATPSQAISVRGSFDRLVLGSRPGTGAETGG
Mb0179|M.bovis_AF2122/97 RRAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSA-----
MLBr_02593|M.leprae_Br4923 GRGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSA-----
Rv1970|M.tuberculosis_H37Rv ANSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSR-----
.:. : . . . : .
MUL_4915|M.ulcerans_Agy99 FGGDPGLHGPKRYDWRKFIGSLKFTLWRLQERVVGQGPPQ----------
MMAR_0181|M.marinum_M FGGDPGLHGPKRYDWRKFIGSLKFTLWRLQERVVGQGPPQ----------
MAB_1699|M.abscessus_ATCC_1997 FGGDPGFHGPKRYDWAKFVGTIKYSLWRLQERVVGQGPAAQGFGVQGPTR
Mflv_0006|M.gilvum_PYR-GCK FAGDPGLHGPKRYNWHQLVGSLRYTLLRLQERVVGKGPGVPQMPVIPSPT
Mvan_0963|M.vanbaalenii_PYR-1 FAGDSGLHGPKRYNWHQLVGSLQYTLYRLQERIVGKGPGVPQVPVMPHPT
MSMEG_1147|M.smegmatis_MC2_155 FAGDQGLHGPKRHDWHQLVGTLKYTLLRLQERVVGQGPGVPQVPVIPSPT
TH_4097|M.thermoresistible__bu FAGDPGLHGPKWSDWHQLVGTLQYTLFRLQERVVGKGPDVPQLPVIPSPT
MAV_0106|M.avium_104 FKGDPAFHGPMRRDWNYLIGSIKYVLWRLQERVVGRGPQTPMGQSPWTPS
Mb0179|M.bovis_AF2122/97 -IDNAFLTGTG---FSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGP
MLBr_02593|M.leprae_Br4923 -MDNAVLTGTG---LSGALRALEQSFGRDPETMIPDVRYTTNPNDAPGGP
Rv1970|M.tuberculosis_H37Rv -IDQGLLTGTR---WECHLTQLELQWGR-TIGQFPSP-CTAGYRGTPGNP
.: : *. : :. * .
MUL_4915|M.ulcerans_Agy99 -----------------------------------------
MMAR_0181|M.marinum_M -----------------------------------------
MAB_1699|M.abscessus_ATCC_1997 -----------------------------------------
Mflv_0006|M.gilvum_PYR-GCK EPGQWAPAPPPGPVPPGPAP-----------AVAPPAPGVP
Mvan_0963|M.vanbaalenii_PYR-1 EPGLIVPVPAPAP-PPG--------------APAPEAPR--
MSMEG_1147|M.smegmatis_MC2_155 EPGEIIVEPGAAAPPEDAPAPEPAPAAQAPAPLPAEAPR--
TH_4097|M.thermoresistible__bu EPGEIIPAPGPAAG-----------------AAPEEAPR--
MAV_0106|M.avium_104 GP-PLPPAPAGQAPPD---------------PMVPEPPR--
Mb0179|M.bovis_AF2122/97 LVERGNRQC--------------------------------
MLBr_02593|M.leprae_Br4923 LVERADRRC--------------------------------
Rv1970|M.tuberculosis_H37Rv LTIAYRWDQGP------------------------------