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MAQPHGLDDAATELPLPARPQFAYPPLERGMELPPGVNGWARPEFRGVVRVFAFAFTRYRVGGGAACVYV DGEPVLDLWAGVAQKGEEWTRDTAPVIFSASKGVTATIIHRLVDRGLLDYRAPVARYWPEFAANGKEAIT VDGILSHTAGLSRLTGIAHNYEEMFDPDLMADRLAAAPVDRYFGKPAYHALSIGWLMGRLAKAVTGRDLE ELYRSELAEPLGVDGIYMGRPPAGAPSQSAALTPYLDRVARSGFIRRAAPSVMGVLDKMPGAKGAASTLY QPGAEMLLADDGHASAAVMDLRCGAGSACCTAPALAKLYAALAGDGSVDGVRLLSPDITRGLGRKNSYRI DHTLGLPMGWHRGYHSLTAPVIGGGFGHIGAGGSFGWADQKRKISVAIVHNRLPRTMVFDQTVIGTFLPS IIRAAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1387 | - | - | 100% (426) | putative esterase/lipase/beta-lactamase |
| M. abscessus ATCC 19977 | MAB_1386 | - | e-139 | 56.60% (424) | putative esterase/lipase/beta-lactamase |
| M. abscessus ATCC 19977 | MAB_4006 | - | e-123 | 54.05% (407) | putative lipase/esterase/beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1958 | lipD | 9e-88 | 44.55% (422) | lipase LIPD |
| M. gilvum PYR-GCK | Mflv_3647 | - | 5e-89 | 45.14% (381) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1923 | lipD | 4e-89 | 45.02% (422) | lipase LIPD |
| M. leprae Br4923 | MLBr_00119 | lipE | 6e-18 | 24.55% (330) | putative hydrolase |
| M. marinum M | MMAR_2828 | lipD | 9e-90 | 46.84% (395) | lipase LipD |
| M. avium 104 | MAV_3275 | - | 8e-89 | 45.52% (391) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3162 | - | 2e-84 | 43.64% (401) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3778 | - | 6e-84 | 46.13% (349) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_2951 | lipD | 5e-89 | 46.58% (395) | lipase LipD |
| M. vanbaalenii PYR-1 | Mvan_2765 | - | 6e-89 | 45.67% (381) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3162|M.smegmatis_MC2_155 -------------MSGHN-RERDAALPH--------GVQGAADPNFACTA
TH_3778|M.thermoresistible__bu --------------------------------------------------
Mflv_3647|M.gilvum_PYR-GCK -------------MTGVNSRERDEALSHGHGGHLPRGVQGAADPNFTCAV
Mvan_2765|M.vanbaalenii_PYR-1 -------------MTGVNNPERDVALSHGHGAALPCGVQGAADPNFTLAV
MAV_3275|M.avium_104 ----------------MDARVDRRAVRVHDDLDAGHRVSGAADSHFGCVV
Mb1958|M.bovis_AF2122/97 MDVAGLPRLAAGTQAAIIHGMAQPPSLLTTDNGLPFGVQGACDSRFTGVI
Rv1923|M.tuberculosis_H37Rv MDVAGLPRLAAGTQAAIIHGMAQPPSLLTTDNGLPFGVQGACDSRFTGVI
MMAR_2828|M.marinum_M --------------------MAQP-SVLTTDDGLPSGVAGACDSRFSGVV
MUL_2951|M.ulcerans_Agy99 --------------------MAQP-SVPTTDDGLPSGVAGACDSRFSGVV
MAB_1387|M.abscessus_ATCC_1997 -MAQPHGLDDAATELPLPARPQFAYPPLERGMELPPGVNGWARPEFRGVV
MLBr_00119|M.leprae_Br4923 -----------------MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVE
MSMEG_3162|M.smegmatis_MC2_155 RAFSRLFPGRRFGGG---ALAVYQDGQPLVDIWTGY--------SDRAGT
TH_3778|M.thermoresistible__bu ---------------------VYLHGEPVVDVWTGY--------ADRRGT
Mflv_3647|M.gilvum_PYR-GCK RAFAQMFPHRRFGGG---ALAVYLNGEPVVDVWTGW--------ADRRGK
Mvan_2765|M.vanbaalenii_PYR-1 RAFAQMFPSRRLGGG---ALAVYLDGEPVVDVWTGW--------ADRRGT
MAV_3275|M.avium_104 RSFASMFPARRFGGG---ALAVYVDGQPVVDVWTGW--------ADRAGQ
Mb1958|M.bovis_AF2122/97 RAFAGLYPGRKFGGG---ALSVYIDDRQVVDVWTGW--------SDRQGK
Rv1923|M.tuberculosis_H37Rv RAFAGLYPGRKFGGG---ALSVYIDGRQVVDVWTGW--------SDRQGK
MMAR_2828|M.marinum_M RAFAGLYPGRKFGGG---ALSVYIEGRQVVDVWTGW--------ADRNGE
MUL_2951|M.ulcerans_Agy99 RAFAGLYPGRKFGGG---ALSVYTEGRQVVDVWTGW--------ADRNGE
MAB_1387|M.abscessus_ATCC_1997 RVFAFAFTRYRVGGG---AACVYVDGEPVLDLWAGV--------AQK-GE
MLBr_00119|M.leprae_Br4923 RIWQATRHWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEK
: ... ::: * ..
MSMEG_3162|M.smegmatis_MC2_155 EYWTADTGAMVFSATKGLASTVIHRLADRGLIDYDTPVSAYWPEFAANGK
TH_3778|M.thermoresistible__bu EYWTADTGAMVFSATKGMAATVVHRLVDRGLLDYDTPVAEYWPEFGANGK
Mflv_3647|M.gilvum_PYR-GCK RRWTADTAPMVFSATKGVAATVIHRLADRGLIDYDAPVAEYWREFGVNGK
Mvan_2765|M.vanbaalenii_PYR-1 RRWTADTGPMVFSATKGVTATVIHRLHDRGLVDYDAPVAEYWREFGANGK
MAV_3275|M.avium_104 RPWSENTAPMVFSATKGMAATVIHRLVDRGLIDYEAPVAEYWPAFAANGK
Mb1958|M.bovis_AF2122/97 VPWTADTGAMVFSATKGLAATVIHRLVDRGLLSYDAPVAEYWPEFGANGK
Rv1923|M.tuberculosis_H37Rv VPWTADTGAMVFSATKGLAATVIHRLVDRGLLSYDAPVAEYWPEFGANGK
MMAR_2828|M.marinum_M VPWTADTGAMVFSATKGLAATVIHRLVDRGLLDYDAPVADYWPEFGVKGK
MUL_2951|M.ulcerans_Agy99 VPWTADTGAMVFSATKGLAATVIHRLVDRGLLDYDAPVADYWPEFGVKGK
MAB_1387|M.abscessus_ATCC_1997 E-WTRDTAPVIFSASKGVTATIIHRLVDRGLLDYRAPVARYWPEFAANGK
MLBr_00119|M.leprae_Br4923 IPVTTDTPFCAYSAAKAITATVVHMLVERGHFSLDDRVCEYLPTYTSYGK
: :* :**:*.:::*::* * :** .. *. * : **
MSMEG_3162|M.smegmatis_MC2_155 AHITVREVMQHRAGLSQLNGVSK--ADMLDHRVMEARIAEASVNRHLYGK
TH_3778|M.thermoresistible__bu AGITVRDVLRHRAGLSHLNGVSK--ADLLDHRRMEERLAAAPVNRLQYGK
Mflv_3647|M.gilvum_PYR-GCK STITVRELMRHRAGLSQLNGAAK--TDLMDHLVMEERLAAAPAS-WLVGR
Mvan_2765|M.vanbaalenii_PYR-1 SAITVRDALRHRAGLSQLNGAGK--ADLLDHAVMEQRLAAAPRS-WLYGK
MAV_3275|M.avium_104 ANMTVRQVMRHQAGLSGLRGATK--EELLDHLVMEERLAAAAPG-RLLGK
Mb1958|M.bovis_AF2122/97 SEVTVSDVLRHRSGLAHLKGVDK--DEVMDHLLMEQKLAAAPLN-RQHGK
Rv1923|M.tuberculosis_H37Rv SEVTVSDVLRHRSGLAHLKGVDK--DEVMDHLLMEQKLAAAPLD-RQHGK
MMAR_2828|M.marinum_M SAITVSDLLRHRSGLSHLKGVGK--KEILDHLRMEEKLAAAPLD-RTHGK
MUL_2951|M.ulcerans_Agy99 SAITVSDLLRHRSGLSHLKGVGK--KEILDHLRMEEKLAAAPLD-RTHGK
MAB_1387|M.abscessus_ATCC_1997 EAITVDGILSHTAGLSRLTGIAHNYEEMFDPDLMADRLAAAPVD-RYFGK
MLBr_00119|M.leprae_Br4923 HRTTIRHVLTHSAGVPFPTGPRPDVTRADDHAYAQQKLSELRPFYRPGLV
*: : * :*:. * * :::
MSMEG_3162|M.smegmatis_MC2_155 SAYHALTYGWLMSGLVRAVTGQGMRELFRTELAEPLNTDGIHLGRPPVGA
TH_3778|M.thermoresistible__bu PAYHALTYGWLLSGLVRAITGCGMRELVRTELAEPLNTDGLHLGRPPAGA
Mflv_3647|M.gilvum_PYR-GCK PAYHAFTFGWLLSGLARSVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQA
Mvan_2765|M.vanbaalenii_PYR-1 PAYHALTFGWLLSGLARSITGKGMRELIRTEVAAPLNTDGLHLGRPPVQA
MAV_3275|M.avium_104 SAYHALTFGWLMSGLGRAVTGKGMRTLIREELAEPLGTDGLYLGRPPAGA
Mb1958|M.bovis_AF2122/97 LAYHAVTYGWLLSGLARAVTGKGMRELFREELARPLNTDGIHLGRPPADS
Rv1923|M.tuberculosis_H37Rv LAYHAVTYGWLLSGLARAVTGKGMRELFREELARPLNTDGIHLGRPPADS
MMAR_2828|M.marinum_M MAYHAVTYGWLLSGLARAVTGKGMRDLFREELARPLDTDGLHLGRPPADA
MUL_2951|M.ulcerans_Agy99 MAYHAVTYGWLLSGLARAVTGKGMRDLFREELARPLDTDGLHLGRPPGDA
MAB_1387|M.abscessus_ATCC_1997 PAYHALSIGWLMGRLAKAVTGRDLEELYRSELAEPLGVDGIYMGRPPAGA
MLBr_00119|M.leprae_Br4923 HIYHALTWGPLMREIIWTATGKEIRDILAAEILDPLGFRWTNFGVAEEDV
***.: * *: : : ** :. : *: **. :* .
MSMEG_3162|M.smegmatis_MC2_155 PTRAAQILGPQRTWPNH-VFDFLAPRFAALE-----FSGFFGSTYCPGVM
TH_3778|M.thermoresistible__bu PTKAAQILAPQGALDIP-VVGAVVPRLAASQ-----ASAMFGAMYFPGMF
Mflv_3647|M.gilvum_PYR-GCK PTQPARIIGPQTRLQNP-IFNAVAPHIAALP-----FSAGFGAMYFPGVK
Mvan_2765|M.vanbaalenii_PYR-1 PTEAAQIIGPQTRLQNP-VFNLVAPRIAALP-----FSAGFGAIYLPGVK
MAV_3275|M.avium_104 PTRVAEIVAPQNLVGSS-IVNYVS-RKVANQ-----LSGGFRAMYFPGMI
Mb1958|M.bovis_AF2122/97 PTKAAQTLLPQAKVPTP-LLDFIAPKVAGLS-----FSGLLGAVYFPGIL
Rv1923|M.tuberculosis_H37Rv PTKAAQTLLPQAKVPTP-LLDFIAPKVAGLS-----FSGLLGAVYFPGIL
MMAR_2828|M.marinum_M PTTAAQTLLPQSKIPTP-LLDFIAPKVAGLS-----FSGLLGAVYFPGIL
MUL_2951|M.ulcerans_Agy99 PTTAAQTLLPQSKIPTP-LLDFIAPKVAGLS-----FSGLLGAVYFPGIL
MAB_1387|M.abscessus_ATCC_1997 PSQSAALTPYLDRVARSGFIRRAAPSVMGVLDKMPGAKGAASTLYQPGAE
MLBr_00119|M.leprae_Br4923 P---LVALSHATGRPLPPIIAAIFRKAIGGT--------------VHEVI
* .. .
MSMEG_3162|M.smegmatis_MC2_155 SLVQGD----TPFLDAEIPAANGVATARGLAKVYGAIANGGRFAGEEFLS
TH_3778|M.thermoresistible__bu SVVQGD----IPFLDSEIPAANAVATARGLAKMYGAIANGGRIDDVRFLS
Mflv_3647|M.gilvum_PYR-GCK SFVQGD----TPLLDGEIPAANGVATARALARMYGAIANEGRIDGLQYLS
Mvan_2765|M.vanbaalenii_PYR-1 ALVQGD----TPLLDGEIPAANGVATARALARMYGAIANGGRIDGTQYLS
MAV_3275|M.avium_104 AAVQGD----TPLLDAEIPAANGVATARGLARMYGAIANGGEVDGIRFLS
Mb1958|M.bovis_AF2122/97 SLLQDD----MPFLDGEVPAVNGVVTARALAKTYGALANDGVIDGTRLLS
Rv1923|M.tuberculosis_H37Rv SLLQDD----MPFLDGEVPAVNGVVTARALAKTYGALANDGVIDGTRLLS
MMAR_2828|M.marinum_M SMLQDD----MPFLDGEIPAVNGVVTARALAKTYAALANDGVIDGMRLLS
MUL_2951|M.ulcerans_Agy99 SMLQDD----MPFLDGEIPAVNGVVTARALAKTYAALANDGVIDGMRLLS
MAB_1387|M.abscessus_ATCC_1997 MLLADDGHASAAVMDLRCGAGSACCTAPALAKLYAALAGDGSVDGVRLLS
MLBr_00119|M.leprae_Br4923 PYTNTP-----PFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLR
..: : . ** *:: * . . . *
MSMEG_3162|M.smegmatis_MC2_155 AATVAGLSGRRS-LSPDRNIG-VPLAFHLGYHS------VPF-GVMAGFG
TH_3778|M.thermoresistible__bu PEIVAGLAGRRN-LRPDRNLG-VPMAFHLGYHG------VPF-GIMPGFG
Mflv_3647|M.gilvum_PYR-GCK RETTAVLAGRRS-LRLDHSMV-MPLSFHLGYHG------LPIPGLLPGFG
Mvan_2765|M.vanbaalenii_PYR-1 GETAAALIGRPS-LRPDHSMV-MPLSFHLGYHG------LPFPGVLPGFG
MAV_3275|M.avium_104 RDLVAGLTGERS-LRPDRNLY-VPLAFHLGYHS------VPIGGVMPGFG
Mb1958|M.bovis_AF2122/97 SQAVRGLTGKSE-LWPDLNLG-LPFTYHQGYQS------SPVPGLLEGYG
Rv1923|M.tuberculosis_H37Rv SQAVRGLTGKSE-LWPDLNLG-LPFTYHQGYQS------SPVPGLLEGYG
MMAR_2828|M.marinum_M SDAVSGLTGKAE-LWPDLNLG-LPFTYHQGYQS------SPVPGLLGGYG
MUL_2951|M.ulcerans_Agy99 SDAVSGLTGKAE-LWPDLNLG-LPFTYHQGYQS------PPVPGLLGGYG
MAB_1387|M.abscessus_ATCC_1997 PDITRGLGRKNS-YRIDHTLG-LPMGWHRGYHS------LTAPVIGGGFG
MLBr_00119|M.leprae_Br4923 SETLLGAVAECRRLRPDFVVGLMPARWGTGFILGTNKFGPFGRNAPAAFG
. * : :* : *: .:*
MSMEG_3162|M.smegmatis_MC2_155 HVGLGGSVGWADPASGLAVGFVHNRLLTPMVF-DMGAFVGLHAVIRNDLA
TH_3778|M.thermoresistible__bu HVGLGGSYGWAEPETGLAIGYVHNRLLTPMLI-DQAAFVGLNALIRRDAA
Mflv_3647|M.gilvum_PYR-GCK HVGLGGSLGWADPETGLAFGFVHNRLLTPMVVSDQAGFVATAALLRRGAS
Mvan_2765|M.vanbaalenii_PYR-1 HVGLGGSLGWADPRSGLSFGYVHNRLLTPLVLSDQAGFVATAALIRRGAA
MAV_3275|M.avium_104 HVGMGGSLGWADPASGVAFSLVHNRLLTPLVMTDHAAFVGIYALIRRAAE
Mb1958|M.bovis_AF2122/97 HIGLGGTIGWADPETGSAFGYVHNRLLT-LLLFDIGSFAGLAALLNSAVV
Rv1923|M.tuberculosis_H37Rv HIGLGGTIGWADPETGSAFGYVHNRLLT-LLLFDIGSFAGLAALLNSAVV
MMAR_2828|M.marinum_M HIGLGGTIGWADPESGSAFGYVHNRLLT-LLLFDIGSFAGLAPLLSSAVS
MUL_2951|M.ulcerans_Agy99 HIGLGGTIGWADPESGSAFGYVHNRLLT-LLLFDIGSFAGLAPLLSSAVS
MAB_1387|M.abscessus_ATCC_1997 HIGAGGSFGWADQKRKISVAIVHNRLPRTMVFDQTVIGTFLPSIIR----
MLBr_00119|M.leprae_Br4923 HLGLVNIAIWADPQRSMAAGLISSGKPG--QDPNAGRYGALMNTITAEIP
*:* . **: : . : . : :
MSMEG_3162|M.smegmatis_MC2_155 RARRRGFEPVPDLGAAPYELSK---PVAG---
TH_3778|M.thermoresistible__bu AARRRGYRPVGDLG-APFDMRK---RVAG---
Mflv_3647|M.gilvum_PYR-GCK QARKNGYRRVREYG-SPFSDVA---ATAV---
Mvan_2765|M.vanbaalenii_PYR-1 AARRNGYRPVREYG-APFTDLT---ATAV---
MAV_3275|M.avium_104 QVRKHGFRPVTEFG-APFREPG---AVAG---
Mb1958|M.bovis_AF2122/97 AARRDDPLEVPHFG-APYSEPRHEQAASGA--
Rv1923|M.tuberculosis_H37Rv AARRDDPLEVPHFG-APYSEPRHEQAASGA--
MMAR_2828|M.marinum_M TARREGPLEVPHFG-ASYRETGQQPLAAGETS
MUL_2951|M.ulcerans_Agy99 TARREGPLEVPHFG-ASYRETGQQPLAAGETS
MAB_1387|M.abscessus_ATCC_1997 AAR-----------------------------
MLBr_00119|M.leprae_Br4923 VH------------------------------