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M. thermoresistible (build 8) TH_3778 (-)

annotation: beta-lactamase
coordinates: 1304739 - 1305863
length: 375

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3778--100% (375)beta-lactamase
M. thermoresistible (build 8)TH_0350lipP4e-3933.69% (377) PROBABLE ESTERASE/LIPASE LIPP
M. thermoresistible (build 8)TH_2342lipE3e-3033.44% (311) PROBABLE LIPASE LIPE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1534lipL1e-13464.19% (377) esterase LipL
M. gilvum PYR-GCKMflv_3647-1e-14668.21% (368) beta-lactamase
M. tuberculosis H37RvRv1497lipL1e-13464.19% (377) esterase LipL
M. leprae Br4923MLBr_00119lipE6e-2931.83% (311) putative hydrolase
M. abscessus ATCC 19977MAB_1386-1e-10053.54% (353) putative esterase/lipase/beta-lactamase
M. marinum MMMAR_2305lipL1e-13864.63% (376) esterase LipL
M. avium 104MAV_3275-1e-14366.76% (376) beta-lactamase
M. smegmatis MC2 155MSMEG_3162-1e-16172.27% (375) beta-lactamase
M. ulcerans Agy99MUL_2951lipD1e-13161.04% (367) lipase LipD
M. vanbaalenii PYR-1Mvan_2765-1e-15372.01% (368) beta-lactamase

CLUSTAL 2.0.9 multiple sequence alignment


TH_3778|M.thermoresistible__bu      --------------------------------------------------
MSMEG_3162|M.smegmatis_MC2_155      -------MSGHN-RERDAALPH----------GVQGAADPNFACTARAFS
Mflv_3647|M.gilvum_PYR-GCK          -------MTGVNSRERDEALSHGH--GGHLPRGVQGAADPNFTCAVRAFA
Mvan_2765|M.vanbaalenii_PYR-1       -------MTGVNNPERDVALSHGH--GAALPCGVQGAADPNFTLAVRAFA
Mb1534|M.bovis_AF2122/97            --------MMVDTGVDHRAVSSHD--GPDAGRRVFGAADPRFACVVRAFA
Rv1497|M.tuberculosis_H37Rv         --------MMVDTGVDHRAVSSHD--GPDAGRRVFGAADPRFACVVRAFA
MMAR_2305|M.marinum_M               --------MTVDIGVNRRAVSSHG--DPDAGHRVSGAADSQFACVVRMFS
MAV_3275|M.avium_104                ----------MDARVDRRAVRVHD--DLDAGHRVSGAADSHFGCVVRSFA
MUL_2951|M.ulcerans_Agy99           -------MAQPSVPTTDDGLPS----------GVAGACDSRFSGVVRAFA
MAB_1386|M.abscessus_ATCC_1997      MAIPLGPNVAATAPVRRDGLYPGDQPGLRLPNGVEGWARPELSAVVRTFE
MLBr_00119|M.leprae_Br4923          ----MTSDGKIRVPTDLDAVTAIG------DEDHSDIDSAAVERIWQATR
                                                                                      

TH_3778|M.thermoresistible__bu      --------------VYLHGEPVVDVWTGY--------ADRRGTEYWTADT
MSMEG_3162|M.smegmatis_MC2_155      RLFPGRRFGGGALAVYQDGQPLVDIWTGY--------SDRAGTEYWTADT
Mflv_3647|M.gilvum_PYR-GCK          QMFPHRRFGGGALAVYLNGEPVVDVWTGW--------ADRRGKRRWTADT
Mvan_2765|M.vanbaalenii_PYR-1       QMFPSRRLGGGALAVYLDGEPVVDVWTGW--------ADRRGTRRWTADT
Mb1534|M.bovis_AF2122/97            SMFPGRRFGGGALAVYLDGQPVVDVWKGW--------ADRAGWVPWSADS
Rv1497|M.tuberculosis_H37Rv         SMFPGRRFGGGALAVYLDGQPVVDVWKGW--------ADRAGWVPWSADS
MMAR_2305|M.marinum_M               SMFPARRFGGGALAVYLDGQPVVDVWKGW--------ADREGEVPWSADS
MAV_3275|M.avium_104                SMFPARRFGGGALAVYVDGQPVVDVWTGW--------ADRAGQRPWSENT
MUL_2951|M.ulcerans_Agy99           GLYPGRKFGGGALSVYTEGRQVVDVWTGW--------ADRNGEVPWTADT
MAB_1386|M.abscessus_ATCC_1997      WMFTKYRLGGGGLSVYVDGEPALDIWAGA--------AAAG--QGWTRDT
MLBr_00119|M.leprae_Br4923          HWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDT
                                                  :  .*.  ::   *         .        : ::

TH_3778|M.thermoresistible__bu      GAMVFSATKGMAATVVHRLVDRGLLDYDTPVAEYWPEFGANGKAGITVRD
MSMEG_3162|M.smegmatis_MC2_155      GAMVFSATKGLASTVIHRLADRGLIDYDTPVSAYWPEFAANGKAHITVRE
Mflv_3647|M.gilvum_PYR-GCK          APMVFSATKGVAATVIHRLADRGLIDYDAPVAEYWREFGVNGKSTITVRE
Mvan_2765|M.vanbaalenii_PYR-1       GPMVFSATKGVTATVIHRLHDRGLVDYDAPVAEYWREFGANGKSAITVRD
Mb1534|M.bovis_AF2122/97            APMVFSATKGMTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRD
Rv1497|M.tuberculosis_H37Rv         APMVFSATKGMTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRD
MMAR_2305|M.marinum_M               APMVFSATKGMAATVIHRLADRGLIDYEAPVAQYWPEFAANGKEKLTVRE
MAV_3275|M.avium_104                APMVFSATKGMAATVIHRLVDRGLIDYEAPVAEYWPAFAANGKANMTVRQ
MUL_2951|M.ulcerans_Agy99           GAMVFSATKGLAATVIHRLVDRGLLDYDAPVADYWPEFGVKGKSAITVSD
MAB_1386|M.abscessus_ATCC_1997      GALVFSASKGIAATVIHRLVDRGLITYDAPVARYWPEFGANGKSSITVRQ
MLBr_00119|M.leprae_Br4923          PFCAYSAAKAITATVVHMLVERGHFSLDDRVCEYLPTYTSYGKHRTTIRH
                                       .:**:*.:::**:* * :** .  :  *. *   :   **   *: .

TH_3778|M.thermoresistible__bu      VLRHRAGLSHLNGVS--KADLLDHRRMEERLAAAPVNRLQYGKPAYHALT
MSMEG_3162|M.smegmatis_MC2_155      VMQHRAGLSQLNGVS--KADMLDHRVMEARIAEASVNRHLYGKSAYHALT
Mflv_3647|M.gilvum_PYR-GCK          LMRHRAGLSQLNGAA--KTDLMDHLVMEERLAAAPAS-WLVGRPAYHAFT
Mvan_2765|M.vanbaalenii_PYR-1       ALRHRAGLSQLNGAG--KADLLDHAVMEQRLAAAPRS-WLYGKPAYHALT
Mb1534|M.bovis_AF2122/97            VMRHQAGLSGLRGAT--QQDLLDHVVMEERLAAAVPG-RLLGKSAYHALT
Rv1497|M.tuberculosis_H37Rv         VMRHQAGLSGLRGAT--QQDLLDHVVMEERLAAAVPG-RLLGKSAYHALT
MMAR_2305|M.marinum_M               VMRHAAGLSGLRGAS--QEDLLDHVVMEERLAAAAPG-RLLGKPAYHALT
MAV_3275|M.avium_104                VMRHQAGLSGLRGAT--KEELLDHLVMEERLAAAAPG-RLLGKSAYHALT
MUL_2951|M.ulcerans_Agy99           LLRHRSGLSHLKGVG--KKEILDHLRMEEKLAAAPLD-RTHGKMAYHAVT
MAB_1386|M.abscessus_ATCC_1997      VLDHRAGLSRLEGIAYHAEEIVDHELMERRLAAAPVD-KFYGKRAYHALT
MLBr_00119|M.leprae_Br4923          VLTHSAGVPFPTGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHALT
                                     : * :*:.   *         **   : :::             ***.*

TH_3778|M.thermoresistible__bu      YGWLLSGLVRAITGCGMRELVRTELAEPLNTDGLHLGRPPAGAPTKAAQI
MSMEG_3162|M.smegmatis_MC2_155      YGWLMSGLVRAVTGQGMRELFRTELAEPLNTDGIHLGRPPVGAPTRAAQI
Mflv_3647|M.gilvum_PYR-GCK          FGWLLSGLARSVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQAPTQPARI
Mvan_2765|M.vanbaalenii_PYR-1       FGWLLSGLARSITGKGMRELIRTEVAAPLNTDGLHLGRPPVQAPTEAAQI
Mb1534|M.bovis_AF2122/97            FGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRPPADAPTRVAEI
Rv1497|M.tuberculosis_H37Rv         FGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRPPADAPTRVAEI
MMAR_2305|M.marinum_M               FGWLMSGLARAVTGKDMRVLFREELAEPLDTDGFHLGRPPAGSPTQVAQI
MAV_3275|M.avium_104                FGWLMSGLGRAVTGKGMRTLIREELAEPLGTDGLYLGRPPAGAPTRVAEI
MUL_2951|M.ulcerans_Agy99           YGWLLSGLARAVTGKGMRDLFREELARPLDTDGLHLGRPPGDAPTTAAQT
MAB_1386|M.abscessus_ATCC_1997      FGWLLAGLARSVTGKDMRELFRTEIADPLGVDGIHLGRPPRTASTKAASM
MLBr_00119|M.leprae_Br4923          WGPLMREIIWTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVP--LVAL
                                    :* *:  :  : **  :* :.  *:  **.     :* .    .   .  

TH_3778|M.thermoresistible__bu      LAPQGALDIP-----VVGAVVPRLAAS-QASAMFGAMYFPGMFSVVQGD-
MSMEG_3162|M.smegmatis_MC2_155      LGPQRTWPNH-----VFDFLAPRFAAL-EFSGFFGSTYCPGVMSLVQGD-
Mflv_3647|M.gilvum_PYR-GCK          IGPQTRLQNP-----IFNAVAPHIAAL-PFSAGFGAMYFPGVKSFVQGD-
Mvan_2765|M.vanbaalenii_PYR-1       IGPQTRLQNP-----VFNLVAPRIAAL-PFSAGFGAIYLPGVKALVQGD-
Mb1534|M.bovis_AF2122/97            IMPQDIAANA-----VLTCAMRRLAH--RFSGGFRSMYFPGAIAAVQGE-
Rv1497|M.tuberculosis_H37Rv         IMPQDIAANA-----VLTCAMRRLAH--RFSGGFRSMYFPGAIAAVQGE-
MMAR_2305|M.marinum_M               IMPQDIAANP-----LVTFAAHKIAN--QFSSGFRSMYFPGVIATVQGE-
MAV_3275|M.avium_104                VAPQNLVGSS-----IVNYVSRKVAN--QLSGGFRAMYFPGMIAAVQGD-
MUL_2951|M.ulcerans_Agy99           LLPQSKIPTP-----LLDFIAPKVAGL-SFSGLLGAVYFPGILSMLQDD-
MAB_1386|M.abscessus_ATCC_1997      YPFLDSMANKPAVGRLLPTVIRAIDRLPGFEGAIGTMYGPGMERILADDG
MLBr_00119|M.leprae_Br4923          SHATGRPLPP-----IIAAIFRKAIGG-TVHEVIPYTNTP----------
                                                   :.                :     *          

TH_3778|M.thermoresistible__bu      ---IPFLDSEIPAANAVATARGLAKMYGAIANGGRIDDVRFLSPEIVAGL
MSMEG_3162|M.smegmatis_MC2_155      ---TPFLDAEIPAANGVATARGLAKVYGAIANGGRFAGEEFLSAATVAGL
Mflv_3647|M.gilvum_PYR-GCK          ---TPLLDGEIPAANGVATARALARMYGAIANEGRIDGLQYLSRETTAVL
Mvan_2765|M.vanbaalenii_PYR-1       ---TPLLDGEIPAANGVATARALARMYGAIANGGRIDGTQYLSGETAAAL
Mb1534|M.bovis_AF2122/97            ---APLLDAEIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGL
Rv1497|M.tuberculosis_H37Rv         ---APLLDAEIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGL
MMAR_2305|M.marinum_M               ---TPMLDAEIPAANGVVTARALARMYGAIANGGEIDGTQFLSRELVAGL
MAV_3275|M.avium_104                ---TPLLDAEIPAANGVATARGLARMYGAIANGGEVDGIRFLSRDLVAGL
MUL_2951|M.ulcerans_Agy99           ---MPFLDGEIPAVNGVVTARALAKTYAALANDGVIDGMRLLSSDAVSGL
MAB_1386|M.abscessus_ATCC_1997      TLNSALYDMQAPAANAVATAPALAKMYAALAGDGSVDGRELLSPETVAGL
MLBr_00119|M.leprae_Br4923          ----PFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLRSETLLGA
                                        .:     *: * * **  *::        * . . . *        

TH_3778|M.thermoresistible__bu      AGRRN-LRPDRNLGVP-----MAFHLG--YHGVPF-GIMPGFGHVGLGGS
MSMEG_3162|M.smegmatis_MC2_155      SGRRS-LSPDRNIGVP-----LAFHLG--YHSVPF-GVMAGFGHVGLGGS
Mflv_3647|M.gilvum_PYR-GCK          AGRRS-LRLDHSMVMP-----LSFHLG--YHGLPIPGLLPGFGHVGLGGS
Mvan_2765|M.vanbaalenii_PYR-1       IGRPS-LRPDHSMVMP-----LSFHLG--YHGLPFPGVLPGFGHVGLGGS
Mb1534|M.bovis_AF2122/97            TRNRRQVLPDRNLLVP-----LNFHLG--YHGMPIGNVMPGFGHVGLGGS
Rv1497|M.tuberculosis_H37Rv         TRNRRQVLPDRNLLVP-----LNFHLG--YHGMPIGNVMPGFGHVGLGGS
MMAR_2305|M.marinum_M               TGERR-LQPDRNLFMP-----MAFHLG--YHSLPIGNVMPGFGHVGMGGS
MAV_3275|M.avium_104                TGERS-LRPDRNLYVP-----LAFHLG--YHSVPIGGVMPGFGHVGMGGS
MUL_2951|M.ulcerans_Agy99           TGKAE-LWPDLNLGLP-----FTYHQG--YQSPPVPGLLGGYGHIGLGGT
MAB_1386|M.abscessus_ATCC_1997      ARKTN-LTIDRTIVFP-----MGMHLG--YMSLPMNGFRGGFGHIGLGGS
MLBr_00119|M.leprae_Br4923          VAECRRLRPDFVVGLMPARWGTGFILGTNKFGPFGRNAPAAFGHLGLVNI
                                      .   :  *  : .           *    .    .   .:**:*: . 

TH_3778|M.thermoresistible__bu      YGWAEPETGLAIGYVHNRLLTPMLI-DQAAFVGLNALIRRDAAAARRRGY
MSMEG_3162|M.smegmatis_MC2_155      VGWADPASGLAVGFVHNRLLTPMVF-DMGAFVGLHAVIRNDLARARRRGF
Mflv_3647|M.gilvum_PYR-GCK          LGWADPETGLAFGFVHNRLLTPMVVSDQAGFVATAALLRRGASQARKNGY
Mvan_2765|M.vanbaalenii_PYR-1       LGWADPRSGLSFGYVHNRLLTPLVLSDQAGFVATAALIRRGAAAARRNGY
Mb1534|M.bovis_AF2122/97            IGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGY
Rv1497|M.tuberculosis_H37Rv         IGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGY
MMAR_2305|M.marinum_M               VGWTDPETGVAFALVHNRLLTPLVATDHAGFVAIYALIRQAAAKARERGY
MAV_3275|M.avium_104                LGWADPASGVAFSLVHNRLLTPLVMTDHAAFVGIYALIRRAAEQVRKHGF
MUL_2951|M.ulcerans_Agy99           IGWADPESGSAFGYVHNRLLT-LLLFDIGSFAGLAPLLSSAVSTARREGP
MAB_1386|M.abscessus_ATCC_1997      MGWADPKRKIAVGFAHNRLPLTMAL-DQISFAFLWPQIVKAVG-------
MLBr_00119|M.leprae_Br4923          AIWADPQRSMAAGLISS--GKPGQDPNAGRYGALMNTITAEIPVH-----
                                      *::*    : .   .         :   :      :            

TH_3778|M.thermoresistible__bu      RPVGDLG-APFDMRK---RVAG---
MSMEG_3162|M.smegmatis_MC2_155      EPVPDLGAAPYELSK---PVAG---
Mflv_3647|M.gilvum_PYR-GCK          RRVREYG-SPFSDVA---ATAV---
Mvan_2765|M.vanbaalenii_PYR-1       RPVREYG-APFTDLT---ATAV---
Mb1534|M.bovis_AF2122/97            QPVTPFG-APYSEPG---AAAG---
Rv1497|M.tuberculosis_H37Rv         QPVTPFG-APYSEPG---AAAG---
MMAR_2305|M.marinum_M               QPVTGIG-APYSEPG---AVAG---
MAV_3275|M.avium_104                RPVTEFG-APFREPG---AVAG---
MUL_2951|M.ulcerans_Agy99           LEVPHFG-ASYRETGQQPLAAGETS
MAB_1386|M.abscessus_ATCC_1997      -------------------------
MLBr_00119|M.leprae_Br4923          -------------------------