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VTGVNNPERDVALSHGHGAALPCGVQGAADPNFTLAVRAFAQMFPSRRLGGGALAVYLDGEPVVDVWTGW ADRRGTRRWTADTGPMVFSATKGVTATVIHRLHDRGLVDYDAPVAEYWREFGANGKSAITVRDALRHRAG LSQLNGAGKADLLDHAVMEQRLAAAPRSWLYGKPAYHALTFGWLLSGLARSITGKGMRELIRTEVAAPLN TDGLHLGRPPVQAPTEAAQIIGPQTRLQNPVFNLVAPRIAALPFSAGFGAIYLPGVKALVQGDTPLLDGE IPAANGVATARALARMYGAIANGGRIDGTQYLSGETAAALIGRPSLRPDHSMVMPLSFHLGYHGLPFPGV LPGFGHVGLGGSLGWADPRSGLSFGYVHNRLLTPLVLSDQAGFVATAALIRRGAAAARRNGYRPVREYGA PFTDLTATAV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2765 | - | - | 100% (430) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_5383 | - | 2e-40 | 33.88% (366) | beta-lactamase |
| M. vanbaalenii PYR-1 | Mvan_5757 | - | 1e-23 | 29.82% (332) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1534 | lipL | 1e-152 | 65.02% (406) | esterase LipL |
| M. gilvum PYR-GCK | Mflv_3647 | - | 0.0 | 84.42% (430) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1497 | lipL | 1e-152 | 65.02% (406) | esterase LipL |
| M. leprae Br4923 | MLBr_00119 | lipE | 8e-26 | 31.41% (312) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1386 | - | 1e-107 | 52.84% (388) | putative esterase/lipase/beta-lactamase |
| M. marinum M | MMAR_2305 | lipL | 1e-155 | 63.93% (427) | esterase LipL |
| M. avium 104 | MAV_3275 | - | 1e-155 | 65.19% (405) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3162 | - | 1e-159 | 65.95% (417) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3778 | - | 1e-153 | 72.01% (368) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_2951 | lipD | 1e-141 | 58.91% (404) | lipase LipD |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1534|M.bovis_AF2122/97 --------MMVDTGVDHRAVSSHD--GPDAGRRVFGAADPRFACVVRAFA
Rv1497|M.tuberculosis_H37Rv --------MMVDTGVDHRAVSSHD--GPDAGRRVFGAADPRFACVVRAFA
MMAR_2305|M.marinum_M --------MTVDIGVNRRAVSSHG--DPDAGHRVSGAADSQFACVVRMFS
MAV_3275|M.avium_104 ----------MDARVDRRAVRVHD--DLDAGHRVSGAADSHFGCVVRSFA
Mvan_2765|M.vanbaalenii_PYR-1 -------MTGVNNPERDVALSHGH--GAALPCGVQGAADPNFTLAVRAFA
Mflv_3647|M.gilvum_PYR-GCK -------MTGVNSRERDEALSHGH--GGHLPRGVQGAADPNFTCAVRAFA
MSMEG_3162|M.smegmatis_MC2_155 --------MSGHNRERDAALPH----------GVQGAADPNFACTARAFS
TH_3778|M.thermoresistible__bu --------------------------------------------------
MUL_2951|M.ulcerans_Agy99 -------MAQPSVPTTDDGLPS----------GVAGACDSRFSGVVRAFA
MAB_1386|M.abscessus_ATCC_1997 MAIPLGPNVAATAPVRRDGLYPGDQPGLRLPNGVEGWARPELSAVVRTFE
MLBr_00119|M.leprae_Br4923 ----MTSDGKIRVPTDLDAVTAIG------DEDHSDIDSAAVERIWQATR
Mb1534|M.bovis_AF2122/97 SMFPGRRFGGGALAVYLDGQPVVDVWKGW--------ADRAGWVPWSADS
Rv1497|M.tuberculosis_H37Rv SMFPGRRFGGGALAVYLDGQPVVDVWKGW--------ADRAGWVPWSADS
MMAR_2305|M.marinum_M SMFPARRFGGGALAVYLDGQPVVDVWKGW--------ADREGEVPWSADS
MAV_3275|M.avium_104 SMFPARRFGGGALAVYVDGQPVVDVWTGW--------ADRAGQRPWSENT
Mvan_2765|M.vanbaalenii_PYR-1 QMFPSRRLGGGALAVYLDGEPVVDVWTGW--------ADRRGTRRWTADT
Mflv_3647|M.gilvum_PYR-GCK QMFPHRRFGGGALAVYLNGEPVVDVWTGW--------ADRRGKRRWTADT
MSMEG_3162|M.smegmatis_MC2_155 RLFPGRRFGGGALAVYQDGQPLVDIWTGY--------SDRAGTEYWTADT
TH_3778|M.thermoresistible__bu --------------VYLHGEPVVDVWTGY--------ADRRGTEYWTADT
MUL_2951|M.ulcerans_Agy99 GLYPGRKFGGGALSVYTEGRQVVDVWTGW--------ADRNGEVPWTADT
MAB_1386|M.abscessus_ATCC_1997 WMFTKYRLGGGGLSVYVDGEPALDIWAG---------AAAAGQG-WTRDT
MLBr_00119|M.leprae_Br4923 HWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDT
: .*. :: * . : ::
Mb1534|M.bovis_AF2122/97 APMVFSATKGMTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRD
Rv1497|M.tuberculosis_H37Rv APMVFSATKGMTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRD
MMAR_2305|M.marinum_M APMVFSATKGMAATVIHRLADRGLIDYEAPVAQYWPEFAANGKEKLTVRE
MAV_3275|M.avium_104 APMVFSATKGMAATVIHRLVDRGLIDYEAPVAEYWPAFAANGKANMTVRQ
Mvan_2765|M.vanbaalenii_PYR-1 GPMVFSATKGVTATVIHRLHDRGLVDYDAPVAEYWREFGANGKSAITVRD
Mflv_3647|M.gilvum_PYR-GCK APMVFSATKGVAATVIHRLADRGLIDYDAPVAEYWREFGVNGKSTITVRE
MSMEG_3162|M.smegmatis_MC2_155 GAMVFSATKGLASTVIHRLADRGLIDYDTPVSAYWPEFAANGKAHITVRE
TH_3778|M.thermoresistible__bu GAMVFSATKGMAATVVHRLVDRGLLDYDTPVAEYWPEFGANGKAGITVRD
MUL_2951|M.ulcerans_Agy99 GAMVFSATKGLAATVIHRLVDRGLLDYDAPVADYWPEFGVKGKSAITVSD
MAB_1386|M.abscessus_ATCC_1997 GALVFSASKGIAATVIHRLVDRGLITYDAPVARYWPEFGANGKSSITVRQ
MLBr_00119|M.leprae_Br4923 PFCAYSAAKAITATVVHMLVERGHFSLDDRVCEYLPTYTSYGKHRTTIRH
.:**:*.:::**:* * :** . : *. * : ** *: .
Mb1534|M.bovis_AF2122/97 VMRHQAGLSGLRGAT--QQDLLDHVVMEERLAAAVPG-RLLGKSAYHALT
Rv1497|M.tuberculosis_H37Rv VMRHQAGLSGLRGAT--QQDLLDHVVMEERLAAAVPG-RLLGKSAYHALT
MMAR_2305|M.marinum_M VMRHAAGLSGLRGAS--QEDLLDHVVMEERLAAAAPG-RLLGKPAYHALT
MAV_3275|M.avium_104 VMRHQAGLSGLRGAT--KEELLDHLVMEERLAAAAPG-RLLGKSAYHALT
Mvan_2765|M.vanbaalenii_PYR-1 ALRHRAGLSQLNGAG--KADLLDHAVMEQRLAAAPRS-WLYGKPAYHALT
Mflv_3647|M.gilvum_PYR-GCK LMRHRAGLSQLNGAA--KTDLMDHLVMEERLAAAPAS-WLVGRPAYHAFT
MSMEG_3162|M.smegmatis_MC2_155 VMQHRAGLSQLNGVS--KADMLDHRVMEARIAEASVNRHLYGKSAYHALT
TH_3778|M.thermoresistible__bu VLRHRAGLSHLNGVS--KADLLDHRRMEERLAAAPVNRLQYGKPAYHALT
MUL_2951|M.ulcerans_Agy99 LLRHRSGLSHLKGVG--KKEILDHLRMEEKLAAAPLD-RTHGKMAYHAVT
MAB_1386|M.abscessus_ATCC_1997 VLDHRAGLSRLEGIAYHAEEIVDHELMERRLAAAPVD-KFYGKRAYHALT
MLBr_00119|M.leprae_Br4923 VLTHSAGVPFPTGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHALT
: * :*:. * ** : ::: ***.*
Mb1534|M.bovis_AF2122/97 FGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRPPADAPTRVAEI
Rv1497|M.tuberculosis_H37Rv FGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRPPADAPTRVAEI
MMAR_2305|M.marinum_M FGWLMSGLARAVTGKDMRVLFREELAEPLDTDGFHLGRPPAGSPTQVAQI
MAV_3275|M.avium_104 FGWLMSGLGRAVTGKGMRTLIREELAEPLGTDGLYLGRPPAGAPTRVAEI
Mvan_2765|M.vanbaalenii_PYR-1 FGWLLSGLARSITGKGMRELIRTEVAAPLNTDGLHLGRPPVQAPTEAAQI
Mflv_3647|M.gilvum_PYR-GCK FGWLLSGLARSVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQAPTQPARI
MSMEG_3162|M.smegmatis_MC2_155 YGWLMSGLVRAVTGQGMRELFRTELAEPLNTDGIHLGRPPVGAPTRAAQI
TH_3778|M.thermoresistible__bu YGWLLSGLVRAITGCGMRELVRTELAEPLNTDGLHLGRPPAGAPTKAAQI
MUL_2951|M.ulcerans_Agy99 YGWLLSGLARAVTGKGMRDLFREELARPLDTDGLHLGRPPGDAPTTAAQT
MAB_1386|M.abscessus_ATCC_1997 FGWLLAGLARSVTGKDMRELFRTEIADPLGVDGIHLGRPPRTASTKAASM
MLBr_00119|M.leprae_Br4923 WGPLMREIIWTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVP--LVAL
:* *: : : ** :* :. *: **. :* . . .
Mb1534|M.bovis_AF2122/97 IMPQDIAANA-----VLTCAMRRLAH--RFSGGFRSMYFPGAIAAVQGE-
Rv1497|M.tuberculosis_H37Rv IMPQDIAANA-----VLTCAMRRLAH--RFSGGFRSMYFPGAIAAVQGE-
MMAR_2305|M.marinum_M IMPQDIAANP-----LVTFAAHKIAN--QFSSGFRSMYFPGVIATVQGE-
MAV_3275|M.avium_104 VAPQNLVGSS-----IVNYVSRKVAN--QLSGGFRAMYFPGMIAAVQGD-
Mvan_2765|M.vanbaalenii_PYR-1 IGPQTRLQNP-----VFNLVAPRIAAL-PFSAGFGAIYLPGVKALVQGD-
Mflv_3647|M.gilvum_PYR-GCK IGPQTRLQNP-----IFNAVAPHIAAL-PFSAGFGAMYFPGVKSFVQGD-
MSMEG_3162|M.smegmatis_MC2_155 LGPQRTWPNH-----VFDFLAPRFAAL-EFSGFFGSTYCPGVMSLVQGD-
TH_3778|M.thermoresistible__bu LAPQGALDIP-----VVGAVVPRLAAS-QASAMFGAMYFPGMFSVVQGD-
MUL_2951|M.ulcerans_Agy99 LLPQSKIPTP-----LLDFIAPKVAGL-SFSGLLGAVYFPGILSMLQDD-
MAB_1386|M.abscessus_ATCC_1997 YPFLDSMANKPAVGRLLPTVIRAIDRLPGFEGAIGTMYGPGMERILADDG
MLBr_00119|M.leprae_Br4923 SHATGRPLPP-----IIAAIFRKAIGG-TVHEVIPYTNTP----------
:. : *
Mb1534|M.bovis_AF2122/97 ---APLLDAEIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGL
Rv1497|M.tuberculosis_H37Rv ---APLLDAEIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGL
MMAR_2305|M.marinum_M ---TPMLDAEIPAANGVVTARALARMYGAIANGGEIDGTQFLSRELVAGL
MAV_3275|M.avium_104 ---TPLLDAEIPAANGVATARGLARMYGAIANGGEVDGIRFLSRDLVAGL
Mvan_2765|M.vanbaalenii_PYR-1 ---TPLLDGEIPAANGVATARALARMYGAIANGGRIDGTQYLSGETAAAL
Mflv_3647|M.gilvum_PYR-GCK ---TPLLDGEIPAANGVATARALARMYGAIANEGRIDGLQYLSRETTAVL
MSMEG_3162|M.smegmatis_MC2_155 ---TPFLDAEIPAANGVATARGLAKVYGAIANGGRFAGEEFLSAATVAGL
TH_3778|M.thermoresistible__bu ---IPFLDSEIPAANAVATARGLAKMYGAIANGGRIDDVRFLSPEIVAGL
MUL_2951|M.ulcerans_Agy99 ---MPFLDGEIPAVNGVVTARALAKTYAALANDGVIDGMRLLSSDAVSGL
MAB_1386|M.abscessus_ATCC_1997 TLNSALYDMQAPAANAVATAPALAKMYAALAGDGSVDGRELLSPETVAGL
MLBr_00119|M.leprae_Br4923 ----PFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLRSETLLGA
.: *: * * ** *:: * . . . *
Mb1534|M.bovis_AF2122/97 TRNRRQVLPDRNLLVP-----LNFHLG--YHGMPIGNVMPGFGHVGLGGS
Rv1497|M.tuberculosis_H37Rv TRNRRQVLPDRNLLVP-----LNFHLG--YHGMPIGNVMPGFGHVGLGGS
MMAR_2305|M.marinum_M TGERR-LQPDRNLFMP-----MAFHLG--YHSLPIGNVMPGFGHVGMGGS
MAV_3275|M.avium_104 TGERS-LRPDRNLYVP-----LAFHLG--YHSVPIGGVMPGFGHVGMGGS
Mvan_2765|M.vanbaalenii_PYR-1 IGRPS-LRPDHSMVMP-----LSFHLG--YHGLPFPGVLPGFGHVGLGGS
Mflv_3647|M.gilvum_PYR-GCK AGRRS-LRLDHSMVMP-----LSFHLG--YHGLPIPGLLPGFGHVGLGGS
MSMEG_3162|M.smegmatis_MC2_155 SGRRS-LSPDRNIGVP-----LAFHLG--YHSVPF-GVMAGFGHVGLGGS
TH_3778|M.thermoresistible__bu AGRRN-LRPDRNLGVP-----MAFHLG--YHGVPF-GIMPGFGHVGLGGS
MUL_2951|M.ulcerans_Agy99 TGKAE-LWPDLNLGLP-----FTYHQG--YQSPPVPGLLGGYGHIGLGGT
MAB_1386|M.abscessus_ATCC_1997 ARKTN-LTIDRTIVFP-----MGMHLG--YMSLPMNGFRGGFGHIGLGGS
MLBr_00119|M.leprae_Br4923 VAECRRLRPDFVVGLMPARWGTGFILGTNKFGPFGRNAPAAFGHLGLVNI
. : * : . * . . .:**:*: .
Mb1534|M.bovis_AF2122/97 IGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGY
Rv1497|M.tuberculosis_H37Rv IGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGY
MMAR_2305|M.marinum_M VGWTDPETGVAFALVHNRLLTPLVATDHAGFVAIYALIRQAAAKARERGY
MAV_3275|M.avium_104 LGWADPASGVAFSLVHNRLLTPLVMTDHAAFVGIYALIRRAAEQVRKHGF
Mvan_2765|M.vanbaalenii_PYR-1 LGWADPRSGLSFGYVHNRLLTPLVLSDQAGFVATAALIRRGAAAARRNGY
Mflv_3647|M.gilvum_PYR-GCK LGWADPETGLAFGFVHNRLLTPMVVSDQAGFVATAALLRRGASQARKNGY
MSMEG_3162|M.smegmatis_MC2_155 VGWADPASGLAVGFVHNRLLTPMVF-DMGAFVGLHAVIRNDLARARRRGF
TH_3778|M.thermoresistible__bu YGWAEPETGLAIGYVHNRLLTPMLI-DQAAFVGLNALIRRDAAAARRRGY
MUL_2951|M.ulcerans_Agy99 IGWADPESGSAFGYVHNRLLT-LLLFDIGSFAGLAPLLSSAVSTARREGP
MAB_1386|M.abscessus_ATCC_1997 MGWADPKRKIAVGFAHNRLPLTMAL-DQISFAFLWPQIVKAVG-------
MLBr_00119|M.leprae_Br4923 AIWADPQRSMAAGLISS--GKPGQDPNAGRYGALMNTITAEIPVH-----
*::* : . . : : :
Mb1534|M.bovis_AF2122/97 QPVTPFG-APYSEPG---AAAG---
Rv1497|M.tuberculosis_H37Rv QPVTPFG-APYSEPG---AAAG---
MMAR_2305|M.marinum_M QPVTGIG-APYSEPG---AVAG---
MAV_3275|M.avium_104 RPVTEFG-APFREPG---AVAG---
Mvan_2765|M.vanbaalenii_PYR-1 RPVREYG-APFTDLT---ATAV---
Mflv_3647|M.gilvum_PYR-GCK RRVREYG-SPFSDVA---ATAV---
MSMEG_3162|M.smegmatis_MC2_155 EPVPDLGAAPYELSK---PVAG---
TH_3778|M.thermoresistible__bu RPVGDLG-APFDMRK---RVAG---
MUL_2951|M.ulcerans_Agy99 LEVPHFG-ASYRETGQQPLAAGETS
MAB_1386|M.abscessus_ATCC_1997 -------------------------
MLBr_00119|M.leprae_Br4923 -------------------------