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LDVAGLPRLAAGTQAAIIHGMAQPPSLLTTDNGLPFGVQGACDSRFTGVIRAFAGLYPGRKFGGGALSVY IDDRQVVDVWTGWSDRQGKVPWTADTGAMVFSATKGLAATVIHRLVDRGLLSYDAPVAEYWPEFGANGKS EVTVSDVLRHRSGLAHLKGVDKDEVMDHLLMEQKLAAAPLNRQHGKLAYHAVTYGWLLSGLARAVTGKGM RELFREELARPLNTDGIHLGRPPADSPTKAAQTLLPQAKVPTPLLDFIAPKVAGLSFSGLLGAVYFPGIL SLLQDDMPFLDGEVPAVNGVVTARALAKTYGALANDGVIDGTRLLSSQAVRGLTGKSELWPDLNLGLPFT YHQGYQSSPVPGLLEGYGHIGLGGTIGWADPETGSAFGYVHNRLLTLLLFDIGSFAGLAALLNSAVVAAR RDDPLEVPHFGAPYSEPRHEQAASGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1958 | lipD | - | 100% (446) | lipase LIPD |
| M. bovis AF2122 / 97 | Mb1534 | lipL | e-133 | 56.72% (402) | esterase LipL |
| M. bovis AF2122 / 97 | Mb2490 | lipP | 4e-43 | 34.77% (371) | esterase/lipase LipP |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3647 | - | 1e-141 | 58.17% (404) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1923 | lipD | 0.0 | 99.55% (446) | lipase LIPD |
| M. leprae Br4923 | MLBr_00119 | lipE | 1e-27 | 30.50% (318) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1386 | - | 1e-103 | 50.25% (404) | putative esterase/lipase/beta-lactamase |
| M. marinum M | MMAR_2828 | lipD | 0.0 | 85.88% (425) | lipase LipD |
| M. avium 104 | MAV_3275 | - | 1e-135 | 56.36% (401) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3162 | - | 1e-142 | 59.36% (406) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3778 | - | 1e-133 | 61.85% (367) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_2951 | lipD | 0.0 | 84.94% (425) | lipase LipD |
| M. vanbaalenii PYR-1 | Mvan_2765 | - | 1e-144 | 59.16% (404) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1958|M.bovis_AF2122/97 MDVAGLPRLAAGTQAAIIHGMAQPPSLLTTDNGLPFGVQGACDSRFTGVI
Rv1923|M.tuberculosis_H37Rv MDVAGLPRLAAGTQAAIIHGMAQPPSLLTTDNGLPFGVQGACDSRFTGVI
MMAR_2828|M.marinum_M --------------------MAQP-SVLTTDDGLPSGVAGACDSRFSGVV
MUL_2951|M.ulcerans_Agy99 --------------------MAQP-SVPTTDDGLPSGVAGACDSRFSGVV
MSMEG_3162|M.smegmatis_MC2_155 -------------MSGHN-RERDAALPH--------GVQGAADPNFACTA
TH_3778|M.thermoresistible__bu --------------------------------------------------
Mflv_3647|M.gilvum_PYR-GCK -------------MTGVNSRERDEALSHGHGGHLPRGVQGAADPNFTCAV
Mvan_2765|M.vanbaalenii_PYR-1 -------------MTGVNNPERDVALSHGHGAALPCGVQGAADPNFTLAV
MAV_3275|M.avium_104 ----------------MDARVDRRAVRVHDDLDAGHRVSGAADSHFGCVV
MAB_1386|M.abscessus_ATCC_1997 ----MAIPLGPNVAATAPVRRDGLYPGDQPGLRLPNGVEGWARPELSAVV
MLBr_00119|M.leprae_Br4923 --------------MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIW
Mb1958|M.bovis_AF2122/97 RAFAGLYPGRKFGGGALSVYIDDRQVVDVWTGW--------SDRQGKVPW
Rv1923|M.tuberculosis_H37Rv RAFAGLYPGRKFGGGALSVYIDGRQVVDVWTGW--------SDRQGKVPW
MMAR_2828|M.marinum_M RAFAGLYPGRKFGGGALSVYIEGRQVVDVWTGW--------ADRNGEVPW
MUL_2951|M.ulcerans_Agy99 RAFAGLYPGRKFGGGALSVYTEGRQVVDVWTGW--------ADRNGEVPW
MSMEG_3162|M.smegmatis_MC2_155 RAFSRLFPGRRFGGGALAVYQDGQPLVDIWTGY--------SDRAGTEYW
TH_3778|M.thermoresistible__bu ------------------VYLHGEPVVDVWTGY--------ADRRGTEYW
Mflv_3647|M.gilvum_PYR-GCK RAFAQMFPHRRFGGGALAVYLNGEPVVDVWTGW--------ADRRGKRRW
Mvan_2765|M.vanbaalenii_PYR-1 RAFAQMFPSRRLGGGALAVYLDGEPVVDVWTGW--------ADRRGTRRW
MAV_3275|M.avium_104 RSFASMFPARRFGGGALAVYVDGQPVVDVWTGW--------ADRAGQRPW
MAB_1386|M.abscessus_ATCC_1997 RTFEWMFTKYRLGGGGLSVYVDGEPALDIWAG---------AAAAGQG-W
MLBr_00119|M.leprae_Br4923 QATRHWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPV
: ... :: * .
Mb1958|M.bovis_AF2122/97 TADTGAMVFSATKGLAATVIHRLVDRGLLSYDAPVAEYWPEFGANGKSEV
Rv1923|M.tuberculosis_H37Rv TADTGAMVFSATKGLAATVIHRLVDRGLLSYDAPVAEYWPEFGANGKSEV
MMAR_2828|M.marinum_M TADTGAMVFSATKGLAATVIHRLVDRGLLDYDAPVADYWPEFGVKGKSAI
MUL_2951|M.ulcerans_Agy99 TADTGAMVFSATKGLAATVIHRLVDRGLLDYDAPVADYWPEFGVKGKSAI
MSMEG_3162|M.smegmatis_MC2_155 TADTGAMVFSATKGLASTVIHRLADRGLIDYDTPVSAYWPEFAANGKAHI
TH_3778|M.thermoresistible__bu TADTGAMVFSATKGMAATVVHRLVDRGLLDYDTPVAEYWPEFGANGKAGI
Mflv_3647|M.gilvum_PYR-GCK TADTAPMVFSATKGVAATVIHRLADRGLIDYDAPVAEYWREFGVNGKSTI
Mvan_2765|M.vanbaalenii_PYR-1 TADTGPMVFSATKGVTATVIHRLHDRGLVDYDAPVAEYWREFGANGKSAI
MAV_3275|M.avium_104 SENTAPMVFSATKGMAATVIHRLVDRGLIDYEAPVAEYWPAFAANGKANM
MAB_1386|M.abscessus_ATCC_1997 TRDTGALVFSASKGIAATVIHRLVDRGLITYDAPVARYWPEFGANGKSSI
MLBr_00119|M.leprae_Br4923 TTDTPFCAYSAAKAITATVVHMLVERGHFSLDDRVCEYLPTYTSYGKHRT
: :* .:**:*.:::**:* * :** . : *. * : **
Mb1958|M.bovis_AF2122/97 TVSDVLRHRSGLAHLKGVD--KDEVMDHLLMEQKLAAAPLN-RQHGKLAY
Rv1923|M.tuberculosis_H37Rv TVSDVLRHRSGLAHLKGVD--KDEVMDHLLMEQKLAAAPLD-RQHGKLAY
MMAR_2828|M.marinum_M TVSDLLRHRSGLSHLKGVG--KKEILDHLRMEEKLAAAPLD-RTHGKMAY
MUL_2951|M.ulcerans_Agy99 TVSDLLRHRSGLSHLKGVG--KKEILDHLRMEEKLAAAPLD-RTHGKMAY
MSMEG_3162|M.smegmatis_MC2_155 TVREVMQHRAGLSQLNGVS--KADMLDHRVMEARIAEASVNRHLYGKSAY
TH_3778|M.thermoresistible__bu TVRDVLRHRAGLSHLNGVS--KADLLDHRRMEERLAAAPVNRLQYGKPAY
Mflv_3647|M.gilvum_PYR-GCK TVRELMRHRAGLSQLNGAA--KTDLMDHLVMEERLAAAPAS-WLVGRPAY
Mvan_2765|M.vanbaalenii_PYR-1 TVRDALRHRAGLSQLNGAG--KADLLDHAVMEQRLAAAPRS-WLYGKPAY
MAV_3275|M.avium_104 TVRQVMRHQAGLSGLRGAT--KEELLDHLVMEERLAAAAPG-RLLGKSAY
MAB_1386|M.abscessus_ATCC_1997 TVRQVLDHRAGLSRLEGIAYHAEEIVDHELMERRLAAAPVD-KFYGKRAY
MLBr_00119|M.leprae_Br4923 TIRHVLTHSAGVPFPTGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIY
*: . : * :*:. * ** : ::: *
Mb1958|M.bovis_AF2122/97 HAVTYGWLLSGLARAVTGKGMRELFREELARPLNTDGIHLGRPPADSPTK
Rv1923|M.tuberculosis_H37Rv HAVTYGWLLSGLARAVTGKGMRELFREELARPLNTDGIHLGRPPADSPTK
MMAR_2828|M.marinum_M HAVTYGWLLSGLARAVTGKGMRDLFREELARPLDTDGLHLGRPPADAPTT
MUL_2951|M.ulcerans_Agy99 HAVTYGWLLSGLARAVTGKGMRDLFREELARPLDTDGLHLGRPPGDAPTT
MSMEG_3162|M.smegmatis_MC2_155 HALTYGWLMSGLVRAVTGQGMRELFRTELAEPLNTDGIHLGRPPVGAPTR
TH_3778|M.thermoresistible__bu HALTYGWLLSGLVRAITGCGMRELVRTELAEPLNTDGLHLGRPPAGAPTK
Mflv_3647|M.gilvum_PYR-GCK HAFTFGWLLSGLARSVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQAPTQ
Mvan_2765|M.vanbaalenii_PYR-1 HALTFGWLLSGLARSITGKGMRELIRTEVAAPLNTDGLHLGRPPVQAPTE
MAV_3275|M.avium_104 HALTFGWLMSGLGRAVTGKGMRTLIREELAEPLGTDGLYLGRPPAGAPTR
MAB_1386|M.abscessus_ATCC_1997 HALTFGWLLAGLARSVTGKDMRELFRTEIADPLGVDGIHLGRPPRTASTK
MLBr_00119|M.leprae_Br4923 HALTWGPLMREIIWTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVPLV
**.*:* *: : : ** :* :. *: **. :* . .
Mb1958|M.bovis_AF2122/97 AAQTLLPQAKVPTP-----LLDFIAPKVAGLS-FSGLLGAVYFPGILSLL
Rv1923|M.tuberculosis_H37Rv AAQTLLPQAKVPTP-----LLDFIAPKVAGLS-FSGLLGAVYFPGILSLL
MMAR_2828|M.marinum_M AAQTLLPQSKIPTP-----LLDFIAPKVAGLS-FSGLLGAVYFPGILSML
MUL_2951|M.ulcerans_Agy99 AAQTLLPQSKIPTP-----LLDFIAPKVAGLS-FSGLLGAVYFPGILSML
MSMEG_3162|M.smegmatis_MC2_155 AAQILGPQRTWPNH-----VFDFLAPRFAALE-FSGFFGSTYCPGVMSLV
TH_3778|M.thermoresistible__bu AAQILAPQGALDIP-----VVGAVVPRLAASQ-ASAMFGAMYFPGMFSVV
Mflv_3647|M.gilvum_PYR-GCK PARIIGPQTRLQNP-----IFNAVAPHIAALP-FSAGFGAMYFPGVKSFV
Mvan_2765|M.vanbaalenii_PYR-1 AAQIIGPQTRLQNP-----VFNLVAPRIAALP-FSAGFGAIYLPGVKALV
MAV_3275|M.avium_104 VAEIVAPQNLVGSS-----IVNYVS-RKVANQ-LSGGFRAMYFPGMIAAV
MAB_1386|M.abscessus_ATCC_1997 AASMYPFLDSMANKPAVGRLLPTVIRAIDRLPGFEGAIGTMYGPGMERIL
MLBr_00119|M.leprae_Br4923 ALSHATGRP--------------------LPPIIAAIFRKAIGGTVHEVI
. : : :
Mb1958|M.bovis_AF2122/97 QDD----MPFLDGEVPAVNGVVTARALAKTYGALANDGVIDGTRLLSSQA
Rv1923|M.tuberculosis_H37Rv QDD----MPFLDGEVPAVNGVVTARALAKTYGALANDGVIDGTRLLSSQA
MMAR_2828|M.marinum_M QDD----MPFLDGEIPAVNGVVTARALAKTYAALANDGVIDGMRLLSSDA
MUL_2951|M.ulcerans_Agy99 QDD----MPFLDGEIPAVNGVVTARALAKTYAALANDGVIDGMRLLSSDA
MSMEG_3162|M.smegmatis_MC2_155 QGD----TPFLDAEIPAANGVATARGLAKVYGAIANGGRFAGEEFLSAAT
TH_3778|M.thermoresistible__bu QGD----IPFLDSEIPAANAVATARGLAKMYGAIANGGRIDDVRFLSPEI
Mflv_3647|M.gilvum_PYR-GCK QGD----TPLLDGEIPAANGVATARALARMYGAIANEGRIDGLQYLSRET
Mvan_2765|M.vanbaalenii_PYR-1 QGD----TPLLDGEIPAANGVATARALARMYGAIANGGRIDGTQYLSGET
MAV_3275|M.avium_104 QGD----TPLLDAEIPAANGVATARGLARMYGAIANGGEVDGIRFLSRDL
MAB_1386|M.abscessus_ATCC_1997 ADDGTLNSALYDMQAPAANAVATAPALAKMYAALAGDGSVDGRELLSPET
MLBr_00119|M.leprae_Br4923 PYTN--TPPFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLRSET
.: *: * * ** *:: * . . . *
Mb1958|M.bovis_AF2122/97 VRGLTGKSE-LWPDLNLGLP-------FTYHQGYQSSPVPGLLEGYGHIG
Rv1923|M.tuberculosis_H37Rv VRGLTGKSE-LWPDLNLGLP-------FTYHQGYQSSPVPGLLEGYGHIG
MMAR_2828|M.marinum_M VSGLTGKAE-LWPDLNLGLP-------FTYHQGYQSSPVPGLLGGYGHIG
MUL_2951|M.ulcerans_Agy99 VSGLTGKAE-LWPDLNLGLP-------FTYHQGYQSPPVPGLLGGYGHIG
MSMEG_3162|M.smegmatis_MC2_155 VAGLSGRRS-LSPDRNIGVP-------LAFHLGYHSVPF-GVMAGFGHVG
TH_3778|M.thermoresistible__bu VAGLAGRRN-LRPDRNLGVP-------MAFHLGYHGVPF-GIMPGFGHVG
Mflv_3647|M.gilvum_PYR-GCK TAVLAGRRS-LRLDHSMVMP-------LSFHLGYHGLPIPGLLPGFGHVG
Mvan_2765|M.vanbaalenii_PYR-1 AAALIGRPS-LRPDHSMVMP-------LSFHLGYHGLPFPGVLPGFGHVG
MAV_3275|M.avium_104 VAGLTGERS-LRPDRNLYVP-------LAFHLGYHSVPIGGVMPGFGHVG
MAB_1386|M.abscessus_ATCC_1997 VAGLARKTN-LTIDRTIVFP-------MGMHLGYMSLPMNGFRGGFGHIG
MLBr_00119|M.leprae_Br4923 LLGAVAECRRLRPDFVVGLMPARWGTGFILGTNKFGPFGRNAPAAFGHLG
. * * : . : . . . .:**:*
Mb1958|M.bovis_AF2122/97 LGGTIGWADPETGSAFGYVHNRLLT-LLLFDIGSFAGLAALLNSAVVAAR
Rv1923|M.tuberculosis_H37Rv LGGTIGWADPETGSAFGYVHNRLLT-LLLFDIGSFAGLAALLNSAVVAAR
MMAR_2828|M.marinum_M LGGTIGWADPESGSAFGYVHNRLLT-LLLFDIGSFAGLAPLLSSAVSTAR
MUL_2951|M.ulcerans_Agy99 LGGTIGWADPESGSAFGYVHNRLLT-LLLFDIGSFAGLAPLLSSAVSTAR
MSMEG_3162|M.smegmatis_MC2_155 LGGSVGWADPASGLAVGFVHNRLLTPMVF-DMGAFVGLHAVIRNDLARAR
TH_3778|M.thermoresistible__bu LGGSYGWAEPETGLAIGYVHNRLLTPMLI-DQAAFVGLNALIRRDAAAAR
Mflv_3647|M.gilvum_PYR-GCK LGGSLGWADPETGLAFGFVHNRLLTPMVVSDQAGFVATAALLRRGASQAR
Mvan_2765|M.vanbaalenii_PYR-1 LGGSLGWADPRSGLSFGYVHNRLLTPLVLSDQAGFVATAALIRRGAAAAR
MAV_3275|M.avium_104 MGGSLGWADPASGVAFSLVHNRLLTPLVMTDHAAFVGIYALIRRAAEQVR
MAB_1386|M.abscessus_ATCC_1997 LGGSMGWADPKRKIAVGFAHNRLPLTMAL-DQISFAFLWPQIVKAVG---
MLBr_00119|M.leprae_Br4923 LVNIAIWADPQRSMAAGLISSGKPG--QDPNAGRYGALMNTITAEIPVH-
: . **:* : . . : : :
Mb1958|M.bovis_AF2122/97 RDDPLEVPHFG-APYSEPRHEQAASGA--
Rv1923|M.tuberculosis_H37Rv RDDPLEVPHFG-APYSEPRHEQAASGA--
MMAR_2828|M.marinum_M REGPLEVPHFG-ASYRETGQQPLAAGETS
MUL_2951|M.ulcerans_Agy99 REGPLEVPHFG-ASYRETGQQPLAAGETS
MSMEG_3162|M.smegmatis_MC2_155 RRGFEPVPDLGAAPYELSK---PVAG---
TH_3778|M.thermoresistible__bu RRGYRPVGDLG-APFDMRK---RVAG---
Mflv_3647|M.gilvum_PYR-GCK KNGYRRVREYG-SPFSDVA---ATAV---
Mvan_2765|M.vanbaalenii_PYR-1 RNGYRPVREYG-APFTDLT---ATAV---
MAV_3275|M.avium_104 KHGFRPVTEFG-APFREPG---AVAG---
MAB_1386|M.abscessus_ATCC_1997 -----------------------------
MLBr_00119|M.leprae_Br4923 -----------------------------