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MSQPQRRVETAPAIAPVPVRTELPGGVHGWAQPEFDRVVRKFASMYVGRIGGGALCVYVDGEPVLDIWAG EARPGMPWTHDTAPIVYSASKGVTATVIHRLADRGLLTYDAPVARYWPQFAANGKESITVREVLSHKSGL AALAPLASTPEELLDHELMEERLAAAPVGRFYGKAAYHAMSYGWLLAGLGRAITGQDMRALYRAEIAEPL GVDGIHLGRPPADSPTIPAGIYAHLEKAVRTPFLSRGLSLGARVIDAIPAARGATGAIHVPGAERIVADN GHTSAPLYDTQMGAGNAICTAPALAKLYAALSNRGSVDGRQLLSAEKTAELARGRGIRPGLPLARDIWDL GYHCFPAPGLLGGFGHMGAGGSTGWADPKRRIAVGLAHNHLILPNPMHNVAFPRLWAATVRSAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4006 | - | - | 100% (414) | putative lipase/esterase/beta-lactamase |
| M. abscessus ATCC 19977 | MAB_1386 | - | e-127 | 57.58% (396) | putative esterase/lipase/beta-lactamase |
| M. abscessus ATCC 19977 | MAB_1387 | - | e-123 | 54.05% (407) | putative esterase/lipase/beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1534 | lipL | 2e-95 | 50.40% (375) | esterase LipL |
| M. gilvum PYR-GCK | Mflv_3647 | - | 4e-97 | 50.53% (376) | beta-lactamase |
| M. tuberculosis H37Rv | Rv1497 | lipL | 2e-95 | 50.40% (375) | esterase LipL |
| M. leprae Br4923 | MLBr_00119 | lipE | 9e-24 | 28.75% (327) | putative hydrolase |
| M. marinum M | MMAR_2305 | lipL | 6e-94 | 48.56% (381) | esterase LipL |
| M. avium 104 | MAV_3275 | - | 2e-96 | 49.14% (409) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3162 | - | 7e-89 | 46.00% (400) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3778 | - | 2e-85 | 48.09% (366) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_2951 | lipD | 4e-91 | 48.42% (380) | lipase LipD |
| M. vanbaalenii PYR-1 | Mvan_2765 | - | 3e-97 | 48.85% (393) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3162|M.smegmatis_MC2_155 -MSGHN-RERDA--ALPH--------GVQGAADPNFACTARAFSR-LFPG
TH_3778|M.thermoresistible__bu --------------------------------------------------
Mflv_3647|M.gilvum_PYR-GCK -MTGVNSRERDE--ALSHGHGGHLPRGVQGAADPNFTCAVRAFAQ-MFPH
Mvan_2765|M.vanbaalenii_PYR-1 -MTGVNNPERDV--ALSHGHGAALPCGVQGAADPNFTLAVRAFAQ-MFPS
Mb1534|M.bovis_AF2122/97 --MMVDTGVDHR--AVSSHDGPDAGRRVFGAADPRFACVVRAFAS-MFPG
Rv1497|M.tuberculosis_H37Rv --MMVDTGVDHR--AVSSHDGPDAGRRVFGAADPRFACVVRAFAS-MFPG
MMAR_2305|M.marinum_M --MTVDIGVNRR--AVSSHGDPDAGHRVSGAADSQFACVVRMFSS-MFPA
MAV_3275|M.avium_104 ----MDARVDRR--AVRVHDDLDAGHRVSGAADSHFGCVVRSFAS-MFPA
MUL_2951|M.ulcerans_Agy99 -MAQPSVPTTDD--GLPS--------GVAGACDSRFSGVVRAFAG-LYPG
MAB_4006|M.abscessus_ATCC_1997 -MSQPQRRVETAPAIAPVPVRTELPGGVHGWAQPEFDRVVRKFAS-MYVG
MLBr_00119|M.leprae_Br4923 MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIWQATRHWYQAGMHPA
MSMEG_3162|M.smegmatis_MC2_155 RRFGGGALAVYQDGQPLVDIWT---GYSDRAGTEYWTADTGAMVFSATKG
TH_3778|M.thermoresistible__bu ---------VYLHGEPVVDVWT---GYADRRGTEYWTADTGAMVFSATKG
Mflv_3647|M.gilvum_PYR-GCK RRFGGGALAVYLNGEPVVDVWT---GWADRRGKRRWTADTAPMVFSATKG
Mvan_2765|M.vanbaalenii_PYR-1 RRLGGGALAVYLDGEPVVDVWT---GWADRRGTRRWTADTGPMVFSATKG
Mb1534|M.bovis_AF2122/97 RRFGGGALAVYLDGQPVVDVWK---GWADRAGWVPWSADSAPMVFSATKG
Rv1497|M.tuberculosis_H37Rv RRFGGGALAVYLDGQPVVDVWK---GWADRAGWVPWSADSAPMVFSATKG
MMAR_2305|M.marinum_M RRFGGGALAVYLDGQPVVDVWK---GWADREGEVPWSADSAPMVFSATKG
MAV_3275|M.avium_104 RRFGGGALAVYVDGQPVVDVWT---GWADRAGQRPWSENTAPMVFSATKG
MUL_2951|M.ulcerans_Agy99 RKFGGGALSVYTEGRQVVDVWT---GWADRNGEVPWTADTGAMVFSATKG
MAB_4006|M.abscessus_ATCC_1997 -RIGGGALCVYVDGEPVLDIWA---GEA-RPG-MPWTHDTAPIVYSASKG
MLBr_00119|M.leprae_Br4923 IQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDTPFCAYSAAKA
.. : . * . : :: .:**:*.
MSMEG_3162|M.smegmatis_MC2_155 LASTVIHRLADRGLIDYDTPVSAYWPEFAANGKAHITVREVMQHRAGLSQ
TH_3778|M.thermoresistible__bu MAATVVHRLVDRGLLDYDTPVAEYWPEFGANGKAGITVRDVLRHRAGLSH
Mflv_3647|M.gilvum_PYR-GCK VAATVIHRLADRGLIDYDAPVAEYWREFGVNGKSTITVRELMRHRAGLSQ
Mvan_2765|M.vanbaalenii_PYR-1 VTATVIHRLHDRGLVDYDAPVAEYWREFGANGKSAITVRDALRHRAGLSQ
Mb1534|M.bovis_AF2122/97 MTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRDVMRHQAGLSG
Rv1497|M.tuberculosis_H37Rv MTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRDVMRHQAGLSG
MMAR_2305|M.marinum_M MAATVIHRLADRGLIDYEAPVAQYWPEFAANGKEKLTVREVMRHAAGLSG
MAV_3275|M.avium_104 MAATVIHRLVDRGLIDYEAPVAEYWPAFAANGKANMTVRQVMRHQAGLSG
MUL_2951|M.ulcerans_Agy99 LAATVIHRLVDRGLLDYDAPVADYWPEFGVKGKSAITVSDLLRHRSGLSH
MAB_4006|M.abscessus_ATCC_1997 VTATVIHRLADRGLLTYDAPVARYWPQFAANGKESITVREVLSHKSGLAA
MLBr_00119|M.leprae_Br4923 ITATVVHMLVERGHFSLDDRVCEYLPTYTSYGKHRTTIRHVLTHSAGVPF
:::**:* * :** . : *. * : ** *: . : * :*:.
MSMEG_3162|M.smegmatis_MC2_155 LN--GVSKADMLDHRVMEARIAEASVNRHLYGKSAYHALTYGWLMSGLVR
TH_3778|M.thermoresistible__bu LN--GVSKADLLDHRRMEERLAAAPVNRLQYGKPAYHALTYGWLLSGLVR
Mflv_3647|M.gilvum_PYR-GCK LN--GAAKTDLMDHLVMEERLAAAPAS-WLVGRPAYHAFTFGWLLSGLAR
Mvan_2765|M.vanbaalenii_PYR-1 LN--GAGKADLLDHAVMEQRLAAAPRS-WLYGKPAYHALTFGWLLSGLAR
Mb1534|M.bovis_AF2122/97 LR--GATQQDLLDHVVMEERLAAAVPG-RLLGKSAYHALTFGWLMSGLAR
Rv1497|M.tuberculosis_H37Rv LR--GATQQDLLDHVVMEERLAAAVPG-RLLGKSAYHALTFGWLMSGLAR
MMAR_2305|M.marinum_M LR--GASQEDLLDHVVMEERLAAAAPG-RLLGKPAYHALTFGWLMSGLAR
MAV_3275|M.avium_104 LR--GATKEELLDHLVMEERLAAAAPG-RLLGKSAYHALTFGWLMSGLGR
MUL_2951|M.ulcerans_Agy99 LK--GVGKKEILDHLRMEEKLAAAPLD-RTHGKMAYHAVTYGWLLSGLAR
MAB_4006|M.abscessus_ATCC_1997 LAPLASTPEELLDHELMEERLAAAPVG-RFYGKAAYHAMSYGWLLAGLGR
MLBr_00119|M.leprae_Br4923 PTGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHALTWGPLMREIIW
** : ::: ***.::* *: :
MSMEG_3162|M.smegmatis_MC2_155 AVTGQGMRELFRTELAEPLNTDGIHLGRPPVGAPTRAAQILG--PQRTWP
TH_3778|M.thermoresistible__bu AITGCGMRELVRTELAEPLNTDGLHLGRPPAGAPTKAAQILA--PQGALD
Mflv_3647|M.gilvum_PYR-GCK SVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQAPTQPARIIG--PQTRLQ
Mvan_2765|M.vanbaalenii_PYR-1 SITGKGMRELIRTEVAAPLNTDGLHLGRPPVQAPTEAAQIIG--PQTRLQ
Mb1534|M.bovis_AF2122/97 AVTGKDMRLLFREELAEPLDTDGLHLGRPPADAPTRVAEIIM--PQDIAA
Rv1497|M.tuberculosis_H37Rv AVTGKDMRLLFREELAEPLDTDGLHLGRPPADAPTRVAEIIM--PQDIAA
MMAR_2305|M.marinum_M AVTGKDMRVLFREELAEPLDTDGFHLGRPPAGSPTQVAQIIM--PQDIAA
MAV_3275|M.avium_104 AVTGKGMRTLIREELAEPLGTDGLYLGRPPAGAPTRVAEIVA--PQNLVG
MUL_2951|M.ulcerans_Agy99 AVTGKGMRDLFREELARPLDTDGLHLGRPPGDAPTTAAQTLL--PQSKIP
MAB_4006|M.abscessus_ATCC_1997 AITGQDMRALYRAEIAEPLGVDGIHLGRPPADSPTIPAGIYAH-LEKAVR
MLBr_00119|M.leprae_Br4923 TATGKEIRDILAAEILDPLGFRWTNFGVAEEDVPLVALSHATGRPLPPII
: ** :* : *: **. :* . *
MSMEG_3162|M.smegmatis_MC2_155 NHVFD----FLAPRFAAL-EFSGFFGSTYCPGVMSLVQG----DTPFLDA
TH_3778|M.thermoresistible__bu IPVVG----AVVPRLAAS-QASAMFGAMYFPGMFSVVQG----DIPFLDS
Mflv_3647|M.gilvum_PYR-GCK NPIFN----AVAPHIAAL-PFSAGFGAMYFPGVKSFVQG----DTPLLDG
Mvan_2765|M.vanbaalenii_PYR-1 NPVFN----LVAPRIAAL-PFSAGFGAIYLPGVKALVQG----DTPLLDG
Mb1534|M.bovis_AF2122/97 NAVLT----CAMRRLAH--RFSGGFRSMYFPGAIAAVQG----EAPLLDA
Rv1497|M.tuberculosis_H37Rv NAVLT----CAMRRLAH--RFSGGFRSMYFPGAIAAVQG----EAPLLDA
MMAR_2305|M.marinum_M NPLVT----FAAHKIAN--QFSSGFRSMYFPGVIATVQG----ETPMLDA
MAV_3275|M.avium_104 SSIVN----YVSRKVAN--QLSGGFRAMYFPGMIAAVQG----DTPLLDA
MUL_2951|M.ulcerans_Agy99 TPLLD----FIAPKVAGL-SFSGLLGAVYFPGILSMLQD----DMPFLDG
MAB_4006|M.abscessus_ATCC_1997 TPFLSRGLSLGARVIDAIPAARGATGAIHVPGAERIVADNGHTSAPLYDT
MLBr_00119|M.leprae_Br4923 AAIFR--------------KAIGGTVHEVIP-----YTN----TPPFLTT
.. . * . *:
MSMEG_3162|M.smegmatis_MC2_155 EIPAANGVATARGLAKVYGAIANGGRFAGEEFLSAATVAGLSGRRS-LSP
TH_3778|M.thermoresistible__bu EIPAANAVATARGLAKMYGAIANGGRIDDVRFLSPEIVAGLAGRRN-LRP
Mflv_3647|M.gilvum_PYR-GCK EIPAANGVATARALARMYGAIANEGRIDGLQYLSRETTAVLAGRRS-LRL
Mvan_2765|M.vanbaalenii_PYR-1 EIPAANGVATARALARMYGAIANGGRIDGTQYLSGETAAALIGRPS-LRP
Mb1534|M.bovis_AF2122/97 EIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGLTRNRRQVLP
Rv1497|M.tuberculosis_H37Rv EIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGLTRNRRQVLP
MMAR_2305|M.marinum_M EIPAANGVVTARALARMYGAIANGGEIDGTQFLSRELVAGLTGERR-LQP
MAV_3275|M.avium_104 EIPAANGVATARGLARMYGAIANGGEVDGIRFLSRDLVAGLTGERS-LRP
MUL_2951|M.ulcerans_Agy99 EIPAVNGVVTARALAKTYAALANDGVIDGMRLLSSDAVSGLTGKAE-LWP
MAB_4006|M.abscessus_ATCC_1997 QMGAGNAICTAPALAKLYAALSNRGSVDGRQLLSAEKTAELARGRG-IRP
MLBr_00119|M.leprae_Br4923 IVPSSNTVSTANELSRFAEIWLRGGELDGIRVLRSETLLGAVAECRRLRP
: : * : ** *:: . * . . . * :
MSMEG_3162|M.smegmatis_MC2_155 DRNIGVP-----LAFHLGYHSVPF---GVMAGFGHVGLGGSVGWADPASG
TH_3778|M.thermoresistible__bu DRNLGVP-----MAFHLGYHGVPF---GIMPGFGHVGLGGSYGWAEPETG
Mflv_3647|M.gilvum_PYR-GCK DHSMVMP-----LSFHLGYHGLPIP--GLLPGFGHVGLGGSLGWADPETG
Mvan_2765|M.vanbaalenii_PYR-1 DHSMVMP-----LSFHLGYHGLPFP--GVLPGFGHVGLGGSLGWADPRSG
Mb1534|M.bovis_AF2122/97 DRNLLVP-----LNFHLGYHGMPIG--NVMPGFGHVGLGGSIGWTDPETG
Rv1497|M.tuberculosis_H37Rv DRNLLVP-----LNFHLGYHGMPIG--NVMPGFGHVGLGGSIGWTDPETG
MMAR_2305|M.marinum_M DRNLFMP-----MAFHLGYHSLPIG--NVMPGFGHVGMGGSVGWTDPETG
MAV_3275|M.avium_104 DRNLYVP-----LAFHLGYHSVPIG--GVMPGFGHVGMGGSLGWADPASG
MUL_2951|M.ulcerans_Agy99 DLNLGLP-----FTYHQGYQSPPVP--GLLGGYGHIGLGGTIGWADPESG
MAB_4006|M.abscessus_ATCC_1997 GLPLAR------DIWDLGYHCFPAP--GLLGGFGHMGAGGSTGWADPKRR
MLBr_00119|M.leprae_Br4923 DFVVGLMPARWGTGFILGTNKFGPFGRNAPAAFGHLGLVNIAIWADPQRS
. : : * : . .:**:* . *::*
MSMEG_3162|M.smegmatis_MC2_155 LAVGFVHNRLLTPMVF-DMGAFVGLHAVIRNDLARARRRGFEPVPDLGAA
TH_3778|M.thermoresistible__bu LAIGYVHNRLLTPMLI-DQAAFVGLNALIRRDAAAARRRGYRPVGDLG-A
Mflv_3647|M.gilvum_PYR-GCK LAFGFVHNRLLTPMVVSDQAGFVATAALLRRGASQARKNGYRRVREYG-S
Mvan_2765|M.vanbaalenii_PYR-1 LSFGYVHNRLLTPLVLSDQAGFVATAALIRRGAAAARRNGYRPVREYG-A
Mb1534|M.bovis_AF2122/97 VAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGYQPVTPFG-A
Rv1497|M.tuberculosis_H37Rv VAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGYQPVTPFG-A
MMAR_2305|M.marinum_M VAFALVHNRLLTPLVATDHAGFVAIYALIRQAAAKARERGYQPVTGIG-A
MAV_3275|M.avium_104 VAFSLVHNRLLTPLVMTDHAAFVGIYALIRRAAEQVRKHGFRPVTEFG-A
MUL_2951|M.ulcerans_Agy99 SAFGYVHNRLLT-LLLFDIGSFAGLAPLLSSAVSTARREGPLEVPHFG-A
MAB_4006|M.abscessus_ATCC_1997 IAVGLAHN----HLILPNPMHNVAFPRLWAATVRSAR-------------
MLBr_00119|M.leprae_Br4923 MAAGLISSG--KPGQDPNAGRYGALMNTITAEIPVH--------------
: . . : .
MSMEG_3162|M.smegmatis_MC2_155 PYELSK---PVAG---
TH_3778|M.thermoresistible__bu PFDMRK---RVAG---
Mflv_3647|M.gilvum_PYR-GCK PFSDVA---ATAV---
Mvan_2765|M.vanbaalenii_PYR-1 PFTDLT---ATAV---
Mb1534|M.bovis_AF2122/97 PYSEPG---AAAG---
Rv1497|M.tuberculosis_H37Rv PYSEPG---AAAG---
MMAR_2305|M.marinum_M PYSEPG---AVAG---
MAV_3275|M.avium_104 PFREPG---AVAG---
MUL_2951|M.ulcerans_Agy99 SYRETGQQPLAAGETS
MAB_4006|M.abscessus_ATCC_1997 ----------------
MLBr_00119|M.leprae_Br4923 ----------------