For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
DATGVDRRVPARLVLATRDGQLPGADLRVYQFHSHQTQVPPLRDIAVIGWQSRAQIALRCGAIRSRAQMS PGDFSILRPGYESTWQWSRGFQATVLYLNERRFADFASEVFDHHVDSVTIRESFQVQDSVIHHGLFLLAT ELRRDEFGAALYRDALVTQLCVHLLRHHAESRLRAHRHPGALNAAQAQQVTDYIEHNLDSDLCLSSLARV AGLSQYHFARLFKKRFGAPPHAYVQRRRIERARHLVLHSDMPLKEVVGVTGFCDQSHLTRAFRRAFDITP AELRRSSD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3996 | - | - | 100% (289) | helix-turn-helix domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_3612 | - | 8e-14 | 33.98% (103) | helix-turn-helix domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_0972 | - | 2e-09 | 26.23% (183) | AraC family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1966c | - | 7e-06 | 30.12% (83) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_2899 | - | 1e-13 | 35.79% (95) | helix-turn-helix domain-containing protein |
| M. tuberculosis H37Rv | Rv1931c | - | 7e-06 | 30.12% (83) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1313 | - | 2e-17 | 34.04% (141) | AraC family transcriptional regulator |
| M. marinum M | MMAR_2855 | - | 4e-06 | 24.60% (187) | transcriptional regulatory protein |
| M. avium 104 | MAV_4981 | - | 2e-06 | 28.57% (147) | transcriptional regulator, AraC family protein |
| M. smegmatis MC2 155 | MSMEG_2590 | - | 2e-13 | 25.29% (257) | AraC-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_3120 | - | 6e-10 | 35.11% (94) | PUTATIVE transcriptional regulator, AraC family with |
| M. ulcerans Agy99 | MUL_2902 | - | 6e-06 | 24.60% (187) | transcriptional regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1966c|M.bovis_AF2122/97 ----------MVIVGFPG--------------------------------
Rv1931c|M.tuberculosis_H37Rv ----------MVIVGFPG--------------------------------
MMAR_2855|M.marinum_M ------MARKVVIVGFPGVQPLDVVGPFEVFAGASLLS--EGGYDVALAS
MUL_2902|M.ulcerans_Agy99 ------MARKVVTVGFPGVQPLDVVGPFEVFAGASLLS--EGGYDVALAS
MAV_4981|M.avium_104 MADSSATPRVVVIVVFDDVTMLDVAGAGEVFAEANRFG---ADYLLKIAS
TH_3120|M.thermoresistible__bu ----------VAALVLDGLAIFEFGVICEVFGVDRTDDGVPPVDFTVCGP
Mflv_2899|M.gilvum_PYR-GCK --------------------------------------------------
MAB_1313|M.abscessus_ATCC_1997 ----------MVFGGFGG--------------------------------
Mvan_3996|M.vanbaalenii_PYR-1 ----------MDATGVDRRVPAR----------------------LVLAT
MSMEG_2590|M.smegmatis_MC2_155 --------------------------------------------------
Mb1966c|M.bovis_AF2122/97 -----------------------DPVDTVILPGGAGVDAARSEPALIDWV
Rv1931c|M.tuberculosis_H37Rv -----------------------DPVDTVILPGGAGVDAARSEPALIDWV
MMAR_2855|M.marinum_M IDERPVATGIGLEFMTTRLPDPSAPVDTVVLPGGGGVDAARDNVALMDWV
MUL_2902|M.ulcerans_Agy99 IDERPVATGIGLEFMTTRLPDPSAPVDTVVLPGGGGVDAARDNVALMDWV
MAV_4981|M.avium_104 VDGRDVTTSIGTRLGVTDAVSSIESADTVLVAGSDNLPRRPIDPELVEAV
TH_3120|M.thermoresistible__bu RAGQPVRTSFGATLTPDSGLDGLAGADLVAIP---AIRQDDYLPEALDAV
Mflv_2899|M.gilvum_PYR-GCK ------------------------------MRAKDLVDARYAEPITVDDL
MAB_1313|M.abscessus_ATCC_1997 -------VALGELQITFVSEPIVEPTEWYFDEPHHVVAVYQGGRILSKEI
Mvan_3996|M.vanbaalenii_PYR-1 RDGQLPGADLRVYQFHSHQTQVPPLRDIAVIGWQSRAQIALRCGAIRSRA
MSMEG_2590|M.smegmatis_MC2_155 ------------------MAGIREVFHARFIDHAYPQHTHDAWTLLIVDT
Mb1966c|M.bovis_AF2122/97 KAVSGTARRVVTVCTGAFLA---AEAGLLG--RTPSDDALG--LCRTFRP
Rv1931c|M.tuberculosis_H37Rv KAVSGTARRVVTVCTGAFLA---AEAGLLG--RTPSDDALG--LCRTFRP
MMAR_2855|M.marinum_M KAAAGTARRVVTVCTGTFLA---AEAGLLDGCRATTHWAFADRLAREFPA
MUL_2902|M.ulcerans_Agy99 KAAAGTARRVVTVCTGTFLA---AEAGLLDGCRATTHWAFADRLAREFPA
MAV_4981|M.avium_104 KSVADRTRRLASICTGSFIL---GQAGLLDGRRATTHWHDVRLFARAFPE
TH_3120|M.thermoresistible__bu RAAADAGAIILTVCSGAFLA---GAAGLLDGRPCTTHWGLTEELARRYPT
Mflv_2899|M.gilvum_PYR-GCK AAAAGLSR---------------------------------AHFSRMFTR
MAB_1313|M.abscessus_ATCC_1997 DFVDGLSRRYLPKVGDVLVVPM-GSRAAITTQGERASFCRFDIPTRLLDQ
Mvan_3996|M.vanbaalenii_PYR-1 QMSPGDFSILRPGYESTWQWSRGFQATVLYLNERRFADFASEVFDHHVDS
MSMEG_2590|M.smegmatis_MC2_155 GIIGYELDRREHGSTGDVVT----------LLPPHVPHNGRAVRPGGFRK
Mb1966c|M.bovis_AF2122/97 R-ISGRSGRCRPDLHAQFA--EGVDRGWSHRRHRPRAGTGRRRPRHRDCP
Rv1931c|M.tuberculosis_H37Rv R-ISGRSGRCRPDLHAQFA--EGVDRGWSHRRHRPRAGTGRRRPRHRDCP
MMAR_2855|M.marinum_M VDVDPDPIFIRSSPKVWTA--AGVTAGIDLALALVEGDHGTEIAQTVARW
MUL_2902|M.ulcerans_Agy99 VDVDPDPIFIRSSPKVWTA--AGVTAGIDLALALVEGDHGTEIAQTVARW
MAV_4981|M.avium_104 ITVEPDALFVCDG-DVFTS--AGISSGIDLALALVEMDYGTELVRAVARW
TH_3120|M.thermoresistible__bu ARVDRNVLYVDDG-DLITS--AGTAAGIDACLHLVRRELGSEVTNTIARH
Mflv_2899|M.gilvum_PYR-GCK TFGESPRAYLQTR-------------RLERAASLLR-----HTDRSVADI
MAB_1313|M.abscessus_ATCC_1997 RDLQPRVAYSDPLILQLASRMYSVADRTDVIARLLRESLADVVRLHLSDH
Mvan_3996|M.vanbaalenii_PYR-1 VTIRESFQVQDSVIHHGLFLLATELRRDEFGAALYRDALVTQLCVHLLRH
MSMEG_2590|M.smegmatis_MC2_155 RVLYLEPDLLTGIGAAVGTPTLADPALRDRISGLHRALGPGDEFEAYSRL
. .
Mb1966c|M.bovis_AF2122/97 DGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPPGAGGHRGRAGGAHRI
Rv1931c|M.tuberculosis_H37Rv DGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPPGAGGHRGRAGGAHRI
MMAR_2855|M.marinum_M LVLYLRRPGGQ-TQFAAPVWMP--RAKRPSIRDVQEA--IEAQPGGPHSI
MUL_2902|M.ulcerans_Agy99 LVLYLRRPCGQ-TQFAAPVWMP--RAKRPSIRDVQEA--IEAQPGGPHSI
MAV_4981|M.avium_104 LVVYLKRAGGQ-SQFSALVEAE--PPPRSPLRKVTAA--ISADPAADHSV
TH_3120|M.thermoresistible__bu MVVPPQRDGGQRQFIDQPIPVR------HSEGFAPHLDWILSNLDKTHTV
Mflv_2899|M.gilvum_PYR-GCK CVMVGLQSVGS----------------------------FTTSFARAYGL
MAB_1313|M.abscessus_ATCC_1997 YAALRPRPERR-RLLDSAMQAR-------------VTEYIEDGLDADISL
Mvan_3996|M.vanbaalenii_PYR-1 HAESRLRAHRHPGALNAAQAQQ-------------VTDYIEHNLDSDLCL
MSMEG_2590|M.smegmatis_MC2_155 AFVVERLQQHLAGAVAPPAPAR------DRRLASRLRELIDSRITTGLTL
:
Mb1966c|M.bovis_AF2122/97 GELAQRAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLEETHDTVV
Rv1931c|M.tuberculosis_H37Rv GELAQRAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLEETHDTVV
MMAR_2855|M.marinum_M EELAHRAAMSPRHFTRVFTGEVGEAPRQYVERVRTEAARRQLEETEDTVV
MUL_2902|M.ulcerans_Agy99 EELAHRAAMSPRHFTRVFTGEVGEAPGRYVERVRTEAARRQLEETEDTVV
MAV_4981|M.avium_104 KSLSARASLSTRQLTRLFQSELGTTPARYVEMVRIDAARAALDAGR-SVA
TH_3120|M.thermoresistible__bu ASLARRANMSPRTFARRFVEETGRTPMQWVTDQRVLYARRLLEETDLDIH
Mflv_2899|M.gilvum_PYR-GCK PPAAYRASMPSAAVHARIPSCILQRDTRPKADSRVKTAHGEKTGANASP-
MAB_1313|M.abscessus_ATCC_1997 SALAGHAQMSTSEFRKAFTEVFGHTPYQFVLDRRMSRAKQLLATTDLSVT
Mvan_3996|M.vanbaalenii_PYR-1 SSLARVAGLSQYHFARLFKKRFGAPPHAYVQRRRIERARHLVLHSDMPLK
MSMEG_2590|M.smegmatis_MC2_155 DEAGEILHADPVHLVRTFGREFGLPPHRYLTGRRVDEAR-RLLLDGMRPA
. . : * *:
Mb1966c|M.bovis_AF2122/97 AIAARCGFGTAETMRRSFIRRVGISPDQYRKAFA----------------
Rv1931c|M.tuberculosis_H37Rv AIAARCGFGTAETMRRSFIRRVGISPDQYRKAFA----------------
MMAR_2855|M.marinum_M AIAARCGFGTAETMRRNFIRRVGISPDQYRKAFA----------------
MUL_2902|M.ulcerans_Agy99 AIAARCGFGTAETMRRNFIRRVGISPDQYRKAFA----------------
MAV_4981|M.avium_104 ESARLAGFGSAETLRRVFVEHLGLSPKAYRDRFRTAARG-----------
TH_3120|M.thermoresistible__bu RIAARCGFGSTTLLRHHFRRVIGVTPSDYRRRFACGSTTSGSTESGAEVT
Mflv_2899|M.gilvum_PYR-GCK --------------------------------------------------
MAB_1313|M.abscessus_ATCC_1997 DISVAVGFSSPSHFATTFKTRIGVTPTAYRSGV-----------------
Mvan_3996|M.vanbaalenii_PYR-1 EVVGVTGFCDQSHLTRAFRRAFDITPAELRRSSD----------------
MSMEG_2590|M.smegmatis_MC2_155 DVAAAVGFHDQSHLHRHFRKMLGTTPARFARRDRTESGDSR---------
Mb1966c|M.bovis_AF2122/97 -
Rv1931c|M.tuberculosis_H37Rv -
MMAR_2855|M.marinum_M -
MUL_2902|M.ulcerans_Agy99 -
MAV_4981|M.avium_104 -
TH_3120|M.thermoresistible__bu D
Mflv_2899|M.gilvum_PYR-GCK -
MAB_1313|M.abscessus_ATCC_1997 -
Mvan_3996|M.vanbaalenii_PYR-1 -
MSMEG_2590|M.smegmatis_MC2_155 -