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TYSPPADIDNRPVAVLGAGTLGRRIALTFATRGGVVHLYDVSEESLQSAKEFLDQRIPELVKARSALGAQ PATIEYYTDLPSAVKDAWYVVESVPEVQALKIDMLGQLDEIAAPDAIIGTNSSSFMSSELIGKVKHPQRF LNTHYGQPPEAPQAELVTDGHTNERIFDILGAELPKHGFVTAVAHKESVGFIINRVWAAVKREALAVVAE GVSTPAEFDRIWVASGMSPIGVFRAIDRVGLDVALDIEDNYIKHFPYIPTTSRDLLQQYVDEGKLGVKSG EGFYHDCPEPSHD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0759c | - | - | 100% (294) | putative dehydrogenase (3-hydroxybutyryl-CoA dehydrogenase FadB) |
| M. abscessus ATCC 19977 | MAB_0904 | - | 8e-25 | 29.50% (278) | putative 3-hydroxyacyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4489c | - | 4e-24 | 32.76% (290) | 3-hydroxyacyl-CoA dehydrogenase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0477 | fadB2 | 3e-24 | 29.58% (284) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0106 | - | 2e-26 | 29.97% (287) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. tuberculosis H37Rv | Rv1715 | fadB3 | 2e-29 | 33.58% (274) | 3-hydroxybutyryl-CoA dehydrogenase FADB3 |
| M. leprae Br4923 | MLBr_02461 | fadB2 | 3e-23 | 29.17% (288) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. marinum M | MMAR_1322 | fadB3 | 7e-69 | 48.40% (281) | 3-hydroxybutyryl-CoA dehydrogenase FadB3 |
| M. avium 104 | MAV_4681 | - | 1e-23 | 28.87% (284) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6791 | - | 1e-26 | 31.83% (289) | 3-hydroxybutyryl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3443 | - | 7e-20 | 27.69% (260) | PUTATIVE 3-hydroxybutyryl-CoA dehydrogenase FadB2 |
| M. ulcerans Agy99 | MUL_2558 | fadB3 | 5e-69 | 48.40% (281) | 3-hydroxybutyryl-CoA dehydrogenase FadB3 |
| M. vanbaalenii PYR-1 | Mvan_0802 | - | 1e-24 | 30.04% (283) | 3-hydroxybutyryl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02461|M.leprae_Br4923 ----------MSDAAIQRVGVVGAGQMGSGIAEVAVRAGVGVTVFETTDT
MAV_4681|M.avium_104 MHDKTIGGETVSDAAIQRVGVVGAGQMGSGIAEVSVRADVDVTVFETTEA
Mb0477|M.bovis_AF2122/97 ----------MSD-AIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEA
TH_3443|M.thermoresistible__bu ------------------------------LRWWHARERCPX-VYDISEE
Mflv_0106|M.gilvum_PYR-GCK -------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYEPSDA
Mvan_0802|M.vanbaalenii_PYR-1 -------------MSIERVGVVGAGQMGSGIAEVAAKAGANVVVYEPSEA
MSMEG_6791|M.smegmatis_MC2_155 ------------MRKINTVTVVGAGYMGGGIAQVLALNGFKVQIADVNAE
Rv1715|M.tuberculosis_H37Rv ---------MLTSHGFSRAAVVGAGLMGRRIAGVLASAGLDVAITDTNAE
MMAR_1322|M.marinum_M --MTGAYTYTFADIRSRPVAVIGAGTLGRRIALMFASRGGTVRIYARRAE
MUL_2558|M.ulcerans_Agy99 --MTGAYTYTFADIRSRPVAVIGAGTLGRRIALMFASRGGTVRIYARRAE
MAB_0759c|M.abscessus_ATCC_199 --MT--YS-PPADIDNRPVAVLGAGTLGRRIALTFATRGGVVHLYDVSEE
: . :
MLBr_02461|M.leprae_Br4923 LVTAGRNRIVKSLERGVSAGKVTERERDSALGHLVFTTDLNDLA-DRQLV
MAV_4681|M.avium_104 LITAGRNRIVKSLERGVSAGKVTERERDRALSKLTFTTDLKDLA-DRQLV
Mb0477|M.bovis_AF2122/97 LITAGRNRIVKSLERAVSAGKVTERERDRALGLLTFTTDLNDLS-DRQLV
TH_3443|M.thermoresistible__bu LTTAGRERIAKSLTRGVQAGKLSEDERSAALDRLRFTTTLADLS-DRQLV
Mflv_0106|M.gilvum_PYR-GCK LVNAGRERITASLERAKAKGKLAADDFEITLARLTFTTDLADLA-DRQLV
Mvan_0802|M.vanbaalenii_PYR-1 LVAAGRDRITASLERAKAKGKLAADDFDATVARLTFTTNLGDLA-DRQLV
MSMEG_6791|M.smegmatis_MC2_155 ATQEALKRLDREAREFEQQGLFGPGSADTIMSNLTASDSLDDAVSDVDYV
Rv1715|M.tuberculosis_H37Rv ILHAAAVEAARVAGAGR--------------GSVAAAADLAAAIPDADLV
MMAR_1322|M.marinum_M QRAQATQYVADNLPKLLQDR-----GFG-EVGSVTATDCLATALEGAWLA
MUL_2558|M.ulcerans_Agy99 QRAQATQYVADNLPKLLQDR-----GFG-EVGSVTATDCLATALEGAWLA
MAB_0759c|M.abscessus_ATCC_199 SLQSAKEFLDQRIPELVKARS----ALGAQPATIEYYTDLPSAVKDAWYV
. : * . .
MLBr_02461|M.leprae_Br4923 IEAIVEDEAVKTKVFAELDRVITDPDAVLASNTSSIPIMKIAAATKNPQR
MAV_4681|M.avium_104 IEAIIEDDAVKAQVFAELDRVVTDPDAVLASNTSSIPIMKLAAATKNPQR
Mb0477|M.bovis_AF2122/97 IEAVVEDEAVKSEIFAELDRVVTDPDAVLASNTSSIPIMKVAAATKQPQR
TH_3443|M.thermoresistible__bu IEAIVEDENVKATVFAELDELLTDPDAVLASNTSSIPIMKLAAATKNPGR
Mflv_0106|M.gilvum_PYR-GCK IEAIIEDEAVKAKVFAQLDEVVTDPDAVLASNTSSIPIMKIAAATKNPSR
Mvan_0802|M.vanbaalenii_PYR-1 IEAIVENEAVKAKVFAELDAVVTDPDAVLASNTSSIPIMKIAAATKNPSR
MSMEG_6791|M.smegmatis_MC2_155 MEAVFEDVDVKKEVLARVCASAR-PDTIIGTNTSTIPVKVLVDAVTHPER
Rv1715|M.tuberculosis_H37Rv IEAVVENLAVKQELFERLATLAP--DAVLATNTSVLPIGAVTERVEDGSR
MMAR_1322|M.marinum_M VESVPEKLEIKTALWGQIDQAAP-PDTIFATNSSSFPSRLMADNVRDKTR
MUL_2558|M.ulcerans_Agy99 VESVPEKLEIKTALWGQIDQAAP-PDTIFATNSSSFPSRLMADNVRDKTR
MAB_0759c|M.abscessus_ATCC_199 VESVPEVQALKIDMLGQLDEIAA-PDAIIGTNSSSFMSSELIGKVKHPQR
:*:: * :* : .: *:::.:*:* : : . . *
MLBr_02461|M.leprae_Br4923 VLGLHFFNPVPVLPLVELVSTLVTDEAAATRAEEFASGVLGKQVVRCSDR
MAV_4681|M.avium_104 VLGLHFFNPVPVLPLVELVSTLVTDEAAAARTEEFASAVLGKQVVRCSDR
Mb0477|M.bovis_AF2122/97 VLGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGKQVVRCSDR
TH_3443|M.thermoresistible__bu VLGLHFFNPVPVLPLVELINTLVTTDEAIARTEKFAAEVLGKQVVRCGDR
Mflv_0106|M.gilvum_PYR-GCK VLGLHFFNPVPVLPLVEVINTLVTSEEAVARVEQFASEVLGKKVVRCGDR
Mvan_0802|M.vanbaalenii_PYR-1 VLGLHFFNPVPVLPLVELVNTLVTSDDAIARVERFAGEVLGKKVVRCGDR
MSMEG_6791|M.smegmatis_MC2_155 FLTVHFSNPAPFIPGVELVAGEATTQEVIDSVKDLLARAG-REGAQVADT
Rv1715|M.tuberculosis_H37Rv VIGTHFWNPPDLIPVVEVVPSARTAPDTADRVVALLTQVGKLPVRVGRDV
MMAR_1322|M.marinum_M LCNTHFYMP-PQFNALDLMSDGETDRGLLDTLLTVLPEFGVHPFEARREC
MUL_2558|M.ulcerans_Agy99 LCNTHFYMP-PQFNALDLMSDGETDRGLLDTLLTVLPEFGVHPFEARREC
MAB_0759c|M.abscessus_ATCC_199 FLNTHYGQP-PEAPQAELVTDGHTNERIFDILGAELPKHGFVTAVAHKES
. *: * ::: * :
MLBr_02461|M.leprae_Br4923 SGFVVNALLVPYLLSAIRIVEAGFATVEDVDKAVLAGLSHPMG---PLRL
MAV_4681|M.avium_104 SGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMG---PLRL
Mb0477|M.bovis_AF2122/97 SGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMG---PLRL
TH_3443|M.thermoresistible__bu SGFVVNALLVPYLLSAIRMVESGYASVEDVDKAVVAGLSHPMG---PLRL
Mflv_0106|M.gilvum_PYR-GCK SGFIVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMG---PLRL
Mvan_0802|M.vanbaalenii_PYR-1 SGFVVNALLVPYLLSAIRMAEAGVATVEDIDTAVVAGLSHPMG---PLRL
MSMEG_6791|M.smegmatis_MC2_155 PGMALNRLQYALLKEATLIVEEGVATKEDVDTIVRTTFGFRLGFFGPFAI
Rv1715|M.tuberculosis_H37Rv PGFIGNRLQHALWREAIALVAEGVCDPKTVDLVVRNTIGLRLATLGPLEN
MMAR_1322|M.marinum_M TGFIFNRVWAAIKRESLAVVAEGVARPEDVDGMFKVNWRVPAG---PFQL
MUL_2558|M.ulcerans_Agy99 TGFIFNRVWAAIKRESLAVVAEGVARPEDVDGMFKVNWRVPAG---PFQL
MAB_0759c|M.abscessus_ATCC_199 VGFIINRVWAAVKREALAVVAEGVSTPAEFDRIWVASGMSPIG---VFRA
*: * : . .: :. * . .* . :
MLBr_02461|M.leprae_Br4923 SDLVGLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGLLGKKSGQGFYT
MAV_4681|M.avium_104 SDLVGLDTLKLIADKMFEEFKEPQYGAPPLLLRMVEAGRLGKKTGQGFYT
Mb0477|M.bovis_AF2122/97 SDLVGLDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGRGFYT
TH_3443|M.thermoresistible__bu SDLVGLDTLKLIADKMFDEFKEPHYGPPPLLVRMVEAGHLGKKTGRGFYT
Mflv_0106|M.gilvum_PYR-GCK SDLIGLDTMKLIADSMYDEYKDPNFAPPPLLQRMVEAGQLGKKSGKGFYS
Mvan_0802|M.vanbaalenii_PYR-1 SDLIGLDTMKLIADSMYDEYKDPHYAPPPLLQRMVEAGQLGKKSGKGFYT
MSMEG_6791|M.smegmatis_MC2_155 ADQAGLDVYVKGYHTLENAFGER-MATPKLLTDNVDAGRYGTKNGKGWTG
Rv1715|M.tuberculosis_H37Rv ADYIGLDLTLAIHDAVIPSLNHDPHPSP-LLRELVAAGQLGARTGHGFLD
MMAR_1322|M.marinum_M MDQVGLDVVLDIENHYADEFPYLPTNVRDLLRSYVDAGKLGVKTGEGFYT
MUL_2558|M.ulcerans_Agy99 MDQVGLDVVLDIENHYADEFPYLPTNVRDLLRSYVDAGKLGVKTGEGFYT
MAB_0759c|M.abscessus_ATCC_199 IDRVGLDVALDIEDNYIKHFPYIPTTSRDLLQQYVDEGKLGVKSGEGFYH
* *** . ** * * * :.*.*:
MLBr_02461|M.leprae_Br4923 Y----------------------------------
MAV_4681|M.avium_104 Y----------------------------------
Mb0477|M.bovis_AF2122/97 Y----------------------------------
TH_3443|M.thermoresistible__bu Y----------------------------------
Mflv_0106|M.gilvum_PYR-GCK Y----------------------------------
Mvan_0802|M.vanbaalenii_PYR-1 Y----------------------------------
MSMEG_6791|M.smegmatis_MC2_155 DFDDETKAAVIAYRNKAYSRMGELLRELGPAPKGA
Rv1715|M.tuberculosis_H37Rv WPAGAREATTARLAQHIAAQLQANEKGRGT-----
MMAR_1322|M.marinum_M -YPNSSDT---------------------------
MUL_2558|M.ulcerans_Agy99 -YPNSSDT---------------------------
MAB_0759c|M.abscessus_ATCC_199 DCPEPSHD---------------------------