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VITRRALLGTTFALAGAAVLAGCGSPARAADPQVSVTGGAIRGTTAGKVHVFRGIPYAQPPTGENRFRSP RPVNPWGGTLNATRFGSDFIQPAGGDPARQEDALYANVWTPSVDGGAKLPVIVYIHGGGWSRGAGSLPVY DGAALAERAGAVVVNFNYRLGAFGFSGHPALEDPTTGLHTNWGLQDQIALLHWVSDNARAFGGDPKNITL VGTSAGGASTWQLSLLPQTRPLLRRIISISQAHVWSPYLSLTQDDATAVFDALAAAQGVSVKDLRKVPAD RIRDWWVAQFAQPRQQRVVGSGRQYRGPVRDPVLLPAFDVHQPLPDIPAISVYTSTEGSFFTGPNAPEPQ APPTDGASLHAAFRDILDQGMPSVSDSTVSDAVALYTDSAKREGRPSDPLALWTELWGDALIRHDILAFT RRAAAQRRAPLYLMEYAHPVKSPYFGVPHESTSPFLFGTYAHPANVAKFGDGSKERETSAAFMDLVAEFV HGRPPASPRLPQWDPVGPDLRQLVLRDGSGTITTPTKTTQLGVLDAVQWGK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0294 | - | - | 100% (541) | putative carboxylesterase, type B |
| M. abscessus ATCC 19977 | MAB_3803c | - | 1e-41 | 33.71% (445) | carboxylesterase |
| M. abscessus ATCC 19977 | MAB_3336c | - | 2e-41 | 29.98% (497) | carboxylesterase LipT |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2071c | lipT | 2e-39 | 43.13% (211) | carboxylesterase LipT |
| M. gilvum PYR-GCK | Mflv_5051 | - | 8e-42 | 39.24% (316) | carboxylesterase, type B |
| M. tuberculosis H37Rv | Rv2045c | lipT | 2e-39 | 43.13% (211) | carboxylesterase LipT |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_4363 | - | 4e-39 | 37.69% (260) | carboxylesterase |
| M. avium 104 | MAV_0492 | - | 2e-52 | 32.70% (523) | para-nitrobenzyl esterase |
| M. smegmatis MC2 155 | MSMEG_1432 | - | 3e-45 | 36.73% (343) | acetylcholinesterase |
| M. thermoresistible (build 8) | TH_3679 | - | 5e-43 | 31.15% (504) | PUTATIVE Carboxylesterase, type B |
| M. ulcerans Agy99 | MUL_2261 | lipT | 1e-38 | 31.74% (438) | carboxylesterase, LipT |
| M. vanbaalenii PYR-1 | Mvan_1303 | - | 2e-43 | 39.30% (285) | carboxylesterase, type B |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2071c|M.bovis_AF2122/97 ------------------MALESATVGSMHERTVRARTATGIVEGFTRDG
Rv2045c|M.tuberculosis_H37Rv ------------------MALESATVGSMHERTVRARTATGIVEGFTRDG
MUL_2261|M.ulcerans_Agy99 ----------------------------MHERTVRARTATGVVEGFTRDG
MMAR_4363|M.marinum_M ---------MTSDIR---RMASDG----YVVETAYG-PVRGAEDGIAAAG
TH_3679|M.thermoresistible__bu ---------MPSTTPPDDRTPDDAPTRPAPAHSAVGSPVVDTVHGPVRGR
Mflv_5051|M.gilvum_PYR-GCK --------MLVALVVAVACGSQAS------PQPAPDPAVVQTSTGPVRGT
Mvan_1303|M.vanbaalenii_PYR-1 MPIPRLGVLAVLMVLVAACGRGDAGDRGHEARSPVDPAVVQTAAGAVRGT
MSMEG_1432|M.smegmatis_MC2_155 -MRRARQVSALLFGLVIVLNAAVVGCRAAEAPVATDPVVVHTASGTVRGL
MAV_0492|M.avium_104 -----------------------------------MSPTVRLAQGVVSGA
MAB_0294|M.abscessus_ATCC_1997 ------MITRRALLGTTFALAGAAVLAGCGSPARAADPQVSVTGGAIRGT
*
Mb2071c|M.bovis_AF2122/97 ----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFANCAPQQRR
Rv2045c|M.tuberculosis_H37Rv ----VHRWRSIPYARAPVGSLRFRAPQPAQPWPGVRHCHTFANCAPQQRR
MUL_2261|M.ulcerans_Agy99 ----VHRWRSIPYARAPIGLLRFRAPRPPQPWSGVRHCHGFTHCSPQQRR
MMAR_4363|M.marinum_M SGVRTKSWKGIRYGAPPVGELRFRAPQPPQPWTEIADATAFGPVCPQP-V
TH_3679|M.thermoresistible__bu DDGVVKVWRGIRYAAAPVGGLRWRAPEPPQPWREPMDAIRVGPACPQP-A
Mflv_5051|M.gilvum_PYR-GCK VADDHRLFAGIPYAAPPVGALRWQGPRPAPKWDGVRDATAYGPRCMQD--
Mvan_1303|M.vanbaalenii_PYR-1 VEPDHRLFAGIPYAAPPIGPLRWRDPEPAPRWDGVRDATAFGSRCLQD--
MSMEG_1432|M.smegmatis_MC2_155 VAEGHRLFAGIPYAAPPVGSLRFAAPEPAASWPGERDATRPGPRCVQD--
MAV_0492|M.avium_104 EDGGVYRFLGMPYAAPPVGDLRWAPPAPPASWAGVRDATRYGNAAIQT--
MAB_0294|M.abscessus_ATCC_1997 TAGKVHVFRGIPYAQPPTGENRFRSPRPVNPWGGTLNATRFGSDFIQP--
: .: *. .* * *: * * * .. *
Mb2071c|M.bovis_AF2122/97 YTVMGIGRYQTRSEDCLTLNVVTPEEPATQP--LPVMVFIHGGGYILGSS
Rv2045c|M.tuberculosis_H37Rv YTVMGIGRYQTRSEDCLTLNVVTPEEPATQP--LPVMVFIHGGGYILGSS
MUL_2261|M.ulcerans_Agy99 YTMLGLGKYQPMSEDCLTLNVVAPEAPTHRP--LPVMVFIHGGGYILGSS
MMAR_4363|M.marinum_M LANMPIDLGAPQDEDCLRLNIWAPANTAPGAA-KPVMVWLHGGAYMLGSA
TH_3679|M.thermoresistible__bu DPRIPLDLGAAIGEDCLNLNVWASSDTEPGDR-KPVLVWVHGGAYVIGAA
Mflv_5051|M.gilvum_PYR-GCK -LDGDLELGRQTDEDCLNLNVWTPPVAGDRPEPKPVMVWIHGGSFVAGSS
Mvan_1303|M.vanbaalenii_PYR-1 -LAGDLELGRQTDEDCLNLNVWTPAAEPGRP--RAVMVWIHGGSFVAGSG
MSMEG_1432|M.smegmatis_MC2_155 -PDADLEHGDNSGEDCLTLNVWTPPVGKDLR---PVMVWIHGGGFVNGSS
MAV_0492|M.avium_104 -VDTGFDPGAPQSEDCLYLNVWTSTLDVGAR--RPVMVWIHGGGFLNGAS
MAB_0294|M.abscessus_ATCC_1997 -----AGGDPARQEDALYANVWTPSVDGGAK--LPVIVYIHGGGWSRGAG
**.* *: :. .*:*::***.: *:.
Mb2071c|M.bovis_AF2122/97 ATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQITLDSNVYLR
Rv2045c|M.tuberculosis_H37Rv ATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPQITLDSNVYLR
MUL_2261|M.ulcerans_Agy99 ATPIYDGAALARRG-CVYVSVNYRLGALGCLDLSSLSTPDIAIDGNLYLR
MMAR_4363|M.marinum_M SQALYDGRRLASSGEVIVVTVNYRLGALGFLDLSSLSHAGRSFDSNVGLR
TH_3679|M.thermoresistible__bu SQPLYHGRELVRRGDVVLVTLNYRLGAFGFLELTALSSGRRRFDTNVGLR
Mflv_5051|M.gilvum_PYR-GCK G--VYDSRRLVARGDIIVVTVNYRLGALGFLAHPALGPPGA--VGNYGLA
Mvan_1303|M.vanbaalenii_PYR-1 G--IYDARRLAARGDIVVVTLNYRLGAPGFLAHPSLGPPGE--VGNYGLA
MSMEG_1432|M.smegmatis_MC2_155 D--VYDASRLASRGDIVVVTVNYRLGTLGFLAHPALEAPGE--VGNYGIA
MAV_0492|M.avium_104 SMDLWQGQHLARRG-VTVVSLNYRLGAFGFLAHPQAG-------GNFGLL
MAB_0294|M.abscessus_ATCC_1997 SLPVYDGAALAERAGAVVVNFNYRLGAFGFSGHPALEDPTTGLHTNWGLQ
::.. *. . *..*****: * . * :
Mb2071c|M.bovis_AF2122/97 DLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPAAKGLFAR
Rv2045c|M.tuberculosis_H37Rv DLVLALRWVHDNIAEFGGDPGNVTIFGESAGAHITATLLAVPAAKGLFAR
MUL_2261|M.ulcerans_Agy99 DLVMALQWIQDNIAEFGGDPDNVTIFGESAGAHITATLLAVPAAKGLFAR
MMAR_4363|M.marinum_M DVLAALHWVRENIAAFGGDPANITLFGESAGAGLVTTLLVTPAARGLFSR
TH_3679|M.thermoresistible__bu DVLFALAWVRDNIAAFGGDPDRVTLFGESAGGGIVTTLLGSPAAAGLFHR
Mflv_5051|M.gilvum_PYR-GCK DQQAALRWVRDNIANFGGDPARVTVAGESAGAMSVCDHLVAPGSDGLFDA
Mvan_1303|M.vanbaalenii_PYR-1 DQQAALRWVRDNIAAFGGDPGKVTVAGESAGAMSVCDHLVAPASQGLFDA
MSMEG_1432|M.smegmatis_MC2_155 DQQAALRWVRDNIAAFGGDPQRVTLAGESAGGTSVCDHLVAPGSAGLFDA
MAV_0492|M.avium_104 DWVAALSWVAENIATFGGDPANVTIFGQSAGGAATRALLHTPSARGLFHR
MAB_0294|M.abscessus_ATCC_1997 DQIALLHWVSDNARAFGGDPKNITLVGTSAGGASTWQLSLLPQTRPLLRR
* * *: :* ***** .:*: * ***. . * : *:
Mb2071c|M.bovis_AF2122/97 AISESP--AAGMVRSREVAAEFAARFANLIGARTQDAANALMQASPAQLV
Rv2045c|M.tuberculosis_H37Rv AISESP--AAGMVRSREVAAEFAARFANLIGARTQDAANALMQASPAQLV
MUL_2261|M.ulcerans_Agy99 AISESP--AAGMVRPREIAAEFATRFARLLGARKHDAASALMRATAAQLV
MMAR_4363|M.marinum_M AIAQSS--PATSVYDRERAQRVAVHLLDKLGVAASD-VDKLTQLPTAAIV
TH_3679|M.thermoresistible__bu AIAQSS--PATSCYGTERAIDVAEQFLGHLGLSPRD-VDRLPDVPVAAIV
Mflv_5051|M.gilvum_PYR-GCK AIVMSG--LCQSQADLPTAEKRSLDYAAQAGCGG-PVPAECLRGLDANAL
Mvan_1303|M.vanbaalenii_PYR-1 AIIMSG--PCQAQAPLPVAEQRSIEYAAALGCADKATAAECLRALPGNKL
MSMEG_1432|M.smegmatis_MC2_155 VVLMSA--PCQVQADLPTAEQRSVAYAAEAGCPDPASAGDCLRALPVDRL
MAV_0492|M.avium_104 AVIQSAGYEDYAVVGSPSYQRVTDASERLFEQLGSADIDELRRLPAEQVR
MAB_0294|M.abscessus_ATCC_1997 IISISQ--AHVWSPYLSLTQDDATAVFDALAAAQGVSVKDLRKVPADRIR
: * :
Mb2071c|M.bovis_AF2122/97 EAQHHLIRQGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHAVPLIVG
Rv2045c|M.tuberculosis_H37Rv EAQHHLIRQGMRKRLGAFPIGPVFGDDYLPMDPVEAMRSGRVHAVPLIVG
MUL_2261|M.ulcerans_Agy99 QTQHRLIDQGMQKRLGAFPIGPTFGDDCLPLDPVEAMRAGQSHKVPLIVG
MMAR_4363|M.marinum_M AASTEVFNEVPVRNPGTLAFVPIVDGDVLTDYPVKVAQEGRSHPVPLLIG
TH_3679|M.thermoresistible__bu EVSKHVFDDVPARRPGTLAFAPIVDGDIVPDYPVALARAGRTLPVPLVIG
Mflv_5051|M.gilvum_PYR-GCK RTPVWYYDIGDDR-----LSGPVTGSAVLPTAPPVAFGDGKAARVPVLMG
Mvan_1303|M.vanbaalenii_PYR-1 RTPVWFYEIGDDR-----LSGPATGSAELPADPVTAFGAGRAARVPVLIG
MSMEG_1432|M.smegmatis_MC2_155 RKPVWYFNIGSDQ-----MTTPVTGTAMLPRAPLRSLG--EAPDVPVLIG
MAV_0492|M.avium_104 QASFDQCGVNPPPGQ-VHTPANLVWYPTVDGRVMEEDFSGWPADVPVMIG
MAB_0294|M.abscessus_ATCC_1997 DWWVAQFAQ-PRQQRVVGSGRQYRGPVRDPVLLPAFDVHQPLPDIPAISV
:* :
Mb2071c|M.bovis_AF2122/97 TNAEEGRLFTRFLG----MLPTNEPMVEELLSGMKP--------ADRERI
Rv2045c|M.tuberculosis_H37Rv TNAEEGRLFTRFLG----MLPTNEPMVEELLSGMKP--------ADRERI
MUL_2261|M.ulcerans_Agy99 TNADEGRLFTRFLK----MLPTNKAMIDELLADTEP--------ATRERI
MMAR_4363|M.marinum_M TNKHEAALFRLMRSP---LMPITPRAITSMFTQIAAE-QPDLQLPTEEEI
TH_3679|M.thermoresistible__bu TNKDEASLFRWMKSP---LLPITPDAIKKMFADIAAE-QPGLRLPTETQI
Mflv_5051|M.gilvum_PYR-GCK TTRDEWTLFVALQHLR-DGKDYAPQEYPRLLADTFG--------ADAPAV
Mvan_1303|M.vanbaalenii_PYR-1 TTRDEWTLFVALQHLR-DGRDYTPEEYPRLLADTFG--------ADARAV
MSMEG_1432|M.smegmatis_MC2_155 TTRDEFTLFVALRYLR-QDQRFTPEEYPELLRQTFG--------ADADAV
MAV_0492|M.avium_104 CTEHEGRFFVQPTMLY-AHPELDPAQVYTQDTLEHMA-R-ALGGERAGDI
MAB_0294|M.abscessus_ATCC_1997 YTSTEGSFFTGPNAPEPQAPPTDGASLHAAFRDILDQGMPSVSDSTVSDA
. * :*
Mb2071c|M.bovis_AF2122/97 TAAYPNYPA-----PSACIQLGG---DFAFSSAAWQIAEAHGANAPTYLY
Rv2045c|M.tuberculosis_H37Rv TAAYPNYPA-----PSACIQLGG---DFAFSSAAWQIAEAHGANAPTYLY
MUL_2261|M.ulcerans_Agy99 TAAYPNYPE-----SAACIQLGG---DFAFNAAAWQIAEAQGVHAPTYLY
MMAR_4363|M.marinum_M GLAYSRLRR-----RARPLSIAT---DVGFRMPSVWLAEGHSRVAPVYLY
TH_3679|M.thermoresistible__bu SAAYRRQRG-----KRLGVGVAS---DIGFRMPSVWFAEGHTAVAPTYLY
Mflv_5051|M.gilvum_PYR-GCK EAHYPLTAF-----SSVALAYAATVTDGVFACAGRRWAGDLAETAPVYFY
Mvan_1303|M.vanbaalenii_PYR-1 AGRYPLSAF-----PDVALAYAATVTDGILACPAERWARQLSRDASVYFY
MSMEG_1432|M.smegmatis_MC2_155 GAHYPLERY-----GGAAQAYSAAVTDSAFSCVAEQMADELPG--TVYAY
MAV_0492|M.avium_104 LAHYAASGL-----SAYEALAELITIGVWHEPALASVERFAALGRRAYHY
MAB_0294|M.abscessus_ATCC_1997 VALYTDSAKREGRPSDPLALWTELWGDALIRHDILAFTRRAAAQRRAPLY
* . . *
Mb2071c|M.bovis_AF2122/97 RYDYAPRTLRWSG------FGATHATELFAVFDIYRTRFGALLTAAADRR
Rv2045c|M.tuberculosis_H37Rv RYDYAPRTLRWSG------FGATHATELFAVFDIYRTRFGALLTAAADRR
MUL_2261|M.ulcerans_Agy99 RYDYAPRTLRWSG------FGATHATELFAVFDIYRTRFGALLTAAADRR
MMAR_4363|M.marinum_M RFDYSTPLLKLLL------VRAAHATELPYVWGNLGGPQDPTLRLGG-AK
TH_3679|M.thermoresistible__bu RFDWSTPTLRLLR------LGAAHATELPYVFGNLDTPKDPTFTLGG-RR
Mflv_5051|M.gilvum_PYR-GCK EFNDRDAPAPDPLRTVPFPVGASHSLELRYLFDTGGAPPP--------SP
Mvan_1303|M.vanbaalenii_PYR-1 EFNDRNAPAPDPLRTLPFPVGASHSLELRYLFDVGGAPPP--------DP
MSMEG_1432|M.smegmatis_MC2_155 EFADRDAPAPEVMRTLPFPVGASHSLELRYLFDVGGAPPL--------NP
MAV_0492|M.avium_104 RFARVSPGARTSG------LLAKHSAEIPYLFGGLTPAGS-------YDE
MAB_0294|M.abscessus_ATCC_1997 LMEYAHPVKSPYF-------GVPHESTSPFLFGTYAHPAN--VAKFGDGS
. * ::.
Mb2071c|M.bovis_AF2122/97 AALRVSNEVQRRWRCFSQIGVP----GD-DWPAYTQDD-----RAVLVFD
Rv2045c|M.tuberculosis_H37Rv AALRVSNEVQRRWRCFSQIGVP----GD-DWPAYTQDD-----RAVLVFD
MUL_2261|M.ulcerans_Agy99 HALRVSDEVIRRWRSFSQTGTP----GE-DWPAYTHTR-----RAVMVID
MMAR_4363|M.marinum_M TAKAVSKRMRTRWINFATQDNPAGPAGEPDWPAYQDGD-----RACLVID
TH_3679|M.thermoresistible__bu TGRQVSQRIRTRWINFAVHGRPDGPPGEPRWHAYDRAE-----RPCLLID
Mflv_5051|M.gilvum_PYR-GCK AQVRLGEQMIDYWASFVKTGD-------PGFPGIDSG------VMSLQPD
Mvan_1303|M.vanbaalenii_PYR-1 AQVRLGEQMVDHWAAFVRAGD-------PGWPGVDAG------VMSLQPD
MSMEG_1432|M.smegmatis_MC2_155 RQQALADQMIGYWSQFVRTGDPAA-EDQPEWPAYSASESSGRQWMSLRPD
MAV_0492|M.avium_104 VDAAVSDAVQHAWVEFARTGVPR-TPDGTDFPSYDTTS-----RQVVVFD
MAB_0294|M.abscessus_ATCC_1997 KERETSAAFMDLVAEFVHGRPP----ASPRLPQWDPVG--PDLRQLVLRD
. . * : *
Mb2071c|M.bovis_AF2122/97 RRCRIEFDPHQHRRIAWDGFSLAN---
Rv2045c|M.tuberculosis_H37Rv RRCRIEFDPHQHRRIAWDGFSLAN---
MUL_2261|M.ulcerans_Agy99 RKSRVEIDPHRHRRLAWDGFSLAR---
MMAR_4363|M.marinum_M KSDRVARDIDAPIRAAWGREVVGFR--
TH_3679|M.thermoresistible__bu RRDRVVRDVDEPIRLTWGSEVLSFR--
Mflv_5051|M.gilvum_PYR-GCK GSRMIEDFDRVHQCVFWDGLG------
Mvan_1303|M.vanbaalenii_PYR-1 GSRMVETFGEVHQCSFWAGLQ------
MSMEG_1432|M.smegmatis_MC2_155 GSRMASDFGEEHQCPFWVGLKEK----
MAV_0492|M.avium_104 DTTEVRPLDANPVTDMIHTLRAAPTRR
MAB_0294|M.abscessus_ATCC_1997 GSGTITTPTKTTQLGVLDAVQWGK---