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M. thermoresistible (build 8) TH_4650 (-)

annotation: long chain fatty acid-CoA ligase
coordinates: 30870 - 32477
length: 536

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4650--100% (536)long chain fatty acid-CoA ligase
M. thermoresistible (build 8)TH_3067-1e-5933.08% (526) PUTATIVE AMP-binding enzyme, putative
M. thermoresistible (build 8)TH_2068fadD37e-5933.14% (525) PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2533cfadD353e-8237.12% (528) AMP-binding domain protein
M. gilvum PYR-GCKMflv_4867-5e-7935.82% (536) acyl-CoA synthetase
M. tuberculosis H37RvRv2505cfadD353e-8237.12% (528) AMP-binding domain protein
M. leprae Br4923MLBr_02546fadD25e-4430.00% (490) acyl-CoA synthetase
M. abscessus ATCC 19977MAB_4377c-1e-7635.98% (528) AMP-binding domain protein
M. marinum MMMAR_3852fadD355e-7836.35% (520) fatty-acid-CoA ligase FadD35
M. avium 104MAV_5077-0.065.79% (535) long chain fatty acid-CoA ligase
M. smegmatis MC2 155MSMEG_5649-2e-7635.97% (531) acyl-CoA synthetase
M. ulcerans Agy99MUL_4126fadD39e-4630.66% (486) acyl-CoA synthetase
M. vanbaalenii PYR-1Mvan_1563-1e-7735.13% (538) acyl-CoA synthetase

CLUSTAL 2.0.9 multiple sequence alignment


TH_4650|M.thermoresistible__bu      --------------MTHLEQAYWPADR--SVPLLETTVSELLRDR-----
MAV_5077|M.avium_104                --------------MRHLTEARWDADR--SVPLTDHTVGGLLAAR-----
Mflv_4867|M.gilvum_PYR-GCK          -----------------MTGSYDAGPT--DVAILEETIGANFARI-----
Mvan_1563|M.vanbaalenii_PYR-1       -----------------MSQSYDAGPT--DTAILEETIGANFERI-----
MSMEG_5649|M.smegmatis_MC2_155      ------------------MKSYDAGPT--GAPVLEETIGANFERI-----
MAB_4377c|M.abscessus_ATCC_199      ------------------MKAYDAGAT--LSPIIEETIGENFERI-----
Mb2533c|M.bovis_AF2122/97           --------MAAAEVVDPNRLSYDRGPS--APSLLESTIGANLAAT-----
Rv2505c|M.tuberculosis_H37Rv        --------MAAAEVVDPNRLSYDRGPS--APSLLESTIGANLAAT-----
MMAR_3852|M.marinum_M               --------MATTAAADQNQLSYDRGPI--APALLEMTIGANLAAT-----
MUL_4126|M.ulcerans_Agy99           ------------------------------MTSDPRTVPTALDRL-----
MLBr_02546|M.leprae_Br4923          MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
                                                                   .    ::   :        

TH_4650|M.thermoresistible__bu      -----ADEFGERVALIGTRHGTGETERLSYAEVYAEAARVAAGLSALAR-
MAV_5077|M.avium_104                -----ALEHPHRVALVGQRHGSGDRVRLSYAELLDEACRAGDALSSLVT-
Mflv_4867|M.gilvum_PYR-GCK          -----ARTHPGRDALVDVAG----GRRWTYAELDAEIDTVARGLMAIGVE
Mvan_1563|M.vanbaalenii_PYR-1       -----AATYPDHEALVDVTG----GRRWTYAELDREIDTVAKGLMSLGTE
MSMEG_5649|M.smegmatis_MC2_155      -----AATYPEHEALVEVAT----GRRWTYAELNDEIDATARGLMALGVD
MAB_4377c|M.abscessus_ATCC_199      -----ARAHPDVGALVDVSG----DRRWTYRELDAEINRVARGLMSLGVA
Mb2533c|M.bovis_AF2122/97           -----AARYGHREALVDMVA----RRRFNYSELLTDVHRLATGLVRAGIG
Rv2505c|M.tuberculosis_H37Rv        -----AARYGHREALVDMVA----RRRFNYSELLTDVHRLATGLVRAGIG
MMAR_3852|M.marinum_M               -----ASQCESRDALVDVRS----GRRWSYAQLLTDVRQLATGLVRAGIG
MUL_4126|M.ulcerans_Agy99           -----VRRLPNHDALVTD------ERSFTVSELNDEVYRAAAALIELGVK
MLBr_02546|M.leprae_Br4923          LPAMPARRSPHRAALIDEEG------TLTYKELDRAAHALANGLIAKGVR
                                         .       **:            .  ::       . .*      

TH_4650|M.thermoresistible__bu      PGSLVALWAPNVIEWPIIQYGAALAGVVLVALNPVLRDDELEYALRHSRA
MAV_5077|M.avium_104                PGGFLALWAPNVVEWPIIQYGAALAGVVLVALNPVLREDELAYALRHCGA
Mflv_4867|M.gilvum_PYR-GCK          RGDRVGIWAPNCPEWVIVQYATAKIGAILVNINPAYRTHELRYVLEQSGV
Mvan_1563|M.vanbaalenii_PYR-1       SGDRVGIWAPNCPEWTIVQYATAKIGAILVNINPAYRTHELSYVLEQSGV
MSMEG_5649|M.smegmatis_MC2_155      KGDRVGIWAPNCAEWIMTQFAAAKVGAILVNINPAYRTHEVAYVLRQSGV
MAB_4377c|M.abscessus_ATCC_199      AGDRVGIWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGV
Mb2533c|M.bovis_AF2122/97           PGDRVGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGV
Rv2505c|M.tuberculosis_H37Rv        PGDRVGIWAPNRWEWVLVQYATAEIGAILVTINPAYRVREVEYALRQSGV
MMAR_3852|M.marinum_M               RGDRVGIWAPNRWEWVLVQYATAEIGAVLVTINPAYQARELEYALRQSGV
MUL_4126|M.ulcerans_Agy99           PAARVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEA
MLBr_02546|M.leprae_Br4923          GGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGA
                                     .  :.: : *   : :   .    *. :: :*.     :      :  .

TH_4650|M.thermoresistible__bu      EVLLHADVSRDYPMAEVAERVCARIPGLRRVSLSETTVWRAAEP------
MAV_5077|M.avium_104                DVLLHADTSRDYAMLEVAQRVCDAIPGLRRVSLSETARWRSTTP------
Mflv_4867|M.gilvum_PYR-GCK          ATLISATQFKTSDYVAMVDEVRPDVPALQRVLFIGTADWDTLRAAGSGVD
Mvan_1563|M.vanbaalenii_PYR-1       STLISATRFKTSDYVAMVDEVRPDVPALQRVLFIGTDDWDRLRSRADVID
MSMEG_5649|M.smegmatis_MC2_155      RTLVSASSFKTSDYASMIAEVRPECPDLLDVVFLDNDDWDRLR--ANQVD
MAB_4377c|M.abscessus_ATCC_199      RTLICAKAFKSSDYVAMASQVMPDAPGLRDVVFIGTSDWTELVAGAERVT
Mb2533c|M.bovis_AF2122/97           AMVIAVASFKDADYAAMLAEVGPRCPDLADVILLESDRWDALAG--AEPD
Rv2505c|M.tuberculosis_H37Rv        AMVIAVASFKDADYAAMLAEVGPRCPDLADVILLESDRWDALAG--AEPD
MMAR_3852|M.marinum_M               AMVIAASGFKGSDYAAILAEVAPGCPELHDVAFLDGDGWAKLAG--SGAD
MUL_4126|M.ulcerans_Agy99           PVLFAMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGTD
MLBr_02546|M.leprae_Br4923          KVIIYDD-----EYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAE
                                      :.               .                              

TH_4650|M.thermoresistible__bu      -VDAAP--VPHDPDT-VAMLQYTSGTTGKPKGVVLNHRAIVNVARLTMET
MAV_5077|M.avium_104                -SAGMINRAPSDPDQ-PVMLQYTSGTTGRPKGVVLTHRALVNVAKLTMEA
Mflv_4867|M.gilvum_PYR-GCK          DADLRRRSGALSNRD-PINIQYTSGTTGFPKGATLSHRNILNNGFFVTEQ
Mvan_1563|M.vanbaalenii_PYR-1       DALLRERSASLSHHD-PVNIQYTSGTTGFPKGATLSHRNILNNGFFVTEQ
MSMEG_5649|M.smegmatis_MC2_155      DAAFHERMATLANTD-PINIQYTSGTTGFPKGATLSHRNILNNGFFVTEL
MAB_4377c|M.abscessus_ATCC_199      ETALRARMSQLSNTD-PINIQYTSGTTGYPKGATLSHRNVLNNGFFVAES
Mb2533c|M.bovis_AF2122/97           LPALQQTAARLDGSD-PVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGEL
Rv2505c|M.tuberculosis_H37Rv        LPALQQTAARLDGSD-PVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGEL
MMAR_3852|M.marinum_M               LVALQEIATTLSADD-PINIQYTSGTTGFPKGVTLSHRNILNNGYLVGEL
MUL_4126|M.ulcerans_Agy99           TGAVTARAAAVSPDD-VSDILFTSGTTGRSKGVLCAHRQSLSASASWAAN
MLBr_02546|M.leprae_Br4923          LIARSSSAPAPKVRKRASIIILTSGTTGTPKGANRNTPASLAPLGGILSK
                                                       :  *****. .**.       :         

TH_4650|M.thermoresistible__bu      LRVPPGAVSFNPLPMFHTAGCVIATLGPLWVG-GTAILAERFTPQSALEV
MAV_5077|M.avium_104                VEAPPAAICVNPLPLFHTAGCVIATLGPLWVG-GTAVPCGRPAPGAVLET
Mflv_4867|M.gilvum_PYR-GCK          IRLQPGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVIPAPAFDPGLTLRA
Mvan_1563|M.vanbaalenii_PYR-1       IRLGPGDRLCIPVPFYHCFGMVMGNLGCTTHGATMVIPAPGFDPGQTLKT
MSMEG_5649|M.smegmatis_MC2_155      IALGPDDRLCIVPPFYHCFGMVMGTLGAVSHGTTIVIPAPGFDPGITLSA
MAB_4377c|M.abscessus_ATCC_199      IQLQAGDRLCIPVPFYHCFGMVMGNLGCTTHGATIVMPAPGFDPGRTLEA
Mb2533c|M.bovis_AF2122/97           LGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRA
Rv2505c|M.tuberculosis_H37Rv        LGYTAQDRICIPVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRA
MMAR_3852|M.marinum_M               LEYTAEDRICIPVPFYHCFGMVMGNLAATSHGACMVIPAPGFDPAATLRA
MUL_4126|M.ulcerans_Agy99           GKITADDRHLCINPFFHNFGYKAGILACLQTG-ATLFPHLTFDPLRTLQA
MLBr_02546|M.leprae_Br4923          VPFRAHEVTLLPAPMFHALGYLHATLAMFLGS--TLVLRRRFKPATVLED
                                        .        *::*  *   . *.    .    .      *  .*  

TH_4650|M.thermoresistible__bu      MRAEGVQVLFYVPTVLAALLDQQR--SSTQPAPRLGIIMGGASNVDPALI
MAV_5077|M.avium_104                LREQHAAVLFYVPAVLRALVEYQR--ESTETAPKLDIIMGGASEVSAELI
Mflv_4867|M.gilvum_PYR-GCK          IETERCTAVYGVPTMFIAMQNHPD--FAERDLSTLRTGIMAGAVCPVEVM
Mvan_1563|M.vanbaalenii_PYR-1       IETERCTAVYGVPTMFIAMQNHAD--FAERDLSSLRTGIMAGAVCPVEVM
MSMEG_5649|M.smegmatis_MC2_155      VESEKCTGLYGVPTMFIAMLGHPD--FANFDLSSLRTGIMAGSVCPIEVM
MAB_4377c|M.abscessus_ATCC_199      IERERCVGVYGVPTMFIAMLADPG--FAHRDLSTLRTGIMAGSVCPVEVM
Mb2533c|M.bovis_AF2122/97           VQDERCTSLYGVPTMFIAELGLPD--FTDYELGSLRTGIMAGAACPVEVM
Rv2505c|M.tuberculosis_H37Rv        VQDERCTSLYGVPTMFIAELGLPD--FTDYELGSLRTGIMAGAACPVEVM
MMAR_3852|M.marinum_M               VQAERCTSLYGVPTMFIAELGLAD--FATYDLSSLRTGIMAGSTCPVEVM
MUL_4126|M.ulcerans_Agy99           IERHRITVLPGPPTIYQTLLDHPA--RDDYDLSSLRFAVTGAATVPVVLV
MLBr_02546|M.leprae_Br4923          IEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELA
                                    :. .    :   *.:                   *   . ..:     : 

TH_4650|M.thermoresistible__bu      TGAADIFGAP-VFNLYGQTELAPVLTLTRPDDGPQDRLSTVGRPLPQVEC
MAV_5077|M.avium_104                DSATATFNAR-VFNLYGQTELAPVLTVTRPGDSRRDRLYTVGRPLPQVDC
Mflv_4867|M.gilvum_PYR-GCK          KRCVEEMHLTEMSIAYGMTETSPVSCQTLIDDDLERRTSTIGRVHPHVEI
Mvan_1563|M.vanbaalenii_PYR-1       KRCVEEMNMSEISIAYGMTETSPVSCQTLIDDDLERRTSSIGRVHPHVEI
MSMEG_5649|M.smegmatis_MC2_155      KRVVADMHMAEVAICYGMTETSPVSCQTLIDDDLDRRTATIGRAHPHVEI
MAB_4377c|M.abscessus_ATCC_199      KRCIDEMHMAGVAIAYGMTETSPVSCQTLFDDDLDRRTATVGRAHPHIEI
Mb2533c|M.bovis_AF2122/97           RKVISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEI
Rv2505c|M.tuberculosis_H37Rv        RKVISRMHMPGVSICYGMTETSPVSTQTRADDSVDRRVGTVGRVGPHLEI
MMAR_3852|M.marinum_M               RKVIDQMHMAGISICYGMTETSPVATQTRSNDSLQRRVTTVGRVGPHLEI
MUL_4126|M.ulcerans_Agy99           ERMQSELDIDIVLTAYGLTEANGMGTMCRADDDALTVATTCGRPFADFEL
MLBr_02546|M.leprae_Br4923          TRALEELGPV-IYNMYGSTEIAFATIAG--PKDLQINSATVGPVVKGVKV
                                          :    :   ** **           ..      : *     .. 

TH_4650|M.thermoresistible__bu      KIIDPHTQQTVPVGVEGEICARGYQQFLEYLHDPHATAQALDREGFVRTG
MAV_5077|M.avium_104                KIIDPIDGRVLPVGQVGEICARGYQQFVEYLHDPDATQSALDTEGFVRTG
Mflv_4867|M.gilvum_PYR-GCK          KIVDPETGEIVERGTPGEFCTRGYSVMLGYWREDEKTAQAIDADGWMHTG
Mvan_1563|M.vanbaalenii_PYR-1       KIVDPDTGHVVERGTPGEFCTRGYSVMLGYWRDEEKTAQAVDADGWMHTG
MSMEG_5649|M.smegmatis_MC2_155      KIIDPDTGETVERGQPGEFCTRGYSVMLGYWNDDEKTREAVDADGWMHTG
MAB_4377c|M.abscessus_ATCC_199      KIVDPNSGETVQRGQSGELCTRGYSVMLGYWNDEAHTREVLDTDGWMHTG
Mb2533c|M.bovis_AF2122/97           KVVDPATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTG
Rv2505c|M.tuberculosis_H37Rv        KVVDPATGETVPRGVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTG
MMAR_3852|M.marinum_M               KVVDPATGRIVPRGTAGEFCTRGYSVMSGYWKAPERTAEVIDPEGWMHTG
MUL_4126|M.ulcerans_Agy99           RIG-PDTGEVLLRGP---------NVMLGYLDDPRATAAAIDADGWLHTG
MLBr_02546|M.leprae_Br4923          KILDDSGK-EVPRGQVGRIFVGNAFPFEGYTGG----GGKQIIDGLLSSG
                                    ::        :  *            :  *             :* : :*

TH_4650|M.thermoresistible__bu      DLGRMDERGYVTVTGRLKELIIRGGENIAPAEVEAVLNALDSRVQAVVLG
MAV_5077|M.avium_104                DLGAMDERGFVTVTGRRKELIIRGGENIAPAEVEESVAQHDCIDEVVAVG
Mflv_4867|M.gilvum_PYR-GCK          DLAVMRPDGYCNIVGRIKDVVIRGGENIYPREIEEFLYTHPDVEDAHVIG
Mvan_1563|M.vanbaalenii_PYR-1       DLAVMRPDGYCNIVGRIKDVVIRGGENIYPREVEEFLYTHPDIEDAQVVG
MSMEG_5649|M.smegmatis_MC2_155      DLAVMREDGYCTIVGRIKDMVIRGGENIYPREIEEFLYTHPDIDDAQVIG
MAB_4377c|M.abscessus_ATCC_199      DLAVMRDDGYCTIIGRLKDMVIRGGENIYPREIEEFLLTHPDIEDVHVVG
Mb2533c|M.bovis_AF2122/97           DLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIG
Rv2505c|M.tuberculosis_H37Rv        DLAEMDPSGYVRIAGRIKDLVVRGGENISPREIEELLHTHPDIVDGHVIG
MMAR_3852|M.marinum_M               DLALMDECGYVQITGRIKDIVVRGGENISPREIEEFLHSHPDIVDAHVVG
MUL_4126|M.ulcerans_Agy99           DIGVLDEAGNLRITDRLKDMYICGGFNVYPAEVEQVLARLDGVADVAVIG
MLBr_02546|M.leprae_Br4923          DVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIG
                                    *:. :   .   : .* .:: : ** *: * *:*  :       :  .:*

TH_4650|M.thermoresistible__bu      VPDDRYGEVVAAVLRSDDKVDAAMKCRLVQQARDRLAGYKIPVRWFTVRE
MAV_5077|M.avium_104                LPDDHFGEIVAVVCRLATTASAGLKDSLLAHARARLAAFKVPARWFVADA
Mflv_4867|M.gilvum_PYR-GCK          VPDDRYGEEVCAWIRMRPGRTALDAAAVREFATDKLAHYKIPRYVHVVDE
Mvan_1563|M.vanbaalenii_PYR-1       VPDARYGEEICAWIRMRPGRRALDAAAVREFAAGKLAHYKIPRYVHVVDE
MSMEG_5649|M.smegmatis_MC2_155      VPDERYGEEICAWIRMKPGRPPLDADKVREFASGKLAHYKIPRYVHVVDE
MAB_4377c|M.abscessus_ATCC_199      VPDEKYGEELCAWVRMRPDRVVIDAVAIRAFASGRLAHYKIPRYVHVVES
Mb2533c|M.bovis_AF2122/97           VPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIARFKIPRYLWIVDE
Rv2505c|M.tuberculosis_H37Rv        VPDAKYGEELMAVVKLRNDAPELTIERLREYCMGRIARFKIPRYLWIVDE
MMAR_3852|M.marinum_M               VPDERMGEELMAVVKLRAGAPELTTGLLREYCAGQIAKFKIPRYLRLVDE
MUL_4126|M.ulcerans_Agy99           IPDHRLGEVGRAFIVARPG-FNLDEKSVIDYTREHLANFKAPRSVRFVDT
MLBr_02546|M.leprae_Br4923          VDDKEWGARLRAFVVKKQD-ATIDEDAIKAYVRDHLARYKVPREVIFLEE
                                    : * . *    .               :      ::* :* *        

TH_4650|M.thermoresistible__bu      FPVTPTGKVQRFALRDAILRQEISEL-------
MAV_5077|M.avium_104                FPVTPTGKVRRFALREAILRDELEEL-------
Mflv_4867|M.gilvum_PYR-GCK          FPMTVTGKIRKVEMREVSARLLGL---------
Mvan_1563|M.vanbaalenii_PYR-1       FPMTVTGKIRKVEMREVSAGLFAD---------
MSMEG_5649|M.smegmatis_MC2_155      FPMTVTGKIRKVQMREETVALLGLEA-------
MAB_4377c|M.abscessus_ATCC_199      FPMTVTGKVRKIEMRQQTIQIFGLPEPGRTDEQ
Mb2533c|M.bovis_AF2122/97           FPMTVTGKVRKVEMRQQALEYLRGQQ-------
Rv2505c|M.tuberculosis_H37Rv        FPMTVTGKVRKVEMRQQALEYLRGQQ-------
MMAR_3852|M.marinum_M               FPMTVTGKVRKVEMRQQAIEYLRGQH-------
MUL_4126|M.ulcerans_Agy99           LPRNAGGKVVKPQLRELA---------------
MLBr_02546|M.leprae_Br4923          LPRNPTGKVLKRELRDFEVH-------------
                                    :* .  **: :  :*: