For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_4586 (-)

annotation: dihydrodipicolinate reductase
coordinates: 185137 - 186207
length: 357

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4586--100% (357)dihydrodipicolinate reductase
M. thermoresistible (build 8)TH_0599-3e-7244.51% (346) conserved hypothetical protein
M. thermoresistible (build 8)TH_4297-1e-5938.42% (354) PUTATIVE putative dihydrodipicolinate reductase, N-terminus

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0949c-2e-6942.77% (346) hypothetical protein Mb0949c
M. gilvum PYR-GCKMflv_1777-1e-16676.75% (357) dihydrodipicolinate reductase
M. tuberculosis H37RvRv0926c-2e-6942.77% (346) hypothetical protein Rv0926c
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4633-4e-6641.16% (345) hypothetical protein MAB_4633
M. marinum MMMAR_4582-2e-7043.64% (346) hypothetical protein MMAR_4582
M. avium 104MAV_2461-1e-16073.39% (357) hypothetical protein MAV_2461
M. smegmatis MC2 155MSMEG_5586-3e-7544.64% (345) hypothetical protein MSMEG_5586
M. ulcerans Agy99MUL_3685-2e-3834.37% (355) hypothetical protein MUL_3685
M. vanbaalenii PYR-1Mvan_4970-1e-16174.79% (357) dihydrodipicolinate reductase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0949c|M.bovis_AF2122/97           ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
Rv0926c|M.tuberculosis_H37Rv        ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
MMAR_4582|M.marinum_M               ----MAIPVVQLGTGNVGLHSLRALITNPEFELTGVWVSSDAKAGKDAAE
MSMEG_5586|M.smegmatis_MC2_155      ----MAIRVAAIGTGNVGRHALRQLITNPAYELTAVWVSSPEKAGKDAGD
MAB_4633|M.abscessus_ATCC_1997      ---MTKTRVAVWGTGNVGQHALAGVITDPSMELVGVWVSGSNKAGKDAGA
Mflv_1777|M.gilvum_PYR-GCK          MERFPVRRVVQFSTGNVGRHSLRAIIGRPDLELVGVHASGPDKIGRDAAQ
Mvan_4970|M.vanbaalenii_PYR-1       -----MRRVVQFSTGNVGRHSLAALIGRPDLELVGVHAASADKIGRDAAE
TH_4586|M.thermoresistible__bu      -----MRRVVQFSTGNVGRHSLRTLIGRPDLELVGVHAAGPEKIGRDAAE
MAV_2461|M.avium_104                -----MRRVIQFSTGNVGRHSLRAIIGRPDLELVGVHAAGPEKIGRDAAQ
MUL_3685|M.ulcerans_Agy99           MSTARPLRVIQWTTGNIGRRSLHAIIGRPDLELVGVYAHGPDKVGVDAAE
                                            *    ***:* ::*  :*  *  **..* . .  * * **. 

Mb0949c|M.bovis_AF2122/97           LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
Rv0926c|M.tuberculosis_H37Rv        LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
MMAR_4582|M.marinum_M               LAGFAESTGVKASTDLDAVLASGPQCAVYNAMADNRLPEALDDYRRVLAA
MSMEG_5586|M.smegmatis_MC2_155      LAGLEVTTGIKATDSLDEVLATEPECAVYTAMADNRLPDALEDYRRILAA
MAB_4633|M.abscessus_ATCC_1997      LAGLDILTGITATTDAAQILALRPDCVVYTAMTDNRLMEALKDLTDLLSA
Mflv_1777|M.gilvum_PYR-GCK          LCGLTEPTGVLATGDLDALLALKPDCVVYTALGETRPMEAIEQMSAILSA
Mvan_4970|M.vanbaalenii_PYR-1       LCGLSDPTGVLATDDLDALIALKPDCVVYTALGETRPMEAIEQMSRLLAA
TH_4586|M.thermoresistible__bu      LCGLSEPTGVIATGDLDALLALQPDCVVYTALGETRPAEAIEQMTKILSA
MAV_2461|M.avium_104                LCGLDEPTGIIATDDIDALVALNADCVVYTSQGETRPMEAIEQMSRFLAA
MUL_3685|M.ulcerans_Agy99           LAGWPDPTGVRATSDIGALLALGADACCYNPLWPN-----IDELVGLLES
                                    *.*    **: *: .   ::*  . .  *..   .     :.:   .* :

Mb0949c|M.bovis_AF2122/97           GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
Rv0926c|M.tuberculosis_H37Rv        GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
MMAR_4582|M.marinum_M               GVNIVGSGPVFLQYPWQVLPDELVKPLEDAAREGNSSLYVSGIDPGFAND
MSMEG_5586|M.smegmatis_MC2_155      GVNVVGSSAVFLQYPWQVLPEELVKPIEDAAHAGGASLFVNGIDPGFAND
MAB_4633|M.abscessus_ATCC_1997      GINVAASAPVFLQYPWGVLPENMLTPIENAAREGNSSIFAGGIDPGFAND
Mflv_1777|M.gilvum_PYR-GCK          GINVVGTSMVWLVTPRQAD-DWLRGPLEQACAAGDSSLYVNGIDPGYSGD
Mvan_4970|M.vanbaalenii_PYR-1       GINVVGTSMVWLVTPRHAD-GWLREPLEQACATGNSSLYVNGIDPGYSGD
TH_4586|M.thermoresistible__bu      GVNVVGTSLVWLATPRQAD-EWLRAPLEQACKAGNSSLFVSGIDPGYSAD
MAV_2461|M.avium_104                GTNVVGTSMVWLVAPRHAE-EWLREPLQRACEAGNTSLYVNGIDPGFSGD
MUL_3685|M.ulcerans_Agy99           GVNVCTS-AAWITGGKQTP--RDRERILAACERGGATIFGSDAHPGMTN-
                                    * *:  :  .::     .        :  *.  *.:::: .. .** :  

Mb0949c|M.bovis_AF2122/97           LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFG-KPMDQIPML
Rv0926c|M.tuberculosis_H37Rv        LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFG-KPMDQIPML
MMAR_4582|M.marinum_M               LLPMALAGTCQSIEQIRCMEIVDYATYDSAVVMFDVMGFG-KPLDEIPML
MSMEG_5586|M.smegmatis_MC2_155      LLPLALAGTCQQIEQIRCMEIVDYATYDSATVMLDVMGFG-KSLDETPML
MAB_4633|M.abscessus_ATCC_1997      LLPLALMGTCQRIDQVRCIEIVDYATYDSATVMFDVMGFG-KPMEETPML
Mflv_1777|M.gilvum_PYR-GCK          TAVHAALSLVTRAESVTIKEIFDYGNYDDYEYTGAAMGFGTTPEDDLPLA
Mvan_4970|M.vanbaalenii_PYR-1       TAVHAALSLVTRASSVTVQEIFDYGNYDDYEYTGTAMGFGNSPQDELPMA
TH_4586|M.thermoresistible__bu      TAVHSALSLVTRARSVTVQEIFDYANYDDWEFTGTTMGFGSAP-DDEPML
MAV_2461|M.avium_104                TLVHAAVSLATRVSSITVQEIFDYGNYDDAEFTGAAMGFGTAPDDDSPMM
MUL_3685|M.ulcerans_Agy99           MVGMVLSGSCERVDEIRITESVDCSTYES-AATQTAMGFS-QHPDTPGLA
                                           .      .:   * .* ..*:.      .***.    :   : 

Mb0949c|M.bovis_AF2122/97           LQPGVLSLAWGSVVRQLAAGLGISLDGVEEMYVREPAPEAFNIASGHIPK
Rv0926c|M.tuberculosis_H37Rv        LQPGVLSLAWGSVVRQLAAGLGISLDGVEEMYVREPAPEAFNIASGHIPK
MMAR_4582|M.marinum_M               LQPGVLSLAWGSVVRQLAAGLGLSLDVVEEMYVREPAPHAFDIASGHIPQ
MSMEG_5586|M.smegmatis_MC2_155      LQPGVLSLAWGSVVRQLAAGLGIELDAVTEEHTRVPAPEDFDIAAGHISE
MAB_4633|M.abscessus_ATCC_1997      LQPGVLSLAWGSVVRQLAAGLGVELDEVTEVYEKLSAPEDFDISSGHIPA
Mflv_1777|M.gilvum_PYR-GCK          FQPGVVTSMFGGLVRNLADQLGVELDDVCQRFEPWYTPQRIECTMMTVEP
Mvan_4970|M.vanbaalenii_PYR-1       FQPGVVASLFGGLVRSLAAHLDVELDEVRERCEPWYTDQRIECTMTTVEP
TH_4586|M.thermoresistible__bu      LMPGVITAMFGGLVRNLADQLGVELDDVRQRTERWFTTERIECRLTTVEP
MAV_2461|M.avium_104                FLPGVIVAMWGGQVRSLADHLGVELDDVRQRIERWFTPERIDCTMMTVQP
MUL_3685|M.ulcerans_Agy99           ESVRVESEVFAESAAMMADAIGATLDKMTFDVTFTAATADTDLGFMKIPA
                                        *    :.  .  :*  :.  ** :        :    :     :  

Mb0949c|M.bovis_AF2122/97           GSAAALRFEVLGLVDGVPAVVLEHVTRLRADLCPEWPQPAQPG-GSYRIE
Rv0926c|M.tuberculosis_H37Rv        GSAAALRFEVLGLVDGVPAVVLEHVTRLRADLCPEWPQPAQPG-GSYRIE
MMAR_4582|M.marinum_M               GSAAALRFEVLGLVDGAPVVVLEHVTRLREDLCPDWPQPAQPG-GSYRIE
MSMEG_5586|M.smegmatis_MC2_155      GTTAAMRFEVRGMVDGKPAVVLEHVTRLRDDLCPEWPQPAQEG-GSYRVE
MAB_4633|M.abscessus_ATCC_1997      GTMAALHFEVRGIKDGRAVTVLEHFTRLREDLAPNWPQPAHEG-GTYRVE
Mflv_1777|M.gilvum_PYR-GCK          GQLAGVRFAAEGVRGGTPVITVEHTTRLTPAAAPDWEYPPAEMDGVHMVI
Mvan_4970|M.vanbaalenii_PYR-1       GRMAAVRFAAEGMRGGEPVITVEHINRLTSAAAPQWEFPPEGHLGVHKVI
TH_4586|M.thermoresistible__bu      GGMAAVRFAVEGMRDDEPVITVEHVTRLTPAAAPDWEFPPDNQPGVHRVV
MAV_2461|M.avium_104                GRMAAVRFATEGVRDGEPVITLEHVTRLTRAAAPDWEYPPDGHTGVHRVV
MUL_3685|M.ulcerans_Agy99           GTVGSVYGYHRGWVGDRNVVSVGFNWTMGNHVVP--PKPLKHG---HVIQ
                                    *  ..:     *  ..  .  : .   :     *    *       : : 

Mb0949c|M.bovis_AF2122/97           ISGEPCYAMDICLSSRH----GDHNHAGLVATAMRIVNAIPAVVAAEPGI
Rv0926c|M.tuberculosis_H37Rv        ISGEPCYAMDICLSSRH----GDHNHAGLVATAMRIVNAIPAVVAAEPGI
MMAR_4582|M.marinum_M               ITGEPSYAMDLCLSSRR----GDHNHAGLVATAMRVVNAIPAVVAAPPGI
MSMEG_5586|M.smegmatis_MC2_155      VTGEPSYALDLCLSSPY----GDHNHAGLVATAARVVNAIPAVFAAPPGI
MAB_4633|M.abscessus_ATCC_1997      ITGEPSYLLDLGSFSAR----GDHNYANLIATAMRVVNAVPAVVAAEAGI
Mflv_1777|M.gilvum_PYR-GCK          VEGEPRIELMTHLSHPS----LDVTDAGCLSTAARAVNAIDWVCDAPAGL
Mvan_4970|M.vanbaalenii_PYR-1       VEGEPRVEVSTHLSHPV----LDVTDAGCVSTAARAVNAIDWVCRAPAGL
TH_4586|M.thermoresistible__bu      VEGEPRIELNTHVSQPF----FDVTEAGCIATAARVINAIDWVCDAPPGL
MAV_2461|M.avium_104                VAGEPRVEINTHVSHPL----FDSTDAGCISTAARVVNAIDWVCRAPQGL
MUL_3685|M.ulcerans_Agy99           VFGLPNMRTVLHCLPPKDWTESGFMGLGMIYTAMPVTNAVPAVVAAKPGI
                                    : * *                 .    . : **    **:  *  *  *:

Mb0949c|M.bovis_AF2122/97           RTTLDLPLITGEGRYAAA----
Rv0926c|M.tuberculosis_H37Rv        RTTLDLPLITGEGRYAAA----
MMAR_4582|M.marinum_M               RTTLELPLVTGKGLYLPPAGAA
MSMEG_5586|M.smegmatis_MC2_155      RTTLDMPLITGKGLYAAR----
MAB_4633|M.abscessus_ATCC_1997      RTTLDLPLITGKGRAV------
Mflv_1777|M.gilvum_PYR-GCK          IGAEDIPPTAMIRGLMW-----
Mvan_4970|M.vanbaalenii_PYR-1       VALENIPPTEMIRGLMW-----
TH_4586|M.thermoresistible__bu      VEAADIPPTSLIRGLMW-----
MAV_2461|M.avium_104                IGVEDIPLAATMRGVLWQDR--
MUL_3685|M.ulcerans_Agy99           VTLADLPPITGRAAL-------
                                        ::*