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VRRVIQFSTGNVGRHSLRAIIGRPDLELVGVHAAGPEKIGRDAAQLCGLDEPTGIIATDDIDALVALNAD CVVYTSQGETRPMEAIEQMSRFLAAGTNVVGTSMVWLVAPRHAEEWLREPLQRACEAGNTSLYVNGIDPG FSGDTLVHAAVSLATRVSSITVQEIFDYGNYDDAEFTGAAMGFGTAPDDDSPMMFLPGVIVAMWGGQVRS LADHLGVELDDVRQRIERWFTPERIDCTMMTVQPGRMAAVRFATEGVRDGEPVITLEHVTRLTRAAAPDW EYPPDGHTGVHRVVVAGEPRVEINTHVSHPLFDSTDAGCISTAARVVNAIDWVCRAPQGLIGVEDIPLAA TMRGVLWQDR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2461 | - | - | 100% (360) | hypothetical protein MAV_2461 |
| M. avium 104 | MAV_1045 | dapB | 5e-75 | 44.48% (353) | dihydrodipicolinate reductase N-terminus domain-containing |
| M. avium 104 | MAV_5137 | - | 4e-61 | 38.31% (355) | homoserine dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0949c | - | 2e-68 | 41.91% (346) | hypothetical protein Mb0949c |
| M. gilvum PYR-GCK | Mflv_1777 | - | 1e-162 | 74.23% (357) | dihydrodipicolinate reductase |
| M. tuberculosis H37Rv | Rv0926c | - | 2e-68 | 41.91% (346) | hypothetical protein Rv0926c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4633 | - | 5e-67 | 40.92% (347) | hypothetical protein MAB_4633 |
| M. marinum M | MMAR_4582 | - | 7e-69 | 42.20% (346) | hypothetical protein MMAR_4582 |
| M. smegmatis MC2 155 | MSMEG_5586 | - | 5e-73 | 44.09% (347) | hypothetical protein MSMEG_5586 |
| M. thermoresistible (build 8) | TH_4586 | - | 1e-160 | 73.39% (357) | PUTATIVE dihydrodipicolinate reductase |
| M. ulcerans Agy99 | MUL_3685 | - | 1e-34 | 32.48% (351) | hypothetical protein MUL_3685 |
| M. vanbaalenii PYR-1 | Mvan_4970 | - | 1e-162 | 73.11% (357) | dihydrodipicolinate reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0949c|M.bovis_AF2122/97 ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
Rv0926c|M.tuberculosis_H37Rv ----MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAE
MMAR_4582|M.marinum_M ----MAIPVVQLGTGNVGLHSLRALITNPEFELTGVWVSSDAKAGKDAAE
MSMEG_5586|M.smegmatis_MC2_155 ----MAIRVAAIGTGNVGRHALRQLITNPAYELTAVWVSSPEKAGKDAGD
MAB_4633|M.abscessus_ATCC_1997 ---MTKTRVAVWGTGNVGQHALAGVITDPSMELVGVWVSGSNKAGKDAGA
Mflv_1777|M.gilvum_PYR-GCK MERFPVRRVVQFSTGNVGRHSLRAIIGRPDLELVGVHASGPDKIGRDAAQ
Mvan_4970|M.vanbaalenii_PYR-1 -----MRRVVQFSTGNVGRHSLAALIGRPDLELVGVHAASADKIGRDAAE
TH_4586|M.thermoresistible__bu -----MRRVVQFSTGNVGRHSLRTLIGRPDLELVGVHAAGPEKIGRDAAE
MAV_2461|M.avium_104 -----MRRVIQFSTGNVGRHSLRAIIGRPDLELVGVHAAGPEKIGRDAAQ
MUL_3685|M.ulcerans_Agy99 MSTARPLRVIQWTTGNIGRRSLHAIIGRPDLELVGVYAHGPDKVGVDAAE
* ***:* ::* :* * **..* . . * * **.
Mb0949c|M.bovis_AF2122/97 LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
Rv0926c|M.tuberculosis_H37Rv LAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAA
MMAR_4582|M.marinum_M LAGFAESTGVKASTDLDAVLASGPQCAVYNAMADNRLPEALDDYRRVLAA
MSMEG_5586|M.smegmatis_MC2_155 LAGLEVTTGIKATDSLDEVLATEPECAVYTAMADNRLPDALEDYRRILAA
MAB_4633|M.abscessus_ATCC_1997 LAGLDILTGITATTDAAQILALRPDCVVYTAMTDNRLMEALKDLTDLLSA
Mflv_1777|M.gilvum_PYR-GCK LCGLTEPTGVLATGDLDALLALKPDCVVYTALGETRPMEAIEQMSAILSA
Mvan_4970|M.vanbaalenii_PYR-1 LCGLSDPTGVLATDDLDALIALKPDCVVYTALGETRPMEAIEQMSRLLAA
TH_4586|M.thermoresistible__bu LCGLSEPTGVIATGDLDALLALQPDCVVYTALGETRPAEAIEQMTKILSA
MAV_2461|M.avium_104 LCGLDEPTGIIATDDIDALVALNADCVVYTSQGETRPMEAIEQMSRFLAA
MUL_3685|M.ulcerans_Agy99 LAGWPDPTGVRATSDIGALLALGADACCYNPLWPN-----IDELVGLLES
*.* **: *: . ::* . . *.. . :.: .* :
Mb0949c|M.bovis_AF2122/97 GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
Rv0926c|M.tuberculosis_H37Rv GINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFAND
MMAR_4582|M.marinum_M GVNIVGSGPVFLQYPWQVLPDELVKPLEDAAREGNSSLYVSGIDPGFAND
MSMEG_5586|M.smegmatis_MC2_155 GVNVVGSSAVFLQYPWQVLPEELVKPIEDAAHAGGASLFVNGIDPGFAND
MAB_4633|M.abscessus_ATCC_1997 GINVAASAPVFLQYPWGVLPENMLTPIENAAREGNSSIFAGGIDPGFAND
Mflv_1777|M.gilvum_PYR-GCK GINVVGTSMVWLVTPRQAD-DWLRGPLEQACAAGDSSLYVNGIDPGYSGD
Mvan_4970|M.vanbaalenii_PYR-1 GINVVGTSMVWLVTPRHAD-GWLREPLEQACATGNSSLYVNGIDPGYSGD
TH_4586|M.thermoresistible__bu GVNVVGTSLVWLATPRQAD-EWLRAPLEQACKAGNSSLFVSGIDPGYSAD
MAV_2461|M.avium_104 GTNVVGTSMVWLVAPRHAE-EWLREPLQRACEAGNTSLYVNGIDPGFSGD
MUL_3685|M.ulcerans_Agy99 GVNVCTS-AAWITGGKQTP--RDRERILAACERGGATIFGSDAHPGMTN-
* *: : .:: . : *. *.:::: .. .** :
Mb0949c|M.bovis_AF2122/97 LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFG-KPMDQIPML
Rv0926c|M.tuberculosis_H37Rv LLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFG-KPMDQIPML
MMAR_4582|M.marinum_M LLPMALAGTCQSIEQIRCMEIVDYATYDSAVVMFDVMGFG-KPLDEIPML
MSMEG_5586|M.smegmatis_MC2_155 LLPLALAGTCQQIEQIRCMEIVDYATYDSATVMLDVMGFG-KSLDETPML
MAB_4633|M.abscessus_ATCC_1997 LLPLALMGTCQRIDQVRCIEIVDYATYDSATVMFDVMGFG-KPMEETPML
Mflv_1777|M.gilvum_PYR-GCK TAVHAALSLVTRAESVTIKEIFDYGNYDDYEYTGAAMGFGTTPEDDLPLA
Mvan_4970|M.vanbaalenii_PYR-1 TAVHAALSLVTRASSVTVQEIFDYGNYDDYEYTGTAMGFGNSPQDELPMA
TH_4586|M.thermoresistible__bu TAVHSALSLVTRARSVTVQEIFDYANYDDWEFTGTTMGFGSAP-DDEPML
MAV_2461|M.avium_104 TLVHAAVSLATRVSSITVQEIFDYGNYDDAEFTGAAMGFGTAPDDDSPMM
MUL_3685|M.ulcerans_Agy99 MVGMVLSGSCERVDEIRITESVDCSTYES-AATQTAMGFS-QHPDTPGLA
. .: * .* ..*:. .***. : :
Mb0949c|M.bovis_AF2122/97 LQPGVLSLAWGSVVRQLAAGLGISLDGVEEMYVREPAPEAFNIASGHIPK
Rv0926c|M.tuberculosis_H37Rv LQPGVLSLAWGSVVRQLAAGLGISLDGVEEMYVREPAPEAFNIASGHIPK
MMAR_4582|M.marinum_M LQPGVLSLAWGSVVRQLAAGLGLSLDVVEEMYVREPAPHAFDIASGHIPQ
MSMEG_5586|M.smegmatis_MC2_155 LQPGVLSLAWGSVVRQLAAGLGIELDAVTEEHTRVPAPEDFDIAAGHISE
MAB_4633|M.abscessus_ATCC_1997 LQPGVLSLAWGSVVRQLAAGLGVELDEVTEVYEKLSAPEDFDISSGHIPA
Mflv_1777|M.gilvum_PYR-GCK FQPGVVTSMFGGLVRNLADQLGVELDDVCQRFEPWYTPQRIECTMMTVEP
Mvan_4970|M.vanbaalenii_PYR-1 FQPGVVASLFGGLVRSLAAHLDVELDEVRERCEPWYTDQRIECTMTTVEP
TH_4586|M.thermoresistible__bu LMPGVITAMFGGLVRNLADQLGVELDDVRQRTERWFTTERIECRLTTVEP
MAV_2461|M.avium_104 FLPGVIVAMWGGQVRSLADHLGVELDDVRQRIERWFTPERIDCTMMTVQP
MUL_3685|M.ulcerans_Agy99 ESVRVESEVFAESAAMMADAIGATLDKMTFDVTFTAATADTDLGFMKIPA
* :. . :* :. ** : : : :
Mb0949c|M.bovis_AF2122/97 GSAAALRFEVLGLVDGVPAVVLEHVTRLRADLCPEWPQPAQPG-GSYRIE
Rv0926c|M.tuberculosis_H37Rv GSAAALRFEVLGLVDGVPAVVLEHVTRLRADLCPEWPQPAQPG-GSYRIE
MMAR_4582|M.marinum_M GSAAALRFEVLGLVDGAPVVVLEHVTRLREDLCPDWPQPAQPG-GSYRIE
MSMEG_5586|M.smegmatis_MC2_155 GTTAAMRFEVRGMVDGKPAVVLEHVTRLRDDLCPEWPQPAQEG-GSYRVE
MAB_4633|M.abscessus_ATCC_1997 GTMAALHFEVRGIKDGRAVTVLEHFTRLREDLAPNWPQPAHEG-GTYRVE
Mflv_1777|M.gilvum_PYR-GCK GQLAGVRFAAEGVRGGTPVITVEHTTRLTPAAAPDWEYPPAEMDGVHMVI
Mvan_4970|M.vanbaalenii_PYR-1 GRMAAVRFAAEGMRGGEPVITVEHINRLTSAAAPQWEFPPEGHLGVHKVI
TH_4586|M.thermoresistible__bu GGMAAVRFAVEGMRDDEPVITVEHVTRLTPAAAPDWEFPPDNQPGVHRVV
MAV_2461|M.avium_104 GRMAAVRFATEGVRDGEPVITLEHVTRLTRAAAPDWEYPPDGHTGVHRVV
MUL_3685|M.ulcerans_Agy99 GTVGSVYGYHRGWVGDRNVVSVGFNWTMGNHVVP--PKPLKHG---HVIQ
* ..: * .. . : . : * * : :
Mb0949c|M.bovis_AF2122/97 ISGEPCYAMDICLSSRH----GDHNHAGLVATAMRIVNAIPAVVAAEPGI
Rv0926c|M.tuberculosis_H37Rv ISGEPCYAMDICLSSRH----GDHNHAGLVATAMRIVNAIPAVVAAEPGI
MMAR_4582|M.marinum_M ITGEPSYAMDLCLSSRR----GDHNHAGLVATAMRVVNAIPAVVAAPPGI
MSMEG_5586|M.smegmatis_MC2_155 VTGEPSYALDLCLSSPY----GDHNHAGLVATAARVVNAIPAVFAAPPGI
MAB_4633|M.abscessus_ATCC_1997 ITGEPSYLLDLGSFSAR----GDHNYANLIATAMRVVNAVPAVVAAEAGI
Mflv_1777|M.gilvum_PYR-GCK VEGEPRIELMTHLSHPS----LDVTDAGCLSTAARAVNAIDWVCDAPAGL
Mvan_4970|M.vanbaalenii_PYR-1 VEGEPRVEVSTHLSHPV----LDVTDAGCVSTAARAVNAIDWVCRAPAGL
TH_4586|M.thermoresistible__bu VEGEPRIELNTHVSQPF----FDVTEAGCIATAARVINAIDWVCDAPPGL
MAV_2461|M.avium_104 VAGEPRVEINTHVSHPL----FDSTDAGCISTAARVVNAIDWVCRAPQGL
MUL_3685|M.ulcerans_Agy99 VFGLPNMRTVLHCLPPKDWTESGFMGLGMIYTAMPVTNAVPAVVAAKPGI
: * * . . : ** **: * * *:
Mb0949c|M.bovis_AF2122/97 RTTLDLPLITGEGRYAAA----
Rv0926c|M.tuberculosis_H37Rv RTTLDLPLITGEGRYAAA----
MMAR_4582|M.marinum_M RTTLELPLVTGKGLYLPPAGAA
MSMEG_5586|M.smegmatis_MC2_155 RTTLDMPLITGKGLYAAR----
MAB_4633|M.abscessus_ATCC_1997 RTTLDLPLITGKGRAV------
Mflv_1777|M.gilvum_PYR-GCK IGAEDIPPTAMIRGLMW-----
Mvan_4970|M.vanbaalenii_PYR-1 VALENIPPTEMIRGLMW-----
TH_4586|M.thermoresistible__bu VEAADIPPTSLIRGLMW-----
MAV_2461|M.avium_104 IGVEDIPLAATMRGVLWQDR--
MUL_3685|M.ulcerans_Agy99 VTLADLPPITGRAAL-------
::*