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aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_4579 | - | - | 100% (502) | putative cyclohexanecarboxylate-CoA ligase |
| M. thermoresistible (build 8) | TH_3821 | - | 4e-64 | 34.86% (479) | PUTATIVE putative adenylate-forming enzyme |
| M. thermoresistible (build 8) | TH_2907 | - | 9e-42 | 28.96% (518) | PUTATIVE AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2405 | mbtA | 2e-34 | 28.74% (501) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. gilvum PYR-GCK | Mflv_2691 | - | 6e-39 | 29.81% (520) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2384 | mbtA | 2e-34 | 28.74% (501) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 4e-26 | 27.58% (475) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_2247c | - | 5e-34 | 27.80% (518) | bifunctional salicyl-AMP ligase/salicyl-S-arcp synthetase |
| M. marinum M | MMAR_3698 | mbtA | 8e-32 | 27.71% (516) | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP |
| M. avium 104 | MAV_2638 | - | 1e-40 | 30.51% (495) | AMP-dependent synthetase and ligase |
| M. smegmatis MC2 155 | MSMEG_4112 | - | 7e-42 | 32.84% (341) | cyclohexanecarboxylate-CoA ligase |
| M. ulcerans Agy99 | MUL_3641 | mbtA | 4e-32 | 27.71% (516) | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 8e-37 | 29.48% (502) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2405|M.bovis_AF2122/97 MPP--KAADGRRPSPDGGLGGFVPFPA-DRAASYRAAGYWSGRTLDTVLS
Rv2384|M.tuberculosis_H37Rv MPP--KAADGRRPSPDGGLGGFVPFPA-DRAASYRAAGYWSGRTLDTVLS
MMAR_3698|M.marinum_M MPV--TSAQPPRPGP---VAGFIPYPP-ERVASYRAAGYWTGRSIGSLLR
MUL_3641|M.ulcerans_Agy99 ------------------MAGFIPYPP-ERVASYRAAGYWTGRSIGSLLR
Mflv_2691|M.gilvum_PYR-GCK MTTGFPIEYGHGLTNGDLKHGFVPFPE-DRAEAYRRAGYWTGRPLDSILT
MAB_2247c|M.abscessus_ATCC_199 MTQP-RSTTTASSAATPALDGFVPFPS-VRADEYRRAGYWTGNTVESLLR
MAV_2638|M.avium_104 ----------------------MPFDHRQLRDKWYSAGWYSDRTCLDAFE
Mvan_0943|M.vanbaalenii_PYR-1 ----------------------------------------MIHNLADIIR
MSMEG_4112|M.smegmatis_MC2_155 ------MTAPTERRLANVLNGQYTPIDDDTAANWRAAGWWENRSIRSLLA
TH_4579|M.thermoresistible__bu -----------------------------------------VQQLAAELV
MLBr_01051|M.leprae_Br4923 -------------------------------------------MLLASLN
:
Mb2405|M.bovis_AF2122/97 DAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGITPGDR
Rv2384|M.tuberculosis_H37Rv DAARRWPDRLAVADAGDRPGHGGLSYAELDQRADRAAAALHGLGITPGDR
MMAR_3698|M.marinum_M QAAARWPDRVGVVDAG-----ASHTFCELDKLADRAAAGFVSLGIAPGDR
MUL_3641|M.ulcerans_Agy99 QAAARWPDRVGVVDAG-----ASHTFCELDKLADRVAAGFVSLGIAPGDR
Mflv_2691|M.gilvum_PYR-GCK DAASRWPDKPAIIDAT-----RSYTFAELDAAADRAAAGLADLGIRPGER
MAB_2247c|M.abscessus_ATCC_199 VSAARRPCHPAVIDEH-----RALSYRELDEAADNAAHAFLRLGIAPGDR
MAV_2638|M.avium_104 AGAVEHKDVPLTFVIG--DSVSSPTVCEIHDRAVALAASLQRLGVRDGDA
Mvan_0943|M.vanbaalenii_PYR-1 VHGRERPGAPALVVGD-----RTVTYGELDDRSSRAAQAFAQAGVGVGDR
MSMEG_4112|M.smegmatis_MC2_155 DAAQAHPDRIALVGRRADGGRVARTYQEFDRNANQVASVLASLGVRPDDA
TH_4579|M.thermoresistible__bu RRAADEPDAVAVIDDAG-----VHTVAEIVEHAGELAEVFDR-ELGGSPT
MLBr_01051|M.leprae_Br4923 PSVVTATDIADAVCVDG---------VVLSRSGLVGAATSVAERVGGARL
: . * :
Mb2405|M.bovis_AF2122/97 VLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLV
Rv2384|M.tuberculosis_H37Rv VLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLV
MMAR_3698|M.marinum_M VLLQLPNSCRFAVALFGLLRAGAIPVMCLPGHRLAELHHFAEVSGAVGLI
MUL_3641|M.ulcerans_Agy99 VLLQLPNSCRFAVALFGLLRAGAIPVMCLPGHRLAELHHFAEVSGAVGLI
Mflv_2691|M.gilvum_PYR-GCK VLLQLPNSCQFAVALFALLRAGVVPVMCLTGHRTAELGHFADVSGAVAVI
MAB_2247c|M.abscessus_ATCC_199 VLLQLPNRASFAVALFGLMRAGAIPVMCLPGHRAAELSHFIEVADAVGLV
MAV_2638|M.avium_104 VAVQLTNRVECAVAYQAVLLCGAVLVPIVHIYGMAEVAFVLDQSAAKVLI
Mvan_0943|M.vanbaalenii_PYR-1 VAFVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHIIADSGAKIVV
MSMEG_4112|M.smegmatis_MC2_155 VVVMLPNWVEYPEFLFGINELGAIYAGIPVAYGDQQAAAILRRSRARVLV
TH_4579|M.thermoresistible__bu VLVQADNSWRTLAAAVAVGLRGGFLAVFSRQAAASEFRFALDDVAPDIVV
MLBr_01051|M.leprae_Br4923 VAVLATPTASTVLAITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWL
* . . * . : . :
Mb2405|M.bovis_AF2122/97 VAD-VASGFDYRPMARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTG
Rv2384|M.tuberculosis_H37Rv VAD-VASGFDYRPMARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTG
MMAR_3698|M.marinum_M VAQ-HAGGFDYRSMAERLVAAHPQLRHVIIDGESGPFLPWSSLSEGA---
MUL_3641|M.ulcerans_Agy99 VAQ-HAGGFDYRSMAERLVAAHPQLRHVIIDGESGPFLPWSSLSEGA---
Mflv_2691|M.gilvum_PYR-GCK VPD-RAGGFDYRDMAASLAAQRPALRHVIVDGEPGDQVSWQSILDFAGPR
MAB_2247c|M.abscessus_ATCC_199 IPD-SAGGFDYRALAVALSQRHPRLRTVVVEGDAGPFASWTSLLKSVEPQ
MAV_2638|M.avium_104 MPE-RHGSIVYSKRLQDLSRIDSLQHVVMLDAEPGEGYLAWSQLDTPAAR
Mvan_0943|M.vanbaalenii_PYR-1 VGQ-DFAG-------HLEAIEDGLDADIVVIGDHPRWPAFDDWVASHPPV
MSMEG_4112|M.smegmatis_MC2_155 IPR-RWRGNNILEQSRRLRDQIPTLQQVIVLDDDGTDLRDGESLWSDHAH
TH_4579|M.thermoresistible__bu ADDPVFRQWTSDGAHERFPRRARALGDWVVASADGP--------------
MLBr_01051|M.leprae_Br4923 GPG------------PSADSAPDGLPHIPVQLDARSWN------------
:
Mb2405|M.bovis_AF2122/97 SPAPPADPGSP---ALLLVSGGTTGMPKLIPRTHDDYVFNATASAALCRL
Rv2384|M.tuberculosis_H37Rv SPAPPADPGSP---ALLLVSGGTTGMPKLIPRTHDDYVFNATASAALCRL
MMAR_3698|M.marinum_M TPDIDVDTTSP---ALLLVSGGTTGTPKLIPRTHDDYVYNATASAQLCRL
MUL_3641|M.ulcerans_Agy99 TPDIDVDTTSP---ALLLVSGGTTGTPKLIPRTHDDYVYNATASAQLCRL
Mflv_2691|M.gilvum_PYR-GCK LGRTPVDPSLP---ALLLVSGGTTGLPKLIARTHDDYVYNAHACAQACEM
MAB_2247c|M.abscessus_ATCC_199 GPLPTVQTDTP---ALLLVSGGTTAAPKLIPRTHEDYVYNATQAARVCGL
MAV_2638|M.avium_104 YRRPAVAADDV---CLLLYTSGTTSAPKGVQHTNNTVLAEQRTMPALLAG
Mvan_0943|M.vanbaalenii_PYR-1 DPGVVTGPDDV---VLLMYTSGTTGAPKGVMLSNTNYVYKTGGVAGPWQF
MSMEG_4112|M.smegmatis_MC2_155 VAARQFPPPDPGQICYLGFTSGTTGEPKGAMHSHNTLIYSARRQAEHIGT
TH_4579|M.thermoresistible__bu -PGDVTRWRGG---SLAAQTSGSTGRPKCVVHSESSLTYAGSCTIDAVGL
MLBr_01051|M.leprae_Br4923 -RYPEPSPDAT---AMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQW
:.*:*. ** :.
Mb2405|M.bovis_AF2122/97 SAD---DVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAA
Rv2384|M.tuberculosis_H37Rv SAD---DVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAA
MMAR_3698|M.marinum_M TAD---DVYLVSLPAAHNFPLACPGILGSMAVGATIVFSTDPSPEAAFTL
MUL_3641|M.ulcerans_Agy99 TAD---DVYLVSLPAAHNFPLACPGILGSMAVGATIVFSTDPSPEAAFTL
Mflv_2691|M.gilvum_PYR-GCK TGE---DAYLVALPAGHNFPLACPGLLGSMTVGAPTVFTADPSPENAFAL
MAB_2247c|M.abscessus_ATCC_199 TQD---DVYLVALPAGHNFPLACPGLLGAISTGATTVFLSDPSPESAFAT
MAV_2638|M.avium_104 KPD---DVSLVTFPPGHIAGVGS--MLRPLLSGARTVFMDGWDPARAVEV
Mvan_0943|M.vanbaalenii_PYR-1 DAD---AVSLAVMPLFHMA--GSGWALAGLWQGATTVVLRDVEPAAILDA
MSMEG_4112|M.smegmatis_MC2_155 EAFGEPVVNLVASPMGHHTGYVWGGVFTVMLAG-TAVHVDRWDPTWGAQV
TH_4579|M.thermoresistible__bu RLG----DRVAALVPLSSVAAACFGMYLPARNGFPMVCLNKWSPDVALEL
MLBr_01051|M.leprae_Br4923 TAD---DVLVHGLPLFHVHGLVLG-LLGSLRIGNRFVHTGKPTPTAYAQA
: * * *
Mb2405|M.bovis_AF2122/97 IERHGVTVTALVPALAKLWAQSCEWEPVTPKSLRLLQVGGSKLEPEDARR
Rv2384|M.tuberculosis_H37Rv IERHGVTVTALVPALAKLWAQSCEWEPVTPKSLRLLQVGGSKLEPEDARR
MMAR_3698|M.marinum_M IERHGVTVTALVPALAKLWTQACDWEPVTPKSLRLLQVGGSRLEPEDARQ
MUL_3641|M.ulcerans_Agy99 IERHGVTVTALVPALAKLWTQACDWEPVIPKSLRLLQVGGSRLEPEDARQ
Mflv_2691|M.gilvum_PYR-GCK IDKHRITVTGLVNALAKLWAQACDWEPVLPTSLRFVQVGGSRMSPEEARF
MAB_2247c|M.abscessus_ATCC_199 IARHRVSVTAVVPSLAQLWAQATAWEPVLPETLRLLQVGGAKLGADDARA
MAV_2638|M.avium_104 VHRFGVTCTAGTPFHLAGILDLGDTGDKLAS-LREFLVGAAPVAEEIGRR
Mvan_0943|M.vanbaalenii_PYR-1 IARHRITNMLLVPAVIQFLLDTDGVAEVDLSTLRVIVYGASPISDDVLVR
MSMEG_4112|M.smegmatis_MC2_155 VREEGVTTFFGAPTFLQDIIR-TELAGDPACPLRCMVVAGAPVPRNLPAQ
TH_4579|M.thermoresistible__bu LREHEVAWTMLVPTMALQLSIQDGAEGALRS-LRAMTVGGGPMDAGALER
MLBr_01051|M.leprae_Br4923 CSEAGGSLYFGVPTVWSRLVADEAVARALRP-ARLLVSGSASLPVPVFDR
. : . * . ... :
Mb2405|M.bovis_AF2122/97 VRTALTPGLQQVFGMAEGLLNFT-RIGDPPEVVEHTQGR-PLCPADELRI
Rv2384|M.tuberculosis_H37Rv VRTALTPGLQQVFGMAEGLLNFT-RIGDPPEVVEHTQGR-PLCPADELRI
MMAR_3698|M.marinum_M AREALTPGLQQVFGMAEGLLNFT-RLEDPPDLLEHTQGR-PLCSADELRI
MUL_3641|M.ulcerans_Agy99 AREALTPGLQQVFGMAEGLLNFT-RLEDPPDLLEHTQGR-PLCSADELRI
Mflv_2691|M.gilvum_PYR-GCK ILDRLTPGMSQIFGMAEGMLNFT-RPGDPEDVVVHTQGR-PMSPHDEMRV
MAB_2247c|M.abscessus_ATCC_199 VRESLTQGLQQVFGMAEGLLCLT-QPGDPTDILDNSQGR-PMCDADEVRI
MAV_2638|M.avium_104 AAQAGISTFRSYGATEHPTVTGE-HEGQPQWARLGTDGK-PLP-GSEIRI
Mvan_0943|M.vanbaalenii_PYR-1 GIERFGPIFAQVYGMTETTGSIT-QLDGPDHVPALLRSCGRPYPWVQIRI
MSMEG_4112|M.smegmatis_MC2_155 AAEALGAYVAPAWGMTECSILTS-CTPDEPDAILRTDGS--VFAGSEVKI
TH_4579|M.thermoresistible__bu AERTLGTTILRVFGMSECLGHTTPHPSDPPEIRLGRDGR--PFPGTTVRA
MLBr_01051|M.leprae_Br4923 LAHLTGHRPIERYGSTESLITLS-TLADGERRAGWVGLP---LAGVQTRL
. . :
Mb2405|M.bovis_AF2122/97 VNADGEPVGPG--EEGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGD
Rv2384|M.tuberculosis_H37Rv VNADGEPVGPG--EEGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGD
MMAR_3698|M.marinum_M VDGAGAPVAPG--AEGELLVRGPYTINGYFCADRDNERCFDPAGFYRSGD
MUL_3641|M.ulcerans_Agy99 VDGAGAPVAPG--AEGELLVRGPYTINGYFCADRDNERCFDPAGFYRSGD
Mflv_2691|M.gilvum_PYR-GCK VDEDGVEVAPG--EEGELLVRGPYTLNGYYRADDANARSFTPDGFYRTGD
MAB_2247c|M.abscessus_ATCC_199 VDEDGADVPAG--ETGELLVRGPYTLNGYYRADADNMRSFTVDGFYRSGD
MAV_2638|M.avium_104 VGSDGTDCPIG--IGGEVVVRGPDQFIGYQDS-ALNTEAFTDDGWFRTGD
Mvan_0943|M.vanbaalenii_PYR-1 VDETGADAVAG--TVGEVWTRSEQNMLGYWNNPDATASTLTADGWLKTGD
MSMEG_4112|M.smegmatis_MC2_155 VDDTGAAVAAG--VVGDLLMRGPGVVYGYYDRPDATRDAYLPGLWFKTGD
TH_4579|M.thermoresistible__bu VDDEGRVCAPG--EVGAGQVKGPSLFLGYARDGAPTPPELTDDGFLPTGD
MLBr_01051|M.leprae_Br4923 VDESGGPVPYDGETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGD
*. * . * :. . ** . : :**
Mb2405|M.bovis_AF2122/97 LVRRRDDG----NLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFSAA
Rv2384|M.tuberculosis_H37Rv LVRRRDDG----NLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFSAA
MMAR_3698|M.marinum_M LVRLRDDG----YLQVTGRVKDVICRCGETISAQDLEEQLLSHPAIRSAA
MUL_3641|M.ulcerans_Agy99 LVRLRDDG----YLQVTGRVKDVICRCGETISAQDLEEQLLSHPAIRSAA
Mflv_2691|M.gilvum_PYR-GCK RVRIFTDGPRAGYVEVTGRVKDVIHRGGETVSATDLEDHLHTHPSVYAAA
MAB_2247c|M.abscessus_ATCC_199 RVRALPGG----YLEVTGRIKDVILRGGESIAALDLESHLQTHPAVYAAA
MAV_2638|M.avium_104 LGHLDAHG----RLTITDRIKDVIIRGGETISSGQVEEVLNAHPAVADGV
Mvan_0943|M.vanbaalenii_PYR-1 AGYVDDDG----YLFLHDRIKDMIVSGGENVYPVEVENVLMTHPAVADAA
MSMEG_4112|M.smegmatis_MC2_155 RADVDENG----WLRLRGRSKDIIIRGGENIPVTDVESAIFDHPDVLNAA
TH_4579|M.thermoresistible__bu LLEVGADG----TVMVRGRQKQMIIRGGRNIDINEVEAAVARMPQASQVC
MLBr_01051|M.leprae_Br4923 VAVVDSGG---MHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVA
* : . ::* * : ::* : *
Mb2405|M.bovis_AF2122/97 AVGLPDQYLGEKICAAVVFAG---APITLAELNGYLDRRGVAAHTRPDQL
Rv2384|M.tuberculosis_H37Rv AVGLPDQYLGEKICAAVVFAG---APITLAELNGYLDRRGVAAHTRPDQL
MMAR_3698|M.marinum_M AVPLPDPDMGELICAAIVFAGPPQTPQTLSGLNDYLEQRGVAAHIRIDRL
MUL_3641|M.ulcerans_Agy99 AVPLPDPDMGELICAAIVFAGPPQTPQTLSGLNDYLEQRGVAAHIRIDRL
Mflv_2691|M.gilvum_PYR-GCK AVALPDEYLGEKICAAVVFTG---PPLTLADLNAFLDERGASTHARPDVL
MAB_2247c|M.abscessus_ATCC_199 AVGLPDQYLGEIVCAAIVFKG---KPVAAAELNQHLQARGAATHSRVDKL
MAV_2638|M.avium_104 AVAAPDSRYGDVVAAVVVLKPG--YALNLDDLRAHFAASGLARQKTPERL
Mvan_0943|M.vanbaalenii_PYR-1 VIGVPDRRWGEAVKAVVVAARG--AQLTEAELIAFARDR-IGGFKLPKSV
MSMEG_4112|M.smegmatis_MC2_155 VIGLPDERLGERVCAVLVTKSG-CPELTVDTLGEYLLGQGLSKHYLPEKV
TH_4579|M.thermoresistible__bu VVPVPDELLGERVAALVVSEAG---GLGLADVTEFLASTGFPKNKWPEFV
MLBr_01051|M.leprae_Br4923 VVGLPDEDLGQRIVAFVVGAEA----LDADELINYVAQQ-LSIHKRPREV
.: ** *: : * :* : . :
Mb2405|M.bovis_AF2122/97 VAMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH
Rv2384|M.tuberculosis_H37Rv VAMPALPTTPIGKIDKRAIVRQLGIATGPVTTQRCH
MMAR_3698|M.marinum_M VAMPSLPTTPVGKIDKKAIASQILTTTAT-------
MUL_3641|M.ulcerans_Agy99 VAMPSLPTTPVGKIDKKAIASQILTTTAT-------
Mflv_2691|M.gilvum_PYR-GCK VPVPSLPTTAVGKVDKKALVAQLTANS---------
MAB_2247c|M.abscessus_ATCC_199 VAVSALPLTAVGKIDKRALLASLTG-----------
MAV_2638|M.avium_104 AIVDELPRTSLGKVRKAQLRSDHFGAARR-------
Mvan_0943|M.vanbaalenii_PYR-1 DFVDVLPRNPSGKLLKRALREPYWDGADRHIG----
MSMEG_4112|M.smegmatis_MC2_155 VHLDELPMTPSGKIQKFKLREQYS------------
TH_4579|M.thermoresistible__bu FSVPELPLNRVGKLSRADAIALATQLAREKQT----
MLBr_01051|M.leprae_Br4923 RFVDALPRNAMGKVLKKQLLFEG-------------
: ** . **: :