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M. thermoresistible (build 8) TH_4227 (-)

annotation: MscS Mechanosensitive ion channel
coordinates: 352901 - 354088
length: 396

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4227--100% (396)MscS Mechanosensitive ion channel
M. thermoresistible (build 8)TH_2299-2e-0624.77% (214) PROBABLE CONSERVED TRANSMEMBRANE PROTEIN
M. thermoresistible (build 8)TH_3952-1e-0524.21% (190) PUTATIVE MscS mechanosensitive ion channel

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2460c-4e-0729.53% (149) transmembrane protein
M. gilvum PYR-GCKMflv_1046-1e-13462.82% (390) MscS mechanosensitive ion channel
M. tuberculosis H37RvRv2434c-4e-0729.53% (149) transmembrane protein
M. leprae Br4923-----
M. abscessus ATCC 19977-----
M. marinum MMMAR_3542-1e-13168.57% (350) hypothetical protein MMAR_3542
M. avium 104MAV_3202-3e-0627.98% (168) transmembrane protein
M. smegmatis MC2 155MSMEG_5496-1e-14265.26% (403) MscS mechanosensitive ion channel
M. ulcerans Agy99MUL_2773-1e-10671.06% (273) hypothetical protein MUL_2773
M. vanbaalenii PYR-1Mvan_5784-1e-14063.93% (402) MscS mechanosensitive ion channel

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3542|M.marinum_M               ------MPEQSQVPSAASVAVSLAWVGGALVGAYLLGVLLSWILKRIGRR
MUL_2773|M.ulcerans_Agy99           -------------------------------------------MPRLSRY
Mflv_1046|M.gilvum_PYR-GCK          ------MDDTLELASATHVASAAAWIAGAVAIAYAVGLAISWLLQRLGRR
Mvan_5784|M.vanbaalenii_PYR-1       ------MDDAIEFTSATHLAVTAAWVAGAIGVAYVAGLAVSWLLQRLGRR
MSMEG_5496|M.smegmatis_MC2_155      MGTQVLMSETIKLESATNFAVTAAWAAGAVALAYGVGLGSNWLVQRVGGR
TH_4227|M.thermoresistible__bu      ------MPEESQLTSATELAVTLAWVAGAVTAAYFLGMGLSWVLHRVGRR
Mb2460c|M.bovis_AF2122/97           --------------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRR
Rv2434c|M.tuberculosis_H37Rv        --------------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRR
MAV_3202|M.avium_104                --------------MSTFDSSSLYWATAVVFGLPLLLIVLTEWHQSLVRK
                                                                                  :   

MMAR_3542|M.marinum_M               SELLRDIAPLTRKPLRATLMVIAAIVAVHGSVHGAVASHGWVDHTLVLLL
MUL_2773|M.ulcerans_Agy99           TVPWPHTAGLP---------------------------------TLVLLL
Mflv_1046|M.gilvum_PYR-GCK          STLLHHAAELTRMPLRATLVVIAASAAVRRTVDADTGWRGFVDHLLVITL
Mvan_5784|M.vanbaalenii_PYR-1       SAVMHDVAHLTRLPLRATLVVIAAGAAVRRTTDEQAVWRGWLDHALILAL
MSMEG_5496|M.smegmatis_MC2_155      SAVLRDAAQLTRRPVRATLMVIAATVAVQRTSDEQARWRGWLDHSLVIAL
TH_4227|M.thermoresistible__bu      SVVLADIALLTRHPVRVILMIIAAGIALQR-ADTEAPWRGGADHLLRILL
Mb2460c|M.bovis_AF2122/97           NSHLARQASLLRNYLLPLGAVLLLLVKASEVP---------AEDPTVRVL
Rv2434c|M.tuberculosis_H37Rv        NSHLARQASLLRNYLLPLGAVLLLLVKASEVP---------AEDPTVRVL
MAV_3202|M.avium_104                HSPLARPAFLLRSYLIPLGALLVLLVNVARMP---------AQFTSVRVL
                                           * *                                       *

MMAR_3542|M.marinum_M               IAAITWLVASLVLVAERRAINQFGGGDATMTDADLHRRRIRTQVTTLRRL
MUL_2773|M.ulcerans_Agy99           IAAITWLVASLVLVAERRAINQFGGGDATVTDADLHRRRIRTQVTTLHRL
Mflv_1046|M.gilvum_PYR-GCK          IATITWTIASLVRVAERQAISRFAGGDEGLTDADRHRRKIKTQVLTLRRI
Mvan_5784|M.vanbaalenii_PYR-1       IATLTWVLVSLVRVVERQVIARFAGGDEGLTDADRHRRKIKTQVTVLRRL
MSMEG_5496|M.smegmatis_MC2_155      IATITWLIAALVMVAERQALTRFAGGDTGLTDADLHRRKVRTQVTLVRRL
TH_4227|M.thermoresistible__bu      IGAITWMIATLVQVAERRVIARFAGGDTGLTDADLHRRRVRTQVTVLRRL
Mb2460c|M.bovis_AF2122/97           TTAFGFLVLVLLLSLLNATLFQGAPQQS-------WRKRLPAIFVDVAR-
Rv2434c|M.tuberculosis_H37Rv        TTAFGFLVLVLLLSLLNATLFQGAPQQS-------WRKRLPAIFVDVAR-
MAV_3202|M.avium_104                ATAFGFVVVVLLLSGLNATIFEGAPEGS-------WRQRVPGIFLDVTR-
                                      :: : :  *:    . .: . .            *:::   .  : * 

MMAR_3542|M.marinum_M               AVAAVVLLGLAAALMTFPAFAALGTALLASAGVLSVVAGLAAQTSLGAVF
MUL_2773|M.ulcerans_Agy99           AVAAVVLLGLAAALMTFPAFAALGTALLASAGVLSVVAGLAAQTSLGAVF
Mflv_1046|M.gilvum_PYR-GCK          AVAIIVMLGAAAALMTFPAFSDIGKTVFASAGVLTVVAGLAAQTSLGSVF
Mvan_5784|M.vanbaalenii_PYR-1       VVALVVVLGAAAALMTFPSFSDIGKTLFASAGVLTVVAGLAAQTSLGSVF
MSMEG_5496|M.smegmatis_MC2_155      VVAVVAVLGVAAALMTFPSFSDIGKTVFASAGVLSVVAGLAAQTSLGAVF
TH_4227|M.thermoresistible__bu      TVAIVVVLGTAAALMTFPSFADIGTTLFASAGVLSVVAGLAAQTSLGAMF
Mb2460c|M.bovis_AF2122/97           ----FALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIV
Rv2434c|M.tuberculosis_H37Rv        ----FALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIV
MAV_3202|M.avium_104                ----FVLIGVGLAVIFSYVWGVRVGGLFTALGVTSVVIGLMLQNSVGQIV
                                        ..::* . *::    :.     :::: ** :** **  *.*:* :.

MMAR_3542|M.marinum_M               AGIQIAFSDAIRVGDVVVLEDKWGRIEEITLTYVVVNLWDQRRLVLPTTY
MUL_2773|M.ulcerans_Agy99           AGIQIAFSDAIRVGDVVVLEDKWGRIEEIALTYVVVNLWDQRRLVLPTTY
Mflv_1046|M.gilvum_PYR-GCK          AGIQIAFSDAIRVGDVVVLEEEWGRIEEITLTYVVVHLWDERRLVLPCTY
Mvan_5784|M.vanbaalenii_PYR-1       AGIQIAFSDAIRVGDIVVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTY
MSMEG_5496|M.smegmatis_MC2_155      AGIQIAFSDAIRVGDVVVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTY
TH_4227|M.thermoresistible__bu      AGLQIAFSNAIRVGDVVVIEKQWGRIEEITLTYVVVTIWDERRLILPCTY
Mb2460c|M.bovis_AF2122/97           SGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTG-SGLQIMPNSM
Rv2434c|M.tuberculosis_H37Rv        SGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTG-SGLQIMPNSM
MAV_3202|M.avium_104                SGLFMLFEQPFRIGDWLDTPAARGRIVEANWRSVHIQTG-HGLQITPNSV
                                    :*: : *.:.:*:.* :      **: *     * :        : * : 

MMAR_3542|M.marinum_M               FTTTPFENWTRNATELLGTVELDVDFAVGLQAMRAELQRQLAG-------
MUL_2773|M.ulcerans_Agy99           FTTTPFENWTRNATELLGTVELDVDFAVGLQAMRAELQRQLAG-------
Mflv_1046|M.gilvum_PYR-GCK          FTSTPFQNWTRNATELLGTAELDVDFTVPFDQMRAELDRLLRA-------
Mvan_5784|M.vanbaalenii_PYR-1       FTDTPFQNWTRNATELLGTAELDVDFTVPFDAMRAELDRMLHA-------
MSMEG_5496|M.smegmatis_MC2_155      FTTTPFQNWTRNATELLGTIELDADFTVPLDAMRVELDRLLRA-------
TH_4227|M.thermoresistible__bu      FTTTPFENWTRNATEVMGLVELDVDFTVPLDEMRAELDHILAAN------
Mb2460c|M.bovis_AF2122/97           LATTAFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPG
Rv2434c|M.tuberculosis_H37Rv        LATTAFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPG
MAV_3202|M.avium_104                LATTSFTNLSRPPGGHQLTLTATFSETDPPDRVCALLRRVADALPQRRPD
                                    :: *.* * :* .           . :   : : . * :   .       

MMAR_3542|M.marinum_M               -----------------------------------------------SEL
MUL_2773|M.ulcerans_Agy99           -----------------------------------------------SEL
Mflv_1046|M.gilvum_PYR-GCK          -----------------------------------------------NPL
Mvan_5784|M.vanbaalenii_PYR-1       -----------------------------------------------NDK
MSMEG_5496|M.smegmatis_MC2_155      -----------------------------------------------DPL
TH_4227|M.thermoresistible__bu      -----------------------------------------------DDL
Mb2460c|M.bovis_AF2122/97           VVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEA
Rv2434c|M.tuberculosis_H37Rv        VVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEA
MAV_3202|M.avium_104                AVAAAVPAGGGEYHVTIGLTSPADDSAAQATLLRWLWYGARREGLRLDGA
                                                                                   .  

MMAR_3542|M.marinum_M               WDQRVGALQVTDAVGGHVRVRILVSAPNAGALWDLRCAVREGMVDWLQRN
MUL_2773|M.ulcerans_Agy99           WDQRVGALQVTDAVGGHVRVRILVSAPNAGALWDLRCAVREGMVDWLQRN
Mflv_1046|M.gilvum_PYR-GCK          WDGRVGVLQVTDAVEGRVRVRMLVSASNAGQLFDLRCDVREGMVAWLQRT
Mvan_5784|M.vanbaalenii_PYR-1       WDGRVGVLQVTDAVEGLVRVRMLVSAPNAGALFDLRCDIREGMVAWLQRT
MSMEG_5496|M.smegmatis_MC2_155      WDQRVGVLQVTDAVGGQVRVRVLVSAPNAGALWDLQCNVREGLVEWLQRT
TH_4227|M.thermoresistible__bu      WDGRLGVLEVTDATGGHVRVWITLSAPNSSALWGLRTAVREAMVKWLQRQ
Mb2460c|M.bovis_AF2122/97           DDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHA
Rv2434c|M.tuberculosis_H37Rv        DDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHA
MAV_3202|M.avium_104                EDDISTPERIERALRMVVAPALRLGPPDQQALVSHARIVRYGADEIVEHA
                                     *      .:  *    *   : :...:   *      :* .    ::: 

MMAR_3542|M.marinum_M               QPAALPRWRVAHSDTRCAEQPACRDAGSGENEQAPG--------------
MUL_2773|M.ulcerans_Agy99           QPAALPRWRVAHSDTRCAGQPACRDAGNGANEQDPG--------------
Mflv_1046|M.gilvum_PYR-GCK          NPGAMPRTRIEHRTDADTARGDAAVPVPGRSQADSGLFSGSIAADRRNRD
Mvan_5784|M.vanbaalenii_PYR-1       NPCALPRKRIEHHNDS-RRHGEATEAPVGRPQAESGLFSGSAAAERRGRA
MSMEG_5496|M.smegmatis_MC2_155      NPGALPRQRIEHESARDTRISDTAAG--GYAQADSGLFTGNPEAERRGRS
TH_4227|M.thermoresistible__bu      GTGALPRWRFEPATAAPAGGPQRGLAYSRRPSGE-GLFSGSAEAQQRART
Mb2460c|M.bovis_AF2122/97           GVVPMGITFVIAGSVRLTVTTD-DGSVVAIATLKKGTFLGLTALTRQPDP
Rv2434c|M.tuberculosis_H37Rv        GVVPMGITFVIAGSVRLTVTTD-DGSVVAIATLKKGTFLGLTALTRQPDP
MAV_3202|M.avium_104                GRVPEKMTFLLAGGVRLTATAP-DGSVVAVGGLDEGSFLGVTALTRQPNL
                                       .     .                         *              

MMAR_3542|M.marinum_M               --------------------------------------------------
MUL_2773|M.ulcerans_Agy99           --------------------------------------------------
Mflv_1046|M.gilvum_PYR-GCK          LTWAHDAR------------------------------------------
Mvan_5784|M.vanbaalenii_PYR-1       MSGAR---------------------------------------------
MSMEG_5496|M.smegmatis_MC2_155      FDHADGDDAKKTEPVPVAAGQTQC--------------------------
TH_4227|M.thermoresistible__bu      FEGPAG--------------------------------------------
Mb2460c|M.bovis_AF2122/97           AGAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRR
Rv2434c|M.tuberculosis_H37Rv        AGAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRR
MAV_3202|M.avium_104                ADAQAVAEVTALEIDREHLVELVTGKPLLLQDLGRTIDERRALVHRAVTA
                                                                                      

MMAR_3542|M.marinum_M               ------------------
MUL_2773|M.ulcerans_Agy99           ------------------
Mflv_1046|M.gilvum_PYR-GCK          ------------------
Mvan_5784|M.vanbaalenii_PYR-1       ------------------
MSMEG_5496|M.smegmatis_MC2_155      ------------------
TH_4227|M.thermoresistible__bu      ------------------
Mb2460c|M.bovis_AF2122/97           DLHQSPAAAGEHRGPARR
Rv2434c|M.tuberculosis_H37Rv        DLHQSPAAAGEHRGPARR
MAV_3202|M.avium_104                EPTPS-------REPVS-