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MDDAIEFTSATHLAVTAAWVAGAIGVAYVAGLAVSWLLQRLGRRSAVMHDVAHLTRLPLRATLVVIAAGA AVRRTTDEQAVWRGWLDHALILALIATLTWVLVSLVRVVERQVIARFAGGDEGLTDADRHRRKIKTQVTV LRRLVVALVVVLGAAAALMTFPSFSDIGKTLFASAGVLTVVAGLAAQTSLGSVFAGIQIAFSDAIRVGDI VVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTYFTDTPFQNWTRNATELLGTAELDVDFTVPFDAMRAE LDRMLHANDKWDGRVGVLQVTDAVEGLVRVRMLVSAPNAGALFDLRCDIREGMVAWLQRTNPCALPRKRI EHHNDSRRHGEATEAPVGRPQAESGLFSGSAAAERRGRAMSGAR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5784 | - | - | 100% (394) | MscS mechanosensitive ion channel |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2460c | - | 2e-05 | 30.33% (122) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1046 | - | 1e-177 | 78.17% (394) | MscS mechanosensitive ion channel |
| M. tuberculosis H37Rv | Rv2434c | - | 2e-05 | 30.33% (122) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3542 | - | 1e-132 | 66.95% (357) | hypothetical protein MMAR_3542 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_5496 | - | 1e-164 | 73.54% (393) | MscS mechanosensitive ion channel |
| M. thermoresistible (build 8) | TH_4227 | - | 1e-140 | 63.93% (402) | PUTATIVE MscS Mechanosensitive ion channel |
| M. ulcerans Agy99 | MUL_2773 | - | 1e-107 | 72.06% (272) | hypothetical protein MUL_2773 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5784|M.vanbaalenii_PYR-1 ------MDDAIEFTSATHLAVTAAWVAGAIGVAYVAGLAVSWLLQRLGRR
Mflv_1046|M.gilvum_PYR-GCK ------MDDTLELASATHVASAAAWIAGAVAIAYAVGLAISWLLQRLGRR
MSMEG_5496|M.smegmatis_MC2_155 MGTQVLMSETIKLESATNFAVTAAWAAGAVALAYGVGLGSNWLVQRVGGR
MMAR_3542|M.marinum_M ------MPEQSQVPSAASVAVSLAWVGGALVGAYLLGVLLSWILKRIGRR
MUL_2773|M.ulcerans_Agy99 -------------------------------------------MPRLSRY
TH_4227|M.thermoresistible__bu ------MPEESQLTSATELAVTLAWVAGAVTAAYFLGMGLSWVLHRVGRR
Mb2460c|M.bovis_AF2122/97 ----------MNLLDSTWFYWAVGIAIG-LPAGLIVLTELHNILVRRNSH
Rv2434c|M.tuberculosis_H37Rv ----------MNLLDSTWFYWAVGIAIG-LPAGLIVLTELHNILVRRNSH
: * .
Mvan_5784|M.vanbaalenii_PYR-1 SAVMHDVAHLTRLPLRATLVVIAAGAAVRRTTDEQAVWRGWLDHALILAL
Mflv_1046|M.gilvum_PYR-GCK STLLHHAAELTRMPLRATLVVIAASAAVRRTVDADTGWRGFVDHLLVITL
MSMEG_5496|M.smegmatis_MC2_155 SAVLRDAAQLTRRPVRATLMVIAATVAVQRTSDEQARWRGWLDHSLVIAL
MMAR_3542|M.marinum_M SELLRDIAPLTRKPLRATLMVIAAIVAVHGSVHGAVASHGWVDHTLVLLL
MUL_2773|M.ulcerans_Agy99 TVPWPHTAGLP---------------------------------TLVLLL
TH_4227|M.thermoresistible__bu SVVLADIALLTRHPVRVILMIIAAGIALQR-ADTEAPWRGGADHLLRILL
Mb2460c|M.bovis_AF2122/97 LARQASLLRNYLLPLGAVLLLLVKASEVP------------AEDPTVRVL
Rv2434c|M.tuberculosis_H37Rv LARQASLLRNYLLPLGAVLLLLVKASEVP------------AEDPTVRVL
*
Mvan_5784|M.vanbaalenii_PYR-1 IATLTWVLVSLVRVVERQVIARFAGGDEGLTDADRHRRKIKTQVTVLRRL
Mflv_1046|M.gilvum_PYR-GCK IATITWTIASLVRVAERQAISRFAGGDEGLTDADRHRRKIKTQVLTLRRI
MSMEG_5496|M.smegmatis_MC2_155 IATITWLIAALVMVAERQALTRFAGGDTGLTDADLHRRKVRTQVTLVRRL
MMAR_3542|M.marinum_M IAAITWLVASLVLVAERRAINQFGGGDATMTDADLHRRRIRTQVTTLRRL
MUL_2773|M.ulcerans_Agy99 IAAITWLVASLVLVAERRAINQFGGGDATVTDADLHRRRIRTQVTTLHRL
TH_4227|M.thermoresistible__bu IGAITWMIATLVQVAERRVIARFAGGDTGLTDADLHRRRVRTQVTVLRRL
Mb2460c|M.bovis_AF2122/97 TTAFGFLVLVLLLSLLN--ATLFQG-------APQQSWRKRLPAIFVD--
Rv2434c|M.tuberculosis_H37Rv TTAFGFLVLVLLLSLLN--ATLFQG-------APQQSWRKRLPAIFVD--
:: : : *: . * * * : : : . :
Mvan_5784|M.vanbaalenii_PYR-1 VVALVVVLGAAAALMTFPSFSDIGKTLFASAGVLTVVAGLAAQTSLGSVF
Mflv_1046|M.gilvum_PYR-GCK AVAIIVMLGAAAALMTFPAFSDIGKTVFASAGVLTVVAGLAAQTSLGSVF
MSMEG_5496|M.smegmatis_MC2_155 VVAVVAVLGVAAALMTFPSFSDIGKTVFASAGVLSVVAGLAAQTSLGAVF
MMAR_3542|M.marinum_M AVAAVVLLGLAAALMTFPAFAALGTALLASAGVLSVVAGLAAQTSLGAVF
MUL_2773|M.ulcerans_Agy99 AVAAVVLLGLAAALMTFPAFAALGTALLASAGVLSVVAGLAAQTSLGAVF
TH_4227|M.thermoresistible__bu TVAIVVVLGTAAALMTFPSFADIGTTLFASAGVLSVVAGLAAQTSLGAMF
Mb2460c|M.bovis_AF2122/97 -VARFALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIV
Rv2434c|M.tuberculosis_H37Rv -VARFALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIV
** ..::* . *:: :. ::*: ** :** ** *.*:* :.
Mvan_5784|M.vanbaalenii_PYR-1 AGIQIAFSDAIRVGDIVVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTY
Mflv_1046|M.gilvum_PYR-GCK AGIQIAFSDAIRVGDVVVLEEEWGRIEEITLTYVVVHLWDERRLVLPCTY
MSMEG_5496|M.smegmatis_MC2_155 AGIQIAFSDAIRVGDVVVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTY
MMAR_3542|M.marinum_M AGIQIAFSDAIRVGDVVVLEDKWGRIEEITLTYVVVNLWDQRRLVLPTTY
MUL_2773|M.ulcerans_Agy99 AGIQIAFSDAIRVGDVVVLEDKWGRIEEIALTYVVVNLWDQRRLVLPTTY
TH_4227|M.thermoresistible__bu AGLQIAFSNAIRVGDVVVIEKQWGRIEEITLTYVVVTIWDERRLILPCTY
Mb2460c|M.bovis_AF2122/97 SGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSG-LQIMPNSM
Rv2434c|M.tuberculosis_H37Rv SGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSG-LQIMPNSM
:*: : *.:.:*:.* : **: *: * : . ::* :
Mvan_5784|M.vanbaalenii_PYR-1 FTDTPFQNWTRNATELLGTAELDVDFTVPFDAMRAELDRMLHA-------
Mflv_1046|M.gilvum_PYR-GCK FTSTPFQNWTRNATELLGTAELDVDFTVPFDQMRAELDRLLRA-------
MSMEG_5496|M.smegmatis_MC2_155 FTTTPFQNWTRNATELLGTIELDADFTVPLDAMRVELDRLLRA-------
MMAR_3542|M.marinum_M FTTTPFENWTRNATELLGTVELDVDFAVGLQAMRAELQRQLAG-------
MUL_2773|M.ulcerans_Agy99 FTTTPFENWTRNATELLGTVELDVDFAVGLQAMRAELQRQLAG-------
TH_4227|M.thermoresistible__bu FTTTPFENWTRNATEVMGLVELDVDFTVPLDEMRAELDHILAAN------
Mb2460c|M.bovis_AF2122/97 LATTAFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPG
Rv2434c|M.tuberculosis_H37Rv LATTAFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPG
:: *.* * :* * . : : : . *:: .
Mvan_5784|M.vanbaalenii_PYR-1 -----------------------------------------------NDK
Mflv_1046|M.gilvum_PYR-GCK -----------------------------------------------NPL
MSMEG_5496|M.smegmatis_MC2_155 -----------------------------------------------DPL
MMAR_3542|M.marinum_M -----------------------------------------------SEL
MUL_2773|M.ulcerans_Agy99 -----------------------------------------------SEL
TH_4227|M.thermoresistible__bu -----------------------------------------------DDL
Mb2460c|M.bovis_AF2122/97 VVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEA
Rv2434c|M.tuberculosis_H37Rv VVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEA
.
Mvan_5784|M.vanbaalenii_PYR-1 WDGRVGVLQVTDAVEGLVRVRMLVSAPNAGALFDLRCDIREG--------
Mflv_1046|M.gilvum_PYR-GCK WDGRVGVLQVTDAVEGRVRVRMLVSASNAGQLFDLRCDVREG--------
MSMEG_5496|M.smegmatis_MC2_155 WDQRVGVLQVTDAVGGQVRVRVLVSAPNAGALWDLQCNVREG--------
MMAR_3542|M.marinum_M WDQRVGALQVTDAVGGHVRVRILVSAPNAGALWDLRCAVREG--------
MUL_2773|M.ulcerans_Agy99 WDQRVGALQVTDAVGGHVRVRILVSAPNAGALWDLRCAVREG--------
TH_4227|M.thermoresistible__bu WDGRLGVLEVTDATGGHVRVWITLSAPNSSALWGLRTAVREA--------
Mb2460c|M.bovis_AF2122/97 DDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHA
Rv2434c|M.tuberculosis_H37Rv DDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHA
* . .* .* * : :*:.: * :* .
Mvan_5784|M.vanbaalenii_PYR-1 ---------------------------MVAWLQRTNPCALPRKRIEHHND
Mflv_1046|M.gilvum_PYR-GCK ---------------------------MVAWLQRTNPGAMPRTRIEHRTD
MSMEG_5496|M.smegmatis_MC2_155 ---------------------------LVEWLQRTNPGALPRQRIEHESA
MMAR_3542|M.marinum_M ---------------------------MVDWLQRNQPAALPRWRVAHSDT
MUL_2773|M.ulcerans_Agy99 ---------------------------MVDWLQRNQPAALPRWRVAHSDT
TH_4227|M.thermoresistible__bu ---------------------------MVKWLQRQGTGALPRWRFEPATA
Mb2460c|M.bovis_AF2122/97 GVVPMGITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPA
Rv2434c|M.tuberculosis_H37Rv GVVPMGITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPA
: *:: .:.
Mvan_5784|M.vanbaalenii_PYR-1 S-RRHGEATEAPVGRPQAESGLFSGSAAAERRGRAMSGAR----------
Mflv_1046|M.gilvum_PYR-GCK ADTARGDAAVPVPGRSQADSGLFSGSIAADRRNRDLTWAHDAR-------
MSMEG_5496|M.smegmatis_MC2_155 RDTRISDTAAG--GYAQADSGLFTGNPEAERRGRSFDHADGDDAKKTEPV
MMAR_3542|M.marinum_M RCAEQPACRDAGSGENEQAPG-----------------------------
MUL_2773|M.ulcerans_Agy99 RCAGQPACRDAGNGANEQDPG-----------------------------
TH_4227|M.thermoresistible__bu APAGGPQRGLAYSRRPSGE-GLFSGSAEAQQRARTFEGPAG---------
Mb2460c|M.bovis_AF2122/97 GAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRD
Rv2434c|M.tuberculosis_H37Rv GAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRD
Mvan_5784|M.vanbaalenii_PYR-1 -----------------
Mflv_1046|M.gilvum_PYR-GCK -----------------
MSMEG_5496|M.smegmatis_MC2_155 PVAAGQTQC--------
MMAR_3542|M.marinum_M -----------------
MUL_2773|M.ulcerans_Agy99 -----------------
TH_4227|M.thermoresistible__bu -----------------
Mb2460c|M.bovis_AF2122/97 LHQSPAAAGEHRGPARR
Rv2434c|M.tuberculosis_H37Rv LHQSPAAAGEHRGPARR