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VGTQVLMSETIKLESATNFAVTAAWAAGAVALAYGVGLGSNWLVQRVGGRSAVLRDAAQLTRRPVRATLM VIAATVAVQRTSDEQARWRGWLDHSLVIALIATITWLIAALVMVAERQALTRFAGGDTGLTDADLHRRKV RTQVTLVRRLVVAVVAVLGVAAALMTFPSFSDIGKTVFASAGVLSVVAGLAAQTSLGAVFAGIQIAFSDA IRVGDVVVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTYFTTTPFQNWTRNATELLGTIELDADFTVPL DAMRVELDRLLRADPLWDQRVGVLQVTDAVGGQVRVRVLVSAPNAGALWDLQCNVREGLVEWLQRTNPGA LPRQRIEHESARDTRISDTAAGGYAQADSGLFTGNPEAERRGRSFDHADGDDAKKTEPVPVAAGQTQC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5496 | - | - | 100% (418) | MscS mechanosensitive ion channel |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2460c | - | 9e-08 | 28.16% (174) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1046 | - | 1e-163 | 73.35% (394) | MscS mechanosensitive ion channel |
| M. tuberculosis H37Rv | Rv2434c | - | 1e-07 | 28.16% (174) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1411 | - | 5e-05 | 32.26% (124) | putative mechanosensitive ion channel |
| M. marinum M | MMAR_3542 | - | 1e-140 | 67.95% (365) | hypothetical protein MMAR_3542 |
| M. avium 104 | MAV_3202 | - | 2e-06 | 30.20% (149) | transmembrane protein |
| M. thermoresistible (build 8) | TH_4227 | - | 1e-143 | 65.26% (403) | PUTATIVE MscS Mechanosensitive ion channel |
| M. ulcerans Agy99 | MUL_2773 | - | 1e-115 | 75.00% (268) | hypothetical protein MUL_2773 |
| M. vanbaalenii PYR-1 | Mvan_5784 | - | 1e-164 | 73.54% (393) | MscS mechanosensitive ion channel |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1046|M.gilvum_PYR-GCK ------MDDTLELASATHVASAAAWIAGAVAIAYAVGLAISWLLQRLGRR
Mvan_5784|M.vanbaalenii_PYR-1 ------MDDAIEFTSATHLAVTAAWVAGAIGVAYVAGLAVSWLLQRLGRR
MSMEG_5496|M.smegmatis_MC2_155 MGTQVLMSETIKLESATNFAVTAAWAAGAVALAYGVGLGSNWLVQRVGGR
MMAR_3542|M.marinum_M ------MPEQSQVPSAASVAVSLAWVGGALVGAYLLGVLLSWILKRIGRR
MUL_2773|M.ulcerans_Agy99 -------------------------------------------MPRLSRY
TH_4227|M.thermoresistible__bu ------MPEESQLTSATELAVTLAWVAGAVTAAYFLGMGLSWVLHRVGRR
Mb2460c|M.bovis_AF2122/97 --------------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRR
Rv2434c|M.tuberculosis_H37Rv --------------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRR
MAV_3202|M.avium_104 --------------MSTFDSSSLYWATAVVFGLPLLLIVLTEWHQSLVRK
MAB_1411|M.abscessus_ATCC_1997 -------MSDLAIQLSESGRDWLIHRPVDIAIYVVLALAVRYVLHRAIDR
Mflv_1046|M.gilvum_PYR-GCK STLLHHAAELTRMPLRATLVVIAASAAVRRTVDADTGWRGFVDHLLVITL
Mvan_5784|M.vanbaalenii_PYR-1 SAVMHDVAHLTRLPLRATLVVIAAGAAVRRTTDEQAVWRGWLDHALILAL
MSMEG_5496|M.smegmatis_MC2_155 SAVLRDAAQLTRRPVRATLMVIAATVAVQRTSDEQARWRGWLDHSLVIAL
MMAR_3542|M.marinum_M SELLRDIAPLTRKPLRATLMVIAAIVAVHGSVHGAVASHGWVDHTLVLLL
MUL_2773|M.ulcerans_Agy99 TVPWPHTAGLP---------------------------------TLVLLL
TH_4227|M.thermoresistible__bu SVVLADIALLTRHPVRVILMIIAAGIALQR-ADTEAPWRGGADHLLRILL
Mb2460c|M.bovis_AF2122/97 NSHLARQASLLRNYLLPLGAVLLLLVKASEVP---------AEDPTVRVL
Rv2434c|M.tuberculosis_H37Rv NSHLARQASLLRNYLLPLGAVLLLLVKASEVP---------AEDPTVRVL
MAV_3202|M.avium_104 HSPLARPAFLLRSYLIPLGALLVLLVNVARMP---------AQFTSVRVL
MAB_1411|M.abscessus_ATCC_1997 LVQGARRPESAEHPRRQWWAFLRRGRDLGE-----------SDRLDETAR
.
Mflv_1046|M.gilvum_PYR-GCK IATITWTIASLVRVAERQAISRFAGGDEGLTDADRHRRKIKTQVLTLRRI
Mvan_5784|M.vanbaalenii_PYR-1 IATLTWVLVSLVRVVERQVIARFAGGDEGLTDADRHRRKIKTQVTVLRRL
MSMEG_5496|M.smegmatis_MC2_155 IATITWLIAALVMVAERQALTRFAGGDTGLTDADLHRRKVRTQVTLVRRL
MMAR_3542|M.marinum_M IAAITWLVASLVLVAERRAINQFGGGDATMTDADLHRRRIRTQVTTLRRL
MUL_2773|M.ulcerans_Agy99 IAAITWLVASLVLVAERRAINQFGGGDATVTDADLHRRRIRTQVTTLHRL
TH_4227|M.thermoresistible__bu IGAITWMIATLVQVAERRVIARFAGGDTGLTDADLHRRRVRTQVTVLRRL
Mb2460c|M.bovis_AF2122/97 TTAFGFLVLVLLLSLLNATLFQGAPQQS-------WRKRLPAIFVDVAR-
Rv2434c|M.tuberculosis_H37Rv TTAFGFLVLVLLLSLLNATLFQGAPQQS-------WRKRLPAIFVDVAR-
MAV_3202|M.avium_104 ATAFGFVVVVLLLSGLNATIFEGAPEGS-------WRQRVPGIFLDVTR-
MAB_1411|M.abscessus_ATCC_1997 LPARTRTLRGRAQDPARDARRR--------------KRRAQRAQTLGSVL
: : . . . :::
Mflv_1046|M.gilvum_PYR-GCK AVAIIVMLGAAAALMTFPAFSDIGKTVFASAGVLTVVAGLAAQTSLGSVF
Mvan_5784|M.vanbaalenii_PYR-1 VVALVVVLGAAAALMTFPSFSDIGKTLFASAGVLTVVAGLAAQTSLGSVF
MSMEG_5496|M.smegmatis_MC2_155 VVAVVAVLGVAAALMTFPSFSDIGKTVFASAGVLSVVAGLAAQTSLGAVF
MMAR_3542|M.marinum_M AVAAVVLLGLAAALMTFPAFAALGTALLASAGVLSVVAGLAAQTSLGAVF
MUL_2773|M.ulcerans_Agy99 AVAAVVLLGLAAALMTFPAFAALGTALLASAGVLSVVAGLAAQTSLGAVF
TH_4227|M.thermoresistible__bu TVAIVVVLGTAAALMTFPSFADIGTTLFASAGVLSVVAGLAAQTSLGAMF
Mb2460c|M.bovis_AF2122/97 ----FALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIV
Rv2434c|M.tuberculosis_H37Rv ----FALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIV
MAV_3202|M.avium_104 ----FVLIGVGLAVIFSYVWGVRVGGLFTALGVTSVVIGLMLQNSVGQIV
MAB_1411|M.abscessus_ATCC_1997 KSAVSFLVLVWVILQSLAILGVNVAPFIASAGIVGVALGFGAQNLVRDFI
:: : . .::: *: *. *: *. : ..
Mflv_1046|M.gilvum_PYR-GCK AGIQIAFSDAIRVGDVVVLEEEWGRIEEITLTYVVVHLWDERRLVLPCTY
Mvan_5784|M.vanbaalenii_PYR-1 AGIQIAFSDAIRVGDIVVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTY
MSMEG_5496|M.smegmatis_MC2_155 AGIQIAFSDAIRVGDVVVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTY
MMAR_3542|M.marinum_M AGIQIAFSDAIRVGDVVVLEDKWGRIEEITLTYVVVNLWDQRRLVLPTTY
MUL_2773|M.ulcerans_Agy99 AGIQIAFSDAIRVGDVVVLEDKWGRIEEIALTYVVVNLWDQRRLVLPTTY
TH_4227|M.thermoresistible__bu AGLQIAFSNAIRVGDVVVIEKQWGRIEEITLTYVVVTIWDERRLILPCTY
Mb2460c|M.bovis_AF2122/97 SGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTG-SGLQIMPNSM
Rv2434c|M.tuberculosis_H37Rv SGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTG-SGLQIMPNSM
MAV_3202|M.avium_104 SGLFMLFEQPFRIGDWLDTPAARGRIVEANWRSVHIQTG-HGLQITPNSV
MAB_1411|M.abscessus_ATCC_1997 TGIFMLFEDQYGVGDVVDVGDAVGTVESVGLRITTVRDLQGTLWYVRNGG
:*: : *.: :.* : * : . . :
Mflv_1046|M.gilvum_PYR-GCK FTSTPFQNWTRNATELLG----TAELDVDFTVPFDQMRAELDRLLRA---
Mvan_5784|M.vanbaalenii_PYR-1 FTDTPFQNWTRNATELLG----TAELDVDFTVPFDAMRAELDRMLHA---
MSMEG_5496|M.smegmatis_MC2_155 FTTTPFQNWTRNATELLG----TIELDADFTVPLDAMRVELDRLLRA---
MMAR_3542|M.marinum_M FTTTPFENWTRNATELLG----TVELDVDFAVGLQAMRAELQRQLAG---
MUL_2773|M.ulcerans_Agy99 FTTTPFENWTRNATELLG----TVELDVDFAVGLQAMRAELQRQLAG---
TH_4227|M.thermoresistible__bu FTTTPFENWTRNATEVMG----LVELDVDFTVPLDEMRAELDHILAAN--
Mb2460c|M.bovis_AF2122/97 LATTAFTNLSRPAGAHEC----SITTTFSTSDPPDKVCAMLNRAASALPH
Rv2434c|M.tuberculosis_H37Rv LATTAFTNLSRPAGAHEC----SITTTFSTSDPPDKVCAMLNRAASALPH
MAV_3202|M.avium_104 LATTSFTNLSRPPGGHQL----TLTATFSETDPPDRVCALLRRVADALPQ
MAB_1411|M.abscessus_ATCC_1997 IARVGNFSQDYAVAFLQIPLSYSADVDLACTIALEAAREAVAE-------
:: . . : : : .
Mflv_1046|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5784|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5496|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_3542|M.marinum_M --------------------------------------------------
MUL_2773|M.ulcerans_Agy99 --------------------------------------------------
TH_4227|M.thermoresistible__bu --------------------------------------------------
Mb2460c|M.bovis_AF2122/97 VKPGVVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLH
Rv2434c|M.tuberculosis_H37Rv VKPGVVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLH
MAV_3202|M.avium_104 RRPDAVAAAVPAGGGEYHVTIGLTSPADDSAAQATLLRWLWYGARREGLR
MAB_1411|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1046|M.gilvum_PYR-GCK -NPLWDGRVGVLQVT--DAVEGRVRVRMLVSASNAGQLFDLRCDVREGMV
Mvan_5784|M.vanbaalenii_PYR-1 -NDKWDGRVGVLQVT--DAVEGLVRVRMLVSAPNAGALFDLRCDIREGMV
MSMEG_5496|M.smegmatis_MC2_155 -DPLWDQRVGVLQVT--DAVGGQVRVRVLVSAPNAGALWDLQCNVREGLV
MMAR_3542|M.marinum_M -SELWDQRVGALQVT--DAVGGHVRVRILVSAPNAGALWDLRCAVREGMV
MUL_2773|M.ulcerans_Agy99 -SELWDQRVGALQVT--DAVGGHVRVRILVSAPNAGALWDLRCAVREGMV
TH_4227|M.thermoresistible__bu -DDLWDGRLGVLEVT--DATGGHVRVWITLSAPNSSALWGLRTAVREAMV
Mb2460c|M.bovis_AF2122/97 LDEADDEFSTAERVE--SALRTVVGPELRLSSSDQQSLARYARLVRYGTD
Rv2434c|M.tuberculosis_H37Rv LDEADDEFSTAERVE--SALRTVVGPELRLSSSDQQSLARYARLVRYGTD
MAV_3202|M.avium_104 LDGAEDDISTPERIE--RALRMVVAPALRLGPPDQQALVSHARIVRYGAD
MAB_1411|M.abscessus_ATCC_1997 -EALRDDVIGAPEMLGIDGITADAISLRLTVAVRANAQWAVERELRRRIL
. * .: . . . :*
Mflv_1046|M.gilvum_PYR-GCK AWLQRTNPGAMPRTRIEHRTDADTARGDAAVPVPGRSQADSGLFSGSIAA
Mvan_5784|M.vanbaalenii_PYR-1 AWLQRTNPCALPRKRIEHHNDS-RRHGEATEAPVGRPQAESGLFSGSAAA
MSMEG_5496|M.smegmatis_MC2_155 EWLQRTNPGALPRQRIEHESARDTRISDTAAG--GYAQADSGLFTGNPEA
MMAR_3542|M.marinum_M DWLQRNQPAALPRWRVAHSDTRCAEQPACRDAGSGENEQAPG--------
MUL_2773|M.ulcerans_Agy99 DWLQRNQPAALPRWRVAHSDTRCAGQPACRDAGNGANEQDPG--------
TH_4227|M.thermoresistible__bu KWLQRQGTGALPRWRFEPATAAPAGGPQRGLAYSRRPSGE-GLFSGSAEA
Mb2460c|M.bovis_AF2122/97 EIVQHAGVVPMGITFVIAGSVRLTVTTD-DGSVVAIATLKKGTFLGLTAL
Rv2434c|M.tuberculosis_H37Rv EIVQHAGVVPMGITFVIAGSVRLTVTTD-DGSVVAIATLKKGTFLGLTAL
MAV_3202|M.avium_104 EIVEHAGRVPEKMTFLLAGGVRLTATAP-DGSVVAVGGLDEGSFLGVTAL
MAB_1411|M.abscessus_ATCC_1997 IAFDENGIRPLYLDGLSSGTVETLEKASR---------------------
.:. . .
Mflv_1046|M.gilvum_PYR-GCK DRRNRDLTWAHDAR------------------------------------
Mvan_5784|M.vanbaalenii_PYR-1 ERRGRAMSGAR---------------------------------------
MSMEG_5496|M.smegmatis_MC2_155 ERRGRSFDHADGDDAKKTEPVPVAAGQTQC--------------------
MMAR_3542|M.marinum_M --------------------------------------------------
MUL_2773|M.ulcerans_Agy99 --------------------------------------------------
TH_4227|M.thermoresistible__bu QQRARTFEGPAG--------------------------------------
Mb2460c|M.bovis_AF2122/97 TRQPDPAGAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKA
Rv2434c|M.tuberculosis_H37Rv TRQPDPAGAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKA
MAV_3202|M.avium_104 TRQPNLADAQAVAEVTALEIDREHLVELVTGKPLLLQDLGRTIDERRALV
MAB_1411|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1046|M.gilvum_PYR-GCK ------------------------
Mvan_5784|M.vanbaalenii_PYR-1 ------------------------
MSMEG_5496|M.smegmatis_MC2_155 ------------------------
MMAR_3542|M.marinum_M ------------------------
MUL_2773|M.ulcerans_Agy99 ------------------------
TH_4227|M.thermoresistible__bu ------------------------
Mb2460c|M.bovis_AF2122/97 QQAIRRDLHQSPAAAGEHRGPARR
Rv2434c|M.tuberculosis_H37Rv QQAIRRDLHQSPAAAGEHRGPARR
MAV_3202|M.avium_104 HRAVTAEPTPS-------REPVS-
MAB_1411|M.abscessus_ATCC_1997 ------------------------