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VSTFDSSSLYWATAVVFGLPLLLIVLTEWHQSLVRKHSPLARPAFLLRSYLIPLGALLVLLVNVARMPAQ FTSVRVLATAFGFVVVVLLLSGLNATIFEGAPEGSWRQRVPGIFLDVTRFVLIGVGLAVIFSYVWGVRVG GLFTALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIGDWLDTPAARGRIVEANWRSVHIQTGHGLQIT PNSVLATTSFTNLSRPPGGHQLTLTATFSETDPPDRVCALLRRVADALPQRRPDAVAAAVPAGGGEYHVT IGLTSPADDSAAQATLLRWLWYGARREGLRLDGAEDDISTPERIERALRMVVAPALRLGPPDQQALVSHA RIVRYGADEIVEHAGRVPEKMTFLLAGGVRLTATAPDGSVVAVGGLDEGSFLGVTALTRQPNLADAQAVA EVTALEIDREHLVELVTGKPLLLQDLGRTIDERRALVHRAVTAEPTPSREPVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3202 | - | - | 100% (473) | transmembrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2460c | - | 1e-173 | 64.86% (461) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_2744 | - | 1e-05 | 34.57% (81) | MscS mechanosensitive ion channel |
| M. tuberculosis H37Rv | Rv2434c | - | 1e-173 | 64.86% (461) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1411 | - | 9e-06 | 25.00% (208) | putative mechanosensitive ion channel |
| M. marinum M | MMAR_3754 | - | 1e-170 | 65.36% (459) | hypothetical protein MMAR_3754 |
| M. smegmatis MC2 155 | MSMEG_3579 | - | 1e-156 | 58.32% (463) | transmembrane protein |
| M. thermoresistible (build 8) | TH_2299 | - | 1e-149 | 57.17% (460) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_3697 | - | 1e-169 | 64.92% (459) | hypothetical protein MUL_3697 |
| M. vanbaalenii PYR-1 | Mvan_3795 | - | 9e-06 | 34.57% (81) | MscS mechanosensitive ion channel |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2460c|M.bovis_AF2122/97 ------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQA
Rv2434c|M.tuberculosis_H37Rv ------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQA
MMAR_3754|M.marinum_M ------MSVFGSAWFYWAVGIAAALPVLVVILTEVQRLLRRRQSALARQV
MUL_3697|M.ulcerans_Agy99 ------MSVFGSAWFYWAVGIAAALPVLVVILTEVQRLLRRRQSALARQV
MAV_3202|M.avium_104 ------MSTFDSSSLYWATAVVFGLPLLLIVLTEWHQSLVRKHSPLARPA
MSMEG_3579|M.smegmatis_MC2_155 -----MRSVLEANWFYWALSVAVGLPIGLVLLTELHNTLARHGSYLARPV
TH_2299|M.thermoresistible__bu -----VSLALDGAWLYWAIGVAVGFPAALILLTELHDAMVRRNSIMARPV
Mflv_2744|M.gilvum_PYR-GCK MDVSSLAFEWTDTSRHWLIEVPIRIVVYIAVALVIRYLVHRMIDRATTGR
Mvan_3795|M.vanbaalenii_PYR-1 MDVSLLAFEWTDTSRHWLIEVPIRIVAYLTVALVIRFVVHRMIDRATTSR
MAB_1411|M.abscessus_ATCC_1997 --MSDLAIQLSESGRDWLIHRPVDIAIYVVLALAVRYVLHRAIDRLVQGA
* : : : : : * . .
Mb2460c|M.bovis_AF2122/97 SLLRNYLLPLGAVLLLLVKASEVPAEDPTVRVLTTAFGFLVLVLLLSLLN
Rv2434c|M.tuberculosis_H37Rv SLLRNYLLPLGAVLLLLVKASEVPAEDPTVRVLTTAFGFLVLVLLLSLLN
MMAR_3754|M.marinum_M GLLRNYVLPLGALLLLMVNATGVPAHDTAVRLLATVFGFLVLVLLLSGLN
MUL_3697|M.ulcerans_Agy99 GLLRNYVLPLGALLLLLVNATGVPAHDTAVRLLATVFGFLVLVLLLSGLN
MAV_3202|M.avium_104 FLLRSYLIPLGALLVLLVNVARMPAQFTSVRVLATAFGFVVVVLLLSGLN
MSMEG_3579|M.smegmatis_MC2_155 SLLRNYILPLAALLILLVKGSEISAEATPVRIVATGFGFVVIILLLSGLN
TH_2299|M.thermoresistible__bu QLLRNYLLPLAALLILLVQAVEVSTEATPVRIVATAFSFAVLILLLSGLN
Mflv_2744|M.gilvum_PYR-GCK TR----------------KNRGGGE---DARPQRTPPLVRRLRDRVPSST
Mvan_3795|M.vanbaalenii_PYR-1 TR----------------KDK-------DAAGARTPPLVRKLRDRVPSSA
MAB_1411|M.abscessus_ATCC_1997 RRPESAEHPRRQWWAFLRRGRDLGESDRLDETARLPARTRTLRGRAQDPA
. :
Mb2460c|M.bovis_AF2122/97 ATLFQGAPQQSWRKRLPAIFVDVARFALIGIGLAVILSYIWGVRVGGLFA
Rv2434c|M.tuberculosis_H37Rv ATLFQGAPQQSWRKRLPAIFVDVARFALIGIGLAVILSYIWGVRVGGLFA
MMAR_3754|M.marinum_M AAVFSGAPQGSWRRRLPVIFVDVARFVLIGAGLAVILSFVWGVRIGGLFT
MUL_3697|M.ulcerans_Agy99 AAVFSGAPQGSWRRRLPVIFVDVARFVLIGAGLAVILSFVWGVRIGGLFT
MAV_3202|M.avium_104 ATIFEGAPEGSWRQRVPGIFLDVTRFVLIGVGLAVIFSYVWGVRVGGLFT
MSMEG_3579|M.smegmatis_MC2_155 ATLFQGAPEGSWRKRIPSIFLDVARFALIAVGVGMIMAYVWGANVGGLFT
TH_2299|M.thermoresistible__bu ATLFHGAPEDTWRKRIPTIFVDVARFALIAVGLALILAYIWGANVGGLFT
Mflv_2744|M.gilvum_PYR-GCK TSEQIIARRQQRAQTIGSVLKSTVSIVLLVWVVLAVLN-VVGVNIAPFIA
Mvan_3795|M.vanbaalenii_PYR-1 SSEQVIARRQQRAQTIGSVLKSTVSIVLLVWVVLAVLN-VLGVNIAPFIA
MAB_1411|M.abscessus_ATCC_1997 RDARRRKRRAQRAQTLGSVLKSAVSFLVLVWVILQSLA-ILGVNVAPFIA
. : : :: ... : :: : : : *..:. :::
Mb2460c|M.bovis_AF2122/97 ALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDDWLETPTARGRVVEV
Rv2434c|M.tuberculosis_H37Rv ALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDDWLETPTARGRVVEV
MMAR_3754|M.marinum_M ALGVTSVVIGLMLQNSVSQIVSGLFMLFEQPFQIDDWLDTTTTRGRIVEV
MUL_3697|M.ulcerans_Agy99 ALGVTSVVIGLMLQNSVSQIVSGLFMLFEQPFQIDDWLDTTTTRGRIVEV
MAV_3202|M.avium_104 ALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIGDWLDTPAARGRIVEA
MSMEG_3579|M.smegmatis_MC2_155 ALGVTSIVLGLALQNAVGQIISGLLLLFEQPFQLGDWLDTPSARGRVVEV
TH_2299|M.thermoresistible__bu ALGVSSIVLGLALQNAVGQIVSGLLVLFEQPFQIGDWVDTPSARGKVVEV
Mflv_2744|M.gilvum_PYR-GCK SAGVVGLAIGFGAQNLVRDFVTGVFMLLEDQYGVGDTVDLGEAVGEVESV
Mvan_3795|M.vanbaalenii_PYR-1 SAGVVGLAIGFGAQNLVRDFVTGVFMLLEDQYGVGDTVDLGEAVGEVESV
MAB_1411|M.abscessus_ATCC_1997 SAGIVGVALGFGAQNLVRDFITGIFMLFEDQYGVGDVVDVGDAVGTVESV
: *: .:.:*: ** * ::::*:::*:*: : :.* :: : * : ..
Mb2460c|M.bovis_AF2122/97 NWRAVHIDTGSGLQIMPNSMLATTAFTNLSRPAGAHECSITTTFSTSDPP
Rv2434c|M.tuberculosis_H37Rv NWRAVHIDTGSGLQIMPNSMLATTAFTNLSRPAGAHECSITTTFSTSDPP
MMAR_3754|M.marinum_M NWRAVHIETGSGLRITPNSVLASTPFTNLSRPAGAYQLAIPTKFSDADAP
MUL_3697|M.ulcerans_Agy99 NWRAVRIETGSGLRITPNSVLASTPFTNLSRPAGAYQLAIPTKFSDADAP
MAV_3202|M.avium_104 NWRSVHIQTGHGLQITPNSVLATTSFTNLSRPPGGHQLTLTATFSETDPP
MSMEG_3579|M.smegmatis_MC2_155 NWRATHIDTGGGLQIMPNSVLAGASFTNLSRPEAAHSLSVTTTFGVSDSP
TH_2299|M.thermoresistible__bu NWRATHIDTGGGLRVIPNSELADASFTNLSRPPGTHTITVPTVFAGGDAP
Mflv_2744|M.gilvum_PYR-GCK GLRITTVRDIDGT-------------------------------------
Mvan_3795|M.vanbaalenii_PYR-1 GLRITTVRDIDGT-------------------------------------
MAB_1411|M.abscessus_ATCC_1997 GLRITTVRDLQGT-------------------------------------
. * . : *
Mb2460c|M.bovis_AF2122/97 DKVCAMLNRAASALPHVKPGVVPATIARGAAEYRTTVRLTSPADEGPTQA
Rv2434c|M.tuberculosis_H37Rv DKVCAMLNRAASALPHVKPGVVPATIARGAAEYRTTVRLTSPADEGPTQA
MMAR_3754|M.marinum_M DRVCALLSRVAAALPQLDGGFLVTTEPVGGTEYCTTIGLRSPAEESAARA
MUL_3697|M.ulcerans_Agy99 DRVCALLSRVAAALPQLDGGFLVTTEPVGGTEYCTTIGLRSPAEESAARA
MAV_3202|M.avium_104 DRVCALLRRVADALPQRRPDAVAAAVPAGGGEYHVTIGLTSPADDSAAQA
MSMEG_3579|M.smegmatis_MC2_155 DAVCALLTRVATQLPQRRAGAAPKAIPLGAGEYKTSIPLRTPADDSAARA
TH_2299|M.thermoresistible__bu DQVCAMLTRVAANLPQLLPGAEPSAAPAGRGEYRTSIPLRTPADDATARS
Mflv_2744|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3795|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1411|M.abscessus_ATCC_1997 --------------------------------------------------
Mb2460c|M.bovis_AF2122/97 TFLRWVWYAARREGLHLDEADDEFSTAERVESALRTVVGPELRLSSSDQQ
Rv2434c|M.tuberculosis_H37Rv TFLRWVWYAARREGLHLDEADDEFSTAERVESALRTVVGPELRLSSSDQQ
MMAR_3754|M.marinum_M TFLRWIWYAARREGLHLNGADDDFSTTERVQHALKTVVAPVMRLSDTDQQ
MUL_3697|M.ulcerans_Agy99 TFLRWIWYAARREGLHLNGADDDFSTTERVQHALKTVVAPVMRLSDTDQQ
MAV_3202|M.avium_104 TLLRWLWYGARREGLRLDGAEDDISTPERIERALRMVVAPALRLGPPDQQ
MSMEG_3579|M.smegmatis_MC2_155 VFLRWLWYAARRAELHLDGETDDFSTPERLTKAVR-QMAPTLRLSHTEQQ
TH_2299|M.thermoresistible__bu TFLRWVWYAARRAGLHLDRSTDDFVTTERLTTALA-AIAPALRLSEAEQQ
Mflv_2744|M.gilvum_PYR-GCK -----LWYVRNGEIARVGNMSQEYAVAR----------------------
Mvan_3795|M.vanbaalenii_PYR-1 -----LWYVRNGEIARVGNMSQEYAVAR----------------------
MAB_1411|M.abscessus_ATCC_1997 -----LWYVRNGGIARVGNFSQDYAVAF----------------------
:** . ::. :: ..
Mb2460c|M.bovis_AF2122/97 SLARYARLVRYGTDEIVQHAGVVPMGITFVIAGSVRLTVTTDDGSVVAIA
Rv2434c|M.tuberculosis_H37Rv SLARYARLVRYGTDEIVQHAGVVPMGITFVIAGSVRLTVTTDDGSVVAIA
MMAR_3754|M.marinum_M ALLSSARIIRFAAGETMEYAGQVPAGMTFLITGRVRLTATAEDGSVVPVT
MUL_3697|M.ulcerans_Agy99 ALLSSARIIRFAAGDTMEYAGQVPAGMTFLITGRVRLTATAEDGSIVPVT
MAV_3202|M.avium_104 ALVSHARIVRYGADEIVEHAGRVPEKMTFLLAGGVRLTATAPDGSVVAVG
MSMEG_3579|M.smegmatis_MC2_155 EVLNHSALVRFGADEIIQEAGEIPTRMSFIVSGRVGVSVAGDGDAVIPVR
TH_2299|M.thermoresistible__bu DLLPRAGIARYGAGEPIQVAGEVPSHMTFVVRGRVRVVAPLADGSAVEVR
Mflv_2744|M.gilvum_PYR-GCK ----------------IEVPVALSADIERAEQVAVEAAEAAVAEKSLAGK
Mvan_3795|M.vanbaalenii_PYR-1 ----------------IEVPVALTADVDRAEQVAHEAAQEAVADPALAGK
MAB_1411|M.abscessus_ATCC_1997 ----------------LQIPLSYSADVDLACTIALEAAREAVAEEALRDD
:: . . : :
Mb2460c|M.bovis_AF2122/97 TLKKGTFLGLTALTRQPDPAGAVALEEVTALQIGREHLEQVVMNKPMLLQ
Rv2434c|M.tuberculosis_H37Rv TLKKGTFLGLTALTRQPDPAGAVALEEVTALQIGREHLEQVVMNKPMLLQ
MMAR_3754|M.marinum_M TLHEGGFLGLTALTRQPNLAGAHALDEVTALEVDREHLEHLVMREPLLLQ
MUL_3697|M.ulcerans_Agy99 TLHEGGFLGLTALTRQPNLAGAHALDEVTALEVDREHLEHLVMREPLLLQ
MAV_3202|M.avium_104 GLDEGSFLGVTALTRQPNLADAQAVAEVTALEIDREHLVELVTGKPLLLQ
MSMEG_3579|M.smegmatis_MC2_155 TLTENDFLGQTALTREGALASAHALTETTVLQISREFLEELVAGNPLLLL
TH_2299|M.thermoresistible__bu IAGPGDFLGQSTLTREPVSTSAYAVDEVTVVELERTVLEDLVTRKPVLLQ
Mflv_2744|M.gilvum_PYR-GCK VLGEPEMLGVQELS-----PDLIKLRMTVKVRPNAQWAVQRRLRRAILQA
Mvan_3795|M.vanbaalenii_PYR-1 VIGEPEMLGVQELS-----PDLIKLRMTVKVRPNAQWAVQRKLRRAILRA
MAB_1411|M.abscessus_ATCC_1997 VIGAPEMLGIDGIT-----ADAISLRLTVAVRANAQWAVERELRRRILIA
:** :: .. : .. :. . . :*
Mb2460c|M.bovis_AF2122/97 ELGRVIDERQRKAQQAIRRDLHQSPAAAGEHRGPARR
Rv2434c|M.tuberculosis_H37Rv ELGRVIDERQRKAQQAIRRDLHQSPAAAGEHRGPARR
MMAR_3754|M.marinum_M DFGHILEERQSKVRRVGGLN-----------------
MUL_3697|M.ulcerans_Agy99 DFGHILEERQSKVRRVGGLN-----------------
MAV_3202|M.avium_104 DLGRTIDERRALVHRAVTAEPTPSREPVS--------
MSMEG_3579|M.smegmatis_MC2_155 ELSRIIDDRRSAARAALTAD-----------------
TH_2299|M.thermoresistible__bu DIGRAIEERRLMARRAVTTQR----------------
Mflv_2744|M.gilvum_PYR-GCK YDEHGIALPYPNGRVHAVGE-----------------
Mvan_3795|M.vanbaalenii_PYR-1 YDEHGIDLPYPGGRMQVAAASE---------------
MAB_1411|M.abscessus_ATCC_1997 FDENGIRPLYLDGLSSGTVETLEKASR----------
. :