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NLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQASLLRNYLLPLGAVLLLLVKASEVPAED PTVRVLTTAFGFLVLVLLLSLLNATLFQGAPQQSWRKRLPAIFVDVARFALIGIGLAVILSYIWGVRVGG LFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSGLQIMP NSMLATTAFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATIARGAAEYRTTV RLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFSTAERVESALRTVVGPELRLSSSDQQSLARYAR LVRYGTDEIVQHAGVVPMGITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALEE VTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPAAAGEHRGPARR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2434c | - | - | 100% (481) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2460c | - | 0.0 | 100.00% (481) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1046 | - | 6e-08 | 25.73% (307) | MscS mechanosensitive ion channel |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1411 | - | 2e-05 | 35.94% (64) | putative mechanosensitive ion channel |
| M. marinum M | MMAR_3756 | - | 0.0 | 75.65% (464) | hypothetical protein MMAR_3756 |
| M. avium 104 | MAV_3202 | - | 1e-173 | 64.86% (461) | transmembrane protein |
| M. smegmatis MC2 155 | MSMEG_3579 | - | 1e-159 | 57.88% (463) | transmembrane protein |
| M. thermoresistible (build 8) | TH_2299 | - | 1e-153 | 57.42% (458) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_3699 | - | 0.0 | 74.57% (464) | hypothetical protein MUL_3699 |
| M. vanbaalenii PYR-1 | Mvan_5784 | - | 3e-05 | 30.33% (122) | MscS mechanosensitive ion channel |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2434c|M.tuberculosis_H37Rv --------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLAR
Mb2460c|M.bovis_AF2122/97 --------MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLAR
MMAR_3756|M.marinum_M --------MNVLGASWFHWAVGIAIGVPVGLILLTELHNSLARRNSHLAR
MUL_3699|M.ulcerans_Agy99 --------MNVLGASWFHWAIGIAIGVPVDLILLTELHNSLARRNSHLAR
MAV_3202|M.avium_104 --------MSTFDSSSLYWATAVVFGLPLLLIVLTEWHQSLVRKHSPLAR
MSMEG_3579|M.smegmatis_MC2_155 -------MRSVLEANWFYWALSVAVGLPIGLVLLTELHNTLARHGSYLAR
TH_2299|M.thermoresistible__bu -------VSLALDGAWLYWAIGVAVGFPAALILLTELHDAMVRRNSIMAR
Mflv_1046|M.gilvum_PYR-GCK MDDTLELASATHVASAAAWIAGAVAIAYAVGLAISWLLQRLGRRSTLLHH
Mvan_5784|M.vanbaalenii_PYR-1 MDDAIEFTSATHLAVTAAWVAGAIGVAYVAGLAVSWLLQRLGRRSAVMHD
MAB_1411|M.abscessus_ATCC_1997 ----MSDLAIQLSESGRDWLIHRPVDIAIYVVLALAVRYVLHRAIDRLVQ
* : : * :
Rv2434c|M.tuberculosis_H37Rv QASLLRNYLLPLGAVLLLLVKASEVPAEDPTVR-----------VLTTAF
Mb2460c|M.bovis_AF2122/97 QASLLRNYLLPLGAVLLLLVKASEVPAEDPTVR-----------VLTTAF
MMAR_3756|M.marinum_M QVTLLRNFLLPLGALLLFLVKASQVPAGEGTVR-----------ILTTVF
MUL_3699|M.ulcerans_Agy99 QVTLLRNFLLPLGALLLFLVKASQVPAGEGTVR-----------ILTTVF
MAV_3202|M.avium_104 PAFLLRSYLIPLGALLVLLVNVARMPAQFTSVR-----------VLATAF
MSMEG_3579|M.smegmatis_MC2_155 PVSLLRNYILPLAALLILLVKGSEISAEATPVR-----------IVATGF
TH_2299|M.thermoresistible__bu PVQLLRNYLLPLAALLILLVQAVEVSTEATPVR-----------IVATAF
Mflv_1046|M.gilvum_PYR-GCK AAELTRMPLRATLVVIAASAAVRRTVDADTGWRGFVDHLLVITLIATITW
Mvan_5784|M.vanbaalenii_PYR-1 VAHLTRLPLRATLVVIAAGAAVRRTTDEQAVWRGWLDHALILALIATLTW
MAB_1411|M.abscessus_ATCC_1997 GARRPESAEHPRRQWWAFLRRGRDLGESD---------------RLDETA
. . .
Rv2434c|M.tuberculosis_H37Rv GFLVLVLLLSLLNATLFQGAPQ-----QSWRKRLPAIFVDVAR-----FA
Mb2460c|M.bovis_AF2122/97 GFLVLVLLLSLLNATLFQGAPQ-----QSWRKRLPAIFVDVAR-----FA
MMAR_3756|M.marinum_M GFLVLVLLLSALNATVFASAPQ-----DSWRKRLPTIFLDVAR-----FA
MUL_3699|M.ulcerans_Agy99 GFLVLVLLLSALNATVFASAPQ-----DSWRKRLPTIFLDVAR-----FA
MAV_3202|M.avium_104 GFVVVVLLLSGLNATIFEGAPE-----GSWRQRVPGIFLDVTR-----FV
MSMEG_3579|M.smegmatis_MC2_155 GFVVIILLLSGLNATLFQGAPE-----GSWRKRIPSIFLDVAR-----FA
TH_2299|M.thermoresistible__bu SFAVLILLLSGLNATLFHGAPE-----DTWRKRIPTIFVDVAR-----FA
Mflv_1046|M.gilvum_PYR-GCK TIASLVRVAERQAISRFAGGDEGLTDADRHRRKIKTQVLTLRRIAVAIIV
Mvan_5784|M.vanbaalenii_PYR-1 VLVSLVRVVERQVIARFAGGDEGLTDADRHRRKIKTQVTVLRRLVVALVV
MAB_1411|M.abscessus_ATCC_1997 RLPARTRTLRGRAQDPARDARR----RKRRAQRAQTLGSVLKS---AVSF
: .. . :: :
Rv2434c|M.tuberculosis_H37Rv LIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFML
Mb2460c|M.bovis_AF2122/97 LIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFML
MMAR_3756|M.marinum_M LIGIGLAMILSYVWGVRVGGIFTALGVTSVVIGLMLQNSVGQIVSGLFML
MUL_3699|M.ulcerans_Agy99 LIGIGLAMILSYVWGVRVGGIFTALGVTSVVIGLMLQNSVGQIVSGLFML
MAV_3202|M.avium_104 LIGVGLAVIFSYVWGVRVGGLFTALGVTSVVIGLMLQNSVGQIVSGLFML
MSMEG_3579|M.smegmatis_MC2_155 LIAVGVGMIMAYVWGANVGGLFTALGVTSIVLGLALQNAVGQIISGLLLL
TH_2299|M.thermoresistible__bu LIAVGLALILAYIWGANVGGLFTALGVSSIVLGLALQNAVGQIVSGLLVL
Mflv_1046|M.gilvum_PYR-GCK MLGAAAALMTFPAFSDIGKTVFASAGVLTVVAGLAAQTSLGSVFAGIQIA
Mvan_5784|M.vanbaalenii_PYR-1 VLGAAAALMTFPSFSDIGKTLFASAGVLTVVAGLAAQTSLGSVFAGIQIA
MAB_1411|M.abscessus_ATCC_1997 LVLVWVILQSLAILGVNVAPFIASAGIVGVALGFGAQNLVRDFITGIFML
:: : . .::: *: :. *: *. : ...:*: :
Rv2434c|M.tuberculosis_H37Rv FEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSG-LQIMPNSMLATTAF
Mb2460c|M.bovis_AF2122/97 FEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSG-LQIMPNSMLATTAF
MMAR_3756|M.marinum_M FEQPFRIDDWLDTPTARGRVVEVNWRAVHIETGTG-LRITPNSVLATTAF
MUL_3699|M.ulcerans_Agy99 FEQPFRIDDWLDTPTARGRVVEVNWRAVHIETGTG-LRITPNSVLATTAF
MAV_3202|M.avium_104 FEQPFRIGDWLDTPAARGRIVEANWRSVHIQTGHG-LQITPNSVLATTSF
MSMEG_3579|M.smegmatis_MC2_155 FEQPFQLGDWLDTPSARGRVVEVNWRATHIDTGGG-LQIMPNSVLAGASF
TH_2299|M.thermoresistible__bu FEQPFQIGDWVDTPSARGKVVEVNWRATHIDTGGG-LRVIPNSELADASF
Mflv_1046|M.gilvum_PYR-GCK FSDAIRVGDVVVLEEEWGRIEEITLTYVVVHLWDERRLVLPCTYFTSTPF
Mvan_5784|M.vanbaalenii_PYR-1 FSDAIRVGDIVVLEDEWGRIEEITLTYVVVHLWDERRLVLPCTYFTDTPF
MAB_1411|M.abscessus_ATCC_1997 FEDQYGVGDVVDVGDAVGTVESVGLRITTVRDLQGTLWYVRNG--GIARV
*.: :.* : * : . . : : .
Rv2434c|M.tuberculosis_H37Rv TNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATI
Mb2460c|M.bovis_AF2122/97 TNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATI
MMAR_3756|M.marinum_M TNLSRPGGSHKCSITTKFAADDAPDKVCAMLTRVASALPNLKSGVMPATV
MUL_3699|M.ulcerans_Agy99 TNLSRPGGSHKCSITTKFAADDAPDKVCAMLTRVASALPNLKSGVMPATV
MAV_3202|M.avium_104 TNLSRPPGGHQLTLTATFSETDPPDRVCALLRRVADALPQRRPDAVAAAV
MSMEG_3579|M.smegmatis_MC2_155 TNLSRPEAAHSLSVTTTFGVSDSPDAVCALLTRVATQLPQRRAGAAPKAI
TH_2299|M.thermoresistible__bu TNLSRPPGTHTITVPTVFAGGDAPDQVCAMLTRVAANLPQLLPGAEPSAA
Mflv_1046|M.gilvum_PYR-GCK QNWTRNATELLGTAELDVDFTVPFDQMRAELDRLLRANPLWDG-------
Mvan_5784|M.vanbaalenii_PYR-1 QNWTRNATELLGTAELDVDFTVPFDAMRAELDRMLHANDKWDG-------
MAB_1411|M.abscessus_ATCC_1997 GNFSQDYAVAFLQIPLSYSADVDLACTIALEA------------------
* :: *
Rv2434c|M.tuberculosis_H37Rv ARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFST
Mb2460c|M.bovis_AF2122/97 ARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFST
MMAR_3756|M.marinum_M ALGGAEYRTTVRIKSPAEDGAAQDTFLRWVWYAARREGLALDGAGDTFST
MUL_3699|M.ulcerans_Agy99 ALGGAEYRTTVRIKSPAEDGAAQDTFLRWVWYAARREGLALDGAGDSYST
MAV_3202|M.avium_104 PAGGGEYHVTIGLTSPADDSAAQATLLRWLWYGARREGLRLDGAEDDIST
MSMEG_3579|M.smegmatis_MC2_155 PLGAGEYKTSIPLRTPADDSAARAVFLRWLWYAARRAELHLDGETDDFST
TH_2299|M.thermoresistible__bu PAGRGEYRTSIPLRTPADDATARSTFLRWVWYAARRAGLHLDRSTDDFVT
Mflv_1046|M.gilvum_PYR-GCK -------RVGVLQVTDAVEGRVRVRMLVSASNAGQLFDLRCDVREGMVAW
Mvan_5784|M.vanbaalenii_PYR-1 -------RVGVLQVTDAVEGLVRVRMLVSAPNAGALFDLRCDIREGMVAW
MAB_1411|M.abscessus_ATCC_1997 ------AREAVAEEALRDDVIGAPEMLGIDGITADAISLRLTVAVRAN--
: : : : :* . *
Rv2434c|M.tuberculosis_H37Rv AERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMG
Mb2460c|M.bovis_AF2122/97 AERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMG
MMAR_3756|M.marinum_M PQRVQDALRAVS-PELKLSLLDQQSLAPYAKVVRYGTDETVQQAGVVPKG
MUL_3699|M.ulcerans_Agy99 PQRVQDALRAVS-PELKLSLLDQQSLAPYAKVVRYGTDETVQQAGVVPKG
MAV_3202|M.avium_104 PERIERALRMVVAPALRLGPPDQQALVSHARIVRYGADEIVEHAGRVPEK
MSMEG_3579|M.smegmatis_MC2_155 PERLTKAVRQMA-PTLRLSHTEQQEVLNHSALVRFGADEIIQEAGEIPTR
TH_2299|M.thermoresistible__bu TERLTTALAAIA-PALRLSEAEQQDLLPRAGIARYGAGEPIQVAGEVPSH
Mflv_1046|M.gilvum_PYR-GCK LQRTN------------PGAMPRTRIEHRTDADTARGDAAVPVPGRS---
Mvan_5784|M.vanbaalenii_PYR-1 LQRTN------------PCALPRKRIEHHNDS-RRHGEATEAPVGRP---
MAB_1411|M.abscessus_ATCC_1997 ------------------AQWAVERELRRRILIAFDENGIRPLYLDG---
Rv2434c|M.tuberculosis_H37Rv ITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALE
Mb2460c|M.bovis_AF2122/97 ITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALE
MMAR_3756|M.marinum_M MSFIIAGSVRLMVTPADGPAVAVGTLGKGAFLGVTALTRQPNPGGAVALE
MUL_3699|M.ulcerans_Agy99 MSFIIAGSVRLMVTPADGPAVVVGTLGKGVFLGVTALTRQPNPGGAVALE
MAV_3202|M.avium_104 MTFLLAGGVRLTATAPDGSVVAVGGLDEGSFLGVTALTRQPNLADAQAVA
MSMEG_3579|M.smegmatis_MC2_155 MSFIVSGRVGVSVAGDGDAVIPVRTLTENDFLGQTALTREGALASAHALT
TH_2299|M.thermoresistible__bu MTFVVRGRVRVVAPLADGSAVEVRIAGPGDFLGQSTLTREPVSTSAYAVD
Mflv_1046|M.gilvum_PYR-GCK ------------------------QADSGLFSGSIAADRRNRDLTWAHDA
Mvan_5784|M.vanbaalenii_PYR-1 ------------------------QAESGLFSGSAAAERRGRAMSGAR--
MAB_1411|M.abscessus_ATCC_1997 -------------------------LSSGTVETLEKASR-----------
. . *
Rv2434c|M.tuberculosis_H37Rv EVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPA
Mb2460c|M.bovis_AF2122/97 EVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPA
MMAR_3756|M.marinum_M EVTVLDIDREYLERIVMSKPALLQELGRLIDERQMKVRQVTQRERVA---
MUL_3699|M.ulcerans_Agy99 EVTVLDIDREYLERIVMSKPALLQELGRLIDEQQMKVRQVTQRERVA---
MAV_3202|M.avium_104 EVTALEIDREHLVELVTGKPLLLQDLGRTIDERRALVHRAVTAEPTPSRE
MSMEG_3579|M.smegmatis_MC2_155 ETTVLQISREFLEELVAGNPLLLLELSRIIDDRRSAARAALTAD------
TH_2299|M.thermoresistible__bu EVTVVELERTVLEDLVTRKPVLLQDIGRAIEERRLMARRAVTTQR-----
Mflv_1046|M.gilvum_PYR-GCK R-------------------------------------------------
Mvan_5784|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_1411|M.abscessus_ATCC_1997 --------------------------------------------------
Rv2434c|M.tuberculosis_H37Rv AAGEHRGPARR
Mb2460c|M.bovis_AF2122/97 AAGEHRGPARR
MMAR_3756|M.marinum_M -----------
MUL_3699|M.ulcerans_Agy99 -----------
MAV_3202|M.avium_104 PVS--------
MSMEG_3579|M.smegmatis_MC2_155 -----------
TH_2299|M.thermoresistible__bu -----------
Mflv_1046|M.gilvum_PYR-GCK -----------
Mvan_5784|M.vanbaalenii_PYR-1 -----------
MAB_1411|M.abscessus_ATCC_1997 -----------