For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_4002 | - | - | 100% (276) | putative probable serine/threonine-protein kinase PknB |
| M. thermoresistible (build 8) | TH_2631 | - | 9e-32 | 34.39% (285) | PUTATIVE serine/threonine protein kinase |
| M. thermoresistible (build 8) | TH_2931 | - | 5e-27 | 36.00% (250) | PUTATIVE methylmalonyl-CoA mutase large subunit |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2115 | pknJ | 5e-39 | 37.98% (287) | transmembrane serine/threonine-protein kinase J |
| M. gilvum PYR-GCK | Mflv_5210 | - | 4e-36 | 37.76% (286) | protein kinase |
| M. tuberculosis H37Rv | Rv2088 | pknJ | 5e-39 | 37.98% (287) | transmembrane serine/threonine-protein kinase J |
| M. leprae Br4923 | MLBr_00016 | pknB | 1e-30 | 32.16% (283) | putative serine/threonine protein kinase |
| M. abscessus ATCC 19977 | MAB_1133c | - | 6e-65 | 47.43% (272) | putative serine/threonine protein kinase |
| M. marinum M | MMAR_2941 | - | 3e-39 | 37.15% (288) | membrane-anchored serine/threonine-protein kinase |
| M. avium 104 | MAV_3463 | - | 2e-37 | 39.01% (282) | protein kinase/peptidyl-prolyl cis-trans isomerase, |
| M. smegmatis MC2 155 | MSMEG_5437 | - | 2e-74 | 51.41% (284) | serine/threonine-protein kinase PknB |
| M. ulcerans Agy99 | MUL_2200 | - | 1e-39 | 37.50% (288) | membrane-anchored serine/threonine-protein kinase |
| M. vanbaalenii PYR-1 | Mvan_1066 | - | 2e-36 | 39.19% (273) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5210|M.gilvum_PYR-GCK MSTPQGGARLGTRFGPYELHSVIGVGGMGEVYRAYDTARERMVAIKLLRP
Mvan_1066|M.vanbaalenii_PYR-1 MSTPKGGSRLGTRFGPYELQSVIGVGGMGEVYRAYDTARERMVAIKLLRP
MAV_3463|M.avium_104 MTLDPDS------FGHYRILELLGRGGMGRVYRAYDATTDRVVALKVLPP
Mb2115|M.bovis_AF2122/97 ---MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVLAA
Rv2088|M.tuberculosis_H37Rv ---MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVLAA
MAB_1133c|M.abscessus_ATCC_199 ------MPVPGEEFHGYVVGSLAGRGGTAQVYLAHRVDDGFEVALKVLEL
MSMEG_5437|M.smegmatis_MC2_155 ----MWVESPGEHIAGFVVEDVAGRGGWAVVYRAR-DAQGRLVALKVLNE
TH_4002|M.thermoresistible__bu ------VLRRGDRFENYVIDDELGRGGSAIVYRAREADGGRVVALKVLDP
MMAR_2941|M.marinum_M -----MPLNEGDIFAGYVIQRLLGTGGMGEVYLAQHPRLPRLDALKILSL
MUL_2200|M.ulcerans_Agy99 -----MPLNEGDIFAGYVIQRLLGTGGMGEVYLAQHPRLPRLDALKILSL
MLBr_00016|M.leprae_Br4923 ------MTTPPHLSDRYELGDILGFGGMSEVHLARDIRLHRDVAVKVLRA
: : * ** . *: * *:*:*
Mflv_5210|M.gilvum_PYR-GCK EMAADHSFQERFRRESRVAARLQEPHVIPVHNFGEIDGVL----YIDMRL
Mvan_1066|M.vanbaalenii_PYR-1 EMAADHSFQERFRRESRVAARLQEPHVIPVHDFGEIDGVL----YIDMRL
MAV_3463|M.avium_104 HLAEDQDFQQRFRREARIAAGLNDPHVVPIHGYGEIDGQL----YVDMRL
Mb2115|M.bovis_AF2122/97 ELSRDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGRL----WIAMQF
Rv2088|M.tuberculosis_H37Rv ELSRDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGRL----WIAMQF
MAB_1133c|M.abscessus_ATCC_199 RHRNPENI-DRLHREFDLAQRFSHPRIVTVFERG--QD------WLTMEA
MSMEG_5437|M.smegmatis_MC2_155 SHREPAHL-ERLRREFEFACRAEHPNVVAMYAAG--DG------WLAMEF
TH_4002|M.thermoresistible__bu HHRSAADL-ERLRREYEFAARLDHPRVVTMYGAG--PG------WLAMEL
MMAR_2941|M.marinum_M DATDDDEFRARFTREAELAATLWHPHIVGVHDRGEFDGRL----WISMDY
MUL_2200|M.ulcerans_Agy99 DATDDDEFRARFTREAELAATLWHPHIVGVHDRGEFDGRL----WISMDY
MLBr_00016|M.leprae_Br4923 DLARDPSFYLRFRREAQNAAALNHPSIVAVYDTGEAETSAGPLPYIVMEY
: *: ** * .* :: :. * :: *
Mflv_5210|M.gilvum_PYR-GCK VEGASLKEVLRSDGP--LQPARAVSIIRQVAAALDDAHANGLVHRDIKPE
Mvan_1066|M.vanbaalenii_PYR-1 VEGASLKDVLRAEGA--LPPARAVSILRQVAAALDAAHANGLVHRDIKPE
MAV_3463|M.avium_104 IEGRDLAHYITENGGR-LSPQRAVAVIEQVAAALDSAHRAGLIHRDVKPM
Mb2115|M.bovis_AF2122/97 VDGGNAEDALRAATMT---TARAVYVIGEVAKALDYAHQQGVIHRDIKPA
Rv2088|M.tuberculosis_H37Rv VDGGNAEDALRAATMT---TARAVYVIGEVAKALDYAHQQGVIHRDIKPA
MAB_1133c|M.abscessus_ATCC_199 LTGGSAKDLVGTNQSW--IIPLKLTLLQQIAGALDFIHDEQVVHCDVKPS
MSMEG_5437|M.smegmatis_MC2_155 IDGRPAISLAVRTD--------QLTALRQIAGALDNIHRLGIVHSDVKPM
TH_4002|M.thermoresistible__bu LAGGPVSNLPRLAD--------RLTALADVAAALDHIHYRGVVHCDVKPA
MMAR_2941|M.marinum_M VDGTDARHLVEQRYRSGMPLEDVIEIVTAVAEALDFAHERRLLHRDVKPA
MUL_2200|M.ulcerans_Agy99 VDGTDTRHLVEQRYRSGMPLEDVIEIVTAVAEALDFAHERRLLHRDVKPA
MLBr_00016|M.leprae_Br4923 VDGATLRDIVHTDGP--MPPQQAIEIVADACQALNFSHQNGIIHRDVKPA
: * : : . **: * ::* *:**
Mflv_5210|M.gilvum_PYR-GCK NVLLTGD-----DFAYLVDFGIAHGGGE----------------------
Mvan_1066|M.vanbaalenii_PYR-1 NVLLTPD-----DFAYLVDFGIAHGGGE----------------------
MAV_3463|M.avium_104 NVLVTTAR----DFVYLIDFGLARAQAD----------------------
Mb2115|M.bovis_AF2122/97 NFLLSRAAG-GDERVLLSDFGIARALGD----------------------
Rv2088|M.tuberculosis_H37Rv NFLLSRAAG-GDERVLLSDFGIARALGD----------------------
MAB_1133c|M.abscessus_ATCC_199 NIMRTR----SGS-AVLTDFGIAQELA-----------------------
MSMEG_5437|M.smegmatis_MC2_155 NILVDK----PFSRAVLIDFGVAHSLAEDVAARLAADATGRLTLDPARRI
TH_4002|M.thermoresistible__bu NILSGEDF--AGTGGVLTDFGVAHAVSEFIKP-----------------D
MMAR_2941|M.marinum_M NILVTEPSESARRRVLLTDFGIAREIDD----------------------
MUL_2200|M.ulcerans_Agy99 NILVTEPSESARRRVLLTDFGIAREIDD----------------------
MLBr_00016|M.leprae_Br4923 NIMISATN-----AVKVMDFGIARAIADS---------------------
*.: : ***:*:
Mflv_5210|M.gilvum_PYR-GCK --ASVTSTGLVVGSSAYMAPERFSGERGGPASDIYSLACLLYESLTGRAP
Mvan_1066|M.vanbaalenii_PYR-1 --ASVTSTGLVVGSSAYMAPERFSGERGGPASDVYSLACLLYESLTGRAP
MAV_3463|M.avium_104 --TALTQTGATMGTVAYMAPERFTG-TTDHRADVYSLACVLHECLTGKRP
Mb2115|M.bovis_AF2122/97 --TGLTSTGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAP
Rv2088|M.tuberculosis_H37Rv --TGLTSTGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAP
MAB_1133c|M.abscessus_ATCC_199 -HADGPRRPVVQTSLPYAAPEVLRGQPVTAATDQYALACTAVELFDGKPP
MSMEG_5437|M.smegmatis_MC2_155 THQSAAPRPQVQASLPYSAPELITGRALSAATDQYALACTAVEILTGLPP
TH_4002|M.thermoresistible__bu AHTVSRRRVPVEASLAYTAPELFGGRPPSAASDEYALACTAVELVTGAPP
MMAR_2941|M.marinum_M KHRLTEAQMAIGT-VAYAAPEQLTGKPLDGRADQYALAATAFHLLAGVPP
MUL_2200|M.ulcerans_Agy99 KHRLTEAQMAIGT-VAYAAPEQLTGRPLDGRADQYALAATAFHLLAGVPP
MLBr_00016|M.leprae_Br4923 --TSVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEILTGEPP
* :** * :* *:*.. . . * *
Mflv_5210|M.gilvum_PYR-GCK FEAAD--VRQVWSAHMFAAPPRPSIMRRGVSRAFDDVIARGMAKNPTERY
Mvan_1066|M.vanbaalenii_PYR-1 FEAAD--VRQVWSAHMFAPPPRPSIMRRGVSRTFDDVVARGMAKQPHDRY
MAV_3463|M.avium_104 FAGDS--LEEQLNAHLNTAPPRPSATAPEVPAAFDAVIARGMAKDPERRY
Mb2115|M.bovis_AF2122/97 FAAGAGAAVAVVAGHLHQPPPTVSDRVPGLSAAMDAVIATAMAKDPMRRF
Rv2088|M.tuberculosis_H37Rv FAAGAGAAVAVVAGHLHQPPPTVSDRVPGLSAAMDAVIATAMAKDPMRRF
MAB_1133c|M.abscessus_ATCC_199 FTART--MLKLADMHLNAAPWPISYRHKYIPRAFDSIVAKAMSKDPLSRY
MSMEG_5437|M.smegmatis_MC2_155 FTATT--AVKMVDQQLNSPPPRISGRAAWIPHAVDAILAKALSKDPERRH
TH_4002|M.thermoresistible__bu FVATT--RMALIDQHLHRPPPALSRRFEWVPRAFDSVLARALAKLPDARY
MMAR_2941|M.marinum_M FDHSN--RAVVVGQHLNMPPPRISKRHPKLAH-LDAAFAKALAKDPDDRY
MUL_2200|M.ulcerans_Agy99 FDHSN--RAVVVGQHLNMPPPRISKRHPKLAH-LDAAFAKALAKDPDDRY
MLBr_00016|M.leprae_Br4923 FIGDS--PVSVAYQHVREDPIPPSQRHEGISVDLDAVVLKALAKNPENRY
* :: * * :. .* . .::* * *.
Mflv_5210|M.gilvum_PYR-GCK ATAGELARAAAAAASAAPVAEPVPPVTPPSTR---QFSGVHPAMTP-PPA
Mvan_1066|M.vanbaalenii_PYR-1 PTAGELARAASAAAEGAPAAETVAPVTPPSTR---QFSTVYPTPPPMPPM
MAV_3463|M.avium_104 QSVTELAEAARAALAPGAVEKPSAPTPQPRAARRVRAAVVGASALTLAVV
Mb2115|M.bovis_AF2122/97 TSAGEFAHAAAAALYGGATDGWVP--PSPAPHVISQGAVPGSPWWQHPVG
Rv2088|M.tuberculosis_H37Rv TSAGEFAHAAAAALYGGATDGWVP--PSPAPHVISQGAVPGSPWWQHPVG
MAB_1133c|M.abscessus_ATCC_199 PTCTEFITLLTHAMT-----------------------------------
MSMEG_5437|M.smegmatis_MC2_155 ESCTEFVDELAAALG-----------------------------------
TH_4002|M.thermoresistible__bu PTCTEFITLVRDALGTGPT-------------------------------
MMAR_2941|M.marinum_M PRCIDFAKALAAGPGSIAEHQARRGATSTEPFDVNAEMSAEALEPARPSG
MUL_2200|M.ulcerans_Agy99 PRCIDFAKALAAGPGSIAEHQARRGATSTEPFDVNAEMSAEALEPARPSG
MLBr_00016|M.leprae_Br4923 QTAAEMRADLIRVHSGQPPEAPKVLTDADRSCLLSSGAGNFGVPRTDALS
::
Mflv_5210|M.gilvum_PYR-GCK PAPIAAAR--------------RPGRGQGALVAGIVVMFVAAAVLALVLV
Mvan_1066|M.vanbaalenii_PYR-1 PAVAPPAR--------------RFSRGQVGLVAATVVMFTAALVLAAVLV
MAV_3463|M.avium_104 AAVVVAMV--------------THGHGSHGATPKTPGSPAPGRTAPPLPA
Mb2115|M.bovis_AF2122/97 SVTALATPPGHGWPPGLPPLPRRPRRYRRGVAAVAAVMVVAAAAVTAVTM
Rv2088|M.tuberculosis_H37Rv SVTALATPPGHGWPPGLPPLPRRPRRYRRGVAAVAAVMVVAAAAVTAVTM
MAB_1133c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_5437|M.smegmatis_MC2_155 --------------------------------------------------
TH_4002|M.thermoresistible__bu --------------------------------------------------
MMAR_2941|M.marinum_M TAPSAQAQPHPSEAGVSTASLGAADQPGAGKARHTKRLERMTVDGTAVSV
MUL_2200|M.ulcerans_Agy99 TAPSAQAQPHPSEAGVSTASLGAADQPGAGKARHTKRLERMTVDGTAVSV
MLBr_00016|M.leprae_Br4923 RQSLDETESDGSIGRWVAVVAVLAVLTIAIVAAFNTFGGNTRDVQVPDVR
Mflv_5210|M.gilvum_PYR-GCK FTG----------GSDPQP-PRIAAPPSSSSDTSTPPSTSAVEG------
Mvan_1066|M.vanbaalenii_PYR-1 FSG----------GDTGSPSPRIAAPPSSSSEAPSTSSASAVEG------
MAV_3463|M.avium_104 FVAPPDLGVNCQYRAVPDPSSRPVSPPPSGRVPTTPGQIGAVIATNLGDI
Mb2115|M.bovis_AF2122/97 TSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRSRLPGLLPPLDDVKNFV
Rv2088|M.tuberculosis_H37Rv TSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRSRLPGLLPPLDDVKNFV
MAB_1133c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_5437|M.smegmatis_MC2_155 --------------------------------------------------
TH_4002|M.thermoresistible__bu --------------------------------------------------
MMAR_2941|M.marinum_M QKRPAGPEQDEEVWLFCVQRYESTGEPHTVIPVELRGTSITGQLANGDAV
MUL_2200|M.ulcerans_Agy99 QKRPAGPEQDEEVWLFCVQRYESTGEPHTVIPVELRGTSITGQLANGDAV
MLBr_00016|M.leprae_Br4923 GQVSADAISALQNRGFKTRTLQKPDSTIPPDHVISTEPGANASVGAGDEI
Mflv_5210|M.gilvum_PYR-GCK ---VSGTDSQGFVG-----HTARCDSGDTPAALIRTSLSL----------
Mvan_1066|M.vanbaalenii_PYR-1 ---VSGTDSQGFVG-----HTARCDSGSTPAALIRTSLSL----------
MAV_3463|M.avium_104 GISLANSESPCAVNSFISLARQRFFDNTQCARLVDSPDGG----------
Mb2115|M.bovis_AF2122/97 GIQNLVAHEPMLQPQTPNGSINPAECWPAVGGGVPSAYDLGTVIG-----
Rv2088|M.tuberculosis_H37Rv GIQNLVAHEPMLQPQTPNGSINPAECWPAVGGGVPSAYDLGTVIG-----
MAB_1133c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_5437|M.smegmatis_MC2_155 --------------------------------------------------
TH_4002|M.thermoresistible__bu --------------------------------------------------
MMAR_2941|M.marinum_M GVSGIWDGSTLFADAVVNYTAANRGRRRSSALKVEGGLKEGEASAPARPP
MUL_2200|M.ulcerans_Agy99 GVSGIWDGSTLFADAVVNYTAANRGRRRSSALKVEGGLKEGEASAPARPP
MLBr_00016|M.leprae_Br4923 TINVSTGPEQREVPDVSSLNYTDAVKKLTSSGFKSFKQANSPSTPELLG-
Mflv_5210|M.gilvum_PYR-GCK -------------------------------------------------A
Mvan_1066|M.vanbaalenii_PYR-1 -------------------------------------------------A
MAV_3463|M.avium_104 -------------------------------------------------S
Mb2115|M.bovis_AF2122/97 ----------------------------------------------FYGL
Rv2088|M.tuberculosis_H37Rv ----------------------------------------------FYGL
MAB_1133c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_5437|M.smegmatis_MC2_155 --------------------------------------------------
TH_4002|M.thermoresistible__bu --------------------------------------------------
MMAR_2941|M.marinum_M GSKSRKGRAFAIVAALLAIAAIAVAAVLTHGFGLWSTSEPGPVVKAQQAT
MUL_2200|M.ulcerans_Agy99 GSKSRKGRAFAIVAALLALAAIAVAAVLTHGFGLWSTSEPGPVVKAQQAT
MLBr_00016|M.leprae_Br4923 -----------------------------KVIGTNPSANQTSAITNVITI
Mflv_5210|M.gilvum_PYR-GCK IIC-----DRGDGDYYYRGERLRDGANREIDGARRS----GDGFTVTGSD
Mvan_1066|M.vanbaalenii_PYR-1 IIC-----ETSDGDYYYRGERLRDGANREIQGAQRS----GDGFVVTGSD
MAV_3463|M.avium_104 LLCGGPDVDGSGGPGYEFADEYPANQYRPDDPALRATLLYPRGTVVMATE
Mb2115|M.bovis_AF2122/97 TIDEPPTGTAPNQVGQLIVAFRDAATAQRHLADLASIWRRCGGRTVTLFR
Rv2088|M.tuberculosis_H37Rv TIDEPPTGTAPNQVGQLIVAFRDAATAQRHLADLASIWRRCGGRTVTLFR
MAB_1133c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_5437|M.smegmatis_MC2_155 --------------------------------------------------
TH_4002|M.thermoresistible__bu --------------------------------------------------
MMAR_2941|M.marinum_M VFSPGGTPDHPGQAGLAIDGDPNSAWPTDTYVDATPFPAFKQGVGLILRL
MUL_2200|M.ulcerans_Agy99 VFSPGGTPDHPGQAGLAIDGDPNSAWPTDTYVDATPFPAFKQGVGLILRL
MLBr_00016|M.leprae_Br4923 IVGSGPETKQIPDVTGQIVEIAQKNLNVYGFTKFSQASVDSPRPTGEVIG
Mflv_5210|M.gilvum_PYR-GCK G--------------ARYDVQPDQL-TISSG--------------GSVDS
Mvan_1066|M.vanbaalenii_PYR-1 G--------------ARYDVQPDQL-TISSN--------------GSVDS
MAV_3463|M.avium_104 GPNTNGSQFALIFHDSEMDPQSTVLGTIDPAGLATLDKIARAGIAGNRPS
Mb2115|M.bovis_AF2122/97 SEWRRPVELSTSVPEVVDGITTMVLTAQGPVLRVREDHAIAAKNNVLVDV
Rv2088|M.tuberculosis_H37Rv SEWRRPVELSTSVPEVVDGITTMVLTAQGPVLRVREDHAIAAKNNVLVDV
MAB_1133c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_5437|M.smegmatis_MC2_155 --------------------------------------------------
TH_4002|M.thermoresistible__bu --------------------------------------------------
MMAR_2941|M.marinum_M AKPTALSEVTIDVPSTGTEVQIRAAGSATPASLSDTTALTPNVALHPGHN
MUL_2200|M.ulcerans_Agy99 AKPTALSEVTIDVPSTGTEVQIRAAGSATPASLSDTTALTPNVALHPGHN
MLBr_00016|M.leprae_Br4923 TNPPKDATVPVDSVIELQVSKGNQFVMPDLSGMFWADAEPRLRALGWTGV
Mflv_5210|M.gilvum_PYR-GCK AEPA--LEYGSAQ---------------------------
Mvan_1066|M.vanbaalenii_PYR-1 AEPA--LEYGSAQ---------------------------
MAV_3463|M.avium_104 GPPANPVTITSVRIG-------------------------
Mb2115|M.bovis_AF2122/97 DIMTPDTSRGQQAVIGITNYILAKIPG-------------
Rv2088|M.tuberculosis_H37Rv DIMTPDTSRGQQAVIGITNYILAKIPG-------------
MAB_1133c|M.abscessus_ATCC_199 ----------------------------------------
MSMEG_5437|M.smegmatis_MC2_155 ----------------------------------------
TH_4002|M.thermoresistible__bu ----------------------------------------
MMAR_2941|M.marinum_M RIRVDSTTKTANVLVWISKLGTTKGESRTAISDITLRAR-
MUL_2200|M.ulcerans_Agy99 RIRVDSTTKTANVLVWISKLGTTKGESRNAISDITLRAR-
MLBr_00016|M.leprae_Br4923 LDKGPDVDAGGSQHNRVAYQNPPAGAGVNRDGIITLKFGQ