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PVPGEEFHGYVVGSLAGRGGTAQVYLAHRVDDGFEVALKVLELRHRNPENIDRLHREFDLAQRFSHPRIV TVFERGQDWLTMEALTGGSAKDLVGTNQSWIIPLKLTLLQQIAGALDFIHDEQVVHCDVKPSNIMRTRSG SAVLTDFGIAQELAHADGPRRPVVQTSLPYAAPEVLRGQPVTAATDQYALACTAVELFDGKPPFTARTML KLADMHLNAAPWPISYRHKYIPRAFDSIVAKAMSKDPLSRYPTCTEFITLLTHAMT*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_1133c | - | - | 100% (267) | putative serine/threonine protein kinase |
M. abscessus ATCC 19977 | MAB_4435 | - | 2e-34 | 33.33% (273) | serine/threonine-protein kinase PknJ |
M. abscessus ATCC 19977 | MAB_0033c | - | 5e-34 | 32.46% (268) | serine/threonine-protein kinase PknB |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2115 | pknJ | 2e-35 | 35.09% (265) | transmembrane serine/threonine-protein kinase J |
M. gilvum PYR-GCK | Mflv_3427 | - | 2e-37 | 36.47% (266) | protein kinase |
M. tuberculosis H37Rv | Rv2088 | pknJ | 2e-35 | 35.09% (265) | transmembrane serine/threonine-protein kinase J |
M. leprae Br4923 | MLBr_00016 | pknB | 6e-35 | 32.21% (267) | putative serine/threonine protein kinase |
M. marinum M | MMAR_2941 | - | 4e-39 | 38.46% (273) | membrane-anchored serine/threonine-protein kinase |
M. avium 104 | MAV_0017 | - | 1e-34 | 32.84% (268) | serine/threonine protein kinase |
M. smegmatis MC2 155 | MSMEG_5437 | - | 5e-61 | 47.75% (289) | serine/threonine-protein kinase PknB |
M. thermoresistible (build 8) | TH_4002 | - | 5e-65 | 47.43% (272) | PUTATIVE putative probable serine/threonine-protein kinase PknB |
M. ulcerans Agy99 | MUL_2200 | - | 8e-39 | 38.10% (273) | membrane-anchored serine/threonine-protein kinase |
M. vanbaalenii PYR-1 | Mvan_0023 | - | 4e-36 | 33.58% (271) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_5437|M.smegmatis_MC2_155 -MWVESPGEHIAGFVVEDVAGRGGWAVVYRARDAQG-RLVALKVLNESHR TH_4002|M.thermoresistible__bu ---VLRRGDRFENYVIDDELGRGGSAIVYRAREADGGRVVALKVLDPHHR MAB_1133c|M.abscessus_ATCC_199 ---MPVPGEEFHGYVVGSLAGRGGTAQVYLAHRVDDGFEVALKVLELRHR Mb2115|M.bovis_AF2122/97 MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVLAAELS Rv2088|M.tuberculosis_H37Rv MAHELSAGSVFAGYRIERMLGAGGMGTVYLARNPDLPRSEALKVLAAELS MMAR_2941|M.marinum_M --MPLNEGDIFAGYVIQRLLGTGGMGEVYLAQHPRLPRLDALKILSLDAT MUL_2200|M.ulcerans_Agy99 --MPLNEGDIFAGYVIQRLLGTGGMGEVYLAQHPRLPRLDALKILSLDAT Mflv_3427|M.gilvum_PYR-GCK --MPLAAGETFAGYTIVRLLGSGGMGEVYLAQHPRLPRRDALKVLPAAVS MLBr_00016|M.leprae_Br4923 ---MTTPPHLSDRYELGDILGFGGMSEVHLARDIRLHRDVAVKVLRADLA MAV_0017|M.avium_104 ---MTTPQHLSDRYELGEILGFGGMSEVHLARDVRLHRDVAVKVLRADLA Mvan_0023|M.vanbaalenii_PYR-1 ---MTTPQHLSDRYEVGEILGFGGMSEVHLARDLRLHRDVAIKVLRADLA : : * ** . *: *: *:*:* MSMEG_5437|M.smegmatis_MC2_155 -EPAHLERLRREFEFACRAEHPNVVAMYAAGD--------GWLAMEFIDG TH_4002|M.thermoresistible__bu -SAADLERLRREYEFAARLDHPRVVTMYGAGP--------GWLAMELLAG MAB_1133c|M.abscessus_ATCC_199 -NPENIDRLHREFDLAQRFSHPRIVTVFERGQ--------DWLTMEALTG Mb2115|M.bovis_AF2122/97 RDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGR----LWIAMQFVDG Rv2088|M.tuberculosis_H37Rv RDLDFRARFVREADVAAGLDHPNIVAVHQRGQFEGR----LWIAMQFVDG MMAR_2941|M.marinum_M DDDEFRARFTREAELAATLWHPHIVGVHDRGEFDGR----LWISMDYVDG MUL_2200|M.ulcerans_Agy99 DDDEFRARFTREAELAATLWHPHIVGVHDRGEFDGR----LWISMDYVDG Mflv_3427|M.gilvum_PYR-GCK ADVEYRKRFEREADIAATLWHPHIVGVHDRGEDAGR----IWISMDYVEG MLBr_00016|M.leprae_Br4923 RDPSFYLRFRREAQNAAALNHPSIVAVYDTGEAETSAGPLPYIVMEYVDG MAV_0017|M.avium_104 RDPSFYLRFRREAQNAAALNHPSIVAVYDTGEAETPSGPLPYIVMEYVDG Mvan_0023|M.vanbaalenii_PYR-1 RDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPTGPLPYIVMEYVDG . *: ** : * ** :* :. * :: *: : * MSMEG_5437|M.smegmatis_MC2_155 RPAISLAVRTD--------QLTALRQIAGALDNIHRLGIVHSDVKPMNIL TH_4002|M.thermoresistible__bu GPVSNLPRLAD--------RLTALADVAAALDHIHYRGVVHCDVKPANIL MAB_1133c|M.abscessus_ATCC_199 GSAKDLVGTNQS--WIIPLKLTLLQQIAGALDFIHDEQVVHCDVKPSNIM Mb2115|M.bovis_AF2122/97 GNAEDALRAAT---MTTARAVYVIGEVAKALDYAHQQGVIHRDIKPANFL Rv2088|M.tuberculosis_H37Rv GNAEDALRAAT---MTTARAVYVIGEVAKALDYAHQQGVIHRDIKPANFL MMAR_2941|M.marinum_M TDARHLVEQRYRSGMPLEDVIEIVTAVAEALDFAHERRLLHRDVKPANIL MUL_2200|M.ulcerans_Agy99 TDTRHLVEQRYRSGMPLEDVIEIVTAVAEALDFAHERRLLHRDVKPANIL Mflv_3427|M.gilvum_PYR-GCK ADAAHLLAEDYRTGLPVAEVAQIVTAVADALDYAHDRHLLHRDVKPANIL MLBr_00016|M.leprae_Br4923 ATLRDIVHTDGP--MPPQQAIEIVADACQALNFSHQNGIIHRDVKPANIM MAV_0017|M.avium_104 VTLRDIVHTDGP--LPPRRAIEIIADACQALNFSHQNGIIHRDVKPANIM Mvan_0023|M.vanbaalenii_PYR-1 VTLRDIVHNDGP--MAPQRAIEVIADACQALNFSHQHGIIHRDVKPANIM : . **: * ::* *:** *:: MSMEG_5437|M.smegmatis_MC2_155 VDKPFS----RAVLIDFGVAHSLAEDVAARLAADATGRLTLDPARRITHQ TH_4002|M.thermoresistible__bu SGEDFAG--TGGVLTDFGVAHAVSEFIKP----DA-------------HT MAB_1133c|M.abscessus_ATCC_199 RTRSGS-----AVLTDFGIAQELA------------------------HA Mb2115|M.bovis_AF2122/97 LSRAAGGDER-VLLSDFGIARALG-----------------------DTG Rv2088|M.tuberculosis_H37Rv LSRAAGGDER-VLLSDFGIARALG-----------------------DTG MMAR_2941|M.marinum_M VTEPSESARRRVLLTDFGIAREID-----------------------DKH MUL_2200|M.ulcerans_Agy99 VTEPSESARRRVLLTDFGIAREID-----------------------DKH Mflv_3427|M.gilvum_PYR-GCK IARP-DSNTRRIMLADFGIARWDN-----------------------DIS MLBr_00016|M.leprae_Br4923 ISATNA-----VKVMDFGIARAIADS-----------------------T MAV_0017|M.avium_104 ISTTNA-----VKVMDFGIARAIADSG----------------------N Mvan_0023|M.vanbaalenii_PYR-1 ISKTGA-----VKVMDFGIARALADAG----------------------N : ***:*: MSMEG_5437|M.smegmatis_MC2_155 SAAPRPQVQASLPYSAPELITGRALSAATDQYALACTAVEILTGLPPFTA TH_4002|M.thermoresistible__bu VSRRRVPVEASLAYTAPELFGGRPPSAASDEYALACTAVELVTGAPPFVA MAB_1133c|M.abscessus_ATCC_199 DGPRRPVVQTSLPYAAPEVLRGQPVTAATDQYALACTAVELFDGKPPFTA Mb2115|M.bovis_AF2122/97 -LTSTGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAPFAA Rv2088|M.tuberculosis_H37Rv -LTSTGSVLATLAYAAPEVLAGQGFDGRADLYSLGCALFRLLTGEAPFAA MMAR_2941|M.marinum_M RLTEAQMAIGTVAYAAPEQLTGKPLDGRADQYALAATAFHLLAGVPPFDH MUL_2200|M.ulcerans_Agy99 RLTEAQMAIGTVAYAAPEQLTGRPLDGRADQYALAATAFHLLAGVPPFDH Mflv_3427|M.gilvum_PYR-GCK GLTATNMTVGTVSYAAPEQLMGQDLDGRADQYALAATAFHLLTGSPPFSH MLBr_00016|M.leprae_Br4923 SVTQTAAVIGTAQYLSPEQARGDSVDARSDVYSLGCVLYEILTGEPPFIG MAV_0017|M.avium_104 SVTQTAAVIGTAQYLSPEQARGDAVDARSDVYSLGCVLYEILTGEPPFTG Mvan_0023|M.vanbaalenii_PYR-1 PVTQTAAVIGTAQYLSPEQARGVKVDARSDVYSLGCVLYEVLTGEPPFVG . : * :** * . :* *:*... .:. * .** MSMEG_5437|M.smegmatis_MC2_155 TT--AVKMVDQQLNSPPPRISGRAAWIPHAVDAILAKALSKDPERRHESC TH_4002|M.thermoresistible__bu TT--RMALIDQHLHRPPPALSRRFEWVPRAFDSVLARALAKLPDARYPTC MAB_1133c|M.abscessus_ATCC_199 RT--MLKLADMHLNAAPWPISYRHKYIPRAFDSIVAKAMSKDPLSRYPTC Mb2115|M.bovis_AF2122/97 GAGAAVAVVAGHLHQPPPTVSDRVPGLSAAMDAVIATAMAKDPMRRFTSA Rv2088|M.tuberculosis_H37Rv GAGAAVAVVAGHLHQPPPTVSDRVPGLSAAMDAVIATAMAKDPMRRFTSA MMAR_2941|M.marinum_M SN--RAVVVGQHLNMPPPRISKRHP-KLAHLDAAFAKALAKDPDDRYPRC MUL_2200|M.ulcerans_Agy99 SN--RAVVVGQHLNMPPPRISKRHP-KLAHLDAAFAKALAKDPDDRYPRC Mflv_3427|M.gilvum_PYR-GCK SN--PAVVISRHLNSAPATVAAHRP-ELAAVDPVLTRALAKNPADRYPRC MLBr_00016|M.leprae_Br4923 DS--PVSVAYQHVREDPIPPSQRHEGISVDLDAVVLKALAKNPENRYQTA MAV_0017|M.avium_104 DS--PVAVAYQHVREDPVPPSQRHEGISADLDAVVLKALAKNPDNRYQTA Mvan_0023|M.vanbaalenii_PYR-1 DS--PVAVAYQHVREDPVPPSQRHAGISPELDAVVLKALAKNPDNRYQTA : ::. * : : .*. . *::* * *. . MSMEG_5437|M.smegmatis_MC2_155 TEFVDELAAALG-------------------------------------- TH_4002|M.thermoresistible__bu TEFITLVRDALGTGPT---------------------------------- MAB_1133c|M.abscessus_ATCC_199 TEFITLLTHAMT-------------------------------------- Mb2115|M.bovis_AF2122/97 GEFAHAAAAALYGGATDGWVPPSPAPHVISQGAVPGS-----PWWQHPVG Rv2088|M.tuberculosis_H37Rv GEFAHAAAAALYGGATDGWVPPSPAPHVISQGAVPGS-----PWWQHPVG MMAR_2941|M.marinum_M IDFAKALAAGPGSIAEHQARRGATSTEPFDVNAEMSAEALEPARPSGTAP MUL_2200|M.ulcerans_Agy99 IDFAKALAAGPGSIAEHQARRGATSTEPFDVNAEMSAEALEPARPSGTAP Mflv_3427|M.gilvum_PYR-GCK ADFAREFNARLDAGAPAHTSR---------------------IRPAVLIP MLBr_00016|M.leprae_Br4923 AEMRADLIRVHSGQPPEAPKVLTDADRSCLLSSGAGNFGVPRTDALSRQS MAV_0017|M.avium_104 AEMRADLVRVHNGEKPEAPKVLTDAERSSLLSSGAGAAGPSRTDPLPRQV Mvan_0023|M.vanbaalenii_PYR-1 AEMRTDLVRVHSGEAPDAPKVFTDAERTSLLAANPAHHRTEPVEPAGRRQ :: MSMEG_5437|M.smegmatis_MC2_155 -------------------------------------------------- TH_4002|M.thermoresistible__bu -------------------------------------------------- MAB_1133c|M.abscessus_ATCC_199 -------------------------------------------------- Mb2115|M.bovis_AF2122/97 SVTALATPPGHGWPPGLPPLPRRPRRYRRGVAAVAAVMVVAAAAVTAVTM Rv2088|M.tuberculosis_H37Rv SVTALATPPGHGWPPGLPPLPRRPRRYRRGVAAVAAVMVVAAAAVTAVTM MMAR_2941|M.marinum_M SAQAQPHPSEAGVSTASLGAADQPGAGKARHTKRLERMTVDGTAVSVQKR MUL_2200|M.ulcerans_Agy99 SAQAQPHPSEAGVSTASLGAADQPGAGKARHTKRLERMTVDGTAVSVQKR Mflv_3427|M.gilvum_PYR-GCK VVLAVLLVAAVAVAAFEFLRADRADRADRADPPPMARTTTITTSPTTSTT MLBr_00016|M.leprae_Br4923 LDETESD---GSIGRWVAVVAVLAVLTIAIVAAFNTFGGNTRDVQVPDVR MAV_0017|M.avium_104 LADSGEDRTVGSVGRWIVAVAALAVLTIIVVIAFNTFGGGARDVQVPDVR Mvan_0023|M.vanbaalenii_PYR-1 PRYAEPERG-GSLGRWLIAVAILAVLTVVVTIGINMFGGGTRDVQVPDVR MSMEG_5437|M.smegmatis_MC2_155 -------------------------------------------------- TH_4002|M.thermoresistible__bu -------------------------------------------------- MAB_1133c|M.abscessus_ATCC_199 -------------------------------------------------- Mb2115|M.bovis_AF2122/97 TSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRSRLPGLLPPLDDVKNFV Rv2088|M.tuberculosis_H37Rv TSHQPRTATPPSAAALSPTSSSTTPPQPPIVTRSRLPGLLPPLDDVKNFV MMAR_2941|M.marinum_M PAGPEQDEEVWLFCVQRYESTGEPHTVIPVELRGTSITGQLANGDAVGVS MUL_2200|M.ulcerans_Agy99 PAGPEQDEEVWLFCVQRYESTGEPHTVIPVELRGTSITGQLANGDAVGVS Mflv_3427|M.gilvum_PYR-GCK TATP------------------------PATPASVVIGANCAPLDATATT MLBr_00016|M.leprae_Br4923 GQVSADAISALQNRGFKTRTLQKPDSTIPPDHVISTEPGANASVGAGDEI MAV_0017|M.avium_104 GQVSADAIAALQNRGFKTRTLQKPDSAIPPDHVIGTDPGANASVSAGDEI Mvan_0023|M.vanbaalenii_PYR-1 GQASADAIATLQNRGFSIRTQQKPDSEVPPDHVIDTDPGANTEVGAGDEI MSMEG_5437|M.smegmatis_MC2_155 -------------------------------------------------- TH_4002|M.thermoresistible__bu -------------------------------------------------- MAB_1133c|M.abscessus_ATCC_199 -------------------------------------------------- Mb2115|M.bovis_AF2122/97 GIQNLVAHEPMLQPQTPNGSIN---------------------------- Rv2088|M.tuberculosis_H37Rv GIQNLVAHEPMLQPQTPNGSIN---------------------------- MMAR_2941|M.marinum_M GIWDGSTLFADAVVNYTAANRGRRRSSALKVEGGLKEGEASAPARPPGSK MUL_2200|M.ulcerans_Agy99 GIWDGSTLFADAVVNYTAANRGRRRSSALKVEGGLKEGEASAPARPPGSK Mflv_3427|M.gilvum_PYR-GCK G--DGTTAYCAAVP----GSAG---------------------------- MLBr_00016|M.leprae_Br4923 TINVSTGPEQREVPDVSSLNYT---------------------------- MAV_0017|M.avium_104 TINVSTGPEQREVPDVSSLSYS---------------------------- Mvan_0023|M.vanbaalenii_PYR-1 TLNVSTGPEQREVPDVSGLSYT---------------------------- MSMEG_5437|M.smegmatis_MC2_155 -------------------------------------------------- TH_4002|M.thermoresistible__bu -------------------------------------------------- MAB_1133c|M.abscessus_ATCC_199 -------------------------------------------------- Mb2115|M.bovis_AF2122/97 -------------------PAECWPAVGGGVPSAYDLGTVIGFYGLTIDE Rv2088|M.tuberculosis_H37Rv -------------------PAECWPAVGGGVPSAYDLGTVIGFYGLTIDE MMAR_2941|M.marinum_M SRKGRAFAIVAALLAIAAIAVAAVLTHGFGLWSTSEPGPVVKAQQATVFS MUL_2200|M.ulcerans_Agy99 SRKGRAFAIVAALLALAAIAVAAVLTHGFGLWSTSEPGPVVKAQQATVFS Mflv_3427|M.gilvum_PYR-GCK -----------------------------TIWSLT---------QGTLPA MLBr_00016|M.leprae_Br4923 ------------------DAVKKLTSSGFKSFKQANSPSTPELLGKVIGT MAV_0017|M.avium_104 ------------------DAVTKLKAAGFSKFKQANSPSTPELLGKVIGT Mvan_0023|M.vanbaalenii_PYR-1 ------------------EAVRRLTEAGFEKFRQTASTSLPEQKDRVLST MSMEG_5437|M.smegmatis_MC2_155 -------------------------------------------------- TH_4002|M.thermoresistible__bu -------------------------------------------------- MAB_1133c|M.abscessus_ATCC_199 -------------------------------------------------- Mb2115|M.bovis_AF2122/97 PPTGTAPNQVGQLIVAFRDAATAQRHLADLASIWRRCGGRTVTLFRSEWR Rv2088|M.tuberculosis_H37Rv PPTGTAPNQVGQLIVAFRDAATAQRHLADLASIWRRCGGRTVTLFRSEWR MMAR_2941|M.marinum_M P--GGTPDHPGQAGLAIDGDPNSAWPTDTYVDATPFPAFKQGVGLILRLA MUL_2200|M.ulcerans_Agy99 P--GGTPDHPGQAGLAIDGDPNSAWPTDTYVDATPFPAFKQGVGLILRLA Mflv_3427|M.gilvum_PYR-GCK P--TSTP------------------PPDP--------------------- MLBr_00016|M.leprae_Br4923 NPSANQTSAITNVITIIVGSGPETKQIPDVTGQIVEIAQKNLNVYGFTKF MAV_0017|M.avium_104 NPPANQTSAITNVITLIVGSGPETKQVPDIAGQTVDIAQKNLTVYGFTKI Mvan_0023|M.vanbaalenii_PYR-1 VPPANQTSAITNEITIVVGKGPATAVVPECVGQTVEVCQQILSASGFTKS MSMEG_5437|M.smegmatis_MC2_155 -------------------------------------------------- TH_4002|M.thermoresistible__bu -------------------------------------------------- MAB_1133c|M.abscessus_ATCC_199 -------------------------------------------------- Mb2115|M.bovis_AF2122/97 RPVELSTSVPEVVDGITTMVLTAQGPVLRVREDHAIAAKNN--------- Rv2088|M.tuberculosis_H37Rv RPVELSTSVPEVVDGITTMVLTAQGPVLRVREDHAIAAKNN--------- MMAR_2941|M.marinum_M KPTALSEVTIDVPSTGTEVQIRAAGSATPASLSDTTALTPNVALHPGHNR MUL_2200|M.ulcerans_Agy99 KPTALSEVTIDVPSTGTEVQIRAAGSATPASLSDTTALTPNVALHPGHNR Mflv_3427|M.gilvum_PYR-GCK ---------------------------TEQPLSDAEAFP----------- MLBr_00016|M.leprae_Br4923 SQASVDSPRPTGEVIGTNPPKDATVPVDSVIELQVSKGNQFVMPDLSGMF MAV_0017|M.avium_104 TQVQVDSPRPAGEVIGTNPPKGQTVPVDSVIELQVSKGNQFIMPDLSGMF Mvan_0023|M.vanbaalenii_PYR-1 VPVEVDSTVAAGQVVGLEPAAGQTVPQDTVIQIQVSRGNQFVMPDLRGQF MSMEG_5437|M.smegmatis_MC2_155 -------------------------------------------------- TH_4002|M.thermoresistible__bu -------------------------------------------------- MAB_1133c|M.abscessus_ATCC_199 -------------------------------------------------- Mb2115|M.bovis_AF2122/97 -----------VLVDVDIMTPDTSRGQQAVIGITNYILAKIPG------- Rv2088|M.tuberculosis_H37Rv -----------VLVDVDIMTPDTSRGQQAVIGITNYILAKIPG------- MMAR_2941|M.marinum_M IRVDSTTKTANVLVWISKLGTTKGESRTAISDITLRAR------------ MUL_2200|M.ulcerans_Agy99 IRVDSTTKTANVLVWISKLGTTKGESRNAISDITLRAR------------ Mflv_3427|M.gilvum_PYR-GCK -----------VLTCMEQTGQTRRECRRAIRESNGQPPLP---------- MLBr_00016|M.leprae_Br4923 WADAEPRLRALGWTGVLDKGPDVDAGGSQHNRVAYQNPPAGAGVNRDGII MAV_0017|M.avium_104 WTDAEPRLRALGWTGILDKGPDVDAGGAQSHRVVYQNPPAGAGVNRDGII Mvan_0023|M.vanbaalenii_PYR-1 WADAEPRLRALGWTGVLDKGADVPNSGQRTNAVVTQSPSPGSGVNYGSRI MSMEG_5437|M.smegmatis_MC2_155 ------ TH_4002|M.thermoresistible__bu ------ MAB_1133c|M.abscessus_ATCC_199 ------ Mb2115|M.bovis_AF2122/97 ------ Rv2088|M.tuberculosis_H37Rv ------ MMAR_2941|M.marinum_M ------ MUL_2200|M.ulcerans_Agy99 ------ Mflv_3427|M.gilvum_PYR-GCK ------ MLBr_00016|M.leprae_Br4923 TLKFGQ MAV_0017|M.avium_104 TLKFGQ Mvan_0023|M.vanbaalenii_PYR-1 TLNFAS