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M. thermoresistible (build 8) TH_0350 (lipP)

annotation: PROBABLE ESTERASE/LIPASE LIPP
coordinates: 785921 - 787165
length: 415

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0350lipP-100% (415)PROBABLE ESTERASE/LIPASE LIPP
M. thermoresistible (build 8)TH_3778-5e-3933.69% (377) PUTATIVE beta-lactamase
M. thermoresistible (build 8)TH_2342lipE1e-2131.07% (354) PROBABLE LIPASE LIPE

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2490lipP1e-16471.39% (388) esterase/lipase LipP
M. gilvum PYR-GCKMflv_3647-2e-4134.51% (368) beta-lactamase
M. tuberculosis H37RvRv2463lipP1e-16471.39% (388) esterase/lipase LipP
M. leprae Br4923MLBr_00119lipE5e-1735.53% (152) putative hydrolase
M. abscessus ATCC 19977MAB_0853-1e-15564.69% (388) esterase/lipase LipP
M. marinum MMMAR_3810lipP1e-16270.10% (388) esterase/lipase LipP
M. avium 104MAV_1709lipP1e-16671.50% (386) carboxylesterase, putative
M. smegmatis MC2 155MSMEG_4680lipP1e-17675.39% (386) carboxylesterase, putative
M. ulcerans Agy99MUL_3735lipP1e-15571.43% (364) esterase/lipase LipP
M. vanbaalenii PYR-1Mvan_5383-4e-5936.90% (393) beta-lactamase

CLUSTAL 2.0.9 multiple sequence alignment


Mb2490|M.bovis_AF2122/97            -------------------MNQPDIKGSCASEFTKVRDAFERNFVLRNEV
Rv2463|M.tuberculosis_H37Rv         -------------------MNQPDIKGSCASEFTKVRDAFERNFVLRNEV
MMAR_3810|M.marinum_M               -------------------MSDVDIYGSCARKFQRVRAAFERNFAQGMEV
MUL_3735|M.ulcerans_Agy99           -----------------------------------------------MEV
MAV_1709|M.avium_104                ---------------MSDLKTDAPIHGSCAPDFVGVRDAFERNFTHGGEV
TH_0350|M.thermoresistible__bu      ---------MS--ETFQPVRSIPAVHGTCAPGFEGVRTAFVDNFTERGEI
MSMEG_4680|M.smegmatis_MC2_155      ---------MRPGGSLTGQQLAIPISGTCAPGFERVRTAFEQNFTERNEV
MAB_0853|M.abscessus_ATCC_1997      ----------------MSTSLDVAVNGTNSPDFDNVRRAFALNFLENDEL
Mvan_5383|M.vanbaalenii_PYR-1       -----------------MWSDMSDVAGLCDPRFESVAAALADEIACGEEL
Mflv_3647|M.gilvum_PYR-GCK          MTGVNSRERDEALSHGHGGHLPRGVQGAADPNFTCAVRAFAQMFPHRRFG
MLBr_00119|M.leprae_Br4923          -MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIWQATRHWYQAGMHP
                                                                                      

Mb2490|M.bovis_AF2122/97            GAAVAVWVDGDLVVN--LWGGSADA------GGTRPWQHDTLATVLSGTK
Rv2463|M.tuberculosis_H37Rv         GAAVAVWVDGDLVVN--LWGGSADA------GGTRPWQHDTLATVLSGTK
MMAR_3810|M.marinum_M               GAAVAVWVDGDLVVN--LWGGSADA------AGTRPWRQDTLTTVLSGSK
MUL_3735|M.ulcerans_Agy99           GAAVAVWVDGDLVVN--LWGGSADA------AGTRPWRQDTLTTVLSGSK
MAV_1709|M.avium_104                GAAVAVWVDGSLVVN--LWGGWADA------ARTRPWQQNTLTTVLSGTK
TH_0350|M.thermoresistible__bu      GAAVAVWVDGELVVD--LWGGSADA------EGRLSWRRDTLASVFSGSK
MSMEG_4680|M.smegmatis_MC2_155      GAAVAVWVEGDLVVS--LWGGHADA------ARTRPWREDTLASVYSGSK
MAB_0853|M.abscessus_ATCC_1997      GAAVAIWVDGELVVN--LWAGWADE------ARTRPWTEDTLAPVYSGTK
Mvan_5383|M.vanbaalenii_PYR-1       GASIAVDLDGELVVD--IWAGYVDR------AKTIPWQRDTIVNFWSCTK
Mflv_3647|M.gilvum_PYR-GCK          GGALAVYLNGEPVVD--VWTGWADR------RGKRRWTADTAPMVFSATK
MLBr_00119|M.leprae_Br4923          AIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDTPFCAYSAAK
                                    .  :.:  .*  *:.  :  *  :               :*     * :*

Mb2490|M.bovis_AF2122/97            ALTATCVHQLVDRGELDLHAPVARYWPEFGQAGKQAITLAMVMSHRSGAI
Rv2463|M.tuberculosis_H37Rv         ALTATCVHQLVDRGELDLHAPVARYWPEFGQAGKQAITLAMVMSHRSGAI
MMAR_3810|M.marinum_M               ALTATCVHQLADRGELDLHAPVARYWPEFGQAGKEAITVAMVLSHRSGVI
MUL_3735|M.ulcerans_Agy99           ALTATCVHQLADRGELNLHAPVARYWPEFRQAGKEAITVAMVLSHRSGVI
MAV_1709|M.avium_104                GLSATCVHQLADRGQLDLQAPVARYWPEFAQAGKQDITLAMVMSHRSGVI
TH_0350|M.thermoresistible__bu      GLTATCVHLLADRGEIDLDAPIARYWPEFGQAGKDAITTAMVLGHRSGVI
MSMEG_4680|M.smegmatis_MC2_155      GLTSTCIHLLADRGEIDLDAPVARYWPEFAQAGKRDITVASVLAHRSGTI
MAB_0853|M.abscessus_ATCC_1997      GLMSTCVHMLVERGVLDLYAPVARYWPEFGQGGKESITLAMVLGHRSGVI
Mvan_5383|M.vanbaalenii_PYR-1       TLTALAALILVDRGELDPFSTVARYWPEFAANGKADIEVRHLLSHTSGVS
Mflv_3647|M.gilvum_PYR-GCK          GVAATVIHRLADRGLIDYDAPVAEYWREFGVNGKSTITVRELMRHRAGLS
MLBr_00119|M.leprae_Br4923          AITATVVHMLVERGHFSLDDRVCEYLPTYTSYGKHRTTIRHVLTHSAGVP
                                     : :     *.:** :.    :..*   :   **       :: * :*  

Mb2490|M.bovis_AF2122/97            GPRGR-LGWEQVADWDFVCEQLAAAEPWWQPGAAQGYHMTTFGFILGEVF
Rv2463|M.tuberculosis_H37Rv         GPRGR-LGWEQVADWDFVCEQLAAAEPWWQPGAAQGYHMTTFGFILGEVF
MMAR_3810|M.marinum_M               GPNAR-MSWQQVTDWDFVCEQLALAEPRWEPGSAQGYHMTTFGFILGEVF
MUL_3735|M.ulcerans_Agy99           GPNAR-MSWQQVTDWDFVCEQLALAEPRWEPGSAQGYHMTTFGFILGEVF
MAV_1709|M.avium_104                GPRTR-MRWEQVADWDYVCEQLAAAEPWWEPGTAQGYHMTTFGFIMGEVF
TH_0350|M.thermoresistible__bu      GPRTP-MRPEQTLDWDAVCAALAAAGPWWPPGAAQGYHMVTFGFILGEIV
MSMEG_4680|M.smegmatis_MC2_155      GPREP-MDWREITDWDAVCTRIAASEPWWPPGTAQGYQVVTFGFILGELV
MAB_0853|M.abscessus_ATCC_1997      GPRTR-LTPEQAANWDEVCEHIARATPWWEPGTAQGYHMATFGFILGEVV
Mvan_5383|M.vanbaalenii_PYR-1       GWQTP-FGVEDIYDWAKATSHLAGQAPWWQPGTASGYHAMNYGHLVGELV
Mflv_3647|M.gilvum_PYR-GCK          QLNG--AAKTDLMDHLVMEERLAAAPASWLVG-RPAYHAFTFGWLLSGLA
MLBr_00119|M.leprae_Br4923          FPTGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHALTWGPLMREII
                                                 :       ::   . :  *    *:  .:* ::  : 

Mb2490|M.bovis_AF2122/97            RRVTGRTVGQYLRTEIAEPLGAD-VHIGLHPGEQLRCADLVDKPHIRQLL
Rv2463|M.tuberculosis_H37Rv         RRVTGRTVGQYLRTEIAEPLGAD-VHIGLHPGEQLRCADLVDKPHIRQLL
MMAR_3810|M.marinum_M               RRITGRTVGQYLRTEIAEPIGAD-VHIGLSPFDQSRCAERVNKPHARDLL
MUL_3735|M.ulcerans_Agy99           RRITGRTVGQYLRTEIAEPIGAD-VHIGLSPFDQSRCAERVNKPHARDLL
MAV_1709|M.avium_104                RRVTGRTIGHYLRTEIAGPFGAD-VHIGLPLAEQHRCAERVNKPHARDLL
TH_0350|M.thermoresistible__bu      RRVTGRSPGRFLRTEIAEPLGAD-VHIGLPHTEHHRCAEMVNKPHIRDVL
MSMEG_4680|M.smegmatis_MC2_155      RRVTGRTLGQYLRTEIAEPLGAD-IHIGLPRSEHRRCAEMVNKPTVRGVL
MAB_0853|M.abscessus_ATCC_1997      RRTTGKTLGQFLRTEIAEPYGLD-VHVGLPHSEHHRCAELINKPYLRDVF
Mvan_5383|M.vanbaalenii_PYR-1       RRITGTPLKDFVAEQIAVPLGAD-VQIGARPEDDHRIAELVPPP-PRDRG
Mflv_3647|M.gilvum_PYR-GCK          RSVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQAPTQPARIIGPQTRLQN
MLBr_00119|M.leprae_Br4923          WTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVP----------LVALS
                                       **      :  ::  * .    :.*    :                 

Mb2490|M.bovis_AF2122/97            ADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNG
Rv2463|M.tuberculosis_H37Rv         ADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNG
MMAR_3810|M.marinum_M               ADVQAPSDPTSLDDHPKAGLSIAMGFAPDDELGSNDLHLWRQLEFPGTNA
MUL_3735|M.ulcerans_Agy99           ADVQAPSDPTSLDDHPKAGLSIAMGFAPDDELGSNDLHLWRQLEFPGTNA
MAV_1709|M.avium_104                ADANAPTDPRSLAEHPKAGLSISMGFAPDDELGSHDLNLWRELEFPGTNG
TH_0350|M.thermoresistible__bu      AAGGAPAHPERLDEHPMAGLAVAMGFIPDDELGSADLTGWRAAEFPATNG
MSMEG_4680|M.smegmatis_MC2_155      ADFGLP-RPTSLDDHPMAGFAVSMDFVPDDELGVHDLSAWRTAEFPSTNG
MAB_0853|M.abscessus_ATCC_1997      R--GAPGEFDCMSDHPLAGPLISGDFIPDDEIARKDIALWRALEFPGTNA
Mvan_5383|M.vanbaalenii_PYR-1       VDRLPPDHPAVKTFAAFPPGAYGAAHAETEAWRRADIG--GANGHGNARG
Mflv_3647|M.gilvum_PYR-GCK          PIFNAVAPHIAALPFSAG---FGAMYFPGVKSFVQGDTPLLDGEIPAANG
MLBr_00119|M.leprae_Br4923          HATGRPLPPIIAAIFRKAIGGTVHEVIPYTNTPPFLTTIVPSSNTVSTAN
                                                                                   :  

Mb2490|M.bovis_AF2122/97            QVSALGLATFYN-GLAQEKLLS--REHMELVRVSQGGFDTDLVLGPRVAD
Rv2463|M.tuberculosis_H37Rv         QVSALGLATFYN-GLAQEKLLS--REHMELVRVSQGGFDTDLVLGPRVAD
MMAR_3810|M.marinum_M               QVSALGLATFYN-ALAQEKLLS--REHMDLVRVSQGGFDTDLVLGPRVAD
MUL_3735|M.ulcerans_Agy99           QVSALGLATFYN-ALAQEKLLS--REHMDLVRVSQGGFDTDLVLGPRVAD
MAV_1709|M.avium_104                QVSALGLATFYN-ALAQEKLLS--REHMDRVRVCQGGLDTDLVLGPRVAD
TH_0350|M.thermoresistible__bu      HVSAVGLATVYH-ALAREQLIS--RGHLERCRMSQGGFDPDLVLGPRVAD
MSMEG_4680|M.smegmatis_MC2_155      HVSALGMATFYN-ALAQEKLLS--RELMERCRVSQGGFDTDLVLGPRVAD
MAB_0853|M.abscessus_ATCC_1997      HVSALGMATFYN-AMALGKLLS--HEHMDVVRVSQGGFDPDVVLGPRVAN
Mvan_5383|M.vanbaalenii_PYR-1       LVRALSPISLGG-TANGVQVVD--PRTVELIFAEQSSGMDQVLFVP--LR
Mflv_3647|M.gilvum_PYR-GCK          VATARALARMYG-AIANEGRIDGLQYLSRETTAVLAGRRSLRLDHSMVMP
MLBr_00119|M.leprae_Br4923          ELSRFAEIWLRGGELDGIRVLR--SETLLGAVAECRRLRPDFVVGLMPAR
                                         .   .          :                     :       

Mb2490|M.bovis_AF2122/97            HGWGLGYMLNQRGVNGPNP-RIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
Rv2463|M.tuberculosis_H37Rv         HGWGLGYMLNQRGVNGPNP-RIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MMAR_3810|M.marinum_M               HGWGLGYMLNQRAVNGPNQ-KIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MUL_3735|M.ulcerans_Agy99           HGWGLGYMLNQRAVNGPNQ-KIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
MAV_1709|M.avium_104                HGWGLGYMLNQRCVNGPNP-RIFGHGGLGGSFGFVDLEHRIGYAYVMNRF
TH_0350|M.thermoresistible__bu      HGWGLGYMLNQRGHAGPNR-RVFGHGGSGGSFGFADLEHRIGYAYVMNNF
MSMEG_4680|M.smegmatis_MC2_155      HGWGLGYMLNQRGVAGPNR-RTFGHGGSGGSFAFVDLEHRIGYAYVMNHF
MAB_0853|M.abscessus_ATCC_1997      HGWGLGYMLNQRCYAGPNQ-KTFGHGGSGGSYAFVDLEHRIGYSYVMNQF
Mvan_5383|M.vanbaalenii_PYR-1       FGIGFGLPTPQSVPAVPDG-KVCWWGGWGGSLVVMDLDRRATFAYVMNKM
Mflv_3647|M.gilvum_PYR-GCK          LSFHLGYHGLPIPGLLPG----FGHVGLGGSLGWADPETGLAFGFVHNRL
MLBr_00119|M.leprae_Br4923          WGTGFILGTNKFGPFGRNAPAAFGHLGLVNIAIWADPQRSMAAGLISSGK
                                     .  :            .        *  .     * :     . : .  

Mb2490|M.bovis_AF2122/97            DATKANADPRSVVLSNEVYAALGVNRS----------------------
Rv2463|M.tuberculosis_H37Rv         DATKANADPRSVVLSNEVYAALGVNRS----------------------
MMAR_3810|M.marinum_M               DASKANADPRSVALSNEVYAALDVAAD----------------------
MUL_3735|M.ulcerans_Agy99           DASKANADPRSVALSNEVYAALDVAAD----------------------
MAV_1709|M.avium_104                DATKANADPRSLALSNEVYSVLGVR------------------------
TH_0350|M.thermoresistible__bu      DATKAHADPRSVALSDAVYSALGVTAHRSAAPVGAAGRR----------
MSMEG_4680|M.smegmatis_MC2_155      DATKCNADPRTVALSNQVYSALGVI------------------------
MAB_0853|M.abscessus_ATCC_1997      DVTKADADPRSVRLINELYTTLGVSPAGESL------------------
Mvan_5383|M.vanbaalenii_PYR-1       GG-GTTGTPRTVRYAKLIDAALQDARG----------------------
Mflv_3647|M.gilvum_PYR-GCK          LTPMVVSDQAGFVATAALLRRGASQARKNGYRRVREYGSPFSDVAATAV
MLBr_00119|M.leprae_Br4923          PGQDPNAG-RYGALMNTITAEIPVH------------------------
                                          .          :