For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VMVDTGVDHRAVSSHDGPDAGRRVFGAADPRFACVVRAFASMFPGRRFGGGALAVYLDGQPVVDVWKGWA DRAGWVPWSADSAPMVFSATKGMTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRDVMRHQAGL SGLRGATQQDLLDHVVMEERLAAAVPGRLLGKSAYHALTFGWLMSGLARAVTGKDMRLLFREELAEPLDT DGLHLGRPPADAPTRVAEIIMPQDIAANAVLTCAMRRLAHRFSGGFRSMYFPGAIAAVQGEAPLLDAEIP AANGVATARALARMYGAIANGGEIDGIRFLSRELVTGLTRNRRQVLPDRNLLVPLNFHLGYHGMPIGNVM PGFGHVGLGGSIGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGYQPVTPFGAP YSEPGAAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1497 | lipL | - | 100% (429) | PROBABLE ESTERASE LIPL |
| M. tuberculosis H37Rv | Rv1923 | lipD | e-134 | 56.97% (402) | lipase LIPD |
| M. tuberculosis H37Rv | Rv2463 | lipP | 4e-40 | 33.42% (380) | esterase/lipase LipP |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1534 | lipL | 0.0 | 100.00% (429) | esterase LipL |
| M. gilvum PYR-GCK | Mflv_3647 | - | 1e-156 | 63.40% (429) | beta-lactamase |
| M. leprae Br4923 | MLBr_00119 | lipE | 7e-29 | 30.03% (313) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_1386 | - | 3e-97 | 49.36% (393) | putative esterase/lipase/beta-lactamase |
| M. marinum M | MMAR_2305 | lipL | 0.0 | 82.75% (429) | esterase LipL |
| M. avium 104 | MAV_3275 | - | 0.0 | 77.52% (427) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_3162 | - | 1e-142 | 63.08% (409) | beta-lactamase |
| M. thermoresistible (build 8) | TH_3778 | - | 1e-134 | 64.19% (377) | PUTATIVE beta-lactamase |
| M. ulcerans Agy99 | MUL_2951 | lipD | 1e-133 | 56.28% (414) | lipase LipD |
| M. vanbaalenii PYR-1 | Mvan_2765 | - | 1e-152 | 65.02% (406) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv1497|M.tuberculosis_H37Rv --------MMVDTGVDHRAVSSHD--GPDAGRRVFGAADPRFACVVRAFA
Mb1534|M.bovis_AF2122/97 --------MMVDTGVDHRAVSSHD--GPDAGRRVFGAADPRFACVVRAFA
MMAR_2305|M.marinum_M --------MTVDIGVNRRAVSSHG--DPDAGHRVSGAADSQFACVVRMFS
MAV_3275|M.avium_104 ----------MDARVDRRAVRVHD--DLDAGHRVSGAADSHFGCVVRSFA
MSMEG_3162|M.smegmatis_MC2_155 -------MSGHN-RERDAALPH----------GVQGAADPNFACTARAFS
TH_3778|M.thermoresistible__bu --------------------------------------------------
Mflv_3647|M.gilvum_PYR-GCK -------MTGVNSRERDEALSHGH--GGHLPRGVQGAADPNFTCAVRAFA
Mvan_2765|M.vanbaalenii_PYR-1 -------MTGVNNPERDVALSHGH--GAALPCGVQGAADPNFTLAVRAFA
MUL_2951|M.ulcerans_Agy99 -------MAQPSVPTTDDGLPS----------GVAGACDSRFSGVVRAFA
MAB_1386|M.abscessus_ATCC_1997 MAIPLGPNVAATAPVRRDGLYPGDQPGLRLPNGVEGWARPELSAVVRTFE
MLBr_00119|M.leprae_Br4923 ----MTSDGKIRVPTDLDAVTAIG------DEDHSDIDSAAVERIWQATR
Rv1497|M.tuberculosis_H37Rv SMFPGRRFGGGALAVYLDGQPVVDVWKGW--------ADRAGWVPWSADS
Mb1534|M.bovis_AF2122/97 SMFPGRRFGGGALAVYLDGQPVVDVWKGW--------ADRAGWVPWSADS
MMAR_2305|M.marinum_M SMFPARRFGGGALAVYLDGQPVVDVWKGW--------ADREGEVPWSADS
MAV_3275|M.avium_104 SMFPARRFGGGALAVYVDGQPVVDVWTGW--------ADRAGQRPWSENT
MSMEG_3162|M.smegmatis_MC2_155 RLFPGRRFGGGALAVYQDGQPLVDIWTGY--------SDRAGTEYWTADT
TH_3778|M.thermoresistible__bu --------------VYLHGEPVVDVWTGY--------ADRRGTEYWTADT
Mflv_3647|M.gilvum_PYR-GCK QMFPHRRFGGGALAVYLNGEPVVDVWTGW--------ADRRGKRRWTADT
Mvan_2765|M.vanbaalenii_PYR-1 QMFPSRRLGGGALAVYLDGEPVVDVWTGW--------ADRRGTRRWTADT
MUL_2951|M.ulcerans_Agy99 GLYPGRKFGGGALSVYTEGRQVVDVWTGW--------ADRNGEVPWTADT
MAB_1386|M.abscessus_ATCC_1997 WMFTKYRLGGGGLSVYVDGEPALDIWAG---------AAAAGQG-WTRDT
MLBr_00119|M.leprae_Br4923 HWYQAGMHPAIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDT
: .*. :: * . : ::
Rv1497|M.tuberculosis_H37Rv APMVFSATKGMTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRD
Mb1534|M.bovis_AF2122/97 APMVFSATKGMTATVIHRLADRGLIDYEAPVAEYWPAFGANGKATLTVRD
MMAR_2305|M.marinum_M APMVFSATKGMAATVIHRLADRGLIDYEAPVAQYWPEFAANGKEKLTVRE
MAV_3275|M.avium_104 APMVFSATKGMAATVIHRLVDRGLIDYEAPVAEYWPAFAANGKANMTVRQ
MSMEG_3162|M.smegmatis_MC2_155 GAMVFSATKGLASTVIHRLADRGLIDYDTPVSAYWPEFAANGKAHITVRE
TH_3778|M.thermoresistible__bu GAMVFSATKGMAATVVHRLVDRGLLDYDTPVAEYWPEFGANGKAGITVRD
Mflv_3647|M.gilvum_PYR-GCK APMVFSATKGVAATVIHRLADRGLIDYDAPVAEYWREFGVNGKSTITVRE
Mvan_2765|M.vanbaalenii_PYR-1 GPMVFSATKGVTATVIHRLHDRGLVDYDAPVAEYWREFGANGKSAITVRD
MUL_2951|M.ulcerans_Agy99 GAMVFSATKGLAATVIHRLVDRGLLDYDAPVADYWPEFGVKGKSAITVSD
MAB_1386|M.abscessus_ATCC_1997 GALVFSASKGIAATVIHRLVDRGLITYDAPVARYWPEFGANGKSSITVRQ
MLBr_00119|M.leprae_Br4923 PFCAYSAAKAITATVVHMLVERGHFSLDDRVCEYLPTYTSYGKHRTTIRH
.:**:*.:::**:* * :** . : *. * : ** *: .
Rv1497|M.tuberculosis_H37Rv VMRHQAGLSGLRGAT--QQDLLDHVVMEERLAAAVPG-RLLGKSAYHALT
Mb1534|M.bovis_AF2122/97 VMRHQAGLSGLRGAT--QQDLLDHVVMEERLAAAVPG-RLLGKSAYHALT
MMAR_2305|M.marinum_M VMRHAAGLSGLRGAS--QEDLLDHVVMEERLAAAAPG-RLLGKPAYHALT
MAV_3275|M.avium_104 VMRHQAGLSGLRGAT--KEELLDHLVMEERLAAAAPG-RLLGKSAYHALT
MSMEG_3162|M.smegmatis_MC2_155 VMQHRAGLSQLNGVS--KADMLDHRVMEARIAEASVNRHLYGKSAYHALT
TH_3778|M.thermoresistible__bu VLRHRAGLSHLNGVS--KADLLDHRRMEERLAAAPVNRLQYGKPAYHALT
Mflv_3647|M.gilvum_PYR-GCK LMRHRAGLSQLNGAA--KTDLMDHLVMEERLAAAPAS-WLVGRPAYHAFT
Mvan_2765|M.vanbaalenii_PYR-1 ALRHRAGLSQLNGAG--KADLLDHAVMEQRLAAAPRS-WLYGKPAYHALT
MUL_2951|M.ulcerans_Agy99 LLRHRSGLSHLKGVG--KKEILDHLRMEEKLAAAPLD-RTHGKMAYHAVT
MAB_1386|M.abscessus_ATCC_1997 VLDHRAGLSRLEGIAYHAEEIVDHELMERRLAAAPVD-KFYGKRAYHALT
MLBr_00119|M.leprae_Br4923 VLTHSAGVPFPTGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHALT
: * :*:. * ** : ::: ***.*
Rv1497|M.tuberculosis_H37Rv FGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRPPADAPTRVAEI
Mb1534|M.bovis_AF2122/97 FGWLMSGLARAVTGKDMRLLFREELAEPLDTDGLHLGRPPADAPTRVAEI
MMAR_2305|M.marinum_M FGWLMSGLARAVTGKDMRVLFREELAEPLDTDGFHLGRPPAGSPTQVAQI
MAV_3275|M.avium_104 FGWLMSGLGRAVTGKGMRTLIREELAEPLGTDGLYLGRPPAGAPTRVAEI
MSMEG_3162|M.smegmatis_MC2_155 YGWLMSGLVRAVTGQGMRELFRTELAEPLNTDGIHLGRPPVGAPTRAAQI
TH_3778|M.thermoresistible__bu YGWLLSGLVRAITGCGMRELVRTELAEPLNTDGLHLGRPPAGAPTKAAQI
Mflv_3647|M.gilvum_PYR-GCK FGWLLSGLARSVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQAPTQPARI
Mvan_2765|M.vanbaalenii_PYR-1 FGWLLSGLARSITGKGMRELIRTEVAAPLNTDGLHLGRPPVQAPTEAAQI
MUL_2951|M.ulcerans_Agy99 YGWLLSGLARAVTGKGMRDLFREELARPLDTDGLHLGRPPGDAPTTAAQT
MAB_1386|M.abscessus_ATCC_1997 FGWLLAGLARSVTGKDMRELFRTEIADPLGVDGIHLGRPPRTASTKAASM
MLBr_00119|M.leprae_Br4923 WGPLMREIIWTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVP--LVAL
:* *: : : ** :* :. *: **. :* . . .
Rv1497|M.tuberculosis_H37Rv IMPQDIAANA-----VLTCAMRRLAH--RFSGGFRSMYFPGAIAAVQGE-
Mb1534|M.bovis_AF2122/97 IMPQDIAANA-----VLTCAMRRLAH--RFSGGFRSMYFPGAIAAVQGE-
MMAR_2305|M.marinum_M IMPQDIAANP-----LVTFAAHKIAN--QFSSGFRSMYFPGVIATVQGE-
MAV_3275|M.avium_104 VAPQNLVGSS-----IVNYVSRKVAN--QLSGGFRAMYFPGMIAAVQGD-
MSMEG_3162|M.smegmatis_MC2_155 LGPQRTWPNH-----VFDFLAPRFAAL-EFSGFFGSTYCPGVMSLVQGD-
TH_3778|M.thermoresistible__bu LAPQGALDIP-----VVGAVVPRLAAS-QASAMFGAMYFPGMFSVVQGD-
Mflv_3647|M.gilvum_PYR-GCK IGPQTRLQNP-----IFNAVAPHIAAL-PFSAGFGAMYFPGVKSFVQGD-
Mvan_2765|M.vanbaalenii_PYR-1 IGPQTRLQNP-----VFNLVAPRIAAL-PFSAGFGAIYLPGVKALVQGD-
MUL_2951|M.ulcerans_Agy99 LLPQSKIPTP-----LLDFIAPKVAGL-SFSGLLGAVYFPGILSMLQDD-
MAB_1386|M.abscessus_ATCC_1997 YPFLDSMANKPAVGRLLPTVIRAIDRLPGFEGAIGTMYGPGMERILADDG
MLBr_00119|M.leprae_Br4923 SHATGRPLPP-----IIAAIFRKAIGG-TVHEVIPYTNTP----------
:. : *
Rv1497|M.tuberculosis_H37Rv ---APLLDAEIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGL
Mb1534|M.bovis_AF2122/97 ---APLLDAEIPAANGVATARALARMYGAIANGGEIDGIRFLSRELVTGL
MMAR_2305|M.marinum_M ---TPMLDAEIPAANGVVTARALARMYGAIANGGEIDGTQFLSRELVAGL
MAV_3275|M.avium_104 ---TPLLDAEIPAANGVATARGLARMYGAIANGGEVDGIRFLSRDLVAGL
MSMEG_3162|M.smegmatis_MC2_155 ---TPFLDAEIPAANGVATARGLAKVYGAIANGGRFAGEEFLSAATVAGL
TH_3778|M.thermoresistible__bu ---IPFLDSEIPAANAVATARGLAKMYGAIANGGRIDDVRFLSPEIVAGL
Mflv_3647|M.gilvum_PYR-GCK ---TPLLDGEIPAANGVATARALARMYGAIANEGRIDGLQYLSRETTAVL
Mvan_2765|M.vanbaalenii_PYR-1 ---TPLLDGEIPAANGVATARALARMYGAIANGGRIDGTQYLSGETAAAL
MUL_2951|M.ulcerans_Agy99 ---MPFLDGEIPAVNGVVTARALAKTYAALANDGVIDGMRLLSSDAVSGL
MAB_1386|M.abscessus_ATCC_1997 TLNSALYDMQAPAANAVATAPALAKMYAALAGDGSVDGRELLSPETVAGL
MLBr_00119|M.leprae_Br4923 ----PFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLRSETLLGA
.: *: * * ** *:: * . . . *
Rv1497|M.tuberculosis_H37Rv TRNRRQVLPDRNLLVP-----LNFHLG--YHGMPIGNVMPGFGHVGLGGS
Mb1534|M.bovis_AF2122/97 TRNRRQVLPDRNLLVP-----LNFHLG--YHGMPIGNVMPGFGHVGLGGS
MMAR_2305|M.marinum_M TGERR-LQPDRNLFMP-----MAFHLG--YHSLPIGNVMPGFGHVGMGGS
MAV_3275|M.avium_104 TGERS-LRPDRNLYVP-----LAFHLG--YHSVPIGGVMPGFGHVGMGGS
MSMEG_3162|M.smegmatis_MC2_155 SGRRS-LSPDRNIGVP-----LAFHLG--YHSVPF-GVMAGFGHVGLGGS
TH_3778|M.thermoresistible__bu AGRRN-LRPDRNLGVP-----MAFHLG--YHGVPF-GIMPGFGHVGLGGS
Mflv_3647|M.gilvum_PYR-GCK AGRRS-LRLDHSMVMP-----LSFHLG--YHGLPIPGLLPGFGHVGLGGS
Mvan_2765|M.vanbaalenii_PYR-1 IGRPS-LRPDHSMVMP-----LSFHLG--YHGLPFPGVLPGFGHVGLGGS
MUL_2951|M.ulcerans_Agy99 TGKAE-LWPDLNLGLP-----FTYHQG--YQSPPVPGLLGGYGHIGLGGT
MAB_1386|M.abscessus_ATCC_1997 ARKTN-LTIDRTIVFP-----MGMHLG--YMSLPMNGFRGGFGHIGLGGS
MLBr_00119|M.leprae_Br4923 VAECRRLRPDFVVGLMPARWGTGFILGTNKFGPFGRNAPAAFGHLGLVNI
. : * : . * . . .:**:*: .
Rv1497|M.tuberculosis_H37Rv IGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGY
Mb1534|M.bovis_AF2122/97 IGWTDPETGVAFALVHNRLLSPLVMTDHAGFVGIYHLIRQAAAQARKRGY
MMAR_2305|M.marinum_M VGWTDPETGVAFALVHNRLLTPLVATDHAGFVAIYALIRQAAAKARERGY
MAV_3275|M.avium_104 LGWADPASGVAFSLVHNRLLTPLVMTDHAAFVGIYALIRRAAEQVRKHGF
MSMEG_3162|M.smegmatis_MC2_155 VGWADPASGLAVGFVHNRLLTPMVF-DMGAFVGLHAVIRNDLARARRRGF
TH_3778|M.thermoresistible__bu YGWAEPETGLAIGYVHNRLLTPMLI-DQAAFVGLNALIRRDAAAARRRGY
Mflv_3647|M.gilvum_PYR-GCK LGWADPETGLAFGFVHNRLLTPMVVSDQAGFVATAALLRRGASQARKNGY
Mvan_2765|M.vanbaalenii_PYR-1 LGWADPRSGLSFGYVHNRLLTPLVLSDQAGFVATAALIRRGAAAARRNGY
MUL_2951|M.ulcerans_Agy99 IGWADPESGSAFGYVHNRLLT-LLLFDIGSFAGLAPLLSSAVSTARREGP
MAB_1386|M.abscessus_ATCC_1997 MGWADPKRKIAVGFAHNRLPLTMAL-DQISFAFLWPQIVKAVG-------
MLBr_00119|M.leprae_Br4923 AIWADPQRSMAAGLISS--GKPGQDPNAGRYGALMNTITAEIPVH-----
*::* : . . : : :
Rv1497|M.tuberculosis_H37Rv QPVTPFG-APYSEPG---AAAG---
Mb1534|M.bovis_AF2122/97 QPVTPFG-APYSEPG---AAAG---
MMAR_2305|M.marinum_M QPVTGIG-APYSEPG---AVAG---
MAV_3275|M.avium_104 RPVTEFG-APFREPG---AVAG---
MSMEG_3162|M.smegmatis_MC2_155 EPVPDLGAAPYELSK---PVAG---
TH_3778|M.thermoresistible__bu RPVGDLG-APFDMRK---RVAG---
Mflv_3647|M.gilvum_PYR-GCK RRVREYG-SPFSDVA---ATAV---
Mvan_2765|M.vanbaalenii_PYR-1 RPVREYG-APFTDLT---ATAV---
MUL_2951|M.ulcerans_Agy99 LEVPHFG-ASYRETGQQPLAAGETS
MAB_1386|M.abscessus_ATCC_1997 -------------------------
MLBr_00119|M.leprae_Br4923 -------------------------