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M. thermoresistible (build 8) TH_2342 (lipE)

annotation: PROBABLE LIPASE LIPE
coordinates: 4601318 - 4602583
length: 422

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2342lipE-100% (422)PROBABLE LIPASE LIPE
M. thermoresistible (build 8)TH_3778-3e-3033.44% (311) PUTATIVE beta-lactamase
M. thermoresistible (build 8)TH_0350lipP2e-2130.99% (355) PROBABLE ESTERASE/LIPASE LIPP

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3804lipE0.076.23% (408) putative lipase LIPE
M. gilvum PYR-GCKMflv_1067-1e-16777.20% (364) beta-lactamase
M. tuberculosis H37RvRv3775lipE0.076.23% (408) lipase LipE
M. leprae Br4923MLBr_00119lipE0.072.30% (408) putative hydrolase
M. abscessus ATCC 19977MAB_0064c-0.078.27% (405) lipase LipE
M. marinum MMMAR_5330lipE0.073.28% (408) lipase LipE
M. avium 104MAV_0246-1e-17970.66% (409) beta-lactamase
M. smegmatis MC2 155MSMEG_6575-0.076.79% (405) beta-lactamase
M. ulcerans Agy99MUL_4410-0.072.51% (411) fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE
M. vanbaalenii PYR-1Mvan_5757-1e-17277.57% (370) beta-lactamase

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_5330|M.marinum_M               --------------------------------------------------
MUL_4410|M.ulcerans_Agy99           MGETYESVTVEIKDQVAQATLIGPGKGNAMGPAFWSELPEVFAALDADRD
Mb3804|M.bovis_AF2122/97            --------------------------------------------------
Rv3775|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00119|M.leprae_Br4923          --------------------------------------------------
MAV_0246|M.avium_104                --------------------------------------------------
Mflv_1067|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5757|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2342|M.thermoresistible__bu      --------------------------------------------------
MSMEG_6575|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0064c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_5330|M.marinum_M               --------------------------------------------------
MUL_4410|M.ulcerans_Agy99           VRAIVITGSGKNFSYGLDVPAMGGTFAPLMAEGALARPRTDFHAEVLRMQ
Mb3804|M.bovis_AF2122/97            --------------------------------------------------
Rv3775|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00119|M.leprae_Br4923          --------------------------------------------------
MAV_0246|M.avium_104                --------------------------------------------------
Mflv_1067|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5757|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2342|M.thermoresistible__bu      --------------------------------------------------
MSMEG_6575|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0064c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_5330|M.marinum_M               --------------------------------------------------
MUL_4410|M.ulcerans_Agy99           KATNAVADCRTPTIASVHGWCIGGGVDLISAVDMRYASADAKFSIREVKL
Mb3804|M.bovis_AF2122/97            --------------------------------------------------
Rv3775|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00119|M.leprae_Br4923          --------------------------------------------------
MAV_0246|M.avium_104                --------------------------------------------------
Mflv_1067|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5757|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2342|M.thermoresistible__bu      --------------------------------------------------
MSMEG_6575|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0064c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_5330|M.marinum_M               --------------------------------------------------
MUL_4410|M.ulcerans_Agy99           AIVADMGSLARLPMILNDGHLRELALTGRDIDAARAEKIGLVNQVFEDAD
Mb3804|M.bovis_AF2122/97            --------------------------------------------------
Rv3775|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00119|M.leprae_Br4923          --------------------------------------------------
MAV_0246|M.avium_104                --------------------------------------------------
Mflv_1067|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5757|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2342|M.thermoresistible__bu      --------------------------------------------------
MSMEG_6575|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0064c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_5330|M.marinum_M               --------------------------------------------------
MUL_4410|M.ulcerans_Agy99           ATLAAAHATATEIAANPPLAVYGVKDVLDQQRASAVAENLRYVAAWNAAF
Mb3804|M.bovis_AF2122/97            --------------------------------------------------
Rv3775|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00119|M.leprae_Br4923          --------------------------------------------------
MAV_0246|M.avium_104                --------------------------------------------------
Mflv_1067|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5757|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2342|M.thermoresistible__bu      --------------------------------------------------
MSMEG_6575|M.smegmatis_MC2_155      --------------------------------------------------
MAB_0064c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_5330|M.marinum_M               -------------------------------------MTEDGRIRVPADL
MUL_4410|M.ulcerans_Agy99           LPSKDLTEGISATFAKRPPQFTGEQAAASTYPRGVASMTEDGRIRVPADL
Mb3804|M.bovis_AF2122/97            ------------------------------------MRAGDGKIRVPADL
Rv3775|M.tuberculosis_H37Rv         ------------------------------------MRAGDGKIRVPADL
MLBr_00119|M.leprae_Br4923          ----------------------------------MTS---DGKIRVPTDL
MAV_0246|M.avium_104                ----------------------------------MTTPTLDGKIRLPADL
Mflv_1067|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_5757|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_2342|M.thermoresistible__bu      ---------------------------MTRDNTTGAGATPDGRIRVPADL
MSMEG_6575|M.smegmatis_MC2_155      ---------------------------------------MTGKISVPADL
MAB_0064c|M.abscessus_ATCC_199      ----------------------------------MTASDQAGRIRVPADL
                                                                                      

MMAR_5330|M.marinum_M               DAVTALGAEDHSEIDSAAIERIWQAARYWYQAGMHPAIQLCIRHNGRVVL
MUL_4410|M.ulcerans_Agy99           DAVTALGAEDHSEIDSAAIERIWQATRYWYQAGMHPAIQLCIRHNGRVVL
Mb3804|M.bovis_AF2122/97            DAVTATGEEDHSEIDGAAVDRIWRAARHWYRAGMHPAIQLCIRHHGRVVL
Rv3775|M.tuberculosis_H37Rv         DAVTATGEEDHSEIDGAAVDRIWRAARHWYRAGMHPAIQLCIRHHGRVVL
MLBr_00119|M.leprae_Br4923          DAVTAIGDEDHSDIDSAAVERIWQATRHWYQAGMHPAIQLCIRQHGRVVL
MAV_0246|M.avium_104                DAVTTIGAEDHSEIDAAAVDRIWAAGRHWYQGGFHPAIQLCIRRHGRVVL
Mflv_1067|M.gilvum_PYR-GCK          ---------------------------------MQPAIQVCLRRDGRVIL
Mvan_5757|M.vanbaalenii_PYR-1       --------------------------MHWYRAGMQPAIQVCLRRDGKVIL
TH_2342|M.thermoresistible__bu      DAVTAVGDEDHTGIDPSAVERIWQAVRHWYRAGMHPAIQVCVRHDGRVVL
MSMEG_6575|M.smegmatis_MC2_155      DAVTTIGDEDHSGIDARAIEQIWDSVRYWYQSGLHPAIQVCLRHKGRVVL
MAB_0064c|M.abscessus_ATCC_199      DSVTDIAEEDHSDIGPAAVERIWQAARYWYQAGMHPAIQVCLRHRGKVIL
                                                                     ::****:*:*: *:*:*

MMAR_5330|M.marinum_M               NRAIGHGWGNAPSDAPDAEKIPVSTDTPFCTYSSAKAITATVAHMLAERG
MUL_4410|M.ulcerans_Agy99           NRAIGHGWGNAPSDAPDAEKIPVSTDTPFCTYSSAKAITATVVHMLAERG
Mb3804|M.bovis_AF2122/97            NRAIGHGWGNAPTDEADAEKIPVTTDTPFCVYSAAKAITATVVHMLVERG
Rv3775|M.tuberculosis_H37Rv         NRAIGHGWGNAPTDEADAEKIPVTTDTPFCVYSAAKAITATVVHMLVERG
MLBr_00119|M.leprae_Br4923          NRAIGHGWGNAPTDPHDAEKIPVTTDTPFCAYSAAKAITATVVHMLVERG
MAV_0246|M.avium_104                NRAIGHGWGNAPTDPPDAEKIPVTPDTPFCVYSAAKGIAATVVHMLVERG
Mflv_1067|M.gilvum_PYR-GCK          DRAIGYAA----------DDVPVRTDTPFCVYSAAKAITTTVTHMLVERG
Mvan_5757|M.vanbaalenii_PYR-1       DRAIGYAW----------DDVPVRTDTPFCVYSAAKAITTTVTHMLVERG
TH_2342|M.thermoresistible__bu      NRAIGHGWGNAPTDPPDAEKVPVRVDTPFCVYSAAKAIATTVVHMLVERG
MSMEG_6575|M.smegmatis_MC2_155      NRAIGHGWGNGPDDSPDTEKILATPETPFCVYSAAKAISSTVVHMLVERG
MAB_0064c|M.abscessus_ATCC_199      NRAIGHGWGNAPTDPVDAEKIPVTTDTPFCVYSAAKAISTTVVHLLVERG
                                    :****:.           :.: .  :****.**:**.*::**.*:*.***

MMAR_5330|M.marinum_M               HFSLDDRVCEYIPSYTSHGKDRTTIRHVLTHSAGVPFPTGPRPDVTRADD
MUL_4410|M.ulcerans_Agy99           HFSLDDRVCEYIPSYTSHGKDHTTIRHVLTHSAGVPFPTGPRPDVTRADD
Mb3804|M.bovis_AF2122/97            HFALDDRVCEYLPSYTSHGKHRTTIRHVLTHSAGVPFPTGPRPDVRRADD
Rv3775|M.tuberculosis_H37Rv         HFALDDRVCEYLPSYTSHGKHRTTIRHVLTHSAGVPFPTGPRPDVRRADD
MLBr_00119|M.leprae_Br4923          HFSLDDRVCEYLPTYTSYGKHRTTIRHVLTHSAGVPFPTGPRPDVTRADD
MAV_0246|M.avium_104                VFSLDDRVCDYIPTFTSHGKHRITIRHVMTHSAGLPFPTGPRPDVTRADD
Mflv_1067|M.gilvum_PYR-GCK          EFSLDDRVCEYLPEYTSHGKDRTTIRHVLTHSAGIPFATGPKPDLKRMDD
Mvan_5757|M.vanbaalenii_PYR-1       AFSLEDRVCDYLPEYTSHGKDRTTIRHVLTHSAGIPFATGPKPDLKRMDD
TH_2342|M.thermoresistible__bu      HLSLDDRVCDHLPGYTSHGKDRTTIRHVLTHSAGVPFATGPRPDLRRMDD
MSMEG_6575|M.smegmatis_MC2_155      YFSLDDRVCDYLPEYTSHGKDRTTIRHVMTHSAGVPIHTGPRPDVTKVND
MAB_0064c|M.abscessus_ATCC_199      ALSLDDRVCEYLPTFTSRGKDRITIRHVMTHSAGIPVPTGPRPDITRMDD
                                     ::*:****:::* :** **.: *****:*****:*. ***:**: : :*

MMAR_5330|M.marinum_M               HEYAARKLGELRPLYPPGLVHIYHALTWGPLMREIIWATTGKEIRDILAT
MUL_4410|M.ulcerans_Agy99           HDYAARKLGELRPLYPPGLVHIYHALTWGPLMREIIWATTRKEIRDILAT
Mb3804|M.bovis_AF2122/97            HEYAVERLGELRPLYRPGLVHIYHALTWGPLMREIVYAATGKEIREILAT
Rv3775|M.tuberculosis_H37Rv         HEYAVERLGELRPLYRPGLVHIYHALTWGPLMREIVYAATGKEIREILAT
MLBr_00119|M.leprae_Br4923          HAYAQQKLSELRPFYRPGLVHIYHALTWGPLMREIIWTATGKEIRDILAA
MAV_0246|M.avium_104                HEYAQQKLGELRPLYRPGLFHMYHALTWGPLVREIVYAATGKEIREILAT
Mflv_1067|M.gilvum_PYR-GCK          SDYTRAMLARMKPVYRPGLIHVYHGVTWGPLMREIISAATGRSIRDILAD
Mvan_5757|M.vanbaalenii_PYR-1       SAYTREMLGRMKPVYPPGLVHMYHGVTWGPLMREIISAATGRSIRDILAE
TH_2342|M.thermoresistible__bu      SEYARTMLGNLKPLYRPGLVHIYHGVTWGPLIREIVSAATGRNIRDILAT
MSMEG_6575|M.smegmatis_MC2_155      SEYTRQQLAALKPVYRPGLIHIYHGLTWGPLIREIVSAATGRNIRDILAE
MAB_0064c|M.abscessus_ATCC_199      SEYTREQLGQLRPLYRPGLVHMYHALTWGPLVREIVLGATGKGIRDILAT
                                      *:   *. ::*.* ***.*:**.:*****:***:  :* : **:*** 

MMAR_5330|M.marinum_M               EILDPLGFRWTNFGVAEEDLPLVAPSHATGRPLPPVIAAAFRKAIGGTVH
MUL_4410|M.ulcerans_Agy99           EILDPLGFRWTNFGVAEEDLPLVAPSHATGRPLPPVIAAAFRKAIGGTVH
Mb3804|M.bovis_AF2122/97            EILDPLGFRWTNFGVAERDVPLVAPSHATGRQLPPVIAAVFRKAIGGTVH
Rv3775|M.tuberculosis_H37Rv         EILDPLGFRWTNFGVAERDVPLVAPSHATGRQLPPVIAAVFRKAIGGTVH
MLBr_00119|M.leprae_Br4923          EILDPLGFRWTNFGVAEEDVPLVALSHATGRPLPPIIAAIFRKAIGGTVH
MAV_0246|M.avium_104                EILDPLGFRWTNFGVAKQDVPLVAPSHATGRTLPPVVAQIFRKAIGGTVH
Mflv_1067|M.gilvum_PYR-GCK          EILTPLGFRWTNYGVAPEDVPLVARSHVTGKPLPAPVAKAFKAAVGGTPQ
Mvan_5757|M.vanbaalenii_PYR-1       EILTPLGFRWTNYGVAAQDVPLVAPSHVTGKPLPAPIAKAFKTAVGGTPQ
TH_2342|M.thermoresistible__bu      EILEPLGFRWTNFGVAPDDVPLVAPSHPTGKPLPAPIAAAFRTAVGGTLH
MSMEG_6575|M.smegmatis_MC2_155      EILEPLKFRWTNYGVRPEEVDLVAPSHVTGKPLPAPIAAAFRAAVGGTPD
MAB_0064c|M.abscessus_ATCC_199      EILDPLGFRWTNYGVAPEDVPLVAPSHPTGKPLPAPMRAAFRAVVGGTMH
                                    *** ** *****:**   :: *** ** **: **. :   *: .:*** .

MMAR_5330|M.marinum_M               EVIPYTNKPLFLRTIIPSSNTVSTANELSRFMEILRRGGELDGVRIMAPE
MUL_4410|M.ulcerans_Agy99           EVIPYTNKPLFLRTIIPSSNTVSTANELSRFMEILRRGGELDGVRIMAPE
Mb3804|M.bovis_AF2122/97            EIIPYTNTPFFLSTILPSSNTVSTANELSRFMEILRRGGELDGVRVLSPE
Rv3775|M.tuberculosis_H37Rv         EIIPYTNTPFFLSTILPSSNTVSTANELSRFMEILRRGGELDGVRVLSPE
MLBr_00119|M.leprae_Br4923          EVIPYTNTPPFLTTIVPSSNTVSTANELSRFAEIWLRGGELDGIRVLRSE
MAV_0246|M.avium_104                EMIPYTNSPMFLTTIIPSSNTVSTAHEMSRFAEIWRRGGELDGVRVISPE
Mflv_1067|M.gilvum_PYR-GCK          QIIPFSNTRQFLTGVIPSSNTVSNAHELSRFAEILCRGGELDGVRVLSAE
Mvan_5757|M.vanbaalenii_PYR-1       QIIPFSNTREFLTGVIPSSNTVSNANELSRFAEILCRGGELDGIRVMSPE
TH_2342|M.thermoresistible__bu      QIIPFSNTPQFLTGVVPSSNTVSNAFELSRFAELLRRGGELDGVRVLAPE
MSMEG_6575|M.smegmatis_MC2_155      RIIPLSNTPLFLTSIVPSSSTVSNADELSRFAEILRRGGELDGVRILRPE
MAB_0064c|M.abscessus_ATCC_199      EIIPMSNQPFFLTGVVPSSNTVSTANELSRFAEILCRGGELDGVRVMSPE
                                    .:** :*   **  ::***.***.* *:*** *:  *******:*:: .*

MMAR_5330|M.marinum_M               TVRSAATECRRLRPDFATGLAPLRWGTGFMLGSNRFGPFGRNAPAAFGHL
MUL_4410|M.ulcerans_Agy99           TVRSAVTECRRLRPDSATGLAPLRWGTGFMLGSNRFGPFGRNAPAAFGHL
Mb3804|M.bovis_AF2122/97            TLRGAVTECRRLRPDFATGLMPLRWGTGFMLGSAKYGPFGRNAPAAFGHL
Rv3775|M.tuberculosis_H37Rv         TLRGAVTECRRLRPDFATGLMPLRWGTGFMLGSAKYGPFGRNAPAAFGHL
MLBr_00119|M.leprae_Br4923          TLLGAVAECRRLRPDFVVGLMPARWGTGFILGTNKFGPFGRNAPAAFGHL
MAV_0246|M.avium_104                TMYHAVAECRRLRPDFAVGLQPARWGTGFILGTNRWGPFGRNAPHAFGSL
Mflv_1067|M.gilvum_PYR-GCK          TLRAATKEARRLRPDLATGLQPMRWGTGYMLGSKRFGPFGRGADGAFGHT
Mvan_5757|M.vanbaalenii_PYR-1       TLRAATKEARRLRPDLATGLQPMRWGTGYMLGSKRFGPFGRDAAGAFGHT
TH_2342|M.thermoresistible__bu      TLRAATRQCRRLRPDLATGGQPLRWGLGYMLGSKRFGPFGRNAPAAFGHT
MSMEG_6575|M.smegmatis_MC2_155      TLRAATAPCRRIRPDVATGLKPMRWGTGYMLGGKRFGPFGRNTESAFGHT
MAB_0064c|M.abscessus_ATCC_199      TIRAAAAPARRLRPDMATGGMPMRWGTGYMLGSKRFGPFGRNSPAAFGHT
                                    *:  *.  .**:*** ..*  * *** *::**  ::*****.:  ***  

MMAR_5330|M.marinum_M               GLVNIATWADPDRGLSVGLINSGKPGRDPDAKRYVALKNAITAEIPPKTV
MUL_4410|M.ulcerans_Agy99           GLVNIATWADPDRGLSVGLINSGKPGRDPDAKRYVALKNAITAEIPPKTV
Mb3804|M.bovis_AF2122/97            GLVNIAVWADPERALSGGLISSGKPGRDPEAGRYGALLNAITAEIPRASS
Rv3775|M.tuberculosis_H37Rv         GLVNIAVWADPERALSGGLISSGKPGRDPEAGRYGALLNAITAEIPRASS
MLBr_00119|M.leprae_Br4923          GLVNIAIWADPQRSMAAGLISSGKPGQDPNAGRYGALMNTITAEIPVH--
MAV_0246|M.avium_104                GLTNIAIWADPARGLAAGVISSGKPGRDPEARRYTALMDTITAAIPRD--
Mflv_1067|M.gilvum_PYR-GCK          GLTDIAVWADPQRALSVAVVSSGKPGPHREAKRYPRLLDRINAEIPRL--
Mvan_5757|M.vanbaalenii_PYR-1       GLTDIVVWADPQRALSVAVVSSGKPGSHREARRYPALLDRINAEIPRVS-
TH_2342|M.thermoresistible__bu      GLVNIAMWADPERRLAAAVVSSGKPGNHREANRYPAVLDRIAAEFPRA--
MSMEG_6575|M.smegmatis_MC2_155      GLVDIAVWADPARSLSAAVVSSGKPGAHFETNRYPAVLNRIAEQIPPG--
MAB_0064c|M.abscessus_ATCC_199      GLVDIAVWADPARALSVGVVSSGKPGNHKEAKRYPALLDLIAAEVPLVG-
                                    **.:*. **** * :: .::.***** . :: **  : : *   .*    

MMAR_5330|M.marinum_M               E
MUL_4410|M.ulcerans_Agy99           E
Mb3804|M.bovis_AF2122/97            G
Rv3775|M.tuberculosis_H37Rv         G
MLBr_00119|M.leprae_Br4923          -
MAV_0246|M.avium_104                -
Mflv_1067|M.gilvum_PYR-GCK          -
Mvan_5757|M.vanbaalenii_PYR-1       -
TH_2342|M.thermoresistible__bu      -
MSMEG_6575|M.smegmatis_MC2_155      -
MAB_0064c|M.abscessus_ATCC_199      -