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M. thermoresistible (build 8) TH_3772 (-)

annotation: putative AAA ATPase containing von Willebrand factor type A (vWA)
coordinates: 4073275 - 4075788
length: 838

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3772--100% (838)putative AAA ATPase containing von Willebrand factor type A (vWA)
M. thermoresistible (build 8)TH_2700-e-10036.73% (825) PUTATIVE putative AAA ATPase containing von Willebrand factor
M. thermoresistible (build 8)TH_4068-2e-6634.42% (581) PUTATIVE putative conserved hypothetical protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2640PPE424e-1331.28% (243) PPE family protein
M. gilvum PYR-GCK-----
M. tuberculosis H37RvRv2608PPE424e-1331.28% (243) PPE family protein
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4141-1e-0521.80% (266) PE/PPE family protein
M. marinum MMMAR_3427-2e-1029.82% (275) PE family protein
M. avium 104-----
M. smegmatis MC2 155MSMEG_0200-1e-14541.72% (906) hypothetical protein MSMEG_0200
M. ulcerans Agy99MUL_0967-3e-0827.49% (342) PE family protein
M. vanbaalenii PYR-1Mvan_3952-2e-0552.83% (53) hypothetical protein Mvan_3952

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3427|M.marinum_M               --------------------MAFLVAEPQVMATVAGQVEEIGSAIGVANE
MUL_0967|M.ulcerans_Agy99           ------------------MAVIDLLASPQAMTATATEVAEIGLAINQADL
Mb2640|M.bovis_AF2122/97            MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSFASVTT
Rv2608|M.tuberculosis_H37Rv         MNFAVLPPEVNSARIFAGAGLGPMLAAASAWDGLAEELHAAAGSFASVTT
TH_3772|M.thermoresistible__bu      --MAKHTKTTRRSKKLATLGVATATATATALTVGAAPPEVETSALRNADV
MSMEG_0200|M.smegmatis_MC2_155      -MAGKNRKRGQRAKKIATL--SAATVTATALTAGIAPIGEANAAVVAREA
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

MMAR_3427|M.marinum_M               FAAG-SISGVAAAAGDEVSAAIASFFAAHGQAYQAVAGQVEAFHTEFQQA
MUL_0967|M.ulcerans_Agy99           AVAG-PTTGLAAAAAAEVSEAIATLFDNYAQGYQAVSRQTAAFHDAFAQT
Mb2640|M.bovis_AF2122/97            GLAGDAWHGPASLAMTRAASPYVGWLNTAAGQAAQAAGQARLAASAFEAT
Rv2608|M.tuberculosis_H37Rv         GLAGDAWHGPASLAMTRAASPYVGWLNTAAGQAAQAAGQARLAASAFEAT
TH_3772|M.thermoresistible__bu      DLLAGIQFYPEPEHIPDLTFGLGAVGYGLSQDFAEMAIRGLVDNISFAAL
MSMEG_0200|M.smegmatis_MC2_155      ALQADVRPFPPPDQIPDITGGLGAAGYDLAQAIGAQVMTSLMESISLAAL
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      ----------------------------MAGQYSVPGKRHSLRRYVATIT
                                                                                      

MMAR_3427|M.marinum_M               LAQAGN--------------------------------------------
MUL_0967|M.ulcerans_Agy99           LFAASD--------------------------------------------
Mb2640|M.bovis_AF2122/97            LAATVSPAMVAANRTRLASLVAANLLGQNAPAIAAAEAEYEQIWAQDVAA
Rv2608|M.tuberculosis_H37Rv         LAATVSPAMVAANRTRLASLVAANLLGQNAPAIAAAEAEYEQIWAQDVAA
TH_3772|M.thermoresistible__bu      AEALGLDLQSQLEN----------------------------VLNNALAM
MSMEG_0200|M.smegmatis_MC2_155      AQAAGIDPQSIATG----------------------------LLNEAIGS
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      AVAATCT-------------------------------------------
                                                                                      

MMAR_3427|M.marinum_M               --AYVQAEAAGAAALAG-----------ALGVPAT---------------
MUL_0967|M.ulcerans_Agy99           --SYVRAEAAAVKALAGLTEPVANLFAPVLSGPES---------------
Mb2640|M.bovis_AF2122/97            MFGYHSAASAVATQLAPIQEGLQQQLQNVLAQLASGNLGSGNVGVGNIGN
Rv2608|M.tuberculosis_H37Rv         MFGYHSAASAVATQLAPIQEGLQQQLQNVLAQLASGNLGSGNVGVGNIGN
TH_3772|M.thermoresistible__bu      LLGPVFGTLGQIPLDLDLVGLVGGLLDQKITAELADTLRPVLEGLEDLPF
MSMEG_0200|M.smegmatis_MC2_155      VLG---GTLDQLP--IDLTGVLQPLLAQVLTPLVSEILG-------ELP-
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

MMAR_3427|M.marinum_M               --------------------------------------------------
MUL_0967|M.ulcerans_Agy99           --------------------------------------------------
Mb2640|M.bovis_AF2122/97            DNIGNANIGFGNRGDANIGIGNIGDRNLGIGNTGNWNIGIGITGNGQIGF
Rv2608|M.tuberculosis_H37Rv         DNIGNANIGFGNRGDANIGIGNIGDRNLGIGNTGNWNIGIGITGNGQIGF
TH_3772|M.thermoresistible__bu      LGSILGDILGPILGGNGNNGLVDMVLGELLGDIIGGILPGAELDLDSLGG
MSMEG_0200|M.smegmatis_MC2_155      IGGALGDALIGVVAG-----LVVSTLALELSDLG---------AIDNVGA
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      --------------------------------------------------
                                                                                      

MMAR_3427|M.marinum_M               SAAAPAATIP--PFPANLTTLVMGGTGIPIPGPGFINLANELYVR----S
MUL_0967|M.ulcerans_Agy99           VAASATALLSGAPLKPVEAALILSESGVPTPSASYISDVYTKYVEPNFPS
Mb2640|M.bovis_AF2122/97            GKPANPDVLVVGNGGPGVTALVMGGTDSLLSLPNIPLLEYAARFITPVHP
Rv2608|M.tuberculosis_H37Rv         GKPANPDVLVVGNGGPGVTALVMGGTDSLLPLPNIPLLEYAARFITPVHP
TH_3772|M.thermoresistible__bu      LLGLLGLDLSQPLNLS-NLNLGLNLVTTGPLFTALKLFGADLGWEPALPN
MSMEG_0200|M.smegmatis_MC2_155      LLAALGLDLSNPLNLSGDPIPGLNLVTTGSPFTFLKLFGVDLGWVPPFPN
Mvan_3952|M.vanbaalenii_PYR-1       -MADLDELYGEIPTRQIAARLGADEAEVSSAVKTLLPVLVGGLQQNALDP
MAB_4141|M.abscessus_ATCC_1997      VLAPLAMESRTIASTLASYVIGIGGNNDGASANIPRKLGG--------AY
                                                           .                          

MMAR_3427|M.marinum_M               ANALLGLNTPEELYPLTGTKS-----------------------------
MUL_0967|M.ulcerans_Agy99           ATAPQGVSTPNGLYPFTGIKD-----------------------------
Mb2640|M.bovis_AF2122/97            GYTATFLETPSQFFPFTGLNS-----------------------------
Rv2608|M.tuberculosis_H37Rv         GYTATFLETPSQFFPFTGLNS-----------------------------
TH_3772|M.thermoresistible__bu      AVAREINETEYLNVGLLSLLN-----------------------------
MSMEG_0200|M.smegmatis_MC2_155      PVAEDINNTEYLKVGLAGLLENLGIELDPIDLDILDLNLLGVDLSVLESV
Mvan_3952|M.vanbaalenii_PYR-1       GTASTIASAAN---SHAGLLDG----------------------------
MAB_4141|M.abscessus_ATCC_1997      SVDYHPVSYPGAIWPVSGLTAP----------------------------
                                           .         .                                

MMAR_3427|M.marinum_M               ---------------------------LTLDASVSEGLTILDNAIMEQLA
MUL_0967|M.ulcerans_Agy99           ---------------------------LSLDISLARGATILNDAILQQLA
Mb2640|M.bovis_AF2122/97            ---------------------------LTYDVSVAQGVTNLHTAIMAQLA
Rv2608|M.tuberculosis_H37Rv         ---------------------------LTYDVSVAQGVTNLHTAIMAQLA
TH_3772|M.thermoresistible__bu      --------------------------TLGLEDLSAALGDLP---IVGDLP
MSMEG_0200|M.smegmatis_MC2_155      LDGLGLGLDLGNSGGLLGGLLGGLGLDLGLDLDALGLGTLDPNEILNLLP
Mvan_3952|M.vanbaalenii_PYR-1       ----------------------------GVDVDQVDEVDGSK--------
MAB_4141|M.abscessus_ATCC_1997      ----------------------------TFKTSVAQGRTNLNDEIVTAGN
                                                                  .                   

MMAR_3427|M.marinum_M               IP--GNTVTVFGVSQSAVIASLEMQKLAALGPAA-------------PTA
MUL_0967|M.ulcerans_Agy99           ALPAGSSVAVLGYSQSAVLSSRVMPKLLAEG----------------VTS
Mb2640|M.bovis_AF2122/97            AG---NEVVVFGTSQSATIATFEMRYLQSLPAHLR------------PGL
Rv2608|M.tuberculosis_H37Rv         AG---NEVVVFGTSQSATIATFEMRYLQSLPAHLR------------PGL
TH_3772|M.thermoresistible__bu      DLIALRVPIVIGVGLGAFAAGAAYNQVVADLANQPGGVN--GAESLLGSY
MSMEG_0200|M.smegmatis_MC2_155      DVVALRIPIVVGFQLGAFAAGAAYQQVVDELPNQPGGANYQGTNPLLGSF
Mvan_3952|M.vanbaalenii_PYR-1       -----AVAKIFGGNDTGQVASALS--------------------------
MAB_4141|M.abscessus_ATCC_1997      QP-----ITIVGYSLGAVVVSKSHSDLLQRYP---------------GGN
                                             :.*    .                                 

MMAR_3427|M.marinum_M               SQLNFVLLGNEMNPNGGLLARFPDLSIPSLGLTFYGGTPSDTIYP-----
MUL_0967|M.ulcerans_Agy99           SQVNFVLLGNPMNPNGGVLARFPDLTLPSLGFTFYGATP-DNAFP-----
Mb2640|M.bovis_AF2122/97            DELSFTLTGNPNRPDGGILTRFG-FSIPQLGFTLSGATP-ADAYP-----
Rv2608|M.tuberculosis_H37Rv         DELSFTLTGNPNRPDGGILTRFG-FSIPQLGFTLSGATP-ADAYP-----
TH_3772|M.thermoresistible__bu      TILPMILLRNPGRANGGLFARMYPLAGLFGIDTVTPETSAQSSGGTVPVL
MSMEG_0200|M.smegmatis_MC2_155      TILPMVLIDNPGRANGGLFARAYPLFRLMGIDTVTPDTQVQSSTSGDSLL
Mvan_3952|M.vanbaalenii_PYR-1       ---------GGGAGNSDLINRLLPILAPIVLAYIGRKLSGGQAQP-----
MAB_4141|M.abscessus_ATCC_1997      PNIQFVLMGSANTPNGGIFARFPWLKIPLADIESNGAWEPDQFKT-----
                                             .    :..:: *   :                         

MMAR_3427|M.marinum_M               ------------------TANYTLEYDGFADFPRYPLNFISDLNAVMGIV
MUL_0967|M.ulcerans_Agy99           ------------------TVSYTLEYDGFADFPRYPINLLADINAVMGIP
Mb2640|M.bovis_AF2122/97            ------------------TVDYAFQYDGVNDFPKYPLNVFATANAIAGIL
Rv2608|M.tuberculosis_H37Rv         ------------------TVDYAFQYDGVNDFPKYPLNVFATANAIAGIL
TH_3772|M.thermoresistible__bu      G----TGLTVGGANLIPVKIDATAEYDFLSDFAAWPNPFSMANNVAALLF
MSMEG_0200|M.smegmatis_MC2_155      NNIQLLGLTVGGANLIPIKVDATAEYLPLSDFAAWPNPFTMTNNVAAALF
Mvan_3952|M.vanbaalenii_PYR-1       ----------------------------------QGQSGGGLGDILGGIL
MAB_4141|M.abscessus_ATCC_1997      -------------------KVINTEYDTYGDFPAYFNP-LALANSIAAIQ
                                                                               :    : 

MMAR_3427|M.marinum_M               YVH--PTYLDLTQAQVDNAIPLATSPGY-----------------SGVTS
MUL_0967|M.ulcerans_Agy99           FVH--ADYQDLTQAQLDSAVQLPTEG-------------------PTQST
Mb2640|M.bovis_AF2122/97            FLH--SGLIALPPDLASGVVQPVSSP-------------------DVLTT
Rv2608|M.tuberculosis_H37Rv         FLH--SGLIALPPDLASGVVQPVSSP-------------------DVLTT
TH_3772|M.thermoresistible__bu      PTY--LLRGLSALDLVDSLGEQLTPQLAQILDNVLQ-----LDEALAINL
MSMEG_0200|M.smegmatis_MC2_155      PTY--ILRNQSIPGVITDLTGQVVGQLLGDLADYVADPGDDPTKGPKLNI
Mvan_3952|M.vanbaalenii_PYR-1       GGG--GQRGAGADNPLGSILGSVLGG------------------------
MAB_4141|M.abscessus_ATCC_1997      YAHPDAYYDRIDPAALDDPDNPNVVKT-----------------VQGNTT
                                                     .                                

MMAR_3427|M.marinum_M               YYILPTENLPLLEPLRAIP----------VIGNPLANLIQPDLKVLVNLG
MUL_0967|M.ulcerans_Agy99           YYMIPTEHLPLLAPLRFIP----------YVGDPLAELLEPNLRVLVNFG
Mb2640|M.bovis_AF2122/97            YILLPSQDLPLLVPLRAIP----------LLGNPLADLIQPDLRVLVELG
Rv2608|M.tuberculosis_H37Rv         YILLPSQDLPLLVPLRAIP----------LLGNPLADLIQPDLRVLVELG
TH_3772|M.thermoresistible__bu      YLTLPMNTLPLLEPLYLATDFINLFTPGFDVNNPIATALNPVLTSLVNLG
MSMEG_0200|M.smegmatis_MC2_155      YYTLDAKSLPLLEPTYLAVDVINLFT-GLNLNNPIGTALSPALTTLVNLG
Mvan_3952|M.vanbaalenii_PYR-1       -----------------------------DKGGPLGDILGGLLGGKK---
MAB_4141|M.abscessus_ATCC_1997      YYLVRAEHLPLLQPLRDLTN--------PIGASFVLDAIEPTLRVFIDMA
                                                                    . :   :   *       

MMAR_3427|M.marinum_M               YGDP---------AYGYSTSPADITTPFGLFP-DVPPHVIADALVAGTKQ
MUL_0967|M.ulcerans_Agy99           YGDP---------AYGYDTGPANVPTPFGLFP-PVSPLTVAEHLAAGTQQ
Mb2640|M.bovis_AF2122/97            YDR---------------TAHQDVPSPFGLFP-DVDWAEVAADLQQGAVQ
Rv2608|M.tuberculosis_H37Rv         YDR---------------TAHQDVPSPFGLFP-DVDWAEVAADLQQGAVQ
TH_3772|M.thermoresistible__bu      YTDVYWDDAKG--QYDRTLLEADIPTGFGTLPADVNWLEVPGNLFASLMR
MSMEG_0200|M.smegmatis_MC2_155      YTDVRRVETADGVEYVRDFDDSDIPTAFGSFP-DVEWAKVPGDVVTQLVR
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      YDR---------------DTGPGTTTQFSFFTPSKNIVDAFNKLPTAIAE
                                                                                      

MMAR_3427|M.marinum_M               GISDFSAD------------------------------------------
MUL_0967|M.ulcerans_Agy99           GIVNSGAA------------------------------------------
Mb2640|M.bovis_AF2122/97            GVNDALSG------------------------------------------
Rv2608|M.tuberculosis_H37Rv         GVNDALSG------------------------------------------
TH_3772|M.thermoresistible__bu      GVQDAFEEGLIGPE-GSNVLRTLLGLIGLDLGGLGAGAAGLSMDGLPELL
MSMEG_0200|M.smegmatis_MC2_155      GVQKAVGDGLVNQSPVPSPLTTLLGLLGLGN----ALPSGGSVLNLPDLN
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      GAHNVENG------------------------------------------
                                                                                      

MMAR_3427|M.marinum_M               -------------IQQMFSQPATLPSPPMLQAPDLMAALAAAPTPVEVVN
MUL_0967|M.ulcerans_Agy99           -------------LQAQG--PPSIPLSDIAHTLTANPPWAGTPALPPSTS
Mb2640|M.bovis_AF2122/97            -------------LGLPPPWQPALPRLF----------------------
Rv2608|M.tuberculosis_H37Rv         -------------LGLPPPWQPALPRLF----------------------
TH_3772|M.thermoresistible__bu      RDAVEDAVGGLGELGGVSPLSSSQPEAAAVPDLGADTLTLKTGQRAAALN
MSMEG_0200|M.smegmatis_MC2_155      ---------GLLPTAGTTNVAARQSEPNTKFEPQAITETKATDPDTTVLN
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      -------LAGATPKQSASPEKPASPPVPQPGPTNPGSATTQIPAPEAPTP
                                                                                      

MMAR_3427|M.marinum_M               TLTKIVSDDYATLLPLADIGTAFVITMPTYDATLFVDQLLQGNLINAFGY
MUL_0967|M.ulcerans_Agy99           PASSIEDFILAVQAANSSISRGFVKTLSTAYATLLPTTDIASELVFTL--
Mb2640|M.bovis_AF2122/97            --------------------------------------------------
Rv2608|M.tuberculosis_H37Rv         --------------------------------------------------
TH_3772|M.thermoresistible__bu      ESDGAGLKENSEQPQDAAGEKTVIDTSTGDESPQPTPDAPREDAIKPPSS
MSMEG_0200|M.smegmatis_MC2_155      LPSPQEKTTVPEPTKKVGGEVKKVVADIDEARAEIEAKVKKANERAKAS-
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      SVVSLSTAEPPAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPDPKS
                                                                                      

MMAR_3427|M.marinum_M               PIAADVGLTAISGGVVALVAIGTLQSNIKDLQSLFP--------------
MUL_0967|M.ulcerans_Agy99           ---PSYNLNLFLDGVIQAING----QPIGD--------------------
Mb2640|M.bovis_AF2122/97            --------------------------------------------------
Rv2608|M.tuberculosis_H37Rv         --------------------------------------------------
TH_3772|M.thermoresistible__bu      KLRTGSNGRGEVRTGLGAPGKHLQQSTERLGQRLQDRADKINDGLRNAGA
MSMEG_0200|M.smegmatis_MC2_155      ----AEKARERTQKAVKDAQDRVNKIADNGRKQIKAVADGVEKAVKDTKQ
Mvan_3952|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      TPPPTKDSVGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKNHLK
                                                                                      

MMAR_3427|M.marinum_M               ---------------------------------------------
MUL_0967|M.ulcerans_Agy99           ---------------------------------------------
Mb2640|M.bovis_AF2122/97            ---------------------------------------------
Rv2608|M.tuberculosis_H37Rv         ---------------------------------------------
TH_3772|M.thermoresistible__bu      GLRNGLTAGPSSKSQPKSQPKTAAKVGAGVGATSDSESGGDE---
MSMEG_0200|M.smegmatis_MC2_155      AVKK-ATAKPTKKTQAGSQNNDNDKK--------DKDAA------
Mvan_3952|M.vanbaalenii_PYR-1       ---------------------------------------------
MAB_4141|M.abscessus_ATCC_1997      SVPGLSEKKNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA